JPH11507825A - Dnアーゼ活性を有する蛋白質 - Google Patents
Dnアーゼ活性を有する蛋白質Info
- Publication number
- JPH11507825A JPH11507825A JP9502488A JP50248897A JPH11507825A JP H11507825 A JPH11507825 A JP H11507825A JP 9502488 A JP9502488 A JP 9502488A JP 50248897 A JP50248897 A JP 50248897A JP H11507825 A JPH11507825 A JP H11507825A
- Authority
- JP
- Japan
- Prior art keywords
- dna
- protein
- present
- immunization
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.図1のアミノ酸配列を含有してなるDNアーゼ活性を有する蛋白質またはそ の機能的誘導体またはその断片。 2.請求項1記載の蛋白質をコードするDNA。 3.該DNAが、 (a)図1のDNAもしくはその断片、 (b)(a)のDNAとハイブリダイズするDNA、または (c)縮重遺伝コドンを介して(a)もしくは(b)のDNAと関連するDNA を含有してなる、請求項2記載のDNA。 4.請求項2または3記載のDNAを含有してなる発現プラスミド。 5.請求項4記載の発現プラスミドを含む形質転換体。 6.好適な条件下で請求項5記載の形質転換体を培養する工程を含む、請求項1 記載の蛋白質の調製方法。 7.請求項1記載の蛋白質に対する抗体。 8.診断および/または治療用試薬としての請求項1記載の蛋白質の使用。 9.診断および/または治療用試薬としての請求項2または3記載のDNAの使 用。 10.診断および/または治療用試薬としての請求項9記載の抗体の使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19521046A DE19521046C1 (de) | 1995-06-09 | 1995-06-09 | Protein mit DNase-Aktivität |
DE19521046.8 | 1995-06-09 | ||
PCT/DE1996/001016 WO1996041887A1 (de) | 1995-06-09 | 1996-06-10 | Protein mit dnase-aktivität |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH11507825A true JPH11507825A (ja) | 1999-07-13 |
JP3811733B2 JP3811733B2 (ja) | 2006-08-23 |
Family
ID=7763997
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50248897A Expired - Fee Related JP3811733B2 (ja) | 1995-06-09 | 1996-06-10 | Dnアーゼ活性を有する蛋白質 |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0842278B1 (ja) |
JP (1) | JP3811733B2 (ja) |
AT (1) | ATE309371T1 (ja) |
DE (2) | DE19521046C1 (ja) |
ES (1) | ES2255076T3 (ja) |
WO (1) | WO1996041887A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006510363A (ja) * | 2002-12-18 | 2006-03-30 | コイ,ヨハネス | 癌およびその前駆病変の検出のための化合物および方法 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995030428A1 (en) * | 1994-05-05 | 1995-11-16 | Human Genome Sciences, Inc. | Human dnase |
US6251648B1 (en) | 1998-04-03 | 2001-06-26 | Human Genome Sciences, Inc. | Gene encoding human Dnase |
EP1249495A1 (de) * | 2001-04-11 | 2002-10-16 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Murine DNase X, diese enthaltendes Arzneimittel und nicht-menschliches Säugetier mit verändertem DNase X-Gen |
JP3989936B2 (ja) * | 2005-04-07 | 2007-10-10 | 進 須永 | 抗腫瘍剤及び新規dnアーゼ |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE68929551T2 (de) * | 1988-12-23 | 2008-03-06 | Genentech, Inc., South San Francisco | Menschliche DNase |
-
1995
- 1995-06-09 DE DE19521046A patent/DE19521046C1/de not_active Expired - Fee Related
-
1996
- 1996-06-10 EP EP96915989A patent/EP0842278B1/de not_active Expired - Lifetime
- 1996-06-10 ES ES96915989T patent/ES2255076T3/es not_active Expired - Lifetime
- 1996-06-10 JP JP50248897A patent/JP3811733B2/ja not_active Expired - Fee Related
- 1996-06-10 AT AT96915989T patent/ATE309371T1/de not_active IP Right Cessation
- 1996-06-10 WO PCT/DE1996/001016 patent/WO1996041887A1/de active IP Right Grant
- 1996-06-10 DE DE59611293T patent/DE59611293D1/de not_active Expired - Lifetime
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006510363A (ja) * | 2002-12-18 | 2006-03-30 | コイ,ヨハネス | 癌およびその前駆病変の検出のための化合物および方法 |
Also Published As
Publication number | Publication date |
---|---|
JP3811733B2 (ja) | 2006-08-23 |
ES2255076T3 (es) | 2006-06-16 |
EP0842278A1 (de) | 1998-05-20 |
ATE309371T1 (de) | 2005-11-15 |
DE59611293D1 (de) | 2005-12-15 |
DE19521046C1 (de) | 1996-08-08 |
WO1996041887A1 (de) | 1996-12-27 |
EP0842278B1 (de) | 2005-11-09 |
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