JPS535315B2 - - Google Patents
Info
- Publication number
- JPS535315B2 JPS535315B2 JP10683276A JP10683276A JPS535315B2 JP S535315 B2 JPS535315 B2 JP S535315B2 JP 10683276 A JP10683276 A JP 10683276A JP 10683276 A JP10683276 A JP 10683276A JP S535315 B2 JPS535315 B2 JP S535315B2
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7200505A FR2166314A1 (en) | 1972-01-07 | 1972-01-07 | 6-substd 5-(4-methyl 1-piperazinyl)carbonyloxy 7-oxo - 5,6-dihydro-pyrrolo (3,4-b)pyrazines - tranquillizers and anticonvuls |
| FR7239731A FR2205318A2 (en) | 1972-11-09 | 1972-11-09 | 6-substd 5-(4-methyl 1-piperazinyl)carbonyloxy 7-oxo - 5,6-dihydro-pyrrolo (3,4-b)pyrazines - tranquillizers and anticonvuls |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5248688A JPS5248688A (en) | 1977-04-18 |
| JPS535315B2 true JPS535315B2 (forum.php) | 1978-02-25 |
Family
ID=26216824
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP48000069A Expired JPS523952B2 (forum.php) | 1972-01-07 | 1973-01-05 | |
| JP51106832A Granted JPS5248688A (en) | 1972-01-07 | 1976-09-08 | Production of pyroro *3*44b* pyrazine derivative |
| JP51106831A Granted JPS5248687A (en) | 1972-01-07 | 1976-09-08 | Production of pyroro *3*44b* pyrazine derivative |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP48000069A Expired JPS523952B2 (forum.php) | 1972-01-07 | 1973-01-05 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP51106831A Granted JPS5248687A (en) | 1972-01-07 | 1976-09-08 | Production of pyroro *3*44b* pyrazine derivative |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US3862149A (forum.php) |
| JP (3) | JPS523952B2 (forum.php) |
| AR (1) | AR195097A1 (forum.php) |
| AT (1) | AT323181B (forum.php) |
| AU (1) | AU466586B2 (forum.php) |
| BE (1) | BE793730A (forum.php) |
| CA (1) | CA991183A (forum.php) |
| CY (1) | CY915A (forum.php) |
| DD (1) | DD102698A5 (forum.php) |
| DE (1) | DE2300491C3 (forum.php) |
| DK (1) | DK139359B (forum.php) |
| FI (1) | FI54124C (forum.php) |
| GB (1) | GB1358680A (forum.php) |
| HK (1) | HK60077A (forum.php) |
| HU (1) | HU164821B (forum.php) |
| IE (1) | IE37056B1 (forum.php) |
| IL (1) | IL41232A (forum.php) |
| LU (1) | LU66800A1 (forum.php) |
| NL (1) | NL7217852A (forum.php) |
| NO (1) | NO136843C (forum.php) |
| OA (1) | OA04285A (forum.php) |
| SE (1) | SE398503B (forum.php) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6297400U (forum.php) * | 1985-12-09 | 1987-06-20 |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2322601A1 (fr) * | 1975-09-04 | 1977-04-01 | Rhone Poulenc Ind | Nouveaux derives de l'isoindoline, leur preparation et les compositions qui les contiennent |
| AR208414A1 (es) * | 1974-11-07 | 1976-12-27 | Rhone Poulenc Ind | Procedimiento para obtener nuevos derivados de la((acil-4piperazinil-1)carboniloxi-5 pirrolinona-2) |
| US4590189A (en) * | 1982-04-02 | 1986-05-20 | Takeda Chemical Industries, Ltd. | Condensed pyrrolinone derivatives, their production and use |
| JPS6169773A (ja) * | 1984-09-14 | 1986-04-10 | Takeda Chem Ind Ltd | イソインドリノン誘導体 |
| FR2607504B1 (fr) * | 1986-12-02 | 1989-01-27 | Rhone Poulenc Sante | Nouveaux derives de l'isoindolinone, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2671800B1 (fr) * | 1991-01-17 | 1993-03-12 | Rhone Poulenc Rorer Sa | Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent. |
