JPH10513350A - ＤＥＣ（樹状細胞及び上皮細胞、２０５ ｋＤａ）の同定、Ｃ型レクチンドメインを有するレセプター、ＤＥＣをコードする核酸、及びこれらの使用 - Google Patents

ＤＥＣ（樹状細胞及び上皮細胞、２０５ ｋＤａ）の同定、Ｃ型レクチンドメインを有するレセプター、ＤＥＣをコードする核酸、及びこれらの使用

Info

Publication number
JPH10513350A
JPH10513350A JP8523726A JP52372696A JPH10513350A JP H10513350 A JPH10513350 A JP H10513350A JP 8523726 A JP8523726 A JP 8523726A JP 52372696 A JP52372696 A JP 52372696A JP H10513350 A JPH10513350 A JP H10513350A
Authority
JP
Japan
Prior art keywords
dec
cells
protein
cell
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8523726A
Other languages
English (en)
Japanese (ja)
Inventor
ラルフ エム スタインマン
マイケル シー ヌッセンツワイグ
ウィリアム ジェイ スウィッガード
ワンピン イーアン
Original Assignee
ザ ロックフェラー ユニヴァーシティ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ザ ロックフェラー ユニヴァーシティ filed Critical ザ ロックフェラー ユニヴァーシティ
Publication of JPH10513350A publication Critical patent/JPH10513350A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6425—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a receptor, e.g. CD4, a cell surface antigen, i.e. not a peptide ligand targeting the antigen, or a cell surface determinant, i.e. a part of the surface of a cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4726—Lectins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP8523726A 1995-01-31 1996-01-31 ＤＥＣ（樹状細胞及び上皮細胞、２０５ ｋＤａ）の同定、Ｃ型レクチンドメインを有するレセプター、ＤＥＣをコードする核酸、及びこれらの使用 Pending JPH10513350A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38152895A 1995-01-31 1995-01-31
US08/381,528 1995-01-31
PCT/US1996/001383 WO1996023882A1 (en) 1995-01-31 1996-01-31 IDENTIFICATION OF DEC, (DENTRITIC AND EPITHELIAL CELLS, 205 kDa), A RECEPTOR WITH C-TYPE LECTIN DOMAINS, NUCLEIC ACIDS ENCODING DEC, AND USES THEREOF

Publications (1)

Publication Number Publication Date
JPH10513350A true JPH10513350A (ja) 1998-12-22

Family

ID=23505379

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8523726A Pending JPH10513350A (ja) 1995-01-31 1996-01-31 ＤＥＣ（樹状細胞及び上皮細胞、２０５ ｋＤａ）の同定、Ｃ型レクチンドメインを有するレセプター、ＤＥＣをコードする核酸、及びこれらの使用

Country Status (6)

Country Link
EP (1) EP0808366A1 (de)
JP (1) JPH10513350A (de)
AU (1) AU716056B2 (de)
CA (1) CA2211993A1 (de)
MX (1) MX9705923A (de)
WO (1) WO1996023882A1 (de)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006501131A (ja) * 2001-11-07 2006-01-12 セルデックス セラピューティクス， インク． 樹状細胞に対するヒトモノクローナル抗体
JP2007501009A (ja) * 2003-08-05 2007-01-25 ザ ロイヤル ヴェテリネリ カレッジ 抗原送達システム
WO2009118778A1 (ja) * 2008-03-25 2009-10-01 国立大学法人東京海洋大学 魚類未成熟生殖細胞表面特異的タンパク質を利用した、魚類未成熟生殖細胞の分離方法
JP2010285450A (ja) * 1999-04-19 2010-12-24 Katholieke Univ Nijmegen 樹状細胞−ｔ細胞の相互作用を調節するための組成物及び方法
JP2016533711A (ja) * 2013-10-11 2016-11-04 オックスフォード バイオセラピューティックス リミテッドＯｘｆｏｒｄ Ｂｉｏｔｈｅｒａｐｅｕｔｉｃｓ Ｌｔｄ がん治療のためのｌｙ７５に対する複合抗体

