JPH11506110A - 免疫原性および免疫刺激性オリゴサッカライド組成物ならびにそれらの作製法および使用法 - Google Patents

免疫原性および免疫刺激性オリゴサッカライド組成物ならびにそれらの作製法および使用法

Info

Publication number
JPH11506110A
JPH11506110A JP9500049A JP50004997A JPH11506110A JP H11506110 A JPH11506110 A JP H11506110A JP 9500049 A JP9500049 A JP 9500049A JP 50004997 A JP50004997 A JP 50004997A JP H11506110 A JPH11506110 A JP H11506110A
Authority
JP
Japan
Prior art keywords
oligosaccharide
composition
carrier
immunogenic
conjugate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP9500049A
Other languages
English (en)
Japanese (ja)
Inventor
ジェイ. マルコルム,アンドリュー
Original Assignee
アルバータ リサーチ カウンセル
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/477,497 external-priority patent/US5866132A/en
Priority claimed from US08/482,626 external-priority patent/US5695768A/en
Priority claimed from CA002153730A external-priority patent/CA2153730A1/en
Priority claimed from CA002153733A external-priority patent/CA2153733A1/en
Application filed by アルバータ リサーチ カウンセル filed Critical アルバータ リサーチ カウンセル
Publication of JPH11506110A publication Critical patent/JPH11506110A/ja
Ceased legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/02Bacterial antigens
    • A61K39/09Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092Streptococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/385Haptens or antigens, bound to carriers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55583Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/60Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031Proteins
    • A61K2039/6037Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/64Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
JP9500049A 1995-06-07 1996-06-06 免疫原性および免疫刺激性オリゴサッカライド組成物ならびにそれらの作製法および使用法 Ceased JPH11506110A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US08/477,497 US5866132A (en) 1995-06-07 1995-06-07 Immunogenic oligosaccharide compositions
US08/482,626 US5695768A (en) 1995-06-07 1995-06-07 Immunostimulating activity of Streptococcus pneumoniae serotype 8 oligosaccharides
CA08/477,497 1995-07-12
CA2,153,730 1995-07-12
CA2,153,733 1995-07-12
CA08/482,626 1995-07-12
CA002153730A CA2153730A1 (en) 1995-07-12 1995-07-12 Immunostimulating activity of streptococcus pneumoniae serotype 8 oligosaccharides
CA002153733A CA2153733A1 (en) 1995-07-12 1995-07-12 Immunogenic oligosaccharide compositions
PCT/CA1996/000387 WO1996040225A1 (en) 1995-06-07 1996-06-06 Immunogenic and immunostimulatory oligosaccharide compositions and methods of making and using them

Publications (1)

Publication Number Publication Date
JPH11506110A true JPH11506110A (ja) 1999-06-02

Family

ID=27427244

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9500049A Ceased JPH11506110A (ja) 1995-06-07 1996-06-06 免疫原性および免疫刺激性オリゴサッカライド組成物ならびにそれらの作製法および使用法

Country Status (10)

Country Link
EP (1) EP0831894A1 (cs)
JP (1) JPH11506110A (cs)
KR (1) KR19990007777A (cs)
AU (1) AU725279B2 (cs)
CZ (1) CZ327897A3 (cs)
IL (1) IL121585A0 (cs)
MX (1) MX9707944A (cs)
NO (1) NO974727L (cs)
NZ (1) NZ309713A (cs)
WO (1) WO1996040225A1 (cs)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012187110A (ja) * 2000-06-20 2012-10-04 Id Biomedical Corp Of Quebec ストレプトコッカス抗原
JP2012530785A (ja) * 2009-06-22 2012-12-06 ワイス・エルエルシー 組成物および黄色ブドウ球菌(Staphylococcusaureus)血清型5および8莢膜多糖コンジュゲート免疫原性組成物を調製するための方法
JP2016536317A (ja) * 2013-11-08 2016-11-24 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム サルモネラコンジュゲートワクチン
JP2017532321A (ja) * 2014-09-26 2017-11-02 マックス プランク ゲゼルシャフト ツゥアー フェデルゥン デル ヴィッセンシャフテン エー フォー 肺炎連鎖球菌血清型8に対するワクチン
JP2020533299A (ja) * 2017-09-07 2020-11-19 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. キャリアタンパク質へのコンジュゲーションのための肺炎球菌多糖の製剤方法
JP2022512345A (ja) * 2018-12-12 2022-02-03 ファイザー・インク 免疫原性多重ヘテロ抗原多糖-タンパク質コンジュゲートおよびその使用
JP2023065429A (ja) * 2014-01-21 2023-05-12 ファイザー・インク コンジュゲート化莢膜糖類抗原を含む免疫原性組成物およびその使用

