JPS53137940A - Polyene compounds - Google Patents

Polyene compounds

Info

Publication number
JPS53137940A
JPS53137940A JP5241878A JP5241878A JPS53137940A JP S53137940 A JPS53137940 A JP S53137940A JP 5241878 A JP5241878 A JP 5241878A JP 5241878 A JP5241878 A JP 5241878A JP S53137940 A JPS53137940 A JP S53137940A
Authority
JP
Japan
Prior art keywords
polyene compounds
polyene
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP5241878A
Other languages
English (en)
Japanese (ja)
Other versions
JPS6332777B2 (OSRAM
Inventor
Peter Loeliger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JPS53137940A publication Critical patent/JPS53137940A/ja
Publication of JPS6332777B2 publication Critical patent/JPS6332777B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/38—Alcohols containing six-membered aromatic rings and other rings and having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/50—Halogenated unsaturated alcohols containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
    • C07C49/792—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5456—Arylalkanephosphonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP5241878A 1977-05-04 1978-05-02 Polyene compounds Granted JPS53137940A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU77254A LU77254A1 (OSRAM) 1977-05-04 1977-05-04

Publications (2)

Publication Number Publication Date
JPS53137940A true JPS53137940A (en) 1978-12-01
JPS6332777B2 JPS6332777B2 (OSRAM) 1988-07-01

Family

ID=19728555

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5241878A Granted JPS53137940A (en) 1977-05-04 1978-05-02 Polyene compounds

Country Status (32)

Country Link
US (1) US4193931A (OSRAM)
JP (1) JPS53137940A (OSRAM)
AR (1) AR220704A1 (OSRAM)
AT (1) AT356647B (OSRAM)
AU (1) AU522598B2 (OSRAM)
BE (1) BE866651A (OSRAM)
BR (1) BR7802807A (OSRAM)
CA (1) CA1114830A (OSRAM)
CH (2) CH641755A5 (OSRAM)
CS (1) CS214853B2 (OSRAM)
CU (1) CU21105A (OSRAM)
DE (1) DE2819213A1 (OSRAM)
DK (1) DK155730C (OSRAM)
ES (2) ES469394A1 (OSRAM)
FI (1) FI66587C (OSRAM)
FR (1) FR2390428A1 (OSRAM)
GB (2) GB1600914A (OSRAM)
GR (1) GR74426B (OSRAM)
HU (1) HU183088B (OSRAM)
IE (1) IE46946B1 (OSRAM)
IL (2) IL54590A (OSRAM)
IT (1) IT1096278B (OSRAM)
LU (1) LU77254A1 (OSRAM)
MC (1) MC1193A1 (OSRAM)
MY (1) MY8500250A (OSRAM)
NL (1) NL7804773A (OSRAM)
NO (1) NO148290C (OSRAM)
NZ (1) NZ187114A (OSRAM)
PH (1) PH14216A (OSRAM)
PT (1) PT67988B (OSRAM)
SE (1) SE436644B (OSRAM)
ZA (1) ZA782415B (OSRAM)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07112952A (ja) * 1993-09-02 1995-05-02 F Hoffmann La Roche Ag 芳香族カルボン酸誘導体及び皮膚・粘膜治療剤
KR20200060459A (ko) * 2017-09-28 2020-05-29 존슨 앤드 존슨 컨수머 인코포레이티드 화장 조성물 및 피부 치료 방법

Families Citing this family (51)

