CA1007643A - Aroyl-substituted phenylacetic acid derivatives - Google Patents

Aroyl-substituted phenylacetic acid derivatives

Info

Publication number
CA1007643A
CA1007643A CA183,576A CA183576A CA1007643A CA 1007643 A CA1007643 A CA 1007643A CA 183576 A CA183576 A CA 183576A CA 1007643 A CA1007643 A CA 1007643A
Authority
CA
Canada
Prior art keywords
aroyl
acid derivatives
phenylacetic acid
substituted phenylacetic
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA183,576A
Other languages
English (en)
Other versions
CA183576S (en
Inventor
Paul A.J. Janssen
Jozef M. Boey
Georges H.P. Van Daele
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of CA1007643A publication Critical patent/CA1007643A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/28—Halogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
    • C07D213/50—Ketonic radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/16—Radicals substituted by halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/20—Free hydroxyl or mercaptan
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
CA183,576A 1972-10-24 1973-10-17 Aroyl-substituted phenylacetic acid derivatives Expired CA1007643A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30007972A 1972-10-24 1972-10-24
US39587773A 1973-09-10 1973-09-10

Publications (1)

Publication Number Publication Date
CA1007643A true CA1007643A (en) 1977-03-29

Family

ID=26971576

Family Applications (1)

Application Number Title Priority Date Filing Date
CA183,576A Expired CA1007643A (en) 1972-10-24 1973-10-17 Aroyl-substituted phenylacetic acid derivatives

Country Status (24)

Country Link
JP (2) JPS5940811B2 (tr)
AT (1) AT333269B (tr)
BE (1) BE806389A (tr)
BG (1) BG25209A3 (tr)
CA (1) CA1007643A (tr)
CH (1) CH597219A5 (tr)
CS (1) CS183719B2 (tr)
DD (1) DD110044A5 (tr)
DE (1) DE2353357C2 (tr)
DK (1) DK154899C (tr)
ES (1) ES419871A1 (tr)
FI (1) FI66369C (tr)
FR (1) FR2203635B1 (tr)
GB (1) GB1446239A (tr)
HU (1) HU168046B (tr)
IE (1) IE38402B1 (tr)
IL (1) IL43570A (tr)
LU (1) LU68666A1 (tr)
NL (1) NL179583C (tr)
NO (1) NO141651C (tr)
PH (1) PH12124A (tr)
SE (1) SE403911B (tr)
SU (1) SU719490A3 (tr)
YU (1) YU37106B (tr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1036466B (it) * 1975-07-08 1979-10-30 Sigurta Farmaceutici Spa Processo per la preparazione di derivati dell acido alfa fenilpropionico
FR2374033A1 (fr) * 1976-12-16 1978-07-13 Rhone Poulenc Ind Nouveaux acides thieno (3,2-b) thienylcarbonylphenylalcanoiques, leurs derives, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2345148A1 (fr) * 1976-03-24 1977-10-21 Lipha Nouvel acide propionique substitue, preparation et application
GB1569404A (en) * 1977-04-22 1980-06-11 Soc D Etudes Prod Chimique (2-isopropyl-4-(2'-theonyl)-5-methyl) phenoxy acetic acid
JPS5538340A (en) * 1978-09-12 1980-03-17 Taiyo Yakuhin Kogyo Kk Preparation of 2- 4-(2-thienylcarbonyl)phenyl propionic acid
JPS5538339A (en) * 1978-09-12 1980-03-17 Taiyo Yakuhin Kogyo Kk Preparation of 2- 4-(2-thienylcarbonyl)phenyl propionic acid
GB2030131B (en) * 1978-09-12 1982-12-22 Taiyo Pharma Ind Process for producing 2-(4-(2-thienyl-carbonyl) phenyl) propionic acid
JPS5823873B2 (ja) * 1979-02-02 1983-05-18 財団法人相模中央化学研究所 置換フェニル酢酸誘導体の製造方法
JPS5825675B2 (ja) * 1979-02-02 1983-05-28 財団法人相模中央化学研究所 ケタ−ル誘導体
ES479300A1 (es) * 1979-04-04 1979-07-01 Cusi Lab Procedimiento de obtencio de &-metil, 4(2'tienil carbonilz) fenil acetato de p-acetamido fenol.
EP0046337A3 (en) * 1980-08-20 1982-09-15 Imperial Chemical Industries Plc Triazole compounds, a process for preparing them, their use as plant and pharmaceutical fungicides and as plant growth regulators and compositions containing them
CA2023954C (en) * 1989-10-17 1999-05-04 Hiroyuki Nohira Process for the optical resolution of 2-(3-benzoyl) phenylpropionic acid
JP6290947B2 (ja) * 2016-02-05 2018-03-07 テックフィールズ バイオケム カンパニー リミテッド 非常に速い皮膚透過率を有するアリール−及びヘテロアリールプロピオン酸の正荷電水溶性プロドラッグ

