JPS5616474A - 5-fluorouracil derivative - Google Patents
5-fluorouracil derivativeInfo
- Publication number
- JPS5616474A JPS5616474A JP9045379A JP9045379A JPS5616474A JP S5616474 A JPS5616474 A JP S5616474A JP 9045379 A JP9045379 A JP 9045379A JP 9045379 A JP9045379 A JP 9045379A JP S5616474 A JPS5616474 A JP S5616474A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- fluorouracil
- compound
- lower acyl
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:5-Fluorouracil derivatives of formula I (R1 is H, lower acyl; R2 is lower alkyl, aryl, aralky).
EXAMPLE: 1-Acety1-3-carbobenzoxy-5-fluorouracil.
USE: Carcinostatic: they have high antitumorigenic activity.
PREPARATION: For example, the reaction of an N1-acy1-5-fluorouracil derivative of formula II (R3 is lower acyl) with a halogen compound of formula X-COOR2 (X is halogen) afford the compound of formula I where R1 is lower acyl. The compound bearing H as R1 is obtained by treating it in a protonic solvent.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9045379A JPS5616474A (en) | 1979-07-18 | 1979-07-18 | 5-fluorouracil derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9045379A JPS5616474A (en) | 1979-07-18 | 1979-07-18 | 5-fluorouracil derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5616474A true JPS5616474A (en) | 1981-02-17 |
Family
ID=13999031
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9045379A Pending JPS5616474A (en) | 1979-07-18 | 1979-07-18 | 5-fluorouracil derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5616474A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6794384B1 (en) | 1998-02-12 | 2004-09-21 | De Montfort University | Hydroxylation activated drug release |
-
1979
- 1979-07-18 JP JP9045379A patent/JPS5616474A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6794384B1 (en) | 1998-02-12 | 2004-09-21 | De Montfort University | Hydroxylation activated drug release |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPS568352A (en) | Aminoalkylvenzene derivative | |
JPS5432460A (en) | Cycloalkylidenemethylphenylacetic acid derivative and their preparation | |
JPS5395977A (en) | 1,4-dihydropyrimidine compounds and process for their preparation | |
JPS56103168A (en) | Thiazole derivative, its preparation, and antihistaminic agent containing the same | |
JPS5616474A (en) | 5-fluorouracil derivative | |
JPS5618989A (en) | Imidazole derivative and its preparation | |
JPS52118464A (en) | Alpha-substituted aminoalkanyloxyindole derivatives and method of preparing the same | |
JPS565462A (en) | Piperazinylalkoxyindanes and their acid addition salt | |
JPS5259169A (en) | Preparation of novel uracil derivatives | |
JPS5242883A (en) | Method of preparing thiosemicarbazones having carcinostatic activity | |
JPS5651460A (en) | Pyrimidine derivative, its preparation, and antitumor agent comprising its derivative | |
JPS5239674A (en) | Imidazole derivatives and agricultural bactericides therefrom | |
JPS554334A (en) | Pyranopyrazole derivative | |
JPS54106481A (en) | Novel 2,3-dioxopiperazine derivative and its preparation | |
JPS55100372A (en) | 5-fluorouracil derivative and its preparation | |
JPS5210279A (en) | A process for preparing uracil derivatives | |
JPS5265264A (en) | Preparation of furan derivatives | |
JPS51148025A (en) | Insecticides, miticides and their preparation | |
JPS5686165A (en) | Pyrazolidin-3-one derivative and its preparation | |
JPS51143697A (en) | A process for preparing novel pyrimido (4,5-d) pyrimidine derivatives | |
JPS5598171A (en) | 5-fluorouracil derivative and its preparation | |
JPS5231079A (en) | Preparation of uracil derivatives | |
JPS51136643A (en) | Process for preparation of aromatic ester derivatives | |
JPS5793971A (en) | Preparation of piperazine derivative | |
JPS55151581A (en) | Benzoxazine derivative and its preparation |