JP2511820B2 - Skin cosmetics - Google Patents
Skin cosmeticsInfo
- Publication number
- JP2511820B2 JP2511820B2 JP17690587A JP17690587A JP2511820B2 JP 2511820 B2 JP2511820 B2 JP 2511820B2 JP 17690587 A JP17690587 A JP 17690587A JP 17690587 A JP17690587 A JP 17690587A JP 2511820 B2 JP2511820 B2 JP 2511820B2
- Authority
- JP
- Japan
- Prior art keywords
- skin
- effect
- test
- twl
- stratum corneum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Description
【発明の詳細な説明】 （技術分野） 本発明は、セラミド、グルコシルセラミド、ガラクト
シルセラミド等のセラミド類と、ジイソプロピルアミン
ジクロロアセテートまたはγ−アミノ酪酸を配合してな
る皮膚老化防止効果（荒肌改善効果、保湿効果、角質層
ターンオーバー促進効果等）と美肌効果に優れた皮膚化
粧料に関する。TECHNICAL FIELD The present invention relates to a skin aging prevention effect (improvement of rough skin) obtained by blending ceramides such as ceramide, glucosylceramide, and galactosylceramide with diisopropylamine dichloroacetate or γ-aminobutyric acid. Effect, moisturizing effect, stratum corneum turnover promoting effect, etc.) and beautiful skin effect.
（従来技術） 老化皮膚とは乾燥して滑らかさのない荒れた肌で、角
質細胞の剥離現象が認められ、結合組織はコラーゲン／
エラスチン比が高く、皺が多い。(Prior Art) Aging skin is dry and rough skin that is exfoliated by keratinocytes and the connective tissue is collagen /
High elastin ratio and many wrinkles.
老化皮膚は細胞代謝機能の低下により角質層のターン
オーバーが遅く、従って皮膚に老化防止効果が付与発現
すると、ターンオーバーが速くなると言われ、種々の皮
膚細胞賦活成分及び血行促進成分を配合した化粧料が提
案されている。しかし、それらの成分を単独で配合して
なる皮膚化粧料は、充分に皮膚老化防止効果を発現する
ものではなかった。It is said that aging skin has a slow turnover of the stratum corneum due to a decrease in cell metabolic function, and therefore, if an anti-aging effect is imparted to the skin, the turnover becomes faster, and a cosmetic containing various skin cell activating components and blood circulation promoting components Fees are proposed. However, the skin cosmetics containing these components alone do not sufficiently exhibit the skin anti-aging effect.
また、近年では、特開昭61−260008号公報、特開昭61
−271205号公報などに記載の如く、皮膚を始めとする生
体組織中に存在することが知られているセラミド類の化
粧料への応用が提案されている。しかし、これらの成分
を単独で配合してなる皮膚化粧料を、皮膚に適用したと
しても皮膚の水分保持機能を亢進して皮膚老化防止効果
を付与することは困難であった。Further, in recent years, JP-A-61-260008 and JP-A-61-260008
As described in JP-A-271205, application of ceramides, which are known to be present in living tissues such as skin, to cosmetics has been proposed. However, it has been difficult to enhance the water-retaining function of the skin and impart the skin anti-aging effect even if the skin cosmetic composition containing these components alone is applied to the skin.
（発明の開示） 皮膚は、個体を外的環境から守る役割、即ち異物の侵
入を防ぎ、体液の喪失を防ぐ役割を果たしている。皮膚
の水分は、真皮から表皮の基底細胞層、更に角質層へと
外層に向うにつれて減少する水分含量の勾配が存在し、
常に皮膚内部から外層部へ移動し、角質層を通じて外部
へ蒸散している。DISCLOSURE OF THE INVENTION The skin plays a role of protecting an individual from the external environment, that is, a role of preventing the invasion of foreign matter and a loss of body fluid. The water content of the skin has a gradient of water content that decreases from the dermis to the basal cell layer of the epidermis and further to the stratum corneum toward the outer layer,
It constantly moves from the inside of the skin to the outer layer and evaporates to the outside through the stratum corneum.