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1226344A (tr) * 1967-07-31 1971-03-24
FR2113760A1 (en) * 1970-11-10 1972-06-30 Roussel Uclaf 5-Arylcarbonyl-3(or 4)-methylthien-2-yl alkanoic acids and esters - with antiinflammatory and analgesic activity

Also Published As

Publication number Publication date
FI66369B (fi) 1984-06-29
NO141651C (no) 1980-04-16
AU6176573A (en) 1975-04-24
SU719490A3 (ru) 1980-02-29
FR2203635B1 (tr) 1977-09-09
PH12124A (en) 1978-11-07
JPS5865243A (ja) 1983-04-18
ES419871A1 (es) 1976-08-01
FI66369C (fi) 1984-10-10
JPS5938237B2 (ja) 1984-09-14
CS183719B2 (en) 1978-07-31
FR2203635A1 (tr) 1974-05-17
JPS5940811B2 (ja) 1984-10-03
IL43570A0 (en) 1974-03-14
DE2353357A1 (de) 1974-05-09
CH597219A5 (tr) 1978-03-31
DK154899C (da) 1989-05-29
DE2353357C2 (de) 1982-04-01
NL7314629A (tr) 1974-04-26
NO141651B (no) 1980-01-07
NL179583C (nl) 1986-10-01
ATA900773A (de) 1976-03-15
YU275973A (en) 1982-06-18
SE403911B (sv) 1978-09-11
LU68666A1 (tr) 1974-01-03
JPS4993346A (tr) 1974-09-05
IL43570A (en) 1977-05-31
DD110044A5 (tr) 1974-12-05
YU37106B (en) 1984-08-31
IE38402L (en) 1974-04-24
DK154899B (da) 1989-01-02
HU168046B (tr) 1976-02-28
IE38402B1 (en) 1978-03-01
BE806389A (nl) 1974-04-23
GB1446239A (en) 1976-08-18
BG25209A3 (en) 1978-08-10
AT333269B (de) 1976-11-10

Similar Documents

Publication Publication Date Title
AU469779B2 (en) Phenylalkenoic acid derivatives
CA1007643A (en) Aroyl-substituted phenylacetic acid derivatives
AU5709073A (en) Trialkoxycinnamoylaminocarbon acid
CA1007221A (en) Pregnane acid derivatives
AU482956B2 (en) Benzoic acid derivatives
AU465326B2 (en) Indole-carboxylic acid derivatives andthe preparation thereof
CA976556A (en) 3-alkoxy-5-substituted phenylacetic acids
AU5816173A (en) Novel phenoxycarboxylic acid derivatives
ZA738203B (en) Aroyl-substituted phenylacetic acid derivatives
AU471195B2 (en) Herbicidal thioprorionic acid derivatives
AU473140B2 (en) New sulfamylbenzoic acid derivatives
CA1002061A (en) Phenoxyallcyclic carboxylic acid derivatives
CA1032162A (en) Phthalazine-1-acetic acid derivatives
AU471234B2 (en) New sulfamylbenzoic acid derivatives
CA873869A (en) Phenylacetic acid derivatives
CA978967A (en) 4-phenyl-4-butenoic acid and derivatives
CA902097A (en) Aminocyclopentanecarboxylic acid derivatives
CA899364A (en) Chromone-carboxylic acid derivatives
CA913093A (en) Phosphanilic acid derivatives
CA914181A (en) 2-phenyl-cyclohexene-3-carboxylic acid derivatives
AU439837B2 (en) Phenylacetic acid derivatives
CA958415A (en) Phenylacetic acid derivatives
AU466893B2 (en) 3-alkoxy-5-substituted phenylacetic acids
AU482726B2 (en) Aroyl-substituted phenylacetic acid derivatives
CA978976A (en) 5-n-pyrrylsalicylic acid