CA2212205C - Use of xanthine derivatives for the modulation of apoptosis - Google Patents
Use of xanthine derivatives for the modulation of apoptosis Download PDFInfo
- Publication number
- CA2212205C CA2212205C CA002212205A CA2212205A CA2212205C CA 2212205 C CA2212205 C CA 2212205C CA 002212205 A CA002212205 A CA 002212205A CA 2212205 A CA2212205 A CA 2212205A CA 2212205 C CA2212205 C CA 2212205C
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- alkyl
- radical
- formula
- cycloalkylalkyl
- compound
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Landscapes
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- Reproductive Health (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19630837.2 | 1996-07-31 | ||
| DE19630837 | 1996-07-31 | ||
| DE19640556A DE19640556A1 (de) | 1996-10-01 | 1996-10-01 | Verwendung von Xanthinderivaten zur Modulation der Apoptose |
| DE19640556.4 | 1996-10-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2212205A1 CA2212205A1 (en) | 1998-01-31 |
| CA2212205C true CA2212205C (en) | 2007-12-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002212205A Expired - Fee Related CA2212205C (en) | 1996-07-31 | 1997-07-30 | Use of xanthine derivatives for the modulation of apoptosis |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5856330A (enExample) |
| EP (1) | EP0821960B1 (enExample) |
| JP (1) | JPH1067662A (enExample) |
| AT (1) | ATE236637T1 (enExample) |
| AU (1) | AU718237B2 (enExample) |
| CA (1) | CA2212205C (enExample) |
| DE (1) | DE59709755D1 (enExample) |
| DK (1) | DK0821960T3 (enExample) |
| ES (1) | ES2191794T3 (enExample) |
| MX (1) | MX9705771A (enExample) |
| PT (1) | PT821960E (enExample) |
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| US6011051A (en) * | 1996-07-31 | 2000-01-04 | Hoechst Aktiengesellschaft | Use of isoxazole and crotonamide derivatives for the modulation of apoptosis |
| DE19860802A1 (de) * | 1998-12-30 | 2000-10-26 | Virgene Pharmaceuticals Ag | Herstellung eines Mittels gegen Hepatitis B-, HI-, Paramyxo und Orthomyxo-Viren |
| US6458930B1 (en) | 2000-11-28 | 2002-10-01 | Cytokinetics, Inc. | Aspergillus fumigatus cofilin |
| GB0123571D0 (en) | 2001-04-05 | 2001-11-21 | Aventis Pharm Prod Inc | Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis |
| FR2825928B1 (fr) * | 2001-06-18 | 2004-04-02 | Ecole Norm Superieure Cachan | Composition pharmaceutique pour le diagnostic, la prevention ou le traitement d'une pathologie tumorale, comprenant un agent modulateur de l'etat polymerisation de l'actine |
| CA2439471A1 (en) | 2001-12-28 | 2003-07-17 | Daiichi Suntory Pharma Co., Ltd. | Promoters of the growth and/or differentiation of hematopoietic stem cells and/or hematopoietic progenitors |
| DE10217254A1 (de) * | 2002-04-15 | 2003-10-23 | Proteosys Ag | Verwendung von Substanzen zur Behandlung von Tumoren |
| GB0224014D0 (en) * | 2002-10-15 | 2002-11-27 | Oxford Glycosciences Uk Ltd | A protein involved in therapy |
Family Cites Families (19)
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| US3737433A (en) * | 1964-09-05 | 1973-06-05 | Albert Ag Chem Werke | Certain oxoalkyldimethylxanthines |
| DE2335170C2 (de) * | 1973-07-11 | 1989-07-20 | Hoechst Ag, 6230 Frankfurt | 1,3-Dialkyl-7-(hydroxyalkyl)-xanthine, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel |
| NL186239B (nl) * | 1975-06-05 | Hoechst Ag | Werkwijze voor de bereiding van een geneesmiddel met antiflogistische en/of analgetische werking, alsmede werkwijze voor de bereiding van een 2-hydroxyethylideencyaanazijnzuuranilide geschikt voor toepassing bij deze werkwijze. | |
| DE3508097A1 (de) * | 1984-07-21 | 1986-02-06 | Hoechst Ag, 6230 Frankfurt | Kombinationspraeparat aus xanthinderivaten und o-acetylsalicylsaeure bzw. deren pharmakologisch vertraeglichen salzen und dessen verwendung |
