JPH10507061A - アデノウイルス中にパッケージされたプラスミドｄｎａを用いる遺伝子送達ベクターおよびパッケージング細胞株 - Google Patents

アデノウイルス中にパッケージされたプラスミドｄｎａを用いる遺伝子送達ベクターおよびパッケージング細胞株

Info

Publication number
JPH10507061A
JPH10507061A JP7528363A JP52836395A JPH10507061A JP H10507061 A JPH10507061 A JP H10507061A JP 7528363 A JP7528363 A JP 7528363A JP 52836395 A JP52836395 A JP 52836395A JP H10507061 A JPH10507061 A JP H10507061A
Authority
JP
Japan
Prior art keywords
adenovirus
dna
vector
heterologous dna
expression vector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP7528363A
Other languages
English (en)
Japanese (ja)
Inventor
ガリー ジェイ． ナベル，
マイケル ジェイ． インペリアル，
タケシ オオノ，
Original Assignee
ザ ユニバーシティ オブ ミシガン
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ザ ユニバーシティ オブ ミシガン filed Critical ザ ユニバーシティ オブ ミシガン
Publication of JPH10507061A publication Critical patent/JPH10507061A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP7528363A 1994-04-28 1995-04-25 アデノウイルス中にパッケージされたプラスミドｄｎａを用いる遺伝子送達ベクターおよびパッケージング細胞株 Pending JPH10507061A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23499094A 1994-04-28 1994-04-28
US08/234,990 1994-04-28
PCT/US1995/005174 WO1995029993A1 (en) 1994-04-28 1995-04-25 Gene delivery vector using plasmid dna packaged into an adenovirus and a packaging cell line

Publications (1)

Publication Number Publication Date
JPH10507061A true JPH10507061A (ja) 1998-07-14

Family

ID=22883604

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7528363A Pending JPH10507061A (ja) 1994-04-28 1995-04-25 アデノウイルス中にパッケージされたプラスミドｄｎａを用いる遺伝子送達ベクターおよびパッケージング細胞株

Country Status (4)

Country Link
EP (1) EP0763103A4 (de)
JP (1) JPH10507061A (de)
CA (1) CA2189067A1 (de)
WO (1) WO1995029993A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020164782A1 (en) 1999-02-10 2002-11-07 Gregory Richard J. Adenovirus vectors for gene therapy
US5670488A (en) * 1992-12-03 1997-09-23 Genzyme Corporation Adenovirus vector for gene therapy
US7252989B1 (en) 1994-04-04 2007-08-07 Board Of Regents, The University Of Texas System Adenovirus supervector system
ES2240980T3 (es) 1994-10-28 2005-10-16 The Trustees Of The University Of Pennsylvania Adenovirus mejorado y metodos de utilizacion del mismo.
CA2218610A1 (en) * 1995-04-17 1996-10-24 Board Of Regents, The University Of Texas System An adenovirus helper-virus system
JP3930052B2 (ja) 1996-02-15 2007-06-13 バイオセンス・インコーポレイテッド カテーテルに基づく手術
WO1997032481A1 (en) * 1996-03-07 1997-09-12 The Regents Of The University Of California Helper-free, totally defective adenovirus for gene therapy
US6544523B1 (en) 1996-11-13 2003-04-08 Chiron Corporation Mutant forms of Fas ligand and uses thereof
WO1999024578A2 (en) 1997-11-06 1999-05-20 Chiron S.P.A. Neisserial antigens
CA2311642A1 (en) * 1997-11-25 1999-06-03 Princeton University Method for preparing adenovirus vectors, vectors so prepared, and uses thereof
AU759573B2 (en) * 1997-12-23 2003-04-17 Crucell Holland B.V. Adeno-associated virus and adenovirus chimeric recombinant viruses useful for the integration of foreign genetic information into the chromosomal DNA of target cells
CA2317815A1 (en) 1998-01-14 1999-07-22 Chiron S.P.A. Neisseria meningitidis antigens
DE69838526T2 (de) 1998-02-05 2008-07-03 Biosense Webster, Inc., Diamond Bar Gerät zum Freisetzen eines Medikaments im Herzen
WO2001031019A2 (en) 1999-10-29 2001-05-03 Chiron Spa Neisserial antigenic peptides
EP2261339B1 (de) 1998-05-01 2017-03-22 GlaxoSmithKline Biologicals SA Antigene und Zusammensetzungen gegen Neisseria meningitidis
US6113913A (en) 1998-06-26 2000-09-05 Genvec, Inc. Recombinant adenovirus
GB9817660D0 (en) 1998-08-13 1998-10-07 Angeletti P Ist Richerche Bio Adenoviral vectors encoding erythropoietin and their use in gene therapy
NZ571167A (en) 1999-04-30 2010-05-28 Novartis Vaccines & Diagnostic Fragments from Neisseria protein ORF 953 and their use in medicaments and diagnostic reagents
GB9911683D0 (en) 1999-05-19 1999-07-21 Chiron Spa Antigenic peptides
GB9916529D0 (en) 1999-07-14 1999-09-15 Chiron Spa Antigenic peptides
PT1248647E (pt) 2000-01-17 2010-11-18 Novartis Vaccines & Diagnostics Srl Vacina de vesícula da membrana externa (omv) compreendendo proteínas de membrana externa de n. meningitidis do serogrupo b
EP2277894A1 (de) 2000-10-27 2011-01-26 Novartis Vaccines and Diagnostics S.r.l. Nukleinsäure und Proteine von Gruppen A und B Streptokokken
GB0107658D0 (en) 2001-03-27 2001-05-16 Chiron Spa Streptococcus pneumoniae
GB0107661D0 (en) 2001-03-27 2001-05-16 Chiron Spa Staphylococcus aureus
JP4413617B2 (ja) 2001-12-12 2010-02-10 カイロン ソチエタ ア レスポンサビリタ リミタータ Ｃｈｌａｍｙｄｉａｔｒａｃｈｏｍａｔｉｓに対する免疫化
GB0308198D0 (en) 2003-04-09 2003-05-14 Chiron Srl ADP-ribosylating bacterial toxin
CN1957082B (zh) 2004-03-29 2014-09-17 株式会社嘉尔药物 新的半乳凝素9突变体蛋白质及其用途
JP4944032B2 (ja) 2004-09-13 2012-05-30 ジェンザイム・コーポレーション 多量体構築物
AR059089A1 (es) 2006-01-20 2008-03-12 Genzyme Corp Administracion intraventricular de una enzima para enfermedades de almacenamiento lisosomal
DK1988823T3 (en) 2006-02-09 2018-12-03 Genzyme Corp SLOW INTRAVENTRICULAR ADMINISTRATION
ATE522541T1 (de) 2006-06-09 2011-09-15 Novartis Ag Bakterielle adhäsine konformere
WO2013119880A1 (en) 2012-02-07 2013-08-15 Global Bio Therapeutics Usa, Inc. Compartmentalized method of nucleic acid delivery and compositions and uses thereof
CN105813579B (zh) 2013-08-08 2019-05-07 全球生物疗法有限公司 用于微创手术过程的夹具装置和其应用
WO2023017494A1 (en) 2021-08-13 2023-02-16 Triovance Holding Llc A skin substitute composition and methods of producing and using the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3534749B2 (ja) * 1991-08-20 2004-06-07 アメリカ合衆国 アデノウイルスが介在する胃腸管への遺伝子の輸送
AU692423B2 (en) * 1992-09-25 1998-06-11 Institut National De La Sante Et De La Recherche Medicale Adenovirus vectors for the transfer of foreign genes into cells of the central nervous system, particularly in brain
FR2705686B1 (fr) * 1993-05-28 1995-08-18 Transgene Sa Nouveaux adénovirus défectifs et lignées de complémentation correspondantes.