この水分蒸散は主に角質層の緻密な細胞組織からなる
防御機能により制御されている。このような皮膚の防御
機能を表現する指標の一つとして、該蒸散量（TWL値）
が挙げられ、例えば健常な皮膚の正常な状態における前
腕部皮表では0.2〜0.3mg/cm2/hrの範囲、通常は0.25mg/
cm2/hr程度以下に保持されている。これに対して、通常
にみられる乾燥皮膚（ドライスキン）あるいは老化皮膚
にみられる乾燥皮膚では、その程度に応じてTWL値は上
記の範囲の上限値もしくはそれより大きな値を示し、皮
膚の水分保持機能が低下していることが認められる。こ
れはそれら乾燥皮膚の場合、角質層の防御機能による通
常の制御限界を超えた状態にあるか、あるいは該防御機
能が衰えていることに由来するものである。This water transpiration is mainly controlled by the defense function consisting of dense cellular tissues of the stratum corneum. The amount of transpiration (TWL value) is one of the indicators that express the protective function of the skin.
, For example in the forearm skin surface in the normal state of healthy skin in the range of 0.2 ~ 0.3 mg / cm 2 / hr, usually 0.25 mg /
It is kept below about cm 2 / hr. On the other hand, in normal dry skin (dry skin) or dry skin found in aged skin, the TWL value shows the upper limit of the above range or a higher value depending on the degree, and It is recognized that the retention function is deteriorated. This is because, in the case of those dry skins, the normal control limit by the defense function of the stratum corneum has been exceeded, or the defense function has deteriorated.
従って、角質層及び層板顆粒の組織を緻密化し、その
防御機能を賦活することができれば、これによって皮膚
の水分保持機能が亢進され、皮膚は健常な状態に保持さ
れると共に、乾燥皮膚の改善ないしは修復が可能となる
のである。更に、老化皮膚の低下した細胞代謝機能を高
め、かつ角質層のターンオーバーが亢進した場合には、
皮膚の老化防止効果が付与発現すると言える。Therefore, if the stratum corneum and lamella granule tissues are densified and their defense function can be activated, the water retention function of the skin is enhanced by this, and the skin is kept in a healthy state, and the improvement of dry skin is also improved. Or it can be repaired. Furthermore, when the deteriorated cell metabolic function of aged skin is enhanced and the turnover of the stratum corneum is enhanced,
It can be said that the effect of preventing skin aging is imparted and expressed.
そこで、本発明者等は、セラミド、グルコシルセラミ
ド、ガラクトシルセラミド等セラミド類及びジイソプロ
ピルアミンジクロロアセテート、γ−アミノ酪酸のヒト
皮膚に対する作用効果に関して鋭意研究した結果、これ
らのセラミド類と、ジイソプロピルアミンジクロロアセ
テートまたはγ−アミノ酪酸を、化粧料中に同時に配合
し、皮膚に適用した時には、皮膚の表面及び皮膚の最外
層である角質層に強い親和性を示し、それらの構造を緻
密化し、水分保持機能を高め、かつ角質層のターンオー
バーを促進し、乾燥皮膚を改善し、あるいは皮膚を健常
な状態に保持してその老化を防ぎ、皮膚に湿潤性（しっ
とり感）、柔軟性（滑らか感）、弾力性を与える美肌効
果を有することを見出し本発明を完成するに至った。Therefore, the present inventors, ceramide, glucosyl ceramide, ceramides such as galactosyl ceramide and diisopropylamine dichloroacetate, as a result of diligent research on the action effect on human skin of γ-aminobutyric acid, these ceramides, diisopropylamine dichloroacetate Or, when γ-aminobutyric acid is simultaneously blended in a cosmetic composition and applied to the skin, it shows a strong affinity for the surface of the skin and the stratum corneum, which is the outermost layer of the skin, and densifies the structure thereof, thereby retaining the water. And promote turnover of the stratum corneum, improve dry skin, or keep the skin in a healthy state to prevent its aging, moisturizing (moisturizing), flexibility (smoothness) on the skin, The present invention has been completed by finding that it has a skin-beautifying effect that gives elasticity.
（発明の目的） 即ち、本発明の目的は、荒肌改善効果、保湿効果、角
質層ターンオーバー促進効果等の皮膚老化防止効果と美
肌効果に優れた皮膚化粧料を提供することにある。(Object of the invention) That is, an object of the present invention is to provide a skin cosmetic excellent in skin aging preventing effects such as rough skin improving effects, moisturizing effects, and stratum corneum turnover promoting effects, and beautiful skin effects.
