WO2003083105A1 - Traitement et prevention de l'angiostenose - Google Patents
Traitement et prevention de l'angiostenose Download PDFInfo
- Publication number
- WO2003083105A1 WO2003083105A1 PCT/JP2002/003048 JP0203048W WO03083105A1 WO 2003083105 A1 WO2003083105 A1 WO 2003083105A1 JP 0203048 W JP0203048 W JP 0203048W WO 03083105 A1 WO03083105 A1 WO 03083105A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- gene
- cells
- smooth muscle
- seq
- virus
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Definitions
- mice with fl injuries were killed at a given B number.
- the plate was washed with PBS containing% DMSO.
Abstract
L'invention concerne des moyens de traitement et de prévention de l'angiosténose, à savoir un vecteur de réplication à expression spécifique en fonction du muscle lisse vasculaire, qui n'agit pas sur les cellules adultes normales se caractérisant par le fait d'avoir le domaine régulateur d'initiation de transcription d'un gène exprimé spécifiquement dans le muscle lisse vasculaire intégré en amont d'un gène précis; elle concerne également des compositions médicales les contenant destinées au traitement et à la prévention de l'angiosténose; ainsi qu'un procédé associé.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/JP2002/003048 WO2003083105A1 (fr) | 2002-03-28 | 2002-03-28 | Traitement et prevention de l'angiostenose |
PCT/JP2003/003809 WO2003083122A1 (fr) | 2002-03-28 | 2003-03-27 | Traitement et prevention de l'angiostenose |
JP2003580555A JPWO2003083122A1 (ja) | 2002-03-28 | 2003-03-27 | 血管狭窄の処置および予防 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/JP2002/003048 WO2003083105A1 (fr) | 2002-03-28 | 2002-03-28 | Traitement et prevention de l'angiostenose |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003083105A1 true WO2003083105A1 (fr) | 2003-10-09 |
Family
ID=28470384
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2002/003048 WO2003083105A1 (fr) | 2002-03-28 | 2002-03-28 | Traitement et prevention de l'angiostenose |
PCT/JP2003/003809 WO2003083122A1 (fr) | 2002-03-28 | 2003-03-27 | Traitement et prevention de l'angiostenose |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2003/003809 WO2003083122A1 (fr) | 2002-03-28 | 2003-03-27 | Traitement et prevention de l'angiostenose |
Country Status (2)
Country | Link |
---|---|
JP (1) | JPWO2003083122A1 (fr) |
WO (2) | WO2003083105A1 (fr) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5186693B2 (ja) * | 2008-01-16 | 2013-04-17 | 独立行政法人科学技術振興機構 | 低酸素状態にある細胞で増殖するウイルスまたは遺伝子を発現するウイルスベクター |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995009010A1 (fr) * | 1993-09-29 | 1995-04-06 | Kirin Beer Kabushiki Kaisha | Medicament contre l'arteriosclerose |
WO1996005321A1 (fr) * | 1994-08-17 | 1996-02-22 | Rhone-Poulenc Rorer S.A. | Therapie genique de la restenose au moyen de vecteur adenovial |
WO1997035974A1 (fr) * | 1996-03-26 | 1997-10-02 | Institut Pasteur | Sequences en amont du gene sm22, vecteurs les contenant et leurs utilisations therapeutiques, notamment dans le traitement des maladies vasculaires |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5516781A (en) * | 1992-01-09 | 1996-05-14 | American Home Products Corporation | Method of treating restenosis with rapamycin |
EP2324829A1 (fr) * | 1993-01-28 | 2011-05-25 | Boston Scientific Limited | Inhibiteur therapeutique de cellules de muscles |
US5585096A (en) * | 1994-06-23 | 1996-12-17 | Georgetown University | Replication-competent herpes simplex virus mediates destruction of neoplastic cells |
JP2002335965A (ja) * | 2001-05-14 | 2002-11-26 | Japan Science & Technology Corp | 細胞特異的発現複製ベクター |
-
2002
- 2002-03-28 WO PCT/JP2002/003048 patent/WO2003083105A1/fr unknown
-
2003
- 2003-03-27 JP JP2003580555A patent/JPWO2003083122A1/ja active Pending
- 2003-03-27 WO PCT/JP2003/003809 patent/WO2003083122A1/fr active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995009010A1 (fr) * | 1993-09-29 | 1995-04-06 | Kirin Beer Kabushiki Kaisha | Medicament contre l'arteriosclerose |
WO1996005321A1 (fr) * | 1994-08-17 | 1996-02-22 | Rhone-Poulenc Rorer S.A. | Therapie genique de la restenose au moyen de vecteur adenovial |
WO1997035974A1 (fr) * | 1996-03-26 | 1997-10-02 | Institut Pasteur | Sequences en amont du gene sm22, vecteurs les contenant et leurs utilisations therapeutiques, notamment dans le traitement des maladies vasculaires |
Non-Patent Citations (1)
Title |
---|
Hisako YAMAMURA et al.: "Identification of the Transcriptional Regulatory Sequences of Human Calponin Promoter and Their Use in Targeting a Conditionally Replicating Herpes Vector to Malignant Human Soft Tissue and Bone Tumors.", Cancer Research, 15 May, 2000 (15.05.00), Vol.61, pages 3969 to 3977 * |
Also Published As
Publication number | Publication date |
---|---|
WO2003083122A1 (fr) | 2003-10-09 |
JPWO2003083122A1 (ja) | 2005-08-04 |
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