* Cited by examiner, † Cited by third party
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US4216312A (en) 1978-08-24 1980-08-05 Hoffmann-La Roche Inc. Furyl substituted polyenes
FI67386C (fi) * 1979-06-21 1985-03-11 Hoffmann La Roche Foerfarande foer framstaellning av nya terapeutiskt anvaendbara sockerderivat
CH651007A5 (de) * 1982-06-24 1985-08-30 Hoffmann La Roche Polyenverbindungen.
DK158947C (da) * 1982-07-06 1991-01-21 Hoffmann La Roche Tetrahydronaphthalin-,benzofuran- og benzothiophenderivater, fremstilling og anvendelse deraf samt rodenticid indeholdende saadanne derivater
US4529600A (en) * 1982-09-09 1985-07-16 Sri International Pentadeuterioretinoids
US4439614A (en) * 1982-09-22 1984-03-27 Sri International 5,6-Methano-5,6-dihydroretinoids
US4464389A (en) * 1982-10-20 1984-08-07 Sri International Esters of retinoic acid and pentaerythritol and monobenzal acetals thereof
US4539154A (en) * 1983-06-15 1985-09-03 Hoffmann-La Roche Inc. Polyene compounds
CH661516A5 (de) * 1983-12-08 1987-07-31 Hoffmann La Roche Phenylnonatetraenoylzuckerderivate.
CH667868A5 (fr) * 1984-09-05 1988-11-15 Oreal Derives du benzonorbornene, leurs procedes de preparation et compositions medicamenteuse et cosmetique les contenant.
FR2580277B1 (fr) * 1985-04-15 1988-06-10 Oreal Nouveaux derives naphtaleniques a action retinoique, le ur procede de preparation et compositions medicamenteuse et cosmetique les contenant
ZW7487A1 (en) * 1986-05-23 1987-12-16 Hoffmann La Roche Tetrahydronaphthaline and indane derivatives
US5030765A (en) * 1986-05-23 1991-07-09 Hoffmann-La Roche Inc. Novel tetrahydronaphthalene and indane derivatives
US5030764A (en) * 1986-05-23 1991-07-09 Hoffmann-La Roche Inc. Novel tetrahydronaphthalene and indane derivatives
AT388728B (de) * 1987-03-17 1989-08-25 Hoffmann La Roche Neue tetrahydronaphthalin- und indanderivate
US5250562A (en) * 1988-02-24 1993-10-05 Hoffmann-La Roche Inc. Stilbene derivatives
US5248696A (en) * 1991-04-18 1993-09-28 World Research Institute For Science And Technology, Inc. Composition and method for treating tumors
US5780676A (en) * 1992-04-22 1998-07-14 Ligand Pharmaceuticals Incorporated Compounds having selective activity for Retinoid X Receptors, and means for modulation of processes mediated by Retinoid X Receptors
US7655699B1 (en) 1992-04-22 2010-02-02 Eisai Inc. Compounds having selective activity for retinoid X receptors, and means for modulation of processes mediated by retinoid X receptors
FR2719041B1 (fr) * 1994-04-26 1996-05-31 Cird Galderma Nouveaux composés polyéniques, compositions pharmaceutiques et cosmétiques les contenant et utilisations.
CN1121374C (zh) * 1994-12-30 2003-09-17 配位体药物股份有限公司 新的三烯类视黄酸化合物及方法
US7115728B1 (en) 1995-01-30 2006-10-03 Ligand Pharmaceutical Incorporated Human peroxisome proliferator activated receptor γ
BR9610875A (pt) 1995-10-06 1999-07-13 Ligand Pharm Inc Modulares rxr seletivos - dimeros e processos para seu uso
US6112489A (en) * 1995-12-12 2000-09-05 Monotech International, Inc. Monocoque concrete structures
WO1998007716A2 (en) * 1996-08-23 1998-02-26 The Board Of Regents For Oklahoma State University Heteroarotinoids-anticancer agents with receptor specificity and tgase activity
FR2752837B1 (fr) * 1996-09-02 1999-11-12 Cird Galderma Nouveaux composes modulateurs des recepteurs hormonaux, les compositions les comprenant et leur utilisation en therapie
AU8588798A (en) * 1997-07-25 1999-02-16 Institut Pasteur Human peroxisome proliferator activated receptor gamma (ppargamma) gene re gulatory sequences and uses therefor
US6534545B1 (en) 1997-09-25 2003-03-18 Galderma Research & Development Unsaturated derivatives at the 4-position of 6-tert-butyl-1,1-dimethylindane and their use in human and veterinary medicine and cosmetics
FR2768731B1 (fr) 1997-09-25 1999-12-10 Cird Galderma Derives insatures en position -4 du 6-tert-butyl-1,1- dimethylindane et leur utilisation en medecine humaine ou veterinaire ainsi qu'en cosmetique
JP2003520758A (ja) * 1998-06-12 2003-07-08 リガンド・ファーマシューティカルズ・インコーポレイテッド 抗エストロゲン耐性乳癌のｒｘｒモジュレーターを用いた処置
US6566372B1 (en) * 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
AU6941200A (en) 1999-08-27 2001-03-26 Ligand Pharmaceuticals Incorporated 8-substituted-6-trifluoromethyl-9-pyrido(3,2-g)quinoline compounds as androgen receptor modulators
CZ2002711A3 (cs) * 1999-08-27 2003-11-12 Ligand Pharmaceuticals Incorporated Modulátory androgenních receptorů, způsoby jejich výroby a způsoby jejich použití
JP2003529545A (ja) 1999-09-14 2003-10-07 リガンド・ファーマシューティカルズ・インコーポレイテッド 改善された薬理学的プロファイルを有するｒｘｒモジュレーター
US8026280B2 (en) 2001-03-27 2011-09-27 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US7312247B2 (en) * 2001-03-27 2007-12-25 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US6495719B2 (en) * 2001-03-27 2002-12-17 Circagen Pharmaceutical Histone deacetylase inhibitors
US7842727B2 (en) * 2001-03-27 2010-11-30 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US6586460B1 (en) 2001-04-02 2003-07-01 The Board Of Regents For Oklahoma State University Heteroarotinoids containing urea or thiourea linker
EP1511477A4 (en) * 2002-05-22 2008-04-09 Errant Gene Therapeutics Llc HISTONE DEACETYLASE INHIBITORS BASED ON ALPHA-KETO-EPOXYDE COMPOUNDS
WO2004046104A2 (en) * 2002-11-20 2004-06-03 Errant Gene Therapeutics, Llc Treatment of lung cells with histone deacetylase inhibitors
US9050310B2 (en) * 2004-06-25 2015-06-09 Minas Theodore Coroneo Treatment of ocular lesions
EP1817020A4 (en) * 2004-11-08 2012-11-21 Errant Gene Therapeutics Inc INHIBITORS OF HISTONATE ACETYLASE
US20060204474A1 (en) * 2005-02-25 2006-09-14 Coroneo Minas T Treatment of epithelial layer lesions
WO2012076842A1 (en) * 2010-12-09 2012-06-14 University Of Durham Synthetic retinoids for control of cell differentiation
US11045441B2 (en) 2015-10-13 2021-06-29 Wisconsin Alumni Research Foundation Use of retinoic acid and analogs thereof to treat central neural apneas
US10966948B2 (en) 2019-07-23 2021-04-06 Johnson & Johnson Surgical Vision, Inc. Compositions and methods for treating the eye
US20200030226A1 (en) 2018-07-27 2020-01-30 Johnson & Johnson Consumer Inc. Botanical and bacterial extracts displaying retinol-like activity
US11197841B2 (en) 2019-07-23 2021-12-14 Johnson & Johnson Surgical Vision, Inc. Compositions and methods for treating the eye
BR112021000724A2 (pt) * 2018-07-27 2021-04-13 Johnson & Johnson Surgical Vision, Inc. Composições e métodos para tratar os olhos
US11969454B2 (en) 2019-11-19 2024-04-30 Johnson & Johnson Surgical Vision, Inc. Compositions and methods for treating the eye

