JPS5441874A - Novel 2-substituted imidazole derivative - Google Patents
Novel 2-substituted imidazole derivativeInfo
- Publication number
- JPS5441874A JPS5441874A JP10764177A JP10764177A JPS5441874A JP S5441874 A JPS5441874 A JP S5441874A JP 10764177 A JP10764177 A JP 10764177A JP 10764177 A JP10764177 A JP 10764177A JP S5441874 A JPS5441874 A JP S5441874A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- novel
- iminoether
- imidazole derivative
- substituted imidazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 2-substituted imidazole Chemical class 0.000 title abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- ODUCDPQEXGNKDN-UHFFFAOYSA-N nitroxyl Chemical compound O=N ODUCDPQEXGNKDN-UHFFFAOYSA-N 0.000 abstract 2
- KNQHBAFIWGORKW-UHFFFAOYSA-N 2,3-diamino-3-oxopropanoic acid Chemical compound NC(=O)C(N)C(O)=O KNQHBAFIWGORKW-UHFFFAOYSA-N 0.000 abstract 1
- ADQDFOKEMISFDX-UHFFFAOYSA-N 2-ethyl-4-hydroxy-1h-imidazole-5-carboxamide Chemical compound CCC1=NC(C(N)=O)=C(O)N1 ADQDFOKEMISFDX-UHFFFAOYSA-N 0.000 abstract 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 231100000957 no side effect Toxicity 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 150000002905 orthoesters Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Abstract
NEW MATERIAL:Imidazole derivatives of formulaI(R is alkyl, cycloalkyl, adamantyl, aralkyl).
EXAMPLE: 2-Ethyl-5-hydroxy-imidazole-4-carboxamide.
USE: Medicines with carsinostatic activity. It shows no side effect of immunosuppresion and has low toxicity. PEPARATION:An iminoether of formula III (A is lower alkoxy, benzylthio) and its salt is reacted with aminomalonic amide in an organic solvent such as methanol at a reaction temperature of 0W100°C to afford the objective compound of formula I. Instead of the iminoether of formula II, an orthoester of formula III (B is lower alkyl) may be employed.
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (15)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10764177A JPS5441874A (en) | 1977-09-06 | 1977-09-06 | Novel 2-substituted imidazole derivative |
AU39492/78A AU507066B1 (en) | 1977-09-06 | 1978-09-01 | 2-Substituted-5-Hydroxy-1h-Imidazole 4-Carbozamide Derivatives |
CH931278A CH636862A5 (en) | 1977-09-06 | 1978-09-05 | 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE DERIVATIVES SUBSTITUTED IN 2-POSITION, THEIR SALTS AND PROCESS FOR THEIR PRODUCTION. |
NL7809075A NL7809075A (en) | 1977-09-06 | 1978-09-05 | NEW 2-SUBSTITUATED 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE DERIVATIVES. |
DK392578A DK392578A (en) | 1977-09-06 | 1978-09-05 | PROCEDURE FOR THE PREPARATION OF 2-SUBSTITUTED 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE DERIVATIVES OR PHARMACEUTICAL ACCEPTABLE SALTS THEREOF |
FR7825487A FR2401916A1 (en) | 1977-09-06 | 1978-09-05 | NEW DERIVATIVES OF 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE SUBSTITUTED IN POSITION 2, THEIR PRODUCTION PROCESS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM |
GB7835686A GB2004544B (en) | 1977-09-06 | 1978-09-05 | 2-substituted 5-hydroxy-1h-imidazole-4-carboxamide derivatives and their preparation and use |
AT0640778A AT367412B (en) | 1977-09-06 | 1978-09-05 | METHOD FOR PRODUCING NEW 2-SUBSTITUTED 5-HYDROXY-1H-IMIDAZOLE-4CARBOXAMIDE DERIVATIVES AND THEIR SALTS |
IT69049/78A IT1160633B (en) | 1977-09-06 | 1978-09-05 | 2-SUBSTITUTED DERIVATIVES OF 5-HYDROXY-1H-IMIDAZOL-4-CARBOXAMIDE |
BE6046598A BE870236A (en) | 1977-09-06 | 1978-09-05 | 5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE DERIVATIVES SUBSTITUTED IN POSITION 2, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING CZ COMPOUNDS |
HU78SU989A HU184188B (en) | 1977-09-06 | 1978-09-05 | Process for the preparation of new 2-substituted-5.hydroxy-1h-imidazol-4-carboxamide derivatives |
CA310,576A CA1110623A (en) | 1977-09-06 | 1978-09-05 | 2-substituted 5-hydroxy-1h-imidazole-4-carboxamide derivatives and their preparation and use |
DE19782838892 DE2838892A1 (en) | 1977-09-06 | 1978-09-06 | 2-SUBSTITUTED-5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE DERIVATIVES, THE PROCESS FOR THEIR MANUFACTURING AND THE PHARMACEUTICAL PRODUCTS CONTAINING THEM |
SE7809373A SE442865B (en) | 1977-09-06 | 1978-09-06 | PHARMACEUTICAL ACTIVE 2-SUBSTITUTED-5-HYDROXY-1H-IMIDAZOLE-4-CARBOXAMIDE DERIVATIVES |
US05/940,131 US4218457A (en) | 1977-09-06 | 1978-09-06 | 2-Substituted 5-hydroxy-1H-imidazole-4-carboxamide derivatives and use |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10764177A JPS5441874A (en) | 1977-09-06 | 1977-09-06 | Novel 2-substituted imidazole derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5441874A true JPS5441874A (en) | 1979-04-03 |
Family
ID=14464332
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10764177A Pending JPS5441874A (en) | 1977-09-06 | 1977-09-06 | Novel 2-substituted imidazole derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5441874A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60124166A (en) * | 1983-12-09 | 1985-07-03 | Canon Inc | Reader |
-
1977
- 1977-09-06 JP JP10764177A patent/JPS5441874A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS60124166A (en) * | 1983-12-09 | 1985-07-03 | Canon Inc | Reader |
JPH058617B2 (en) * | 1983-12-09 | 1993-02-02 | Canon Kk |
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