Also Published As

Publication number Publication date
CA2189067A1 (en) 1995-11-09
EP0763103A4 (de) 1998-07-15
EP0763103A1 (de) 1997-03-19
WO1995029993A1 (en) 1995-11-09

Similar Documents

Publication Publication Date Title
JPH10507061A (ja) アデノウイルス中にパッケージされたプラスミドｄｎａを用いる遺伝子送達ベクターおよびパッケージング細胞株
JP3755827B2 (ja) 組み込み可能な組み換えアデノウィルス、それらの製造及びそれらの治療的利用
JP2022184901A (ja) モジュラーＡＡＶ送達システムによるＣＲＩＳＰＲ－Ｃａｓゲノム編集
JP7263327B2 (ja) 細胞の遺伝子修飾のための非組込みｄｎａベクター
KR100403708B1 (ko) 재조합아데노-수반바이러스(aav)제조방법및이의용도
US20050101018A1 (en) Viral vector encoding pigment epithelium-derived factor
JPH10507079A (ja) 治療遺伝子と免疫保護遺伝子とを含む欠陥アデノウイルス
JPH11507835A (ja) 組換えアデノウイルス、ａａｖを作製するためのその使用、相補的細胞系、及び、該アデノウイルスを含む医薬組成物
JPH08510122A (ja) 動物起源のアデノウイルスベクターおよび遺伝子治療におけるそれらの使用
KR102636351B1 (ko) 고활성 조절 요소
JPH11508770A (ja) 組織特異的ウイルスベクター
JPH08501703A (ja) 欠陥組換えアデノウイルスベクター及び遺伝子治療での使用
WO1997025446A9 (en) Recombinase-mediated generation of adenoviral vectors
JP2001504325A (ja) 回帰的配列シャフリングおよび選択による遺伝子治療の最適化のための方法
NZ330553A (en) Recombinase-mediated generation of adenoviral vectors where all adenoviral genes of all regions E1 to E4 and L1 to L5 of the adenoviral genome are eliminated
JP2001502883A (ja) ミニアデノウイルスベクター
JP4386971B2 (ja) スプライシング配列を含んでなる組換えアデノウイルスベクター
KR100368292B1 (ko) 암의유전자치료용재조합아테노바이러스
KR20010032146A (ko) 아데노바이러스 벡터 및 상동 재조합 현상을 줄이는 방법
KR20220078650A (ko) 이중 바이러스 및 이중 종양용해 바이러스 및 치료 방법
KR100402540B1 (ko) 생체내외인성형질감염및발현용의약배합물
JP2002543792A (ja) ベクターによるトランスポゾン配列の供給及び組込み
JPH10506018A (ja) 不活化ＩＶａ２遺伝子を有する欠陥組換えアデノウィルス
JP2001503279A (ja) ターゲットを定めて遺伝子を誘導発現させるための新規な構築物及びベクター
KR20140015999A (ko) 신규 ＭＡＲｓ 및 이를 이용하여 목적 단백질을 생산하는 방법