EP0592569A4 - Composition and method for transdermal delivery of diclofenac. - Google Patents

Composition and method for transdermal delivery of diclofenac.

Info

Publication number
EP0592569A4
EP0592569A4 EP19920915035 EP92915035A EP0592569A4 EP 0592569 A4 EP0592569 A4 EP 0592569A4 EP 19920915035 EP19920915035 EP 19920915035 EP 92915035 A EP92915035 A EP 92915035A EP 0592569 A4 EP0592569 A4 EP 0592569A4
Authority
EP
European Patent Office
Prior art keywords
diclofenac
composition
transdermal delivery
transdermal
delivery
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19920915035
Other languages
German (de)
French (fr)
Other versions
EP0592569A1 (en
Inventor
Charles J Ii Betlach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aveva Drug Deliverty Systems Inc
Original Assignee
Sano Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sano Corp filed Critical Sano Corp
Publication of EP0592569A4 publication Critical patent/EP0592569A4/en
Publication of EP0592569A1 publication Critical patent/EP0592569A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
EP92915035A 1991-07-03 1992-06-12 Composition and method for transdermal delivery of diclofenac Withdrawn EP0592569A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72535291A 1991-07-03 1991-07-03
US725352 1991-07-03
PCT/US1992/005104 WO1993000873A1 (en) 1991-07-03 1992-06-12 Composition and method for transdermal delivery of diclofenac

Publications (2)

Publication Number Publication Date
EP0592569A4 true EP0592569A4 (en) 1994-03-15
EP0592569A1 EP0592569A1 (en) 1994-04-20

Family

ID=24914192

Family Applications (1)

Application Number Title Priority Date Filing Date
EP92915035A Withdrawn EP0592569A1 (en) 1991-07-03 1992-06-12 Composition and method for transdermal delivery of diclofenac

Country Status (6)

Country Link
US (1) US5374661A (en)
EP (1) EP0592569A1 (en)
JP (1) JPH06509099A (en)
AU (1) AU2259692A (en)
CA (1) CA2112751A1 (en)
WO (1) WO1993000873A1 (en)

