JPH10306010A - Skin cosmetic - Google Patents

Skin cosmetic

Info

Publication number
JPH10306010A
JPH10306010A JP13436797A JP13436797A JPH10306010A JP H10306010 A JPH10306010 A JP H10306010A JP 13436797 A JP13436797 A JP 13436797A JP 13436797 A JP13436797 A JP 13436797A JP H10306010 A JPH10306010 A JP H10306010A
Authority
JP
Japan
Prior art keywords
skin
effect
present
cosmetics
test
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP13436797A
Other languages
Japanese (ja)
Inventor
Takeshi Ikemoto
毅 池本
Aki Soejima
亜紀 副島
Kimio Shimamura
公雄 島村
Yasushi Kuwabara
裕史 桑原
Minoru Aoki
穣 青木
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanebo Ltd
Original Assignee
Kanebo Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd filed Critical Kanebo Ltd
Priority to JP13436797A priority Critical patent/JPH10306010A/en
Publication of JPH10306010A publication Critical patent/JPH10306010A/en
Pending legal-status Critical Current

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Abstract

PROBLEM TO BE SOLVED: To obtain a skin cosmetics manifesting antiaging, bihada effects, excellent in feeling to the skin, by containing ethylglucoside, α-hydoxy acids and polyalcohol. SOLUTION: This cosmetic contains (A) ethylglucoside (e.g. α-form, etc.), (B) α-hydroxy acid (e.g. glycolic acid, malic acid, etc.) and (C) polyalcohol (e.g. glycerin, dipropylene-glycol, etc.). The formulating amount of the individual component in the prescribed cosmetics is preferably, 0.001-10.0 wt.% for component A, 0.05-20.0%, for component B, 0.01-20%, for component C.

Description

【発明の詳細な説明】DETAILED DESCRIPTION OF THE INVENTION

【0001】[0001]

【発明の属する技術分野】本発明は、皮膚化粧料に関
し、更に詳しくは、優れた老化防止(荒れ肌改善効果、
角質改善効果)、美肌効果を発現、付与し得るととも
に、使用感(ベトツキ感の無い)に優れた皮膚化粧料に
関する。
TECHNICAL FIELD The present invention relates to a skin cosmetic, and more particularly, to an excellent anti-aging (effect of improving rough skin,
The present invention relates to a skin cosmetic composition which can express and impart a skin effect and a beautiful skin effect, and which is excellent in use feeling (no stickiness).

【0002】[0002]

【従来の技術】加齢に伴う皮膚表面の変化、例えば、乾
燥、こじわ、肌のきめの変化、しみなどは、化粧品によ
るスキンケアで改善され得る問題である(傳田光洋 総
説:日本化粧品技術者会誌、30巻、4号、377−3
87、1996)。高齢者の多くにみられる、乾燥し荒
れ肌様の皮膚表面の状態は、角質層の形態や機能の変化
によるものとされている(バーワン 他:アーカイブス
ダーマトロジー、127巻、5号、666−672、
1991)。荒れ肌、すなわち皮膚の乾燥は基本的には
角質層の水保持性とバリア性の低下を主体とした水調節
系及び防御系の障害によって発生するものである。19
52年にブランク(ブランク:ジャーナルオブ インベ
スティガティーブ ダーマトロジー、18巻、433−
440、1952)が水蒸発に対するバリアが角質層に
あり、角質層の水和はおもに水によることを証明したこ
とが端著となり、保湿と乾燥・荒れ肌の研究が始まった
と言えよう(安倍 隆 総説:日本香粧品科学会誌、2
0巻、2号、100−114、1996)。
2. Description of the Related Art Age-related changes in the skin surface such as dryness, wrinkles, changes in skin texture, and spots are problems that can be improved by skin care using cosmetics (Review of Mitsuhiro Denda: Japanese cosmetics engineer) Journal, Vol. 30, No. 4, 377-3
87, 1996). The condition of the dry, rough skin-like skin surface seen in many elderly people is attributed to changes in the morphology and function of the stratum corneum (Berwan et al .: Archives Dermatology, Vol. 127, No. 5, No. 5, 666-672). ,
1991). Rough skin, that is, dry skin, is basically caused by impairment of the water regulation system and defense system mainly due to the decrease in water retention and barrier properties of the stratum corneum. 19
Blank in 1975 (Blank: Journal of Investigativ Dermatology, 18, 433-
(440, 1952) proved that the barrier to water evaporation was in the stratum corneum, and that hydration of the stratum corneum was mainly due to water. : Journal of the Japan Cosmetic Science Society, 2
0, 2, 100-114, 1996).

