JPH11505265A - Igf−iの投与法 - Google Patents
Igf−iの投与法Info
- Publication number
- JPH11505265A JPH11505265A JP8535717A JP53571796A JPH11505265A JP H11505265 A JPH11505265 A JP H11505265A JP 8535717 A JP8535717 A JP 8535717A JP 53571796 A JP53571796 A JP 53571796A JP H11505265 A JPH11505265 A JP H11505265A
- Authority
- JP
- Japan
- Prior art keywords
- igf
- days
- administered
- period
- mammal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.哺乳動物内の慢性障害の治療によりその生物学的反応を維持するための、哺 乳動物へのインスリン様増殖因子-I(IGF-I)の投与法で、哺乳動物内で最大の 生物学的反応を生じる一定期間IGF-Iのさらすために、治療上効果的な量のIGF- Iを投与し、それからIGF-Iをその前に投与した期間と同等かそれ以下の一定期 間上記投与を中止し、それから哺乳動物内で最大の生物学的反応を生じる一定期 間IGF-Iのさらすために、治療上効果的な量のIGF-Iを投与し、それからIGF-I をその直前に投与した期間と同等かそれ以下の一定期間上記投与を中止し、そし て哺乳動物内で維持された生物学的反応を成し遂げる、または持続させるために 必要な期間だけ、この投与と投与の中止のパターンを繰り返すことを含む投与法 。 2.哺乳動物がヒトである請求項1の方法。 3.慢性障害が慢性腎機能不全である請求項1の方法。 4.慢性障害が糖尿病である請求項1の方法。 5.慢性障害が同化作用障害である請求項1の方法。 6.慢性障害が神経学的、心臓病の、または免疫学的障害である請求項1の方法 。 7.IGF-Iを投与する場合、それが少なくとも一日一回連続的に投与される請求 項1の方法。 8.IGF-Iを投与する場合、それが長く作用する処方である請求項1の方法。 9.哺乳動物内で最大の生物学的反応を生じる期間が約3から5日であり、哺乳動 物の治療の中止期間が約2から4日である請求項1の方法。 10.哺乳動物内で最大の生物学的反応を生じる期間が約7から12日であり、哺乳 動 物の治療の中止期間が約2から7日である請求項1の方法。 11.さらに治療の過程の間哺乳動物にもう一つの薬剤を投与することを含む請求 項1の方法。 12.薬剤が成長ホルモンである請求項11の方法。 13.薬剤が心房性ナトリウム利尿ペプチドである請求項11の方法。 14.薬剤がACE阻害剤である請求項11の方法。 15.薬剤がIGF-I結合タンパク質または酸不安定サブユニットである請求項11の 方法。 16.IGF-IがIGF結合タンパク質または酸不安定サブユニットと複合している請 求項1の方法。 17.IGF-Iが皮下にまたは静脈に投与される請求項1の方法。 18.哺乳動物内の慢性腎機能不全の治療法で、約3から12日間インスリン様増殖 因子-I(IGF-I)にさらすために哺乳動物にIGF-Iの治療上効果的な量を投与し 、それから約2から7日間上記投与を中止し、それから約3から12日間IGF-Iにさ らすために哺乳動物にIGF-Iの治療上効果的な量を投与し、それから約2から7日 間上記投与を中止し、そして哺乳動物内で維持された腎機能を成し遂げる、また は持続させるのに必要な期間だけこの投与と投与の中止のパターンを繰り返し、 上記投与の中止の期間はIGF-Iをその直前に投与した期間と同等かそれ以下の一 定期間であることを含む治療法。 19.IGF-Iを投与する場合それは約3から5日間投与され、それを投与しない場合 それは約2から4日間投与されない請求項18の方法。 20.IGF-Iを投与する場合それは4日間投与され、それを投与しない場合それは3 日間投与されない請求項19の方法。 21.IGF-Iを投与する場合それは約7から12日間投与され、それを投与しない場 合それは約2から7日間投与されない請求項18の方法。 22.IGF-Iを投与する場合、それが少なくとも一日一回連続的に投与される請求 項18の方法。 23.IGF-Iを投与する場合、それが持続放出方式で投与される請求項18の方法。 24.哺乳動物がヒトである請求項18の方法。 25.一日当たり投与されるIGF-Iの量が約10μg/kgから約160μg/kgである請求 項24の方法。 26.IGF-Iを投与する場合、それが皮下経路で毎日または毎日二回投与される請 求項25の方法。 27.哺乳動物が末期慢性腎機能不全を明示している請求項18の方法。 28.IGF結合タンパク質または酸不安定サブユニットまたは両方の効果的な量がI GF-Iと共に投与される請求項18の方法。 29.IGF-IがIGF結合タンパク質または酸不安定サブユニットと複合している請 求項18の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/445,805 US5741776A (en) | 1995-05-22 | 1995-05-22 | Method of administration of IGF-I |
US08/445,805 | 1995-05-22 | ||
PCT/US1996/006704 WO1996037216A1 (en) | 1995-05-22 | 1996-05-09 | Method of administration of igf-i |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008267372A Division JP2009132682A (ja) | 1995-05-22 | 2008-10-16 | Igf−iの投与法 |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH11505265A true JPH11505265A (ja) | 1999-05-18 |
Family
ID=23770265
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8535717A Withdrawn JPH11505265A (ja) | 1995-05-22 | 1996-05-09 | Igf−iの投与法 |
