JPH11513405A - 創傷治癒のためのpdgf、kgf、igf、およびigfbpの配合物 - Google Patents
創傷治癒のためのpdgf、kgf、igf、およびigfbpの配合物Info
- Publication number
- JPH11513405A JPH11513405A JP9515071A JP51507197A JPH11513405A JP H11513405 A JPH11513405 A JP H11513405A JP 9515071 A JP9515071 A JP 9515071A JP 51507197 A JP51507197 A JP 51507197A JP H11513405 A JPH11513405 A JP H11513405A
- Authority
- JP
- Japan
- Prior art keywords
- dna molecule
- pharmaceutical composition
- igf
- pdgf
- kgf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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Landscapes
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.血小板由来増殖因子(PDGF)の生物学的活性を有する第1のポリペプチドおよ びケラチノサイト増殖因子(KGF)の生物学的活性を有する第2のポリペプチドを 含む、上皮組織の修復のための薬学的組成物。 2.前記第1のポリペプチドが、全長PDGFポリペプチドを含む、請求項1に記載 の薬学的組成物。 3.前記第1のポリペプチドが、全長PDGFポリペプチドの生物学的に活性なフラ グメントを含む、請求項1に記載の薬学的組成物。 4.前記第1のポリペプチドが、PDGFA鎖およびPDGFB鎖からなる群より選択さ れるPDGF鎖を含む、請求項1に記載の薬学的組成物。 5.前記第1のポリペプチドが、宿主細胞においてPDGFをコードするDNA分子の 発現によって産生され、ここで、該宿主細胞が、細菌細胞、酵母細胞、哺乳動物 細胞、および昆虫細胞からなる群より選択される細胞を含む、請求項1に記載の 薬学的組成物。 6.前記第2のポリペプチドが、全長KGFを含む、請求項1に記載の薬学的組成 物。 7.前記第2のポリペプチドが、全長KGFポリペプチドの生物学的に活性なフラ グメントを含む、請求項1に記載の薬学的組成物。 8.前記第2のポリペプチドが、宿主細胞においてKGFをコードするDNA分子の発 現によって産生され、ここで、該宿主細胞が、細菌細胞、酵母細胞、哺乳動物細 胞、および昆虫細胞からなる群より選択される細胞を含む、請求項1に記載の薬 学的組成物。 9.薬学的に受容可能なキャリアをさらに含む、請求項1に記載の薬学的組成物 。 10.上皮組織を修復する方法であって、修復されるべき該組織に、請求項1に 記載の薬学的組成物を適用する工程を包含する、方法。 11.前記上皮組織が、皮膚、胃内膜、および腸内膜からなる群より選択される 、請求項10に記載の方法。 12.前記薬学的組成物が、局所、経口、皮内、皮下、管腔内、胃内、および腹 腔内からなる群より選択される様式で適用される、請求項10に記載の方法。 13.上皮細胞の損傷を修復または予防する方法であって、保護または修復され るべき該細胞に、PDGFを含む薬学的組成物およびKGFを含む組成物を適用する工 程を包含する、方法。 14.PDGFを含む前記薬学的組成物およびKGFを含む前記薬学的組成物が、同一 の薬学的組成物である、請求項13に記載の方法。 15.PDGFおよびKGFの適用が、同時である、請求項13に記載の方法。 16.上皮細胞の損傷を修復する方法であって、該上皮細胞に、第1のDNA分子 および第2のDNA分子を含む薬学的組成物を適用する工程を包含し、ここで、該 第1のDNA分子がPDGFをコードする第1のヌクレオチド配列を含み、そして該第 2のDNA分子がKGFをコードする第2のヌクレオチド配列を含む、方法。 17.前記第1のDNA分子が、分泌リーダーコードヌクレオチド配列をさらに含 み、ここで、該分泌リーダーが、PDGFの分泌に十分である、請求項16に記載の 方法。 18.前記第1のDNA分子が、分泌リーダーコードヌクレオチド配列をさらに含 み、ここで、該分泌リーダーが、KGFの分泌に十分である、請求項16に記載の 方法。 19.前記第1および第2のDNA分子が、同一のプラスミド上に存在する、請求 項16に記載の方法。 20.前記第1および第2のDNA分子が、別のプラスミド上に存在する、請求項 16に記載の方法。 21.前記第1のDNA分子が、リポソーム中にカプセル化される、請求項16に 記載の方法。 22.前記第2のDNA分子が、リポソーム中にカプセル化される、請求項16に 記載の方法。 23.上皮細胞の予防および修復のための、請求項1に記載の薬学的組成物およ びその使用のための説明書を備えた、キット。 24.第1のDNA分子および第2のDNA分子を含むキットであって、ここで、該第 1のDNA分子は、PDGFをコードする第1のヌクレオチド配列を含み、そして該第 2のDNA配列は、KGFをコードする第2のヌクレオチド配列を含む、キット。 25.インシュリン様増殖因子(IGF)の生物学的活性を有する第3のポリヌクレ オチドをも含む、請求項1に記載の薬学的組成物。 