JPS4993346A - - Google Patents

Info

Publication number
JPS4993346A
JPS4993346A JP48118585A JP11858573A JPS4993346A JP S4993346 A JPS4993346 A JP S4993346A JP 48118585 A JP48118585 A JP 48118585A JP 11858573 A JP11858573 A JP 11858573A JP S4993346 A JPS4993346 A JP S4993346A
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP48118585A
Other languages
Japanese (ja)
Other versions
JPS5940811B2 (ja
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of JPS4993346A publication Critical patent/JPS4993346A/ja
Publication of JPS5940811B2 publication Critical patent/JPS5940811B2/ja
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28Halogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/38Heterocyclic compounds having sulfur as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/76Unsaturated compounds containing keto groups
    • C07C59/84Unsaturated compounds containing keto groups containing six membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46Oxygen atoms
    • C07D213/50Ketonic radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10Oxygen atoms
    • C07D309/12Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/16Radicals substituted by halogen atoms or nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/20Free hydroxyl or mercaptan
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
JP48118585A 1972-10-24 1973-10-23 アロイル置換フエニル酢酸誘導体類の製造方法 Expired JPS5940811B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US30007972A 1972-10-24 1972-10-24
US39587773A 1973-09-10 1973-09-10
US395877 1973-09-10
US300079 1989-01-19

Publications (2)

Publication Number Publication Date
JPS4993346A true JPS4993346A (tr) 1974-09-05
JPS5940811B2 JPS5940811B2 (ja) 1984-10-03

Family

ID=26971576

Family Applications (2)

Application Number Title Priority Date Filing Date
JP48118585A Expired JPS5940811B2 (ja) 1972-10-24 1973-10-23 アロイル置換フエニル酢酸誘導体類の製造方法
JP57093264A Expired JPS5938237B2 (ja) 1972-10-24 1982-06-02 アロイル置換フエニル酢酸誘導体類の製法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP57093264A Expired JPS5938237B2 (ja) 1972-10-24 1982-06-02 アロイル置換フエニル酢酸誘導体類の製法

Country Status (24)

Country Link
JP (2) JPS5940811B2 (tr)
AT (1) AT333269B (tr)
BE (1) BE806389A (tr)
BG (1) BG25209A3 (tr)
CA (1) CA1007643A (tr)
CH (1) CH597219A5 (tr)
CS (1) CS183719B2 (tr)
DD (1) DD110044A5 (tr)
DE (1) DE2353357C2 (tr)
DK (1) DK154899C (tr)
ES (1) ES419871A1 (tr)
FI (1) FI66369C (tr)
FR (1) FR2203635B1 (tr)
GB (1) GB1446239A (tr)
HU (1) HU168046B (tr)
IE (1) IE38402B1 (tr)
IL (1) IL43570A (tr)
LU (1) LU68666A1 (tr)
NL (1) NL179583C (tr)
NO (1) NO141651C (tr)
PH (1) PH12124A (tr)
SE (1) SE403911B (tr)
SU (1) SU719490A3 (tr)
YU (1) YU37106B (tr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5538339A (en) * 1978-09-12 1980-03-17 Taiyo Yakuhin Kogyo Kk Preparation of 2- 4-(2-thienylcarbonyl)phenyl propionic acid
JPS5538340A (en) * 1978-09-12 1980-03-17 Taiyo Yakuhin Kogyo Kk Preparation of 2- 4-(2-thienylcarbonyl)phenyl propionic acid
JPS55104216A (en) * 1979-02-02 1980-08-09 Sagami Chem Res Center Production of substituted arylacetic acid derivative
JPS55104276A (en) * 1979-02-02 1980-08-09 Sagami Chem Res Center Ketal derivative
JP2016130241A (ja) * 2016-02-05 2016-07-21 テックフィールズ バイオケム カンパニー リミテッド 非常に速い皮膚透過率を有するアリール−及びヘテロアリールプロピオン酸の正荷電水溶性プロドラッグ