（発明の構成） 本発明は、セラミド、グルコシルセラミド、ガラクト
シルセラミドの少なくとも一種と、ジイソプロピルアミ
ンジクロロアセテートまたはγ−アミノ酪酸とを配合し
てなる皮膚化粧料である。(Structure of the Invention) The present invention is a skin cosmetic comprising at least one of ceramide, glucosylceramide, and galactosylceramide, and diisopropylamine dichloroacetate or γ-aminobutyric acid.
（構成の具体的な説明） 本発明に用いるセラミド、グルコシルセラミド、ガラ
クトシルセラミドは、人、豚、牛、馬、羊などの哺乳動
物の表皮に微量存在する化合物であって（バイオケミス
トリー、アンド、フィジオロジー、オブ、ザ、スキン、
第363頁〜第381頁、Biochemistry and Physiology of t
he Skin,Oxford University Press,Inc.1983 New York,
ジャーナル、オブ、リピッド、リサーチ 第24巻 1983
年を参照）、これらの動物表皮より通常の抽出方法にて
得ることが可能である。本発明においては、特開昭61−
271205号公報や生化学実験書（脂質の生化学、生化学実
験講座、第３巻、20〜21頁、1974年、日本生化学会編、
東京化学同人）に記載されている製造方法により得られ
るセラミド、グルコシルセラミド、ガラクトシルセラミ
ドを用いることができる。ここでセラミドは、Ｎ−アシ
ルスフィンゴシン、Ｎ−（α−ヒドロキシアシル）−フ
ィトスフィンゴシン、Ｎ−アシルフィトスフィンゴシン
などの混合物である。また、グルコシルセラミドは主に
Ｎ−アシルグルコシルフィンゴシン、Ｎ−（α−ヒドロ
キシアシル）−グルコシルフィトスフィンゴシン、Ｎ−
（α−ヒドロキシアシル）−グルコシルスフィンゴシ
ン、Ｎ−（アシル−ω−ヒドロキシアシル）グルコシル
スフィンゴシンなどの混合物である。ガラクトシルセラ
ミドは主にＮ−アシルガラクトシルスフィンゴシン、Ｎ
−（α−ヒドロキシアシル）−ガラクトシルフィトスフ
ィンゴシン、Ｎ−（α−ヒドロキシアシル）−ガラクト
シルスフィンゴシンなどの混合物である。(Specific Description of Configuration) Ceramide, glucosylceramide, and galactosylceramide used in the present invention are compounds that are present in trace amounts in the epidermis of mammals such as humans, pigs, cows, horses, and sheep (Biochemistry, And, Physiology, ob, the, skin,
Pp.363-381, Biochemistry and Physiology of t
he Skin, Oxford University Press, Inc.1983 New York,
Journal, Ob, Lipid, Research Vol. 24, 1983
It can be obtained from these animal epidermis by a conventional extraction method. In the present invention, JP-A-61-1
271205 bulletin and biochemistry experiment manual (lipid biochemistry, biochemistry experiment course, Volume 3, pages 20-21, 1974, edited by the Japanese Biochemical Society,
Ceramide, glucosylceramide, and galactosylceramide obtained by the production method described in Tokyo Kagaku Dojin) can be used. Here, the ceramide is a mixture of N-acyl sphingosine, N- (α-hydroxyacyl) -phytosphingosine, N-acyl phytosphingosine and the like. Further, glucosylceramide is mainly N-acylglucosylphingosine, N- (α-hydroxyacyl) -glucosylphytosphingosine, N-
It is a mixture of (α-hydroxyacyl) -glucosylsphingosine, N- (acyl-ω-hydroxyacyl) glucosylsphingosine and the like. Galactosylceramide is mainly N-acylgalactosylsphingosine, N
It is a mixture of-(α-hydroxyacyl) -galactosylphytosphingosine, N- (α-hydroxyacyl) -galactosylsphingosine, and the like.
