JPH1067662A - アポプトーシスのモジュレーションのためのキサンチン誘導体の使用 - Google Patents
アポプトーシスのモジュレーションのためのキサンチン誘導体の使用Info
- Publication number
- JPH1067662A JPH1067662A JP9204345A JP20434597A JPH1067662A JP H1067662 A JPH1067662 A JP H1067662A JP 9204345 A JP9204345 A JP 9204345A JP 20434597 A JP20434597 A JP 20434597A JP H1067662 A JPH1067662 A JP H1067662A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alkyl
- group
- hydrogen atom
- integer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- CPHXVZPWWAURML-UHFFFAOYSA-N 8-methyl-7-propyl-3H-purine-2,6-dione Chemical compound CCCn1c(C)nc2[nH]c(=O)[nH]c(=O)c12 CPHXVZPWWAURML-UHFFFAOYSA-N 0.000 claims 2
- MVCKCEDAMDIWAO-UHFFFAOYSA-N 2-cyano-n-(4-cyanophenyl)-3-cyclopropyl-3-hydroxyprop-2-enamide Chemical compound C=1C=C(C#N)C=CC=1NC(=O)C(C#N)=C(O)C1CC1 MVCKCEDAMDIWAO-UHFFFAOYSA-N 0.000 claims 1
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- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 5
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- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
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Landscapes
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| DE19630837 | 1996-07-31 | ||
| DE19640556:4 | 1996-10-01 | ||
| DE19630837:2 | 1996-10-01 | ||
| DE19640556A DE19640556A1 (de) | 1996-10-01 | 1996-10-01 | Verwendung von Xanthinderivaten zur Modulation der Apoptose |
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| EP (1) | EP0821960B1 (enExample) |
| JP (1) | JPH1067662A (enExample) |
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| US7282201B2 (en) | 2001-12-28 | 2007-10-16 | Asubio Pharma Co., Ltd. | Methods of promoting the growth or differentiation of hematopoietic stem or progenitor cells by non-muscle type cofilin |
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| US6011051A (en) * | 1996-07-31 | 2000-01-04 | Hoechst Aktiengesellschaft | Use of isoxazole and crotonamide derivatives for the modulation of apoptosis |
| DE19860802A1 (de) * | 1998-12-30 | 2000-10-26 | Virgene Pharmaceuticals Ag | Herstellung eines Mittels gegen Hepatitis B-, HI-, Paramyxo und Orthomyxo-Viren |
| US6458930B1 (en) | 2000-11-28 | 2002-10-01 | Cytokinetics, Inc. | Aspergillus fumigatus cofilin |
| GB0123571D0 (en) | 2001-04-05 | 2001-11-21 | Aventis Pharm Prod Inc | Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis |
| FR2825928B1 (fr) * | 2001-06-18 | 2004-04-02 | Ecole Norm Superieure Cachan | Composition pharmaceutique pour le diagnostic, la prevention ou le traitement d'une pathologie tumorale, comprenant un agent modulateur de l'etat polymerisation de l'actine |
| DE10217254A1 (de) * | 2002-04-15 | 2003-10-23 | Proteosys Ag | Verwendung von Substanzen zur Behandlung von Tumoren |
| GB0224014D0 (en) * | 2002-10-15 | 2002-11-27 | Oxford Glycosciences Uk Ltd | A protein involved in therapy |
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| US3737433A (en) * | 1964-09-05 | 1973-06-05 | Albert Ag Chem Werke | Certain oxoalkyldimethylxanthines |
| DE2335170C2 (de) * | 1973-07-11 | 1989-07-20 | Hoechst Ag, 6230 Frankfurt | 1,3-Dialkyl-7-(hydroxyalkyl)-xanthine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| NL186239B (nl) * | 1975-06-05 | Hoechst Ag | Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze. | |
| DE3508097A1 (de) * | 1984-07-21 | 1986-02-06 | Hoechst Ag, 6230 Frankfurt | Kombinationspraeparat aus xanthinderivaten und o-acetylsalicylsaeure bzw. deren pharmakologisch vertraeglichen salzen und dessen verwendung |
| DE3525801A1 (de) * | 1985-07-19 | 1987-01-22 | Hoechst Ag | Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung |
| IL106859A (en) * | 1986-12-31 | 1996-10-16 | Hoechst Roussel Pharma | Pentoxifilin metabolites and pharmaceutical preparations containing them for the treatment of VIH and similar diseases |
| IL99811A (en) * | 1990-10-30 | 1996-03-31 | Roussel Uclaf | 3-cycloalkyl-propanamides their tautomer forms and their salts preparation process and compositions containing them |
| WO1992007566A2 (en) * | 1990-11-01 | 1992-05-14 | Board Of Regents, The University Of Texas System | Antifungal activity of and prevention of drug induced nephrotoxicity by methylxanthine analogues |
| DE59207086D1 (de) * | 1991-05-23 | 1996-10-17 | Hoechst Ag | Die Verwendung von 1-(5-Oxohexyl)-3-methyl-7-n-propyl-xanthin in der Gefässchirurgie |
| JP3566719B2 (ja) * | 1991-05-24 | 2004-09-15 | フレッド ハッチンソン キャンサー リサーチ センター | 外来性刺激に対する細胞性応答の調整 |
| MX9203323A (es) * | 1991-07-11 | 1994-07-29 | Hoechst Ag | El empleo de derivados de xantina para el tratamiento de lesiones secundarias de las celulas nerviosas y trastornos funcionales despues de traumas craneo-cerebrales. |
| TW209834B (enExample) * | 1991-12-11 | 1993-07-21 | Hoechst Ag | |
| GB9200275D0 (en) * | 1992-01-08 | 1992-02-26 | Roussel Lab Ltd | Chemical compounds |
| ATE146078T1 (de) * | 1992-02-22 | 1996-12-15 | Hoechst Ag | Verwendung von xanthinderivaten zur behandlung von muskelschädigungen nach vollständiger unterbrechung der blutzirkulation |
| US5763446A (en) * | 1992-03-26 | 1998-06-09 | University Of Southern California | Use of pentoxifylline and other tumor necrosis factor blockers for the treatment of aids-associated optic neuropathy and other central nervous system diseases |
| GB9321083D0 (en) * | 1993-10-13 | 1993-12-01 | Univ Mcgill | Phosphatase inhibitors in channel diseases |
| US5519042A (en) * | 1994-01-13 | 1996-05-21 | Hoechst Aktiengesellschaft | Method of treating hyperproliferative vascular disease |
| WO1996005836A2 (en) * | 1994-08-25 | 1996-02-29 | Medical University Of South Carolina | Methods of treating cold symptoms using pentoxifylline |
| ATE220549T1 (de) * | 1994-12-29 | 2002-08-15 | Univ California | Verbindungen zur hemmung der ceramid vermittelten signalübertragung |
-
1997
- 1997-07-23 US US08/899,023 patent/US5856330A/en not_active Expired - Lifetime
- 1997-07-28 DE DE59709755T patent/DE59709755D1/de not_active Expired - Fee Related
- 1997-07-28 ES ES97112939T patent/ES2191794T3/es not_active Expired - Lifetime
- 1997-07-28 DK DK97112939T patent/DK0821960T3/da active
- 1997-07-28 AT AT97112939T patent/ATE236637T1/de not_active IP Right Cessation
- 1997-07-28 EP EP97112939A patent/EP0821960B1/de not_active Expired - Lifetime
- 1997-07-28 PT PT97112939T patent/PT821960E/pt unknown
- 1997-07-29 AU AU32367/97A patent/AU718237B2/en not_active Ceased
- 1997-07-30 CA CA002212205A patent/CA2212205C/en not_active Expired - Fee Related
- 1997-07-30 MX MX9705771D patent/MX9705771A/es not_active IP Right Cessation
- 1997-07-30 JP JP9204345A patent/JPH1067662A/ja not_active Ceased
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7282201B2 (en) | 2001-12-28 | 2007-10-16 | Asubio Pharma Co., Ltd. | Methods of promoting the growth or differentiation of hematopoietic stem or progenitor cells by non-muscle type cofilin |
Also Published As
| Publication number | Publication date |
|---|---|
| AU3236797A (en) | 1998-02-05 |
| EP0821960B1 (de) | 2003-04-09 |
| CA2212205A1 (en) | 1998-01-31 |
| EP0821960A1 (de) | 1998-02-04 |
| ES2191794T3 (es) | 2003-09-16 |
| DE59709755D1 (de) | 2003-05-15 |
| DK0821960T3 (da) | 2003-07-21 |
| US5856330A (en) | 1999-01-05 |
| MX9705771A (es) | 1998-08-30 |
| AU718237B2 (en) | 2000-04-13 |
| PT821960E (pt) | 2003-08-29 |
| ATE236637T1 (de) | 2003-04-15 |
| CA2212205C (en) | 2007-12-04 |
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