【0003】このような加齢に伴う皮膚表面の改善剤と
して、皮膚表面に適度な湿潤感及び柔軟性を与える種々
の皮膚外用剤が提案されている。例えば、多価アルコー
ルなど高い吸湿性と保水性を有する化合物は、保湿剤と
して皮膚化粧料に汎用されている。更に、特開平6−1
45037号公報ではアミノ酸、アミノ酸の誘導体及び
尿素からなる群から選ばれる一種又は二種以上と、トレ
ハロースとを含有する皮膚外用剤。特開平6−2792
58号公報ではα−ヒドロキシ酸と、ビタミンE群化合
物又はその誘導体との結合複合体を配合して成る、皮膚
外用剤。特開平6−279261号公報ではムコ多糖の
一種又は二種以上と乳糖とを含有する皮膚外用剤などが
提案されている。
[0003] As such an agent for improving the skin surface with aging, various external preparations for the skin which give the skin surface an appropriate moist feeling and flexibility have been proposed. For example, compounds having high hygroscopicity and water retention, such as polyhydric alcohols, are widely used as humectants in skin cosmetics. Further, Japanese Unexamined Patent Application Publication No.
No. 45037 discloses an external preparation for skin containing one or more selected from the group consisting of amino acids, amino acid derivatives and urea, and trehalose. JP-A-6-2792
No. 58 discloses a skin external preparation comprising a combined complex of an α-hydroxy acid and a vitamin E group compound or a derivative thereof. JP-A-6-279261 proposes an external preparation for skin containing one or more mucopolysaccharides and lactose.

【0004】本発明に係わるエチルグルコシドに関し
て、本発明者らは、先に日本酒に含まれるα−エチルグ
ルコシドが、ケラチノサイトの角化促進効果を有し、荒
れ肌を予防・改善することを報告した(第37回SCC
J研究討論会、講演要旨集、43−45、1995年1
1月16日)。
Regarding the ethyl glucoside according to the present invention, the present inventors have previously reported that α-ethyl glucoside contained in sake has a keratinocyte keratinization promoting effect and prevents and improves rough skin ( 37th SCC
J Research Discussion, Proceedings, 43-45, 1995
January 16).

【0005】また、α−ヒドロキシ酸は、果物、ワイン
などに含まれ古くから化粧料に用いられてきている。そ
の作用機構として、表皮角質層の結合力を緩め、密に重
なりあった角質層を薄くするために、乾皮症やシワ改善
作用を有することが知られているが(ジャーナル オブ
アメリカンアカデミー ダーマトロジー、11巻、5
号、867頁、1974)、充分な皮膚の老化防止作用
は得られない。
[0005] Further, α-hydroxy acids are contained in fruits, wines and the like, and have been used in cosmetics for a long time. As its mechanism of action, it is known that it has an xeroderma and wrinkle-improving effect in order to loosen the bonding force of the stratum corneum of the epidermis and make the densely stratum corneum thinner (Journal of American Academy Dermatology) , 11 volumes, 5
No., p. 867, 1974), a sufficient antiaging effect of the skin cannot be obtained.

【0006】更に、多価アルコールは、高い吸湿性と保
水性とを有し、保湿剤として皮膚化粧料に汎用されてい
る。
[0006] Furthermore, polyhydric alcohols have high hygroscopicity and water retention properties, and are widely used as humectants in skin cosmetics.

【0007】しかしながら、本発明に係わるこれら化合
物の効果は充分ではなく、また使用感(ベトツキ感)も
満足するものではなく、更に皮膚の一部分に着目した機
能改善であるため、優れた皮膚表面の改善剤は未だ得ら
れていない。
However, the effects of these compounds according to the present invention are not sufficient, the feeling of use (stickiness) is not satisfactory, and the function is improved by focusing on a part of the skin. An improver has not yet been obtained.