| AU3275993A (en) * | 1991-12-02 | 1993-06-28 | Sepracor, Inc. | Methods and compositions for treating sleep disorders, convulsive seizures, and other disorders using optically pure (-) zopiclone |
| US5786357A (en) | 1991-12-02 | 1998-07-28 | Sepracor Inc. | Methods and compositions for treating sleep disorders, convulsive seizures and other disorders using optically pure (+) zopiclone |
| AU3245593A (en) * | 1991-12-02 | 1993-06-28 | Sepracor, Inc. | Methods and compositions for treating sleep disorders, convulsive seizures, and other disorders using optically pure (+) zopiclone |
| US6348485B1 (en) | 1998-06-09 | 2002-02-19 | Takeda Chemical Industries, Ltd. | Method for treating or preventing sleep disorders |
| US6339086B1 (en) * | 1999-05-14 | 2002-01-15 | Swpracor, Inc. | Methods of making and using N-desmethylzopiclone |
| ES2203319B1 (es) * | 2002-04-03 | 2005-03-01 | Universidad De Oviedo | Nuevos carbonatos opticamente activos como intermedios en la sintesis de (+)-zopiclona. |
| US20050176680A1 (en) | 2003-12-11 | 2005-08-11 | Sepracor, Inc. | Combination of sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression |
| CA2614209A1 (en) * | 2005-07-06 | 2007-01-11 | Sepracor Inc. | Combinations of eszopiclone and o-desmethylvenlafaxine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders |
| AU2006264317B2 (en) | 2005-07-06 | 2012-02-23 | Sunovion Pharmaceuticals Inc. | Combinations of eszopiclone and trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine, and methods of treatment of menopause and mood, anxiety, and cognitive disorders |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| CA2620333A1 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| US7476737B2 (en) * | 2005-09-05 | 2009-01-13 | Dr. Reddy's Laboratories Limited | Eszopiclone process |
| JP2009512711A (ja) | 2005-10-21 | 2009-03-26 | ブレインセルス，インコーポレイティド | Ｐｄｅ阻害による神経新生の調節 |
| EP2314289A1 (en) | 2005-10-31 | 2011-04-27 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| EP1984371A1 (en) * | 2006-02-03 | 2008-10-29 | Synthon B.V. | Zopiclone resolution using l-tartaric acid |
| US20100216734A1 (en) * | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| EP1991212A1 (en) * | 2006-03-08 | 2008-11-19 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| WO2007109799A2 (en) * | 2006-03-23 | 2007-09-27 | Teva Pharmaceutical Industries Ltd. | Polymorphs of eszopiclone malate |
| WO2007124025A2 (en) * | 2006-04-20 | 2007-11-01 | Teva Pharmaceutical Industries Ltd. | Methods for preparing eszopiclone crystalline form a, substantially pure eszopiclone and optically enriched eszopiclone |
| CN101058581B (zh) * | 2006-04-21 | 2011-06-08 | 天津天士力集团有限公司 | 右佐匹克隆中间体6-(5-氯-2-吡啶基)-5,7-二氧代-6,7-二氢-5H-吡咯并[3,4-b]吡嗪的制备方法 |
| US20100009983A1 (en) * | 2006-05-09 | 2010-01-14 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| CA2651862A1 (en) * | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| US20080015197A1 (en) * | 2006-06-26 | 2008-01-17 | Alex Mainfeld | Process for the preparatrion of zopiclone |
| KR20090064418A (ko) * | 2006-09-08 | 2009-06-18 | 브레인셀즈 인코퍼레이션 | 4-아실아미노피리딘 유도체 포함 조합물 |