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997045449A1 (en) * 1996-05-29 1997-12-04 Derek Nigel John Hart Dendritic cell receptor
US6046158A (en) * 1996-12-20 2000-04-04 Board Of Regents The University Of Texas Systems Unique dendritic cell-associated C-type lectins, dectin-1 and dectin-2; compositions and uses thereof
US7071171B1 (en) 1996-12-20 2006-07-04 Board Of Regents The University Of Texas System Unique dendritic cell-associated c-type lectins, dectin-1 and dectin-2 compositions and uses thereof
EP0973538B1 (de) 1997-04-10 2008-03-12 University of Southern California Sich an extrazelluläre matrixbestandteile anbindende modifizierte proteine
US6004798A (en) * 1997-05-14 1999-12-21 University Of Southern California Retroviral envelopes having modified hypervariable polyproline regions
JP2002507392A (ja) * 1998-02-11 2002-03-12 マキシジェン， インコーポレイテッド 遺伝子ワクチンの免疫調節特性の最適化
CA2408594A1 (en) 2000-05-08 2001-11-15 Medarex, Inc. Human monoclonal antibodies to dendritic cells
US7485314B2 (en) 2002-05-06 2009-02-03 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Induction of antigen specific immunologic tolerance
WO2004026326A2 (en) 2002-09-20 2004-04-01 Stichting Katholieke Universiteit Antigen uptake receptor for candida albicans on dendritic cells
US7691591B2 (en) 2002-09-20 2010-04-06 Stichting Katholieke Universiteit Methods of identifying and isolating cells expressing DC-sign
US9243064B2 (en) 2003-01-31 2016-01-26 Celldex Therapeutics Inc. Antibody vaccine conjugates and uses therefor
US9259459B2 (en) 2003-01-31 2016-02-16 Celldex Therapeutics Inc. Antibody vaccine conjugates and uses therefor
WO2005058244A2 (en) 2003-12-15 2005-06-30 Alexion Pharmaceuticals, Inc. Novel anti-dc-sign antibodies
NZ585556A (en) 2007-11-07 2012-07-27 Celldex Therapeutics Inc Antibodies that bind human dendritic and epithelial cell 205 (dec-205)
US9517257B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US9850296B2 (en) 2010-08-10 2017-12-26 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US9518087B2 (en) 2010-08-10 2016-12-13 Ecole Polytechnique Federale De Lausanne (Epfl) Erythrocyte-binding therapeutics
US10946079B2 (en) 2014-02-21 2021-03-16 Ecole Polytechnique Federale De Lausanne Glycotargeting therapeutics
US10046056B2 (en) 2014-02-21 2018-08-14 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
EP3107563B1 (de) 2014-02-21 2021-04-07 Ecole Polytechnique Fédérale de Lausanne (EPFL) EPFL-TTO Glyco-targetierende therapeutika
US10953101B2 (en) 2014-02-21 2021-03-23 École Polytechnique Fédérale De Lausanne (Epfl) Glycotargeting therapeutics
US11253579B2 (en) 2017-06-16 2022-02-22 The University Of Chicago Compositions and methods for inducing immune tolerance
US11306157B2 (en) 2018-12-21 2022-04-19 California Institute Of Technology Expedient synthesis of core disaccharide building blocks from natural polysaccharides for heparan sulfate oligosaccharide assembly
WO2021091539A1 (en) * 2019-11-05 2021-05-14 Versiti Blood Research Institute Foundation, Inc. A murine model of fetal/neonatal alloimmune thrombocytopenia