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3452085A (en) * 1966-02-11 1969-06-24 Carbo Erba Spa Alpha-(5-indanyl)-butyric acid
US3781314A (en) * 1971-07-14 1973-12-25 Hoffmann La Roche Polyene compounds
BE793108A (fr) * 1971-12-22 1973-06-21 Hoffmann La Roche Derives polyeniques
DE2431198C2 (de) * 1973-07-02 1987-04-30 Takeda Chemical Industries, Ltd., Osaka Chinonderivate und sie enthaltende pharmazeutische Zubereitungen
CH582668A5 (OSRAM) * 1973-08-10 1976-12-15 Hoffmann La Roche
CH585709A5 (OSRAM) * 1973-08-24 1977-03-15 Hoffmann La Roche
CH592598A5 (OSRAM) * 1973-10-30 1977-10-31 Hexachimie
AR206619A1 (es) * 1974-02-07 1976-08-06 Hexachimie Procedimiento para peparar acidos 5-indanilaceticos
FR2276035A1 (fr) * 1974-06-28 1976-01-23 Lipha Nouveaux derives de l'indane
JPS51125235A (en) * 1974-09-26 1976-11-01 Hoffmann La Roche Preparation of polyene compounds
US4054589A (en) * 1974-09-26 1977-10-18 Hoffmann-La Roche Inc. Novel 9-substituted phenyl-3,7-dimethyl-nona-2,4,6,8-tetraene esters