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69708318T3 (de) 1996-08-27 2006-11-16 Novartis Vaccines and Diagnostics, Inc., Emeryville Neisseria meningitidis serogruppe b glykokonjugate und verfahren zu deren verwendung
RU2233172C2 (ru) * 1997-07-17 2004-07-27 Бакстэ Хелскеа С.А. Иммуногенный коньюгат полисахарид h. influenzae - порин менингококка группы b (варианты), способ его получения, фармацевтическая композиция и способ индукции иммунного ответа у животного в отношении h.influenzae
NZ502437A (en) * 1997-07-17 2001-11-30 Baxter Healthcare Sa Immunogenic conjugates comprising H. influenzae type b (Hib) polysaccharide-recombinant refolded meningococcal outer membrane protein (rPorB) conjugate
US7018637B2 (en) 1998-02-23 2006-03-28 Aventis Pasteur, Inc Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines
US6573245B1 (en) 1998-04-28 2003-06-03 Galenica Pharmaceuticals, Inc. Modified polysaccharide adjuvant-protein antigen conjugates, the preparation thereof and the use thereof
US6436653B1 (en) 1998-12-15 2002-08-20 Exiqon A/S Method for introduction of reporter groups into bacterial lipopolysaccharide-derived carbohydrates and the subsequent coupling of such derivatives onto solid surfaces
EP3000820A1 (en) * 2014-09-26 2016-03-30 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Synthetic vaccines against Streptococcus pneumoniae serotype 8
US9107906B1 (en) 2014-10-28 2015-08-18 Adma Biologics, Inc. Compositions and methods for the treatment of immunodeficiency
MY199856A (en) 2016-08-05 2023-11-25 Sanofi Pasteur Inc Multivalent pneumococcal polysaccharide-protein conjugate composition
KR102467074B1 (ko) 2016-08-05 2022-11-11 사노피 파스퇴르 인코포레이티드 다가 폐렴구균 다당류-단백질 접합체 조성물
US10259865B2 (en) 2017-03-15 2019-04-16 Adma Biologics, Inc. Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection
JP6950099B2 (ja) 2018-02-05 2021-10-13 サノフィ パスツール インコーポレイティッド 多価肺炎球菌多糖体−タンパク質複合体組成物
MX2020007939A (es) 2018-02-05 2020-09-03 Sanofi Pasteur Inc Composicion del conjugado proteina-polisacarido multivalente nuemococica.
KR20190121713A (ko) 2018-04-18 2019-10-28 에스케이바이오사이언스(주) 스트렙토코커스 뉴모니애 협막 다당류 및 그의 면역원성 접합체
CN113607939B (zh) * 2021-08-05 2024-10-22 艾美探索者生命科学研发有限公司 肺炎球菌多糖结合疫苗各型结合原液吸附率测定方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6230726A (ja) * 1985-07-05 1987-02-09 ビオチーネ エセ.ピー.アー. 糖たんぱく質結合体
JPH01500561A (ja) * 1986-04-16 1989-03-01 ザ ブリガム アンド ウィメンズ ホスピタル,インコーポレイテッド 細菌抗原、抗体、ワクチン及びその製造方法
JPH05148157A (ja) * 1991-01-28 1993-06-15 Merck & Co Inc 肺炎連鎖球菌からの多糖抗原
JPH06503233A (ja) * 1990-12-18 1994-04-14 ザ ボード オブ リージェンツ オブ ザ ユニヴァーシティ オブ ワシントン 透析物ペレットを有する透析物生成システム
JPH06340550A (ja) * 1990-09-28 1994-12-13 American Cyanamid Co 改良されたオリゴ糖結合体ワクチン