セラミド、グルコシルセラミド、ガラクトシルセラミ
ドの配合量は皮膚化粧料（組成物）の総量を基準として
0.01〜3.0重量％（以下、Wt％と略記する）の範囲が好
適である。ジイソプロピルアミンジクロロアセテートま
たはγ−アミノ酪酸の配合量は皮膚化粧料の総量を基準
として0.002〜2.0Wt％の範囲が好適である。ここで、セ
ラミド類の配合量は、0.01Wt％未満では効果が充分に達
成されず、3.0Wt％を超えてもその増加分に見合った効
果の向上は望めない。ジイソプロピルアミンジクロロア
セテートまたはγ−アミノ酪酸の配合量は、0.002Wt％
未満では効果が充分に達成されず、2.0Wt％を超えても
その増加分に見合った効果の向上は望めない。The amount of ceramide, glucosylceramide, and galactosylceramide is based on the total amount of skin cosmetics (composition)
The range of 0.01 to 3.0% by weight (hereinafter abbreviated as Wt%) is preferable. The compounding amount of diisopropylamine dichloroacetate or γ-aminobutyric acid is preferably 0.002 to 2.0 Wt% based on the total amount of the skin cosmetics. Here, if the blending amount of the ceramides is less than 0.01 Wt%, the effect is not sufficiently achieved, and if the blending amount exceeds 3.0 Wt%, the improvement of the effect commensurate with the increase cannot be expected. The compounding amount of diisopropylamine dichloroacetate or γ-aminobutyric acid is 0.002 Wt%
If it is less than 2.0%, the effect is not sufficiently achieved, and if it exceeds 2.0 Wt%, the improvement of the effect commensurate with the increase cannot be expected.
本発明の皮膚化粧料は、例えばローション類、乳液
類、クリーム類、パック類等に適用することができる。The skin cosmetic of the present invention can be applied to, for example, lotions, emulsions, creams, packs and the like.
尚、本発明の皮膚化粧料には上記の他に色素、香料、
防腐剤、界面活性剤、顔料、抗酸化剤等を本発明の目的
を達成する範囲内で適宜配合することができる。In addition to the above, the skin cosmetics of the present invention include dyes, fragrances,
Preservatives, surfactants, pigments, antioxidants and the like can be appropriately added within the range where the object of the present invention is achieved.
また、本発明の皮膚化粧料の皮膚老化防止効果を評価
するために用いた荒肌改善効果試験、保湿効果試験、角
質層ターンオーバー改善効果試験、美肌効果試験（官能
テスト）は下記の通りである。Further, the rough skin improving effect test, the moisturizing effect test, the stratum corneum turnover improving effect test, and the skin beautifying effect test (sensory test) used for evaluating the skin aging prevention effect of the skin cosmetic of the present invention are as follows. is there.
（１）荒肌改善効果試験 荒れ肌、乾燥皮膚及び老人性乾皮症状を訴える中高年
被験者20名の下脚を対象として４週間続塗布効果を調べ
た。被験者の左側下脚試験部位に１日１回約1gの試料を
塗布し、試験開始前及び終了後の皮膚の状態を下記の判
定基準により判定した。右側下脚は試料を塗布せず対照
とした。(1) Rough skin improving effect test The lower leg of 20 middle-aged and elderly subjects complaining of rough skin, dry skin and senile psoriasis was examined for 4 weeks continuous application effect. About 1 g of the sample was applied to the left lower leg test site of the test subject once a day, and the condition of the skin before and after the start of the test was evaluated according to the following criteria. The lower right leg was not coated with the sample and served as a control.
皮膚乾燥度の判定基準 −：正常 ±：軽微乾燥、落屑なし ＋：乾燥、落屑軽度 ＋＋：乾燥、落屑中等度 ＋＋＋：乾燥、落屑顕著 試験前後の試験部位と対照部位の判定結果を比較し、
皮膚乾燥度が２段階以上改善された場合（例えば、＋→
−、＋＋→±）を有効、１段階改善された場合をやや有
効、変化がなかった場合を無効とした。試験結果は有
効、やや有効となった被験者の人数で示した。Criteria for skin dryness-: Normal ±: Minor dryness, no desquamation +: Dryness, mild desquamation ++: Dryness, moderate desquamation +++: Dryness, remarkable desquamation Compare the determination results of the test site before and after the test with the control site,
When the skin dryness is improved by two or more steps (for example, + →
−, ++ → ±) is valid, 1 is slightly improved when it is improved, and is invalid when there is no change. The test results were shown by the number of subjects who were valid or slightly valid.
