JPS5441874A - Novel 2-substituted imidazole derivative - Google Patents

Novel 2-substituted imidazole derivative

Info

Publication number
JPS5441874A
JPS5441874A JP10764177A JP10764177A JPS5441874A JP S5441874 A JPS5441874 A JP S5441874A JP 10764177 A JP10764177 A JP 10764177A JP 10764177 A JP10764177 A JP 10764177A JP S5441874 A JPS5441874 A JP S5441874A
Authority
JP
Japan
Prior art keywords
formula
novel
iminoether
imidazole derivative
substituted imidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10764177A
Other languages
Japanese (ja)
Inventor
Toshio Atami
Yuzo Tarumi
Noboru Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP10764177A priority Critical patent/JPS5441874A/en
Priority to AU39492/78A priority patent/AU507066B1/en
Priority to CH931278A priority patent/CH636862A5/en
Priority to NL7809075A priority patent/NL7809075A/en
Priority to DK392578A priority patent/DK392578A/en
Priority to FR7825487A priority patent/FR2401916A1/en
Priority to GB7835686A priority patent/GB2004544B/en
Priority to AT0640778A priority patent/AT367412B/en
Priority to IT69049/78A priority patent/IT1160633B/en
Priority to BE6046598A priority patent/BE870236A/en
Priority to HU78SU989A priority patent/HU184188B/en
Priority to CA310,576A priority patent/CA1110623A/en
Priority to DE19782838892 priority patent/DE2838892A1/en
Priority to SE7809373A priority patent/SE442865B/en
Priority to US05/940,131 priority patent/US4218457A/en
Publication of JPS5441874A publication Critical patent/JPS5441874A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:Imidazole derivatives of formulaI(R is alkyl, cycloalkyl, adamantyl, aralkyl).
EXAMPLE: 2-Ethyl-5-hydroxy-imidazole-4-carboxamide.
USE: Medicines with carsinostatic activity. It shows no side effect of immunosuppresion and has low toxicity. PEPARATION:An iminoether of formula III (A is lower alkoxy, benzylthio) and its salt is reacted with aminomalonic amide in an organic solvent such as methanol at a reaction temperature of 0W100°C to afford the objective compound of formula I. Instead of the iminoether of formula II, an orthoester of formula III (B is lower alkyl) may be employed.
COPYRIGHT: (C)1979,JPO&Japio
JP10764177A 1977-09-06 1977-09-06 Novel 2-substituted imidazole derivative Pending JPS5441874A (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
JP10764177A JPS5441874A (en) 1977-09-06 1977-09-06 Novel 2-substituted imidazole derivative
AU39492/78A AU507066B1 (en) 1977-09-06 1978-09-01 2-Substituted-5-Hydroxy-1h-Imidazole 4-Carbozamide Derivatives
CH931278A CH636862A5 (en) 1977-09-06 1978-09-05 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE DERIVATIVES SUBSTITUTED IN 2-POSITION, THEIR SALTS AND PROCESS FOR THEIR PRODUCTION.
NL7809075A NL7809075A (en) 1977-09-06 1978-09-05 NEW 2-SUBSTITUATED 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE DERIVATIVES.
DK392578A DK392578A (en) 1977-09-06 1978-09-05 PROCEDURE FOR THE PREPARATION OF 2-SUBSTITUTED 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF
FR7825487A FR2401916A1 (en) 1977-09-06 1978-09-05 NEW DERIVATIVES OF 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE SUBSTITUTED IN POSITION 2, THEIR PRODUCTION PROCESS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM
GB7835686A GB2004544B (en) 1977-09-06 1978-09-05 2-substituted 5-hydroxy-1h-imidazole-4-carboxamide derivatives and their preparation and use
AT0640778A AT367412B (en) 1977-09-06 1978-09-05 METHOD FOR PRODUCING NEW 2-SUBSTITUTED 5-HYDROXY-1H-IMIDAZOLE-4CARBOXAMIDE DERIVATIVES AND THEIR SALTS
IT69049/78A IT1160633B (en) 1977-09-06 1978-09-05 2-SUBSTITUTED DERIVATIVES OF 5-HYDROXY-1H-IMIDAZOL-4-CARBOXAMIDE
BE6046598A BE870236A (en) 1977-09-06 1978-09-05 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE DERIVATIVES SUBSTITUTED IN POSITION 2, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING CZ COMPOUNDS
HU78SU989A HU184188B (en) 1977-09-06 1978-09-05 Process for the preparation of new 2-substituted-5.hydroxy-1h-imidazol-4-carboxamide derivatives
CA310,576A CA1110623A (en) 1977-09-06 1978-09-05 2-substituted 5-hydroxy-1h-imidazole-4-carboxamide derivatives and their preparation and use
DE19782838892 DE2838892A1 (en) 1977-09-06 1978-09-06 2-SUBSTITUTED-5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND THE PHARMACEUTICAL PRODUCTS CONTAINING THEM
SE7809373A SE442865B (en) 1977-09-06 1978-09-06 PHARMACEUTICAL ACTIVE 2-SUBSTITUTED-5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE DERIVATIVES
US05/940,131 US4218457A (en) 1977-09-06 1978-09-06 2-Substituted 5-hydroxy-1H-imidazole-4-carboxamide derivatives and use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP10764177A JPS5441874A (en) 1977-09-06 1977-09-06 Novel 2-substituted imidazole derivative

Publications (1)

Publication Number Publication Date
JPS5441874A true JPS5441874A (en) 1979-04-03

Family

ID=14464332

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10764177A Pending JPS5441874A (en) 1977-09-06 1977-09-06 Novel 2-substituted imidazole derivative

Country Status (1)

Country Link
JP (1) JPS5441874A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60124166A (en) * 1983-12-09 1985-07-03 Canon Inc Reader

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60124166A (en) * 1983-12-09 1985-07-03 Canon Inc Reader
JPH058617B2 (en) * 1983-12-09 1993-02-02 Canon Kk

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