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2059692C (en) * 1991-01-28 2004-11-16 Peter J. Kniskern Pneumoccoccal polysaccharide conjugate vaccine

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6230726A (ja) * 1985-07-05 1987-02-09 ビオチーネ エセ.ピー.アー. 糖たんぱく質結合体
JPH01500561A (ja) * 1986-04-16 1989-03-01 ザ ブリガム アンド ウィメンズ ホスピタル,インコーポレイテッド 細菌抗原、抗体、ワクチン及びその製造方法
JPH06340550A (ja) * 1990-09-28 1994-12-13 American Cyanamid Co 改良されたオリゴ糖結合体ワクチン
JPH06503233A (ja) * 1990-12-18 1994-04-14 ザ ボード オブ リージェンツ オブ ザ ユニヴァーシティ オブ ワシントン 透析物ペレットを有する透析物生成システム
JPH05148157A (ja) * 1991-01-28 1993-06-15 Merck & Co Inc 肺炎連鎖球菌からの多糖抗原

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
IMMUNOLOGY LETTERS, vol. 30, JPN4007017246, 1991, pages 267 - 274, ISSN: 0000868582 *
INFECTION AND IMMUNITY, vol. 62, no. 3, JPN4007017245, 1994, pages 799 - 808, ISSN: 0000868581 *
MOLECULAR IMMUNOLOGY, vol. 23, no. 4, JPN4007017247, 1986, pages 385 - 391, ISSN: 0000868583 *
NATO ASI SERIES, SERIES A: LIFE SCIENCES, vol. 252, JPN4007017244, 1993, pages 219 - 233, ISSN: 0000868580 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012187110A (ja) * 2000-06-20 2012-10-04 Id Biomedical Corp Of Quebec ストレプトコッカス抗原
JP2012530785A (ja) * 2009-06-22 2012-12-06 ワイス・エルエルシー 組成物および黄色ブドウ球菌(Staphylococcusaureus)血清型5および8莢膜多糖コンジュゲート免疫原性組成物を調製するための方法
JP2016536317A (ja) * 2013-11-08 2016-11-24 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム サルモネラコンジュゲートワクチン
JP2023065429A (ja) * 2014-01-21 2023-05-12 ファイザー・インク コンジュゲート化莢膜糖類抗原を含む免疫原性組成物およびその使用
JP2017532321A (ja) * 2014-09-26 2017-11-02 マックス プランク ゲゼルシャフト ツゥアー フェデルゥン デル ヴィッセンシャフテン エー フォー 肺炎連鎖球菌血清型8に対するワクチン
JP2020533299A (ja) * 2017-09-07 2020-11-19 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. キャリアタンパク質へのコンジュゲーションのための肺炎球菌多糖の製剤方法
US12161721B2 (en) 2017-09-07 2024-12-10 Merck Sharp & Dohme Llc Processes for the formulation of pneumococcal polysaccharides for conjugation to a carrier protein
JP2022512345A (ja) * 2018-12-12 2022-02-03 ファイザー・インク 免疫原性多重ヘテロ抗原多糖-タンパク質コンジュゲートおよびその使用

Also Published As

Publication number Publication date
AU725279B2 (en) 2000-10-12
IL121585A0 (en) 1998-02-08
KR19990007777A (ko) 1999-01-25
WO1996040225A1 (en) 1996-12-19
MX9707944A (es) 1998-06-30
NO974727D0 (no) 1997-10-13
CZ327897A3 (cs) 1998-02-18
AU5994496A (en) 1996-12-30
NZ309713A (en) 1999-11-29
EP0831894A1 (en) 1998-04-01
NO974727L (no) 1997-12-08

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