| US20080103165A1 (en) * | 2006-09-19 | 2008-05-01 | Braincells, Inc. | Ppar mediated modulation of neurogenesis |
| US7786304B2 (en) * | 2006-11-06 | 2010-08-31 | Centaur Pharmaceutical Pvt. Ltd. | Process for the preparation of eszopiclone |
| WO2008094690A2 (en) * | 2007-01-31 | 2008-08-07 | Teva Pharmaceutical Industries Ltd. | Methods for preparing eszopiclone |
| US20080305171A1 (en) * | 2007-06-07 | 2008-12-11 | Kristin Anne Arnold | Pyrrolopyrazine, formulations, methods of manufacture, and methods of use there |
| US20090018336A1 (en) * | 2007-06-25 | 2009-01-15 | Nina Finkelstein | Racemization process of R-zopiclone |
| EP2020403A1 (en) | 2007-08-02 | 2009-02-04 | Esteve Quimica, S.A. | Process for the resolution of zopiclone and intermediate compounds |
| WO2009063486A2 (en) * | 2007-08-06 | 2009-05-22 | Usv Limited | Process for preparation of dextrorotatory isomer of 6-(5-chloro-pyrid-2-yi)-5-[(4-methyl -1-piperazinyl) carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo [3,4-b] pyrazine (eszopiclone) |
| JP2011506427A (ja) * | 2007-12-11 | 2011-03-03 | シプラ・リミテッド | ゾピクロンおよびその多形相の新規製造方法 |
| US8198278B2 (en) * | 2007-12-19 | 2012-06-12 | Sunovion Pharmaceuticals Inc. | Besylate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine |
| US8212036B2 (en) | 2007-12-19 | 2012-07-03 | Sunovion Pharmaceuticals Inc. | Maleate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine |
| CA2747000C (en) * | 2007-12-19 | 2013-09-03 | Sunovion Pharmaceuticals Inc. | Maleate, besylate, and l-malate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5h-pyrrolo[3,4-b]pyrazine |
| US8268832B2 (en) * | 2007-12-19 | 2012-09-18 | Sunovion Pharmaceuticals Inc. | Maleate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine |
| US8198277B2 (en) * | 2007-12-19 | 2012-06-12 | Sunovion Pharmaceuticals Inc. | L-malate salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine |
| US8269005B2 (en) * | 2007-12-19 | 2012-09-18 | Sunovion Pharmaceuticals Inc. | L-malate salts of 6-(5-chloro-2-Pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-Oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine |
| WO2009085988A1 (en) * | 2007-12-19 | 2009-07-09 | Sepracor Inc. | Salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7- dihydro-5h-pyrrolo[3,4-b]pyrazine |
| CN100467471C (zh) * | 2007-12-19 | 2009-03-11 | 齐鲁天和惠世制药有限公司 | 佐匹克隆的制备方法 |
| JP2012516348A (ja) | 2009-01-30 | 2012-07-19 | サノビオン ファーマシューティカルズ インク | ６−（５−クロロ−２−ピリジル）−５−［（４−メチル−１−ピペラジニル）カルボニルオキシ］−７−オキソ−６，７−ジヒドロ−５Ｈ−ピロロ［３，４−ｂ］ピラジンの被覆錠剤及びコーティングの効果を測定する方法 |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| CN105399745A (zh) * | 2015-12-17 | 2016-03-16 | 天津华津制药有限公司 | 一种吡嗪并羟基吡咯烷酮类化合物的制备方法 |
| EP3468545A4 (en) | 2016-06-08 | 2020-07-22 | President and Fellows of Harvard College | METHODS AND COMPOSITIONS FOR REDUCING TACTILE DYSFUNCTION AND ANXIETY ASSOCIATED WITH AUTISM SPECTRUM DISORDER, RETT SYNDROME AND FRAGILE X SYNDROME |
| CN106220630B (zh) * | 2016-07-23 | 2019-12-10 | 迪嘉药业集团有限公司 | 一种n-取代吡咯并[3,4-b]吡嗪-5,7(6h)-二酮的制备方法 |
| EP3797097A4 (en) | 2018-05-22 | 2022-03-09 | President and Fellows of Harvard College | Compositions and methods for reducing tactile dysfunction, anxiety, and social impairment |