26.IGFが、IGF-1およびIGF-2からなる群より選択されるIGFを含む、請求項2 5に記載の薬学的組成物。 27.インシュリン様増殖因子結合タンパク質(IGFBP)の生物学的活性を有する 第4のポリヌクレオチドをも含む、請求項25に記載の薬学的組成物。 28.前記IGFBPが、IGFBP-1、IGFBP-2、IGFBP-3、IGFBP-4、IGFBP-5、およびIG FBP-6からなる群より選択されるIGFBPを含む、請求項27に記載の薬学的組成物 。 29.前記第3のポリペプチドが、全長IGFを含む、請求項25に記載の薬学的 組成物。 30.前記第3のポリペプチドが、IGFの生物学的に活性なフラグメントを含む 、請求項25に記載の薬学的組成物。 31.前記第4のポリペプチドが、全長IGFBPを含む、請求項27に記載の薬学 的組成物。 32.前記第4のポリペプチドが、IGFBPの生物学的に活性なフラグメントを含 む、請求項27に記載の薬学的組成物。 33.前記第3のポリペプチドが、宿主細胞においてIGFをコードするDNA分子の 発現によって産生され、ここで、該宿主細胞が、細菌細胞、酵母細胞、哺乳動物 細胞、および昆虫細胞からなる群より選択される細胞を含む、請求項25に記載 の薬学的組成物。 34.前記第4のポリペプチドが、宿主細胞においてIGFBPをコードするDNA分子 の発現によって産生され、ここで、該宿主細胞が、細菌細胞、酵母細胞、哺乳動 物細胞、および昆虫細胞からなる群より選択される細胞を含む、請求項27に記 載の薬学的組成物。 35.薬学的に受容可能なキャリアをさらに含む、請求項25に記載の薬学的組 成物。 36.薬学的に受容可能なキャリアをさらに含む、請求項27に記載の薬学的組 成物。 37.上皮組織を修復する方法であって、修復されるべき該組織に請求項25に 記載の薬学的組成物を適用する工程を包含する、方法。 38.上皮組織を修復する方法であって、修復されるべき該組織に請求項27に 記載の薬学的組成物を適用する工程を包含する、方法。 39.前記上皮組織が、皮膚、胃内膜、および腸内膜からなる群より選択される 組織を含む、請求項37に記載の方法。 40.前記上皮組織が、皮膚、胃内膜、および腸内膜からなる群より選択される 組織を含む、請求項38に記載の方法。 41.前記薬学的組成物が、局所、経口、皮内、皮下、管腔内、胃内、および腹 腔内からなる群より選択される様式で適用される、請求項39に記載の方法。 42.前記薬学的組成物が、局所、経口、皮内、皮下、管腔内、胃内、および腹 腔内からなる群より選択される様式で適用される、請求項40に記載の方法。 43.上皮細胞の損傷を修復または予防する方法であって、保護または修復され るべき該細胞に、請求項13に記載の薬学的組成物を適用する工程を包含し、そ してIGFを含む組成物をさらに包含する、方法。 44.上皮細胞の損傷を修復または予防する方法であって、保護または修復され るべき該細胞に、請求項43に記載の薬学的組成物を適用する工程を包含し、そ してIGFBPを含む組成物をさらに包含する、方法。 45.上皮細胞の損傷を修復する方法であって、該上皮細胞に、第1のDNA分子 、第2のDNA分子、および第3のDNA分子を含む薬学的組成物を適用する工程を包 含し、ここで、該第1のDNA分子はPDGFをコードする第1のヌクレオチド配列を 含み、該第2のDNA分子はKGFをコードする第2のヌクレオチド配列を含み、そし て該第3のDNA分子はIGFをコードする第3のヌクレオチド配列を含む、方法。 46.上皮細胞の損傷を修復する方法であって、該上皮細胞に、第1のDNA分子 、第2のDNA分子、第3のDNA分子、および第4のDNA分子を含む薬学的組成物を 、適用する工程を包含し、ここで、該第1のDNA分子はPDGFをコードする第1の ヌクレオチド配列を含み、該第2のDNA分子はKGFをコードする第2のヌクレオチ ド配列を含み、該第3のDNA分子はIGFをコードする第3のヌクレオチド配列を含 み、そして該第4のDNA分子はIGFBPをコードする第4のヌクレオチド配列を含む 、方法。 47.第1のDNA分子、第2のDNA分子、および第3のDNA分子を含むキットであ って、ここで、該第1のDNA分子はPDGFをコードする第1のヌクレオチド配列を 含み、該第2のDNA分子はKGFをコードする第2のヌクレオチド配列を含み、そし て該第3のDNA分子はIGFをコードする第3のヌクレオチド配列を含む、キット。 48.第1のDNA分子、第2のDNA分子、第3のDNA分子、および第4のDNA分子を 含むキットであって、ここで、該第1のDNA分子はPDGFをコードする第1のヌク レオチド配列を含み、該第2のDNA分子はKGFをコードする第2のヌクレオチド配 列を含み、該第3のDNA分子はIGFをコードする第3のヌクレオチド配列を含み、 そして該第4のDNA分子はIGFBPをコードする第4のヌクレオチド配列を含む、キ ット。 49.クリーム、フォーム、注射溶液、スプレー、ゲルマトリックス、スポンジ 、点滴剤、および洗浄液からなる群より選択される組成物を含む、請求項1に記 載の薬学的組成物。 50.クリーム、フォーム、注射溶液、スプレー、ゲルマトリックス、スポンジ 、点滴剤、および洗浄液からなる群より選択される組成物を含む、請求項25に 記載の薬学的組成物。 51.クリーム、フォーム、注射溶液、スプレー、ゲルマトリックス、スポンジ 、点滴剤、および洗浄液からなる群より選択される組成物を含む、請求項27に 記載の薬学的組成物。