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1036466B (it) * 1975-07-08 1979-10-30 Sigurta Farmaceutici Spa Processo per la preparazione di derivati dell acido alfa fenilpropionico
FR2374033A1 (fr) * 1976-12-16 1978-07-13 Rhone Poulenc Ind Nouveaux acides thieno (3,2-b) thienylcarbonylphenylalcanoiques, leurs derives, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2345148A1 (fr) * 1976-03-24 1977-10-21 Lipha Nouvel acide propionique substitue, preparation et application
GB1569404A (en) * 1977-04-22 1980-06-11 Soc D Etudes Prod Chimique (2-isopropyl-4-(2'-theonyl)-5-methyl) phenoxy acetic acid
GB2030131B (en) * 1978-09-12 1982-12-22 Taiyo Pharma Ind Process for producing 2-(4-(2-thienyl-carbonyl) phenyl) propionic acid
ES479300A1 (es) * 1979-04-04 1979-07-01 Cusi Lab Procedimiento de obtencio de &-metil, 4(2'tienil carbonilz) fenil acetato de p-acetamido fenol.
EP0046337A3 (en) * 1980-08-20 1982-09-15 Imperial Chemical Industries Plc Triazole compounds, a process for preparing them, their use as plant and pharmaceutical fungicides and as plant growth regulators and compositions containing them
CA2023954C (en) * 1989-10-17 1999-05-04 Hiroyuki Nohira Process for the optical resolution of 2-(3-benzoyl) phenylpropionic acid

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1226344A (tr) * 1967-07-31 1971-03-24
FR2113760A1 (en) * 1970-11-10 1972-06-30 Roussel Uclaf 5-Arylcarbonyl-3(or 4)-methylthien-2-yl alkanoic acids and esters - with antiinflammatory and analgesic activity

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5538339A (en) * 1978-09-12 1980-03-17 Taiyo Yakuhin Kogyo Kk Preparation of 2- 4-(2-thienylcarbonyl)phenyl propionic acid
JPS5538340A (en) * 1978-09-12 1980-03-17 Taiyo Yakuhin Kogyo Kk Preparation of 2- 4-(2-thienylcarbonyl)phenyl propionic acid
JPS5728709B2 (tr) * 1978-09-12 1982-06-18
JPS5728708B2 (tr) * 1978-09-12 1982-06-18
JPS55104216A (en) * 1979-02-02 1980-08-09 Sagami Chem Res Center Production of substituted arylacetic acid derivative
JPS55104276A (en) * 1979-02-02 1980-08-09 Sagami Chem Res Center Ketal derivative
JPS5823873B2 (ja) * 1979-02-02 1983-05-18 財団法人相模中央化学研究所 置換フェニル酢酸誘導体の製造方法
JPS5825675B2 (ja) * 1979-02-02 1983-05-28 財団法人相模中央化学研究所 ケタ−ル誘導体
JP2016130241A (ja) * 2016-02-05 2016-07-21 テックフィールズ バイオケム カンパニー リミテッド 非常に速い皮膚透過率を有するアリール−及びヘテロアリールプロピオン酸の正荷電水溶性プロドラッグ

Also Published As

Publication number Publication date
FI66369B (fi) 1984-06-29
NO141651C (no) 1980-04-16
AU6176573A (en) 1975-04-24
SU719490A3 (ru) 1980-02-29
FR2203635B1 (tr) 1977-09-09
PH12124A (en) 1978-11-07
JPS5865243A (ja) 1983-04-18
ES419871A1 (es) 1976-08-01
FI66369C (fi) 1984-10-10
JPS5938237B2 (ja) 1984-09-14
CS183719B2 (en) 1978-07-31
FR2203635A1 (tr) 1974-05-17
JPS5940811B2 (ja) 1984-10-03
IL43570A0 (en) 1974-03-14
DE2353357A1 (de) 1974-05-09
CH597219A5 (tr) 1978-03-31
DK154899C (da) 1989-05-29
DE2353357C2 (de) 1982-04-01
NL7314629A (tr) 1974-04-26
NO141651B (no) 1980-01-07
NL179583C (nl) 1986-10-01
ATA900773A (de) 1976-03-15
YU275973A (en) 1982-06-18
SE403911B (sv) 1978-09-11
CA1007643A (en) 1977-03-29
LU68666A1 (tr) 1974-01-03
IL43570A (en) 1977-05-31
DD110044A5 (tr) 1974-12-05
YU37106B (en) 1984-08-31
IE38402L (en) 1974-04-24
DK154899B (da) 1989-01-02
HU168046B (tr) 1976-02-28
IE38402B1 (en) 1978-03-01
BE806389A (nl) 1974-04-23
GB1446239A (en) 1976-08-18
BG25209A3 (en) 1978-08-10
AT333269B (de) 1976-11-10

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