IL118356A0 - Method of administration of IGF-I - Google Patents
Method of administration of IGF-IInfo
- Publication number
- IL118356A0 IL118356A0 IL11835696A IL11835696A IL118356A0 IL 118356 A0 IL118356 A0 IL 118356A0 IL 11835696 A IL11835696 A IL 11835696A IL 11835696 A IL11835696 A IL 11835696A IL 118356 A0 IL118356 A0 IL 118356A0
- Authority
- IL
- Israel
- Prior art keywords
- administration
- mammal
- igf
- period
- time
- Prior art date
Links
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 title abstract 5
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 title abstract 5
- 241000124008 Mammalia Species 0.000 abstract 5
- 230000008512 biological response Effects 0.000 abstract 2
- 230000004071 biological effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/556—Angiotensin converting enzyme inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Zoology (AREA)
- Neurology (AREA)
- AIDS & HIV (AREA)
- Dermatology (AREA)
- Child & Adolescent Psychology (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Tropical Medicine & Parasitology (AREA)
Abstract
A method is disclosed that comprises administering insulin-like growth factor-I (IGF-I) to a mammal so as to sustain its biological activity in the mammal comprising administering a therapeutically effective amount of IGF-I to the mammal to provide an exposure to IGF-I for a period of time that stimulates the maximum biological response in the mammal, then discontinuing said administration for a period of time equal to or less than the time period used for administration, and repeating this pattern of administration and discontinuance of administration for a period as long as necessary to achieve or maintain the desired biological response in the mammal.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/445,805 US5741776A (en) | 1995-05-22 | 1995-05-22 | Method of administration of IGF-I |
Publications (1)
Publication Number | Publication Date |
---|---|
IL118356A0 true IL118356A0 (en) | 1996-09-12 |
Family
ID=23770265
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11835696A IL118356A0 (en) | 1995-05-22 | 1996-05-22 | Method of administration of IGF-I |
Country Status (16)
Country | Link |
---|---|
US (1) | US5741776A (en) |
EP (1) | EP0827408B1 (en) |
JP (2) | JPH11505265A (en) |
AT (1) | ATE343395T1 (en) |
AU (1) | AU699113B2 (en) |
CA (1) | CA2218018A1 (en) |
DE (1) | DE69636654T2 (en) |
DK (1) | DK0827408T3 (en) |
ES (1) | ES2275276T3 (en) |
HK (1) | HK1009744A1 (en) |
IL (1) | IL118356A0 (en) |
MX (1) | MX9708918A (en) |
NZ (1) | NZ307913A (en) |
PT (1) | PT827408E (en) |
WO (1) | WO1996037216A1 (en) |
ZA (1) | ZA963995B (en) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6239172B1 (en) * | 1997-04-10 | 2001-05-29 | Nitrosystems, Inc. | Formulations for treating disease and methods of using same |
US20110196039A9 (en) * | 1994-10-05 | 2011-08-11 | Kaesemeyer Wayne H | Controlled release arginine formulations |
CA2265972A1 (en) * | 1996-09-16 | 1998-03-26 | Philip D. Acott | Use of igf-i for the treatment of polycystic kidney disease and related indications |
ATE233097T1 (en) | 1997-11-07 | 2003-03-15 | Chiron Corp | METHOD FOR PRODUCING SUSTAINED RELEASE IGF-I FORMULATIONS |
WO1999051262A2 (en) | 1998-04-03 | 1999-10-14 | Chiron Corporation | Use of igfi for treating articular cartilage disorders |
JP3971108B2 (en) * | 1999-01-06 | 2007-09-05 | ジェネンテック・インコーポレーテッド | Insulin-like growth factor (IGF) I mutant |