（２）保湿効果試験（TWL値低減率） 前述の荒肌改善効果試験開始前及び終了後の被験者皮
膚を対象として４週間連続塗布前及び塗布後のTWL値及
びTWL値の低減率（水分保持機能亢進効果）を下記の如
く算出して、保湿効果を調べた。(2) Moisturizing effect test (TWL value reduction rate) TWL value and TWL value reduction rate (water retention) before and after continuous application for 4 weeks on the subject's skin before and after the rough skin improvement effect test described above. The moisturizing effect was investigated by calculating the function enhancing effect) as follows.
TWL値 密閉した皮表上の空気の一定時間内の湿度変化を電気
抵抗にて測定する方法を用いた。TWL value The method of measuring the humidity change of the air on the sealed skin surface within a certain time by electric resistance was used.
即ち、被試験者の皮表を測定用セルで密閉し、セルに
強制乾燥した空気を通気してセル内を乾燥空気で充分置
換した後、乾燥空気の通気を停止してその時点でのセル
内の相対湿度RHs（％）を求め、次いで10分間放置して
再びセル内の相対湿度RH10（％）を測定し、この時の湿
度変化から下記の式によりTWL値（mg/cm2/hr）を算出し
た。That is, the skin of the test subject is sealed with a measuring cell, forced dry air is passed through the cell to sufficiently replace the inside of the cell with dry air, and then the dry air is stopped and the cell at that time is stopped. The relative humidity RHs (%) in the cell is determined, and then left for 10 minutes, the relative humidity RH 10 (%) in the cell is measured again, and the TWL value (mg / cm 2 / hr).
但し、Dt:測定温度下（ｔ℃）での空気中の飽和水蒸
気の密度（mg/） V:セルの容積（） S:測定面積（cm2） TWL値の低減率 TWL値の低減率は、試料塗布前後のTWL値、TWLA及びTW
LBを下記の式に代入して算出した。 However, Dt: density of saturated water vapor in air at measurement temperature (t ° C) (mg /) V: cell volume () S: measurement area (cm 2 ) Reduction rate of TWL value Reduction rate of TWL value is , TWL values before and after sample application, TWL A and TW
L B was calculated by substituting into the following equation.
TWL値低減率＝（１−TWLB/TWLA）×100（％） TWLA:試料塗布前のTWL値 TWLB:試料塗布後のTWL値 TWL値の低減率が20％以上の場合を「有効」、低減率
が20％未満の場合を「無効」とした。試験結果は、20人
中の「有効」であった被験者の人数で表示した。TWL value reduction rate = (1-TWL B / TWL A ) × 100 (%) TWL A : TWL value before sample application TWL B : TWL value after sample application When the TWL value reduction rate is 20% or more, “Effective” and the reduction rate of less than 20% was defined as “invalid”. The test results were displayed by the number of subjects who were “effective” in 20 persons.
（３）角質層ターンオーバー改善効果試験 蛍光色素のダンシルクロライドを白色ワセリン中に５
重量％配合した軟膏を作り、荒れ肌、乾燥皮膚及び老人
性乾皮症状を訴える中高年被験者20名の前腕部皮膚に24
時間閉塞貼付し、角質層にダンシルクロライドを浸透結
合させる。その後、左腕の同じ部位に被験試料を、右腕
に対照として白色ワセリンを１日２回（朝・夕）塗布
し、毎日ダンシルクロライドの蛍光を調べ、その蛍光が
消失するまでの日数を角質層のターンオーバー速度とし
た。尚、通常のターンオーバー速度は、14〜16日である
が、老化した皮膚では18日前後に延び、賦活された状態
では短縮される傾向にあることが知られている。(3) Test for improvement of stratum corneum turnover A fluorescent dye, dansyl chloride, was added to white petrolatum 5 times.
