JPH10501990A - 複製能力のある単純ヘルペスウイルスは新生細胞の破壊を媒介する - Google Patents
複製能力のある単純ヘルペスウイルスは新生細胞の破壊を媒介するInfo
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- JPH10501990A JPH10501990A JP8503296A JP50329696A JPH10501990A JP H10501990 A JPH10501990 A JP H10501990A JP 8503296 A JP8503296 A JP 8503296A JP 50329696 A JP50329696 A JP 50329696A JP H10501990 A JPH10501990 A JP H10501990A
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.(i)機能性γ34.5遺伝子産物、および(ii)リボヌクレオチド還元酵素をとも に発現でき複製能を有する単純ヘルペスウイルス。 2.ウイルスベクターのゲノムが、(i)γ34.5遺伝子、および(ii)リボヌクレオ チド還元酵素遺伝子の双方の変化を含む、単純ヘルペスウイルスベクター。 3.被験者の腫瘍細胞を死滅させる方法であって、 (A) (i)γ34.5遺伝子、および(ii)リボヌクレオチド還元酵素遺伝子が変化し た単純ヘルペスウイルスベクター、ならびに (B) 該ベクターのための薬学的に許容され得る賦形剤 を含む薬学的組成物を該被験者に投与する段階を含み、この結果、該ベクターに よって該腫瘍細胞がインサイチューで変化し、これにより該腫瘍細胞が死滅する 方法。 4.腫瘍細胞が、星状細胞腫、乏突起神経膠細胞腫、髄膜腫、神経線維腫、膠芽 細胞腫、上衣細胞腫、神経鞘腫、神経線維肉腫および髄芽細胞腫よりなる群から 選ばれる一類型のものである、請求の範囲3記載の方法。 5.腫瘍細胞が、黒色腫細胞、膵臓癌細胞、前立腺癌腫細胞、乳癌細胞、肺癌細 胞、結腸癌細胞、リンパ腫細胞、肝癌細胞、ならびに中皮腫および類表皮癌の細 胞よりなる群から選ばれる、請求の範囲3記載の方法。 6.被験者の腫瘍細胞を死滅させる方法であって、単純ヘルペスウイルスベクタ ーを該被験者に投与する段階を含み、該ベクターが、ウイルス複製に必要な少な くとも1種類のウイルスタンパク質の発現を制御し、かつ選択的に、または正常 細胞よりも高いレベルで腫瘍細胞において誘導される、腫瘍細胞特異性プロモー ターを含む方法。 7.プロモーターが、選択的に、神経系の腫瘍細胞で発現できる請求の範囲6記 載の方法。 8.腫瘍細胞が、膠芽細胞腫、髄芽細胞腫、髄膜腫、神経線維肉腫、星状細胞腫 、乏突起神経膠細胞腫、神経線維腫、上衣細胞腫および神経鞘腫よりなる群から 選ばれる一類型のものである請求の範囲6記載の方法。 9.腫瘍細胞が、黒色腫、肺癌、前立腺癌腫、乳癌、膵臓癌、結腸癌、リンパ腫 、 肝癌、ならびに中皮腫および類表皮癌よりなる群から選ばれる一類型のものであ る請求の範囲6記載の方法。 10.ベクターが、γ34.5遺伝子およびリボヌクレオチド還元酵素遺伝子で変化 している請求の範囲6記載の方法。 11.単純ヘルペスウイルスの複製能を有するベクターを調製する方法であって、 (A) 該単純ヘルペスウイルスのウイルスゲノムを単離する段階;および (B) ウイルスが(1)抗ウイルス剤に感受性であり、(2)腫瘍細胞を死滅させ、そ して(3)低下した汎毒性を発現するように、該ゲノムを永久的に変化させる段階 を含む方法。 12.ベクターの単純ヘルペスウイルスがHSV−1である、請求の範囲11記載の方法 。 13.ベクターの単純ヘルペスウイルスがHSV−2である、請求の範囲11記載の方法 。 14.単純ヘルペスウイルスの感染に対して被験者を防護する方法であって、 (A) 該ウイルスのゲノムが(i)γ34.5遺伝子、および(ii)リボヌクレオチド還 元酵素遺伝子で変化している単純ヘルペスウイルスベクター;ならびに (B) 該ベクターのための薬学的に許容される賦形剤 を含む薬学的組成物を該被験者に投与する段階を含む方法。 15.腫瘍細胞に免疫応答を誘発する方法であって、 (A) 該ウイルスのゲノムが、(i)被験者に免疫応答を誘発できる望ましいタン パク質をコードする発現可能な非単純ヘルペスウイルスヌクレオチド配列を含み 、(ii)γ34.5遺伝子およびリボヌクレオチド還元酵素遺伝子で変化している単 純ヘルペスウイルス;ならびに (B) 該ウイルスのための薬学的に許容され得る賦形薬 を含む薬学的組成物を該被験者に投与する段階を含む方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US08/264,581 | 1994-06-23 | ||
US08/264,581 US5585096A (en) | 1994-06-23 | 1994-06-23 | Replication-competent herpes simplex virus mediates destruction of neoplastic cells |
PCT/US1995/007858 WO1996000007A1 (en) | 1994-06-23 | 1995-06-23 | Replication-competent herpes simplex virus mediates destruction of neoplastic cells |
Publications (2)
Publication Number | Publication Date |
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JPH10501990A true JPH10501990A (ja) | 1998-02-24 |