| DE3525801A1 (de) * | 1985-07-19 | 1987-01-22 | Hoechst Ag | Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung |
| IL106861A (en) * | 1986-12-31 | 1997-02-18 | Hoechst Roussel Pharma | Pentoxifylline metabolites and pharmaceutical formulations containing them for inhibiting the activity of interleukin-1 and leukocyte-derived cytokines |
| IL99811A (en) * | 1990-10-30 | 1996-03-31 | Roussel Uclaf | 3-cycloalkyl-propanamides their tautomer forms and their salts preparation process and compositions containing them |
| AU9084991A (en) * | 1990-11-01 | 1992-05-26 | Board Of Regents, The University Of Texas System | Antifungal activity of and prevention of drug induced nephrotoxicity by methylxanthine analogues |
| DE59207086D1 (de) * | 1991-05-23 | 1996-10-17 | Hoechst Ag | Die Verwendung von 1-(5-Oxohexyl)-3-methyl-7-n-propyl-xanthin in der Gefässchirurgie |
| AU664189B2 (en) * | 1991-05-24 | 1995-11-09 | Fred Hutchinson Cancer Research Center | Modulation of cellular response to external stimuli |
| MX9203323A (es) * | 1991-07-11 | 1994-07-29 | Hoechst Ag | El empleo de derivados de xantina para el tratamiento de lesiones secundarias de las celulas nerviosas y trastornos funcionales despues de traumas craneo-cerebrales. |
| TW209834B (enExample) * | 1991-12-11 | 1993-07-21 | Hoechst Ag | |
| GB9200275D0 (en) * | 1992-01-08 | 1992-02-26 | Roussel Lab Ltd | Chemical compounds |
| TW288977B (enExample) * | 1992-02-22 | 1996-10-21 | Hoechst Ag | |
| US5763446A (en) * | 1992-03-26 | 1998-06-09 | University Of Southern California | Use of pentoxifylline and other tumor necrosis factor blockers for the treatment of aids-associated optic neuropathy and other central nervous system diseases |
| GB9321083D0 (en) * | 1993-10-13 | 1993-12-01 | Univ Mcgill | Phosphatase inhibitors in channel diseases |
| US5519042A (en) * | 1994-01-13 | 1996-05-21 | Hoechst Aktiengesellschaft | Method of treating hyperproliferative vascular disease |
| AU3539795A (en) * | 1994-08-25 | 1996-03-14 | Medical University Of South Carolina | Methods of treating cold symptoms using pentoxifylline |
| DE69527438T2 (de) * | 1994-12-29 | 2003-03-06 | The Regents Of The University Of California, Oakland | Verbindungen zur hemmung der ceramid vermittelten signalübertragung |
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1997
- 1997-07-23 US US08/899,023 patent/US5856330A/en not_active Expired - Lifetime
- 1997-07-28 DK DK97112939T patent/DK0821960T3/da active
- 1997-07-28 ES ES97112939T patent/ES2191794T3/es not_active Expired - Lifetime
- 1997-07-28 EP EP97112939A patent/EP0821960B1/de not_active Expired - Lifetime
- 1997-07-28 DE DE59709755T patent/DE59709755D1/de not_active Expired - Fee Related
- 1997-07-28 AT AT97112939T patent/ATE236637T1/de not_active IP Right Cessation
- 1997-07-28 PT PT97112939T patent/PT821960E/pt unknown
- 1997-07-29 AU AU32367/97A patent/AU718237B2/en not_active Ceased
- 1997-07-30 JP JP9204345A patent/JPH1067662A/ja not_active Ceased
- 1997-07-30 CA CA002212205A patent/CA2212205C/en not_active Expired - Fee Related
- 1997-07-30 MX MX9705771D patent/MX9705771A/es not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0821960B1 (de) | 2003-04-09 |
| DE59709755D1 (de) | 2003-05-15 |
| ATE236637T1 (de) | 2003-04-15 |
| ES2191794T3 (es) | 2003-09-16 |
| PT821960E (pt) | 2003-08-29 |
| JPH1067662A (ja) | 1998-03-10 |
| DK0821960T3 (da) | 2003-07-21 |
| AU3236797A (en) | 1998-02-05 |
| AU718237B2 (en) | 2000-04-13 |
| EP0821960A1 (de) | 1998-02-04 |
| MX9705771A (es) | 1998-08-30 |
| CA2212205A1 (en) | 1998-01-31 |
| US5856330A (en) | 1999-01-05 |
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