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AUPN814496A0 (en) * 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
DE19641259A1 (en) * 1996-10-07 1998-04-16 Kade Pharma Fab Gmbh Medicines based on diclofenac
US5976566A (en) * 1997-08-29 1999-11-02 Macrochem Corporation Non-steroidal antiinflammtory drug formulations for topical application to the skin
US6193996B1 (en) * 1998-04-02 2001-02-27 3M Innovative Properties Company Device for the transdermal delivery of diclofenac
KR100550965B1 (en) * 1998-12-31 2006-09-20 주식회사 엘지생활건강 Composition for promoting transdermal absorption of vitamins
US6399093B1 (en) 1999-05-19 2002-06-04 Advanced Medical Instruments Method and composition to treat musculoskeletal disorders
JP2000351729A (en) * 1999-06-08 2000-12-19 Shionogi & Co Ltd Percutaneous absorption preparation of thromboxane a2 receptor antagonist
US20030104041A1 (en) * 1999-12-16 2003-06-05 Tsung-Min Hsu Transdermal and topical administration of drugs using basic permeation enhancers
MXPA03001406A (en) 2000-08-15 2004-05-04 Surmodics Inc Medicament incorporation matrix.
PE20040321A1 (en) * 2002-08-22 2004-07-15 Novartis Consumer Health Sa TOPICAL COMPOSITION INCLUDING DICLOFENACO
US20040224010A1 (en) * 2002-11-15 2004-11-11 Optime Therapeutics, Inc. Ophthalmic liposome compositions and uses thereof
WO2008049020A2 (en) * 2006-10-17 2008-04-24 Nuvo Research Diclofenac gel
HU227970B1 (en) * 2007-07-10 2012-07-30 Egis Gyogyszergyar Nyrt Pharmaceutical compositions containing silicones of high volatility
US20100100060A1 (en) * 2008-10-17 2010-04-22 Novartis Ag Applicator for pharmaceutical product and method of using same
US8546450B1 (en) 2009-03-31 2013-10-01 Nuvo Research Inc. Treatment of pain with topical diclofenac compounds
US8618164B2 (en) 2009-03-31 2013-12-31 Nuvo Research Inc. Treatment of pain with topical diclofenac compounds
US8439896B2 (en) * 2009-11-13 2013-05-14 The Invention Science Fund I, Llc Device, system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject
US8894630B2 (en) * 2009-11-13 2014-11-25 The Invention Science Fund I, Llc Device, system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject
US8888761B2 (en) * 2009-11-13 2014-11-18 The Invention Science Fund I, Llc Device, system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject
WO2013084995A1 (en) * 2011-12-07 2013-06-13 久光製薬株式会社 Adhesive patch
US10813897B2 (en) * 2011-12-27 2020-10-27 Cmpd Licensing, Llc Composition and method for compounded therapy
US8623882B2 (en) * 2012-02-06 2014-01-07 Innovative Med Concepts, LLC Aciclovir and diclofenac combination therapy for functional somatic syndromes
US8853189B2 (en) * 2012-05-31 2014-10-07 Prima Innovations, Llc Antispasmodic 1,2-Diols and 1,2,3-triols
US10045965B2 (en) 2012-07-31 2018-08-14 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
US11154535B2 (en) 2012-07-31 2021-10-26 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
US10045935B2 (en) 2012-07-31 2018-08-14 Egis Pharmaceuticals Plc Transdermal formulation containing COX inhibitors
WO2014068600A1 (en) 2012-11-02 2014-05-08 Zydus Technologies Limited Stable transdermal pharmaceutical drug delivery system comprising diclofenac
US9012402B1 (en) 2014-06-11 2015-04-21 James Blanchard Gel for topical delivery of NSAIDs to provide relief of musculoskeletal pain and methods for its preparation
EP3191082A1 (en) * 2014-09-10 2017-07-19 Novartis Consumer Health S.A. Topical diclofenac sodium compositions
CN110545796A (en) 2017-03-07 2019-12-06 耶路撒冷希伯来大学伊森姆研究发展有限公司 Local delivery system for active compounds
US11129818B2 (en) 2017-06-07 2021-09-28 Arcutis Biotherapeutics, Inc. Topical roflumilast formulation having improved delivery and plasma half life
US9895359B1 (en) 2017-06-07 2018-02-20 Arcutis, Inc. Inhibition of crystal growth of roflumilast
US10821075B1 (en) 2017-07-12 2020-11-03 James Blanchard Compositions for topical application of a medicaments onto a mammalian body surface
US11534493B2 (en) * 2017-09-22 2022-12-27 Arcutis Biotherapeutics, Inc. Pharmaceutical compositions of roflumilast in aqueous blends of water-miscible, pharmaceutically acceptable solvents
FR3104962B1 (en) * 2019-12-20 2021-12-31 Oreal Cosmetic composition comprising at least one polar oil, one aliphatic monoalcohol, a mixture of polyols and at least one hydrophilic active
CN112870180B (en) * 2021-03-24 2023-11-07 中国药科大学 Diclofenac sodium abdominal navel patch suitable for postoperative pain relief of anorectal and preparation method thereof
EP4112043A1 (en) * 2021-06-30 2023-01-04 GSK Consumer Healthcare SARL Nano-complex composition comprising diclofenac
CN114259461B (en) * 2021-11-29 2023-09-12 海南全星制药有限公司 Diclofenac sodium gel and preparation method thereof
EP4223280A1 (en) * 2022-02-02 2023-08-09 GSK Consumer Healthcare SARL Diclofenac formulations

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0245126A2 (en) * 1986-05-07 1987-11-11 Taro Ogiso Percutaneous absorption preparation and process for preparing same
EP0368339A2 (en) * 1988-11-11 1990-05-16 Eisai Co., Ltd. Pharmaceutical preparation for percutaneous administration containing bunazosin or its salt