【0008】[0008]

【発明が解決しようとする課題】すなわち、本発明の目
的は、老化防止効果(荒れ肌改善効果、角質改善効
果)、美肌効果を発現、付与し得るとともに、使用感
(ベトツキ感の無い)に優れる皮膚化粧料を提供するこ
とにある。
That is, an object of the present invention is to provide an anti-aging effect (rough skin improving effect, keratin improving effect) and a beautiful skin effect, and to be excellent in use feeling (no stickiness). An object of the present invention is to provide a skin cosmetic.

【0009】[0009]

【課題を解決するための手段】これらの実情からみて、
本発明者らは、老化防止効果(荒れ肌改善効果、角質改
善効果)、美肌効果を発現、付与し得るとともに、使用
感(ベトツキ感の無い)に優れる皮膚化粧料を鋭意探索
した結果、下記の構成からなる皮膚化粧料がそれを満足
することを見出した。上記の目的は、エチルグルコシ
ド、α−ヒドロキシ酸及び多価アルコールを含有するこ
とを特徴とする皮膚化粧料によって達成できる。すなわ
ち、エチルグルコシド、α−ヒドロキシ酸及び多価アル
コールを併用することにより、それらの相乗作用によ
り、優れた皮膚老化防止効果が発現する。
[Means for Solving the Problems] In view of these circumstances,
Means for Solving the Problems The present inventors have intensively searched for skin cosmetics that can exhibit and impart an anti-aging effect (rough skin improving effect, keratin improving effect) and a beautiful skin effect and have an excellent feeling in use (no stickiness). It has been found that a skin cosmetic comprising the above composition satisfies it. The above object can be achieved by a skin cosmetic comprising ethyl glucoside, α-hydroxy acid and polyhydric alcohol. That is, when ethyl glucoside, α-hydroxy acid and polyhydric alcohol are used in combination, an excellent skin aging prevention effect is exhibited by their synergistic action.

【0010】[0010]

【発明の実施の形態】BEST MODE FOR CARRYING OUT THE INVENTION

【0011】以下に、本発明の実施の形態を詳述する。Hereinafter, embodiments of the present invention will be described in detail.

【0012】本発明で用いるエチルグルコシドには、上
記報告で、構造異性体が存在することを示しているが、
荒れ肌改善作用が確認されているα体もしくはその混合
体を使用することが望ましい。本発明の皮膚化粧料への
配合量は、0.001〜10.0重量%(以下、wt%
と略す)が好ましい。
The above report shows that ethyl glucoside used in the present invention has a structural isomer.
It is desirable to use an α-isomer which has been confirmed to have a rough skin improving effect or a mixture thereof. The compounding amount of the skin cosmetic of the present invention is 0.001 to 10.0% by weight (hereinafter, wt%).
Is abbreviated).

【0013】また、本発明で用いるαーヒドロキシ酸に
は、グリコール酸、リンゴ酸、酒石酸、クエン酸、乳酸
などを挙げることができる。本発明の皮膚化粧料への配
合量は、0.05〜20.0wt%が好ましい。
The α-hydroxy acid used in the present invention includes glycolic acid, malic acid, tartaric acid, citric acid, lactic acid and the like. The blending amount in the skin cosmetic of the present invention is preferably 0.05 to 20.0 wt%.

【0014】更に、本発明で用いる多価アルコールに
は、グリセリン、ジプロピレングリコール、1、3−ブ
チレングリコール、ポリエチレングリコール等が挙げら
れる。本成分は、一種以上を組み合わせて使用すること
ができ、皮膚化粧料への配合量は、用いる多価アルコー
ルの組み合わせにより異なるが、0.01〜20.0w
t%が好ましい。
Further, the polyhydric alcohol used in the present invention includes glycerin, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol and the like. This component can be used in combination of one or more kinds, and the amount to be blended into the skin cosmetic varies depending on the combination of the polyhydric alcohol used, but is 0.01 to 20.0 w.
t% is preferred.

【0015】なお、皮膚化粧料には、入浴剤も含まれる
ものである。
[0015] Skin cosmetics also include bath additives.