WO2000040612A1 (en) * | 1999-01-06 | 2000-07-13 | Genentech, Inc. | Insulin-like growth factor (igf) i mutant variants |
WO2000050006A2 (en) | 1999-02-26 | 2000-08-31 | Chiron Corporation | Microemulsions with adsorbed macromoelecules and microparticles |
US6040292A (en) * | 1999-06-04 | 2000-03-21 | Celtrix Pharmaceuticals, Inc. | Methods for treating diabetes |
US7713739B1 (en) | 2000-11-17 | 2010-05-11 | Novartis Vaccines And Diagnostics, Inc. | Microparticle-based transfection and activation of dendritic cells |
DE19951471A1 (en) * | 1999-10-26 | 2001-05-03 | Forssmann Wolf Georg | Use of urodilatin for the treatment of chronic renal failure with residual kidney functions |
AU2001263215A1 (en) * | 2000-05-16 | 2001-11-26 | Genentech Inc. | Method for treating cartilage disorders |
WO2005020933A2 (en) | 2003-09-02 | 2005-03-10 | University Of South Florida | Nanoparticles for drug-delivery |
DK2274978T3 (en) * | 2003-09-12 | 2015-06-15 | Ipsen Biopharmaceuticals Inc | Methods of treating an insulin-like growth factor-I (IGF-I) deficiency |
US20090012499A1 (en) * | 2005-02-08 | 2009-01-08 | Japan As Rep. By Pres. Of Nat. Cardiovascular Ctr. | Novel method for treating chronic severe heart failure by using insulin-like growth factor-1 (igf-1) |
SI2510942T1 (en) | 2005-04-07 | 2016-01-29 | Cardiorentis Ag | Use of natriuretic peptide for treating heart failure |
US8158582B2 (en) * | 2005-06-02 | 2012-04-17 | Tercica, Inc. | Methods for treatment of insulin-like growth factor-1 deficiency |
WO2007014167A2 (en) * | 2005-07-22 | 2007-02-01 | Five Prime Therapeutics, Inc. | Compositions for and methods of treating epithelial diseases with growth factors |
ES2325432B1 (en) * | 2006-01-13 | 2010-06-09 | Universidad De Malaga | USE OF LOW DOSE OF IGF-I IN AGING FOR ITS NEUROPROTECTORS, ANTIOXIDANTS AND ANABOLIZING EFFECTS. |
CL2007002502A1 (en) * | 2006-08-31 | 2008-05-30 | Hoffmann La Roche | VARIANTS OF THE SIMILAR GROWTH FACTOR TO HUMAN INSULIN-1 (IGF-1) PEGILATED IN LISIN; METHOD OF PRODUCTION; FUSION PROTEIN THAT UNDERSTANDS IT; AND ITS USE TO TREAT ALZHEIMER'S DISEASE. |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE8703625D0 (en) * | 1987-09-18 | 1987-09-18 | Kabivitrum Ab | NEW MEDICAL USE |
US4876242A (en) * | 1987-09-21 | 1989-10-24 | Merck & Co., Inc. | Human insulin-like growth factor analoges with reduced binding to serum carrier proteins and their production in yeast |
ATE86496T1 (en) * | 1988-02-05 | 1993-03-15 | Ciba Geigy Ag | USE OF IGF I IN THE MANUFACTURE OF A PREPARATION FOR THE TREATMENT OF KIDNEY DISEASES. |
US4988675A (en) * | 1988-02-05 | 1991-01-29 | Ciba-Geigy Corporation | Method for preventing secondary effects |
US5093317A (en) * | 1989-06-05 | 1992-03-03 | Cephalon, Inc. | Treating disorders by application of insulin-like growth factor |
GB8920381D0 (en) * | 1989-09-08 | 1989-10-25 | Greater Glasgow Health Board | Treatment of insulin-resistant diabetes |
US5126324A (en) * | 1990-06-07 | 1992-06-30 | Genentech, Inc. | Method of enhancing growth in patients using combination therapy |
US5374620A (en) * | 1990-06-07 | 1994-12-20 | Genentech, Inc. | Growth-promoting composition and its use |
SE9100099D0 (en) * | 1991-01-11 | 1991-01-11 | Kabi Pharmacia Ab | USE OF GROWTH FACTOR |
US5187151A (en) * | 1991-02-12 | 1993-02-16 | Genentech, Inc. | Use of binding protein with igf-i as an anabolic growth promoting agent |