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US3524916A (en) * 1966-07-09 1970-08-18 Takeda Chemical Industries Ltd Griseofulvin-ethylene glycol monosalicylate compositions
DK135267A (en) * 1971-02-25
US4009254A (en) * 1974-05-06 1977-02-22 Colgate-Palmolive Company Topical compositions
US4048310A (en) * 1976-02-24 1977-09-13 E. R. Squibb & Sons, Inc. Topical steroid formulation in form of lotion or cream
US4687781A (en) * 1978-03-03 1987-08-18 Endorfin, Inc. Analgesic and anti-inflammatory compositions
GB2023000B (en) * 1978-06-17 1982-10-13 Kowa Co Antinflammatory analgesic gelled ointments
BR7904612A (en) * 1978-07-24 1980-04-08 Unilever Nv COMPOSITION COSMETICALLY ACCEPTABLE FOR TOPICAL APPLICATION, PROCESS TO PREPARE A COMPOSITION, APPLICATOR AND PROCESS TO PROVIDE SKIN ADVANTAGE
US4954487A (en) * 1979-01-08 1990-09-04 The Procter & Gamble Company Penetrating topical pharmaceutical compositions
US4341783A (en) * 1980-07-31 1982-07-27 Lemmon Company Topical use of dyphylline and dyphylline containing compositions
AT370721B (en) * 1981-02-24 1983-04-25 Ciba Geigy Ag METHOD FOR PRODUCING NEW SALTS OF 2- (2,6-DICHLORANILINO) -PHENYLACETIC ACID, THE
JPS5829706A (en) * 1981-08-14 1983-02-22 Toko Yakuhin Kogyo Kk Antiphlogistic and analgesic agent for external use
CH655656B (en) * 1982-10-07 1986-05-15
IL67445A (en) * 1982-12-09 1985-11-29 Teva Pharma Ethoxycarbonyloxy ethyl esters of non-steroidal anti-inflammatory carboxylic acids
CH655507B (en) * 1983-01-12 1986-04-30
US4710497A (en) * 1983-05-20 1987-12-01 Nitto Electric Industrial Co., Ltd. Method for percutaneously administering physiologically active agents
US4543251A (en) * 1983-12-09 1985-09-24 Toko Yakuhin Industry Co., Ltd. Gel preparations for external application
US4670254A (en) * 1983-12-09 1987-06-02 Toko Yakuhin Industry Co., Ltd. Gel preparations for topical application of diclofenac sodium
CA1249968A (en) * 1984-04-05 1989-02-14 Kazuo Kigasawa Ointment base
JPS60224638A (en) * 1984-04-23 1985-11-09 Kao Corp Percutaneous absorption promoter and external drug containing same
JPS6160620A (en) * 1984-09-03 1986-03-28 Teijin Ltd Pharmaceutical composition containing pyroglutamic acid ester
DE3446873A1 (en) * 1984-12-21 1986-07-10 Merckle Gmbh LIQUID DICLOFENAC PREPARATIONS
US4778786A (en) * 1985-04-03 1988-10-18 Minnetonka, Inc. Composition for transdermal drug delivery
JPS61280426A (en) * 1985-06-04 1986-12-11 Ikeda Mohandou:Kk Anti-inflammatory and analgesic application agent
DE3522550A1 (en) * 1985-06-24 1987-01-02 Klinge Co Chem Pharm Fab SPRAYABLE PHARMACEUTICAL PREPARATION FOR TOPICAL APPLICATION
JPS6272611A (en) * 1985-09-27 1987-04-03 Kao Corp Skin external preparation
US4946870A (en) * 1986-06-06 1990-08-07 Union Carbide Chemicals And Plastics Company Inc. Delivery systems for pharmaceutical or therapeutic actives
CH666621A5 (en) * 1986-06-27 1988-08-15 Ciba Geigy Ag TOPICALLY APPLICABLE PHARMACEUTICAL COMPOSITIONS WITH SYSTEMIC EFFECT.
US5164416A (en) * 1989-02-03 1992-11-17 Lintec Corporation Transdermal therapeutic formulation containing a limonene
US4948581A (en) * 1989-02-17 1990-08-14 Dojin Iyaku-Kako Co., Ltd. Long acting diclofenac sodium preparation
US4996193A (en) * 1989-03-03 1991-02-26 The Regents Of The University Of California Combined topical and systemic method of administration of cyclosporine
US5095037B1 (en) * 1989-12-21 1995-12-19 Nissho Kk Combined anti-inflammatory agent

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0245126A2 (en) * 1986-05-07 1987-11-11 Taro Ogiso Percutaneous absorption preparation and process for preparing same
EP0368339A2 (en) * 1988-11-11 1990-05-16 Eisai Co., Ltd. Pharmaceutical preparation for percutaneous administration containing bunazosin or its salt

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9300873A1 *

Also Published As

Publication number Publication date
US5374661A (en) 1994-12-20
CA2112751A1 (en) 1993-01-21
WO1993000873A1 (en) 1993-01-21
AU2259692A (en) 1993-02-11
EP0592569A1 (en) 1994-04-20
JPH06509099A (en) 1994-10-13

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19931230

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IT LI LU NL SE

RHK1 Main classification (correction)

Ipc: A61K 31/195

17Q First examination report despatched

Effective date: 19970320

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 19970731