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07112952A (ja) * 1993-09-02 1995-05-02 F Hoffmann La Roche Ag 芳香族カルボン酸誘導体及び皮膚・粘膜治療剤
KR20200060459A (ko) * 2017-09-28 2020-05-29 존슨 앤드 존슨 컨수머 인코포레이티드 화장 조성물 및 피부 치료 방법
JP2020535202A (ja) * 2017-09-28 2020-12-03 ジョンソン・アンド・ジョンソン・コンシューマー・インコーポレイテッドＪｏｈｎｓｏｎ ＆ Ｊｏｈｎｓｏｎ Ｃｏｎｓｕｍｅｒ Ｉｎｃ． 化粧品組成物及び皮膚の処置方法

Also Published As

Publication number Publication date
PT67988B (en) 1980-05-05
MY8500250A (en) 1985-12-31
SE436644B (sv) 1985-01-14
AU522598B2 (en) 1982-06-17
ZA782415B (en) 1979-04-25
NL7804773A (nl) 1978-11-07
NZ187114A (en) 1980-11-14
LU77254A1 (OSRAM) 1979-01-18
GB1600914A (en) 1981-10-21
DE2819213A1 (de) 1978-11-16
IL54590A (en) 1982-02-28
CH641755A5 (de) 1984-03-15
NO781586L (no) 1978-11-07
CU21105A (es) 1981-12-04
FR2390428A1 (fr) 1978-12-08
HU183088B (en) 1984-04-28
IT7823003A0 (it) 1978-05-04
DK155730B (da) 1989-05-08
ATA320478A (de) 1979-10-15
SE7805136L (sv) 1978-11-05
DK195378A (da) 1978-11-05
US4193931A (en) 1980-03-18
IT1096278B (it) 1985-08-26
DK155730C (da) 1989-10-02
CA1114830A (en) 1981-12-22
CS214853B2 (en) 1982-06-25
FI781227A7 (fi) 1978-11-05
BR7802807A (pt) 1979-01-02
ES475240A1 (es) 1979-05-16
DE2819213C2 (OSRAM) 1987-09-24
CH642380A5 (de) 1984-04-13
FI66587B (fi) 1984-07-31
NO148290C (no) 1983-09-14
GR74426B (OSRAM) 1984-06-28
AU3576278A (en) 1979-11-08
PH14216A (en) 1981-04-02
FR2390428B1 (OSRAM) 1983-03-04
GB1600915A (en) 1981-10-21
IL54590A0 (en) 1978-07-31
AT356647B (de) 1980-05-12
IE46946B1 (en) 1983-11-16
JPS6332777B2 (OSRAM) 1988-07-01
BE866651A (fr) 1978-11-03
AR220704A1 (es) 1980-11-28
NO148290B (no) 1983-06-06
FI66587C (fi) 1984-11-12
IE780864L (en) 1978-11-04
IL61697A0 (en) 1981-01-30
ES469394A1 (es) 1979-02-01
MC1193A1 (fr) 1979-02-23
PT67988A (en) 1978-06-01

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