US5202119A (en) * | 1991-06-28 | 1993-04-13 | Genentech, Inc. | Method of stimulating immune response |
WO1993000109A1 (en) * | 1991-06-28 | 1993-01-07 | Genentech, Inc. | Method of stimulating immune response using growth hormone |
SE9201573D0 (en) * | 1992-05-19 | 1992-05-19 | Kabi Pharmacia Ab | USE OF IGF-1 |
NZ253867A (en) * | 1992-06-12 | 1996-08-27 | Cephalon Inc | Treating peripheral neuropathy using igf-1 or igf-3 |
DK0661990T3 (en) * | 1992-08-26 | 2002-06-17 | Celtrix Pharma | Method for systemic treatment of catabolic conditions and systemic tissue damage |
US5273961A (en) * | 1992-09-22 | 1993-12-28 | Genentech, Inc. | Method of prophylaxis of acute renal failure |
JPH08502969A (en) * | 1992-10-29 | 1996-04-02 | ジェネンテク,インコーポレイテッド | How to prevent or treat obesity |
EP0642350A4 (en) * | 1993-01-25 | 1995-06-28 | Beth Israel Hospital | Method for modifying, diagnosing, and screening for igf-i sensitive cell barrier properties. |
DE69431631T2 (en) * | 1993-09-20 | 2003-07-31 | Celtrix Pharma | TREATMENT OF HEMATOLOGICAL DISORDERS WITH AN IGF-1 / IGFBP-3 COMPLEX |
WO1995013824A1 (en) * | 1993-11-15 | 1995-05-26 | Celtrix Pharmaceuticals, Inc. | Method of treating renal disease by administering igf-i and igfbp-3 |
US5610134A (en) * | 1994-04-15 | 1997-03-11 | Genentech, Inc. | Treatment of congestive heart failure |
US5565428A (en) * | 1995-05-22 | 1996-10-15 | Genentech, Inc. | Method of administration of IGF-I |
-
1995
- 1995-05-22 US US08/445,805 patent/US5741776A/en not_active Expired - Lifetime
-
1996
- 1996-05-09 PT PT96915698T patent/PT827408E/en unknown
- 1996-05-09 DE DE69636654T patent/DE69636654T2/en not_active Expired - Lifetime
- 1996-05-09 AU AU57406/96A patent/AU699113B2/en not_active Ceased
- 1996-05-09 ES ES96915698T patent/ES2275276T3/en not_active Expired - Lifetime
- 1996-05-09 WO PCT/US1996/006704 patent/WO1996037216A1/en active IP Right Grant
- 1996-05-09 CA CA002218018A patent/CA2218018A1/en not_active Abandoned
- 1996-05-09 AT AT96915698T patent/ATE343395T1/en active
- 1996-05-09 EP EP96915698A patent/EP0827408B1/en not_active Expired - Lifetime
- 1996-05-09 DK DK96915698T patent/DK0827408T3/en active
- 1996-05-09 NZ NZ307913A patent/NZ307913A/en not_active IP Right Cessation
- 1996-05-09 JP JP8535717A patent/JPH11505265A/en not_active Withdrawn
- 1996-05-20 ZA ZA9603995A patent/ZA963995B/en unknown
- 1996-05-22 IL IL11835696A patent/IL118356A0/en unknown
-
1997
- 1997-11-19 MX MX9708918A patent/MX9708918A/en not_active IP Right Cessation
-
1998
- 1998-09-10 HK HK98110559A patent/HK1009744A1/en not_active IP Right Cessation
-
2008
- 2008-10-16 JP JP2008267372A patent/JP2009132682A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0827408A1 (en) | 1998-03-11 |
HK1009744A1 (en) | 1999-06-11 |
DE69636654D1 (en) | 2006-12-07 |
AU699113B2 (en) | 1998-11-19 |
DK0827408T3 (en) | 2007-02-26 |
US5741776A (en) | 1998-04-21 |
ATE343395T1 (en) | 2006-11-15 |
JPH11505265A (en) | 1999-05-18 |
PT827408E (en) | 2007-01-31 |
ZA963995B (en) | 1997-11-20 |
WO1996037216A1 (en) | 1996-11-28 |
JP2009132682A (en) | 2009-06-18 |
NZ307913A (en) | 2005-07-29 |
MX9708918A (en) | 1998-06-30 |
CA2218018A1 (en) | 1996-11-28 |
AU5740696A (en) | 1996-12-11 |
ES2275276T3 (en) | 2007-06-01 |
EP0827408B1 (en) | 2006-10-25 |
DE69636654T2 (en) | 2007-10-04 |
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