JP3726841B2 JP3726841B2 (ja) | 2005-12-14 |
Family
ID=23006703
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP50329696A Expired - Fee Related JP3726841B2 (ja) | 1994-06-23 | 1995-06-23 | 複製能力のある単純ヘルペスウイルスは新生細胞の破壊を媒介する |
Country Status (9)
Country | Link |
---|---|
US (1) | US5585096A (ja) |
EP (2) | EP0766512B1 (ja) |
JP (1) | JP3726841B2 (ja) |
AT (2) | ATE409751T1 (ja) |
AU (2) | AU679644B2 (ja) |
CA (1) | CA2193491C (ja) |
DE (2) | DE69535851D1 (ja) |
DK (1) | DK0766512T3 (ja) |
WO (1) | WO1996000007A1 (ja) |
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JP2003508055A (ja) * | 1999-08-31 | 2003-03-04 | ザ ジェネラル ホスピタル コーポレイション | ヘルペスγ34.5遺伝子発現の細胞特異的および/または腫瘍特異的プロモーター再標的化 |
WO2005024016A1 (ja) * | 2003-09-02 | 2005-03-17 | Keio University | ヒトグリオーマ治療に有用な変異hsvベクター |
JP2014506563A (ja) * | 2011-01-22 | 2014-03-17 | レニショー ピーエルシー | 対流強化送達(ced)による選択的複製性単純ヘルペスウイルスベクターの脳への送達 |
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- 1994-06-23 US US08/264,581 patent/US5585096A/en not_active Expired - Lifetime
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- 1995-06-23 DE DE69535584T patent/DE69535584T2/de not_active Expired - Fee Related
- 1995-06-23 DK DK95924631T patent/DK0766512T3/da active
- 1995-06-23 AT AT04001555T patent/ATE371036T1/de not_active IP Right Cessation
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1997
- 1997-10-02 AU AU39888/97A patent/AU3988897A/en not_active Abandoned
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003508055A (ja) * | 1999-08-31 | 2003-03-04 | ザ ジェネラル ホスピタル コーポレイション | ヘルペスγ34.5遺伝子発現の細胞特異的および/または腫瘍特異的プロモーター再標的化 |
WO2005024016A1 (ja) * | 2003-09-02 | 2005-03-17 | Keio University | ヒトグリオーマ治療に有用な変異hsvベクター |
JP2014506563A (ja) * | 2011-01-22 | 2014-03-17 | レニショー ピーエルシー | 対流強化送達(ced)による選択的複製性単純ヘルペスウイルスベクターの脳への送達 |
Also Published As
Publication number | Publication date |
---|---|
AU679644B2 (en) | 1997-07-03 |
EP0766512A4 (en) | 1999-04-14 |
US5585096A (en) | 1996-12-17 |
EP0766512B1 (en) | 2008-10-01 |
EP1428887A1 (en) | 2004-06-16 |
DE69535584T2 (de) | 2008-05-15 |
ATE371036T1 (de) | 2007-09-15 |
EP1428887B1 (en) | 2007-08-22 |
ATE409751T1 (de) | 2008-10-15 |
DK0766512T3 (da) | 2009-02-09 |
CA2193491C (en) | 2010-04-06 |
EP0766512A1 (en) | 1997-04-09 |
AU3988897A (en) | 1998-01-08 |
JP3726841B2 (ja) | 2005-12-14 |
AU2906095A (en) | 1996-01-19 |
CA2193491A1 (en) | 1996-01-04 |
DE69535851D1 (de) | 2008-11-13 |
WO1996000007A1 (en) | 1996-01-04 |
DE69535584D1 (de) | 2007-10-04 |
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