| EP3801512A4 (en) | 2018-05-29 | 2022-01-19 | President and Fellows of Harvard College | COMPOSITIONS AND METHODS FOR REDUCING TOUCH DYSFUNCTION, ANXIETY AND SOCIAL DISABILITY |
| EP3946390A4 (en) | 2019-03-25 | 2022-12-21 | President and Fellows of Harvard College | COMPOSITIONS AND METHODS TO REDUCE TACTILE DYSFUNCTION, ANXIETY AND SOCIAL DISABILITIES |
| CN114437027A (zh) * | 2021-12-22 | 2022-05-06 | 深圳市祥根生物医药有限公司 | 一种佐匹克隆n-氧化杂质的制备方法 |
-
1972
- 1972-12-14 OA OA54780A patent/OA04285A/xx unknown
- 1972-12-28 DD DD167951A patent/DD102698A5/xx unknown
- 1972-12-29 US US319876A patent/US3862149A/en not_active Expired - Lifetime
- 1972-12-29 NL NL7217852A patent/NL7217852A/xx unknown
-
1973
- 1973-01-04 AU AU50754/73A patent/AU466586B2/en not_active Expired
- 1973-01-04 HU HURO691A patent/HU164821B/hu unknown
- 1973-01-04 IL IL41232A patent/IL41232A/xx unknown
- 1973-01-04 IE IE12/73A patent/IE37056B1/xx unknown
- 1973-01-05 JP JP48000069A patent/JPS523952B2/ja not_active Expired
- 1973-01-05 CA CA160,620A patent/CA991183A/fr not_active Expired
- 1973-01-05 SE SE7300159A patent/SE398503B/xx active Protection Beyond IP Right Term
- 1973-01-05 GB GB79073A patent/GB1358680A/en not_active Expired
- 1973-01-05 AR AR246000A patent/AR195097A1/es active
- 1973-01-05 AT AT10073A patent/AT323181B/de active
- 1973-01-05 NO NO62/73A patent/NO136843C/no unknown
- 1973-01-05 DK DK6973AA patent/DK139359B/da not_active IP Right Cessation
- 1973-01-05 BE BE793730D patent/BE793730A/xx active Protection Beyond IP Right Term
- 1973-01-05 FI FI27/73A patent/FI54124C/fi active
- 1973-01-05 LU LU66800A patent/LU66800A1/xx unknown
- 1973-01-05 DE DE2300491A patent/DE2300491C3/de not_active Expired
- 1973-01-05 CY CY915A patent/CY915A/xx unknown
-
1976
- 1976-09-08 JP JP51106832A patent/JPS5248688A/ja active Granted
- 1976-09-08 JP JP51106831A patent/JPS5248687A/ja active Granted
-
1977
- 1977-12-01 HK HK600/77A patent/HK60077A/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6297400U (forum.php) * | 1985-12-09 | 1987-06-20 |
Also Published As
| Publication number | Publication date |
|---|---|
| AR195097A1 (es) | 1973-09-10 |
| SE398503B (sv) | 1977-12-27 |
| IL41232A (en) | 1975-12-31 |
| DE2300491A1 (de) | 1973-07-19 |
| NO136843C (no) | 1977-11-16 |
| FI54124C (fi) | 1978-10-10 |
| IE37056L (en) | 1973-07-07 |
| JPS5231358B2 (forum.php) | 1977-08-13 |
| NO136843B (no) | 1977-08-08 |
| JPS5248687A (en) | 1977-04-18 |
| NL7217852A (forum.php) | 1973-07-10 |
| HK60077A (en) | 1977-12-09 |
| HU164821B (forum.php) | 1974-04-11 |
| AU5075473A (en) | 1974-07-04 |
| OA04285A (fr) | 1979-12-31 |
| BE793730A (fr) | 1973-07-05 |
| AU466586B2 (en) | 1975-10-30 |
| JPS4876892A (forum.php) | 1973-10-16 |
| DE2300491C3 (de) | 1978-05-18 |
| FI54124B (fi) | 1978-06-30 |
| CY915A (en) | 1977-12-23 |
| DE2300491B2 (de) | 1977-09-08 |
| LU66800A1 (forum.php) | 1973-07-18 |
| CA991183A (fr) | 1976-06-15 |
| DK139359C (forum.php) | 1979-07-09 |
| US3862149A (en) | 1975-01-21 |
| JPS523952B2 (forum.php) | 1977-01-31 |
| IE37056B1 (en) | 1977-04-27 |
| IL41232A0 (en) | 1973-03-30 |
| GB1358680A (en) | 1974-07-03 |
| DD102698A5 (forum.php) | 1973-12-20 |
| AT323181B (de) | 1975-06-25 |
| DK139359B (da) | 1979-02-05 |
| JPS5248688A (en) | 1977-04-18 |