JP2008267372A Pending JP2009132682A (ja) | 1995-05-22 | 2008-10-16 | Igf−iの投与法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008267372A Pending JP2009132682A (ja) | 1995-05-22 | 2008-10-16 | Igf−iの投与法 |
Country Status (16)
Country | Link |
---|---|
US (1) | US5741776A (ja) |
EP (1) | EP0827408B1 (ja) |
JP (2) | JPH11505265A (ja) |
AT (1) | ATE343395T1 (ja) |
AU (1) | AU699113B2 (ja) |
CA (1) | CA2218018A1 (ja) |
DE (1) | DE69636654T2 (ja) |
DK (1) | DK0827408T3 (ja) |
ES (1) | ES2275276T3 (ja) |
HK (1) | HK1009744A1 (ja) |
IL (1) | IL118356A0 (ja) |
MX (1) | MX9708918A (ja) |
NZ (1) | NZ307913A (ja) |
PT (1) | PT827408E (ja) |
WO (1) | WO1996037216A1 (ja) |
ZA (1) | ZA963995B (ja) |
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JP2003512434A (ja) * | 1999-10-26 | 2003-04-02 | ファリス バイオテック ゲゼルシャフト ミット ベシュレンクテル ハフツング | 残された腎機能を有する慢性腎不全を治療するためのウロジラチンの使用 |
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-
1995
- 1995-05-22 US US08/445,805 patent/US5741776A/en not_active Expired - Lifetime
-
1996
- 1996-05-09 EP EP96915698A patent/EP0827408B1/en not_active Expired - Lifetime
- 1996-05-09 DK DK96915698T patent/DK0827408T3/da active
- 1996-05-09 ES ES96915698T patent/ES2275276T3/es not_active Expired - Lifetime
- 1996-05-09 DE DE69636654T patent/DE69636654T2/de not_active Expired - Lifetime
- 1996-05-09 CA CA002218018A patent/CA2218018A1/en not_active Abandoned
- 1996-05-09 PT PT96915698T patent/PT827408E/pt unknown
- 1996-05-09 WO PCT/US1996/006704 patent/WO1996037216A1/en active IP Right Grant
- 1996-05-09 AT AT96915698T patent/ATE343395T1/de active
- 1996-05-09 NZ NZ307913A patent/NZ307913A/en not_active IP Right Cessation
- 1996-05-09 JP JP8535717A patent/JPH11505265A/ja not_active Withdrawn
- 1996-05-09 AU AU57406/96A patent/AU699113B2/en not_active Ceased
- 1996-05-20 ZA ZA9603995A patent/ZA963995B/xx unknown
- 1996-05-22 IL IL11835696A patent/IL118356A0/xx unknown
-
1997
- 1997-11-19 MX MX9708918A patent/MX9708918A/es not_active IP Right Cessation
-
1998
- 1998-09-10 HK HK98110559A patent/HK1009744A1/xx not_active IP Right Cessation
-
2008
- 2008-10-16 JP JP2008267372A patent/JP2009132682A/ja active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003512434A (ja) * | 1999-10-26 | 2003-04-02 | ファリス バイオテック ゲゼルシャフト ミット ベシュレンクテル ハフツング | 残された腎機能を有する慢性腎不全を治療するためのウロジラチンの使用 |
Also Published As
Publication number | Publication date |
---|---|
NZ307913A (en) | 2005-07-29 |
WO1996037216A1 (en) | 1996-11-28 |
CA2218018A1 (en) | 1996-11-28 |
PT827408E (pt) | 2007-01-31 |
JP2009132682A (ja) | 2009-06-18 |
AU699113B2 (en) | 1998-11-19 |
EP0827408A1 (en) | 1998-03-11 |
ZA963995B (en) | 1997-11-20 |
EP0827408B1 (en) | 2006-10-25 |
AU5740696A (en) | 1996-12-11 |
DE69636654D1 (de) | 2006-12-07 |
MX9708918A (es) | 1998-06-30 |
US5741776A (en) | 1998-04-21 |
DE69636654T2 (de) | 2007-10-04 |
DK0827408T3 (da) | 2007-02-26 |
IL118356A0 (en) | 1996-09-12 |
HK1009744A1 (en) | 1999-06-11 |
ES2275276T3 (es) | 2007-06-01 |
ATE343395T1 (de) | 2006-11-15 |
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