【0016】本発明の皮膚化粧料の剤型は、特に限定さ
れるものではなく、クリーム状、乳液状、ローション
状、軟膏状、パウダー状などの通常の皮膚化粧料の剤型
を適用することができる。
The dosage form of the skin cosmetic of the present invention is not particularly limited, and the dosage form of a normal skin cosmetic such as cream, milky lotion, lotion, ointment or powder may be applied. Can be.

【0017】また、本発明の皮膚化粧料は、他の成分と
して、乳化剤、油性物質、保湿剤、増粘剤、香料、防腐
剤、抗酸化剤、着色剤等を本発明の目的を達成する範囲
内で適宜配合し得る。
Further, the skin cosmetic of the present invention achieves the object of the present invention by using, as other components, an emulsifier, an oily substance, a humectant, a thickener, a fragrance, a preservative, an antioxidant, and a coloring agent. It can be appropriately blended within the range.

【0018】[0018]

【実施例】以下、実施例及び比較例に基づいて本発明を
更に詳細に説明する。なお、実施例に記載の(1)荒れ
肌改善効果の測定方法、(2)角質改善効果の測定方
法、(3)官能テストは下記の通りである。
The present invention will be described below in more detail with reference to Examples and Comparative Examples. In addition, (1) the measuring method of the rough skin improvement effect described in an Example, (2) the measuring method of the keratin improvement effect, and (3) the sensory test are as follows.

【0019】(1)荒れ肌改善効果の測定方法 下脚に荒れ肌を持つ中高年被験者10名を対象として4
週間連続塗布効果を調べた。すなわち、被験者の左側下
脚試験部位に1日2回(朝、夕)約0.5g の試料を5
×10cmの区画に塗布し、試験開始前および終了後の皮
膚の状態を表1の判定基準により判定した。なお、右側
下脚は被験試料を塗布せず対象とした。
(1) Measuring Method of Rough Skin Improving Effect Four 10 subjects of middle-aged and elderly subjects having rough skin on the lower leg were measured.
Weekly continuous application effect was examined. That is, 5 g of a sample of about 0.5 g twice a day (morning and evening) was placed on the left lower leg test site of the subject.
It was applied to a section of × 10 cm, and the condition of the skin before and after the test was determined according to the criteria shown in Table 1. In addition, the lower leg on the right side was used as a target without applying the test sample.

【0020】[0020]

【表1】 [Table 1]

【0021】そして、試験前後の試験部位と対照部位の
判定結果を比較し、皮膚乾燥度が2段階以上改善された
場合(例えば+→−、++→±)を「有効」、1段階改
善された場合を「やや有効」、変化がなかった場合を
「無効」とした。なお、試験結果は「有効」、「やや有
効」となった被験者の人数で示した。
Then, the results of the judgment of the test site and the control site before and after the test are compared, and when the degree of dryness of the skin is improved by two or more stages (for example, + → −, ++ → ±), “effective” is improved by one stage. The case was evaluated as "slightly valid" and the case without any change was regarded as "invalid". In addition, the test result was shown by the number of subjects who became "effective" and "slightly effective".

【0022】(2)角質改善(角質細胞の抗剥離性増
大)効果の測定方法 前記の荒れ肌改善測定試験終了後の被験部皮膚にスコッ
チテープ(メンディングテープ、ニチバン社)を接着
し、これを剥離したときテープに付着した角質細胞の状
態を走査型電子顕微鏡によって、詳細に調べ、表2の判
定基準によって皮膚角質層細胞剥離性を分類し、角質改
善効果を求めた。
(2) Method for measuring the effect of improving keratin (enhancing the exfoliative properties of keratinocytes) A scotch tape (Mending Tape, Nichiban Co.) is adhered to the skin of the test area after the above-described measurement test for improving rough skin. The state of the keratinous cells adhered to the tape when peeled was examined in detail by a scanning electron microscope, and the keratinocyte peeling properties of the skin were classified according to the criteria shown in Table 2 to determine the keratin improving effect.