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PCT/US1996/015623 WO1997013857A1 (en) | 1995-10-11 | 1996-09-27 | Combination pdgf, kgf, igf and igfbp for wound healing |
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-
1996
- 1996-09-27 DK DK04019502T patent/DK1486565T3/da active
- 1996-09-27 DE DE69637332T patent/DE69637332T2/de not_active Expired - Lifetime
- 1996-09-27 ES ES04019502T patent/ES2293137T3/es not_active Expired - Lifetime
- 1996-09-27 AU AU72488/96A patent/AU7248896A/en not_active Abandoned
- 1996-09-27 DE DE69633194T patent/DE69633194T2/de not_active Expired - Lifetime
- 1996-09-27 ES ES96933952T patent/ES2224178T3/es not_active Expired - Lifetime
- 1996-09-27 WO PCT/US1996/015623 patent/WO1997013857A1/en active IP Right Grant
- 1996-09-27 AT AT96933952T patent/ATE274056T1/de active
- 1996-09-27 PT PT96933952T patent/PT871730E/pt unknown
- 1996-09-27 EP EP96933952A patent/EP0871730B1/en not_active Expired - Lifetime
- 1996-09-27 EP EP04019502A patent/EP1486565B1/en not_active Expired - Lifetime
- 1996-09-27 PT PT04019502T patent/PT1486565E/pt unknown
- 1996-09-27 JP JP9515071A patent/JPH11513405A/ja not_active Withdrawn
-
2000
- 2000-11-27 US US09/723,449 patent/US6903078B1/en not_active Expired - Fee Related
-
2004
- 2004-12-28 HK HK04110265A patent/HK1067382A1/xx not_active IP Right Cessation
-
2005
- 2005-05-02 US US11/120,154 patent/US20050250695A1/en not_active Abandoned
-
2007
- 2007-04-11 JP JP2007104234A patent/JP2007182461A/ja active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010510225A (ja) * | 2006-11-15 | 2010-04-02 | コーダ セラピューティクス, インコーポレイテッド | 創傷治癒のための改善された方法および組成物 |
Also Published As
Publication number | Publication date |
---|---|
DE69633194T2 (de) | 2005-09-08 |
HK1067382A1 (en) | 2005-04-08 |
DE69633194D1 (de) | 2004-10-21 |
EP1486565B1 (en) | 2007-11-21 |
US6903078B1 (en) | 2005-06-07 |
DK1486565T3 (da) | 2008-03-10 |
PT1486565E (pt) | 2008-02-28 |
AU7248896A (en) | 1997-04-30 |
ES2293137T3 (es) | 2008-03-16 |
JP2007182461A (ja) | 2007-07-19 |
EP0871730B1 (en) | 2004-08-18 |
PT871730E (pt) | 2004-11-30 |
US20050250695A1 (en) | 2005-11-10 |
WO1997013857A1 (en) | 1997-04-17 |
DE69637332T2 (de) | 2008-10-09 |
DE69637332D1 (de) | 2008-01-03 |
ATE274056T1 (de) | 2004-09-15 |
EP0871730A1 (en) | 1998-10-21 |
EP1486565A1 (en) | 2004-12-15 |
ES2224178T3 (es) | 2005-03-01 |
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