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010285450A (ja) * 1999-04-19 2010-12-24 Katholieke Univ Nijmegen 樹状細胞−ｔ細胞の相互作用を調節するための組成物及び方法
JP2006501131A (ja) * 2001-11-07 2006-01-12 セルデックス セラピューティクス， インク． 樹状細胞に対するヒトモノクローナル抗体
JP4799821B2 (ja) * 2001-11-07 2011-10-26 セルデックス リサーチ コーポレイション 樹状細胞に対するヒトモノクローナル抗体
JP2007501009A (ja) * 2003-08-05 2007-01-25 ザ ロイヤル ヴェテリネリ カレッジ 抗原送達システム
WO2009118778A1 (ja) * 2008-03-25 2009-10-01 国立大学法人東京海洋大学 魚類未成熟生殖細胞表面特異的タンパク質を利用した、魚類未成熟生殖細胞の分離方法
JP5408802B2 (ja) * 2008-03-25 2014-02-05 国立大学法人東京海洋大学 魚類未成熟生殖細胞表面特異的タンパク質を利用した、魚類未成熟生殖細胞の分離方法
JP2016533711A (ja) * 2013-10-11 2016-11-04 オックスフォード バイオセラピューティックス リミテッドＯｘｆｏｒｄ Ｂｉｏｔｈｅｒａｐｅｕｔｉｃｓ Ｌｔｄ がん治療のためのｌｙ７５に対する複合抗体

Also Published As

Publication number Publication date
MX9705923A (es) 1998-07-31
WO1996023882A1 (en) 1996-08-08
AU716056B2 (en) 2000-02-17
CA2211993A1 (en) 1996-08-08
AU4970296A (en) 1996-08-21
EP0808366A1 (de) 1997-11-26

Similar Documents

Publication Publication Date Title
JPH10513350A (ja) ＤＥＣ（樹状細胞及び上皮細胞、２０５ ｋＤａ）の同定、Ｃ型レクチンドメインを有するレセプター、ＤＥＣをコードする核酸、及びこれらの使用
WO1996023882A9 (en) IDENTIFICATION OF DEC, (DENTRITIC AND EPITHELIAL CELLS, 205 kDa), A RECEPTOR WITH C-TYPE LECTIN DOMAINS, NUCLEIC ACIDS ENCODING DEC, AND USES THEREOF
Skelly et al. Making sense of the schistosome surface
KR100996936B1 (ko) 베타 아밀로이드 펩티드를 인식하는 인간화된 항체
US20210017213A1 (en) Glycan Analysis and Profiling
US8038986B2 (en) Immunogenic compositions and diagnostic and therapeutic uses thereof
JP2003509340A (ja) 変性疾患、神経疾患、自己免疫疾患に付随する病的状態を検出、予防又は治療するための、ポリペプチドの使用
CN102099372A (zh) 抗淀粉样蛋白免疫原性组合物、方法和应用
US8383767B2 (en) Immunogenic protein carrier containing an antigen presenting cell binding domain and a cysteine-rich domain
Kusel et al. The schistosome in the mammalian host: understanding the mechanisms of adaptation
JP5977936B2 (ja) 膵構造から誘導される糖ペプチド、抗体ならびに診断および治療におけるそれらの応用
JP3558347B2 (ja) 自己免疫疾患、とくに多発性硬化症の診断および治療における使用のためのアルファｂクリスタリン
PT1279677E (pt) Péptidos miméticos de gd 3
JP2002205999A (ja) Ｇｍ２特異的抗体の製造方法
JP5386361B2 (ja) エンテロコッカス・フェカリス菌抗原および／またはエンテロコッカス・フェシウム菌抗原
JP2000502244A (ja) トキソプラズマ・ゴンディ糖複合体
JP3842304B2 (ja) 癌の診断、治療薬
WO2002064787A1 (fr) Neurotonine et utilisation
WO2004034981A2 (en) Compositions and methods for inhibiting group b streptococcus-induced pulmonary hypertension in neonates
JPH03173899A (ja) 生体由来のタンパク質
JP2003502010A (ja) 産 物
JP2003528025A (ja) 免疫反応調節物質アルファ２マクログロブリン複合体
Ellis Analysis of Trichinella spiralis surface and secreted glycoproteins that bind protective antibodies
JPH07112999A (ja) 組換えダニアレルゲン
JPH11514848A (ja) 黒色腫関連タンパク質