【0023】[0023]

【表2】 [Table 2]

【0024】判定は4週間連続塗布後の試験部位の評価
点と対照部位のそれとの差が2点以上の場合を「有
効」、1点以上の場合を「やや有効」、0点の場合を
「無効」とした。なお、試験結果は「有効」、「やや有
効」となった被験者の人数で示した。
[0024] The judgment is "valid" when the difference between the evaluation point of the test site and that of the control site after continuous application for 4 weeks is 2 or more, "slightly effective" when it is 1 or more, and 0 when it is not. "Invalid". In addition, the test result was shown by the number of subjects who became "effective" and "slightly effective".

【0025】(3)官能テスト(美肌効果) 荒れ肌、小じわ、乾燥肌などを訴える女子被験者(35
〜55才)10人に被験試料を適当量顔面に1日2回
(朝、夕)、連続1カ月間塗布して1カ月後の効果を評
価した。なお、試験結果は、皮膚の湿潤性、平滑性、弾
力性の各項目に対して、「皮膚の潤いが生じた」、「皮
膚が滑らかになった」、「皮膚に張りが生じた」と回答
した人数で示した。
(3) Sensory test (beautiful skin effect) Female subjects complaining of rough skin, fine lines, dry skin, etc. (35
Appropriate amount of the test sample was applied to the face twice a day (morning and evening) for 10 consecutive persons for 10 months, and the effect after one month was evaluated. The test results were as follows: for each item of skin wettability, smoothness, and elasticity, "skin was moistened", "skin became smooth", and "skin became taut" The number of respondents is shown.

【0026】実施例1、比較例1〜3(化粧水) 組成Example 1, Comparative Examples 1 to 3 (Lotion)

【0027】[0027]

【表3】 [Table 3]

【0028】調製方法 表3に記載の処方で、常法に従って、化粧水を調製し
た。
Preparation Method A lotion was prepared according to the formulation shown in Table 3 according to a conventional method.

【0029】特性 表3の各化粧水について、前記(3)官能テストを実施
した。その結果を表4に示す。
Characteristics For each lotion shown in Table 3, the above-mentioned (3) sensory test was carried out. Table 4 shows the results.

【0030】[0030]

【表4】 [Table 4]

【0031】表4から明らかなように、実施例1は湿潤
性、平滑性、弾力性の各項目とも、比較例1〜3と比べ
て格段に優れていた。
As is evident from Table 4, Example 1 was remarkably excellent in all of the wettability, smoothness and elasticity items as compared with Comparative Examples 1 to 3.

【0032】実施例2、比較例4〜5(乳液) 組成Example 2, Comparative Examples 4 and 5 (Emulsion)

【0033】[0033]

【表5】 [Table 5]

【0034】調製方法 表5の(A)群の原料を70℃で溶解した後、あらかじ
め75℃に加熱しておいた原料(B)群へ撹拌しながら
徐々に加え、予備乳化を行った。その後、ホモジナイザ
ーを用いて乳化を完全に行い、30℃まで冷却した。
Preparation Method After the raw materials in the group (A) in Table 5 were melted at 70 ° C., they were gradually added to the raw material (B) group, which had been heated to 75 ° C. in advance, with stirring, to perform preliminary emulsification. Thereafter, emulsification was completely performed using a homogenizer, and the mixture was cooled to 30 ° C.

【0035】特性 表5の各乳液について、前記(1)荒れ肌改善試験、及
び(2)角質改善効果試験を実施した。その結果を表6
に示す。
Characteristics Each of the emulsions shown in Table 5 was subjected to the (1) rough skin improvement test and (2) keratin improvement effect test. Table 6 shows the results.
Shown in

【0036】[0036]

【表6】 [Table 6]

【0037】表6から明らかなように、実施例2は、荒
れ肌改善効果、角質改善効果の各項目とも、比較例4〜
5と比べて格段に優れていた。
As is clear from Table 6, Example 2 shows that Comparative Example 4 to Comparative Example 4 show the respective items of the rough skin improvement effect and the keratin improvement effect.
It was much better than 5.

【0038】実施例3、比較例6〜7(クリーム) 組成Example 3, Comparative Examples 6 and 7 (Cream) Composition

【0039】[0039]

【表7】 [Table 7]

【0040】調製方法 表7の(A)群の原料を70℃で溶解した後、あらかじ
め75℃に加熱しておいた原料(B)群へ撹拌しながら
徐々に加え、予備乳化を行った。その後、ホモジナイザ
ーを用いて乳化を完全に行い、30℃まで冷却した。
Preparation Method The raw materials of the group (A) in Table 7 were dissolved at 70 ° C., and gradually added to the raw material (B) group, which had been heated to 75 ° C. in advance, with stirring, to perform preliminary emulsification. Thereafter, emulsification was completely performed using a homogenizer, and the mixture was cooled to 30 ° C.

【0041】特性 表7から明らかなように、実施例3のクリームは比較例
5及び6のクリームに比較して、優れた美肌効果及び優
れた皮膚老化防止効果(荒れ肌改善効果、角質改善効
果)を示した。
Characteristics As is clear from Table 7, the cream of Example 3 has excellent skin beautiful effect and excellent skin aging prevention effect (rough skin improving effect, keratin improving effect) as compared with the creams of Comparative Examples 5 and 6. showed that.

【0042】実施例4(入浴剤) 組成Example 4 (bath additive) Composition

【0043】[0043]

【表8】 [Table 8]

【0044】調製方法 表8に記載の処方で、常法に従って、入浴剤を調製し
た。
Preparation Method A bath agent was prepared according to the formulation shown in Table 8 according to a conventional method.

【0045】特性 入浴剤30g を、およそ200リットルの温水に溶解
し、2週間連用したところ、本実施例4の入浴剤は比較
例7に対し、優れた美肌効果及び優れた皮膚老化防止効
果(荒れ肌改善効果、角質改善効果)を示した。
Characteristics 30 g of the bathing agent was dissolved in about 200 liters of warm water and continuously used for 2 weeks. The bathing agent of the present Example 4 was superior to Comparative Example 7 in terms of the excellent skin beautiful effect and the excellent skin aging prevention effect ( Rough skin improvement effect, keratin improvement effect).

【0046】[0046]

【発明の効果】以上記載のように、本発明が皮膚老化防
止効果(荒れ肌改善効果、角質改善効果)、美肌効果に
優れた有用な皮膚化粧料を提供することは明かである。
As described above, it is apparent that the present invention provides a useful skin cosmetic which is excellent in skin aging prevention effect (rough skin improvement effect, keratin improvement effect) and skin beautiful effect.

───────────────────────────────────────────────────── フロントページの続き (72)発明者 桑原 裕史 神奈川県小田原市寿町5丁目3番28号 鐘 紡株式会社化粧品研究所内 (72)発明者 青木 穣 神奈川県小田原市寿町5丁目3番28号 鐘 紡株式会社化粧品研究所内 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Hiroshi Kuwahara 5-3-28 Kotobukicho, Odawara City, Kanagawa Prefecture Inside the Kanebo Cosmetics Research Institute (72) Inventor Jo Aoki 5-3-3 Kotobukicho, Odawara City, Kanagawa Prefecture No. 28 Kanebo Cosmetics Research Laboratory

Claims (1)

【特許請求の範囲】[Claims] 【請求項1】 エチルグルコシド、α−ヒドロキシ酸及
び多価アルコールを含有することを特徴とする皮膚化粧
料。
1. A skin cosmetic comprising ethyl glucoside, α-hydroxy acid and polyhydric alcohol.
JP13436797A 1997-05-07 1997-05-07 Skin cosmetic Pending JPH10306010A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13436797A JPH10306010A (en) 1997-05-07 1997-05-07 Skin cosmetic

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13436797A JPH10306010A (en) 1997-05-07 1997-05-07 Skin cosmetic

Publications (1)

Publication Number Publication Date
JPH10306010A true JPH10306010A (en) 1998-11-17

Family

ID=15126729

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13436797A Pending JPH10306010A (en) 1997-05-07 1997-05-07 Skin cosmetic

Country Status (1)

Country Link
JP (1) JPH10306010A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008273851A (en) * 2007-04-26 2008-11-13 Kao Corp External preparation for skin

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008273851A (en) * 2007-04-26 2008-11-13 Kao Corp External preparation for skin

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