24% on the skin of the forearm of 20 middle-aged and elderly subjects complaining rough skin, dry skin, and senile psoriasis by making an ointment blended by weight%
Time-blocking is applied and dansyl chloride is permeated and bonded to the stratum corneum. After that, a test sample was applied to the same site on the left arm, and white petrolatum was applied to the right arm twice a day (morning and evening) as a control, and the fluorescence of dansyl chloride was examined every day. The turnover speed was used. The normal turnover speed is 14 to 16 days, but it is known that the aged skin tends to extend around 18 days and tend to shorten in the activated state.
試料塗布部のターンオーバー速度が対照部の比較して
10％以上短縮された場合を、「有効」、５％以上の場合
を「やや有効」、５％以下、無変化、増大の場合は「無
効」とした。試験の結果は、「有効」あるいは「やや有
効」と回答した被験者の数で示した。Compared to the control part, the turnover speed of the sample application part
A reduction of 10% or more was designated as "effective", a reduction of 5% or more as "slightly effective", a reduction of 5% or less, no change, and an increase of "ineffective". The results of the test are shown by the number of subjects who answered "effective" or "somewhat effective".
（４）美肌効果試験（官能テスト） 荒れ肌、乾燥肌及び老人性乾皮症状等を訴える中高年
女子被験者20人が試料を１日２回（朝・夕）連続３ヶ月
間使用後の効果を評価した。試験結果は、皮膚の湿潤
性、平滑性、弾力性の各項目に対して、皮膚に潤いが生
じた、皮膚が滑らかになった、皮膚に張りが生じたと回
答した人数で示した。(4) Skin beautification test (sensory test) Twenty middle-aged female subjects complaining rough skin, dry skin, and senile psoriasis, etc. evaluated the effect after using the sample twice a day (morning / evening) for 3 consecutive months. did. The test results were expressed by the number of people who answered that the skin was moistened, the skin became smooth, and the skin became taut for each item of skin wettability, smoothness, and elasticity.
実施例１〜６、比較例１〜５ 〔二層型スキンローション〕 下記の組成の如く、二層型スキンローション基剤にセ
ラミド（如何、Cerと略記する）、グルコシルセラミド
（如何、GluCと略記する）、ガラクトシルセラミド（以
下、GalCと略記する）と、ジイソプロピルアミンジクロ
ロアセテート（以下、DADAと略記する）またはγ−アミ
ノ酪酸（以下、GABAと略記する）とをそれぞれ第１表に
記載の如く配合した各試料を調製し、各試験に使用し
た。Examples 1 to 6 and Comparative Examples 1 to 5 [Two-layer skin lotion] A two-layer skin lotion base having a ceramide (how abbreviated as Cer) and glucosyl ceramide (how abbreviated as GluC) as shown in the following compositions. , Galactosylceramide (hereinafter abbreviated as GalC), and diisopropylamine dichloroacetate (hereinafter abbreviated as DADA) or γ-aminobutyric acid (hereinafter abbreviated as GABA), respectively, as described in Table 1. Each formulated sample was prepared and used in each test.
（２）調製法 （Ｃ）成分のセラミド類を予め（Ａ）成分中に、
（Ｄ）成分のDADA、GABAを（Ｂ）成分中に溶解した後、
（Ａ）成分と（Ｂ）成分を各々80℃に加温溶解したもの
を混合した。次いで攪拌しつつ30℃迄冷却して各ローシ
ョンを調製した。 (2) Preparation method The ceramides of the component (C) are previously added to the component (A),
After dissolving the (D) component DADA and GABA in the (B) component,
Each of the components (A) and (B) dissolved by heating at 80 ° C. was mixed. Then, each lotion was prepared by cooling to 30 ° C. with stirring.
（３）特性 各二層型スキンローションの諸試験を実施した結果を
第１表右欄に記載した。(3) Properties The results of various tests of each two-layer type skin lotion are shown in the right column of Table 1.
比較例１〜５のセラミド類或いはDADA、GABAを単独で
配合した化粧料と比較して、両成分を同時に配合した実
施例１〜６の本発明の皮膚化粧料は諸試験の全てに亘っ
て良好なる結果が認められた。Compared with the cosmetics in which the ceramides of Comparative Examples 1 to 5 or DADA and GABA were blended alone, the skin cosmetics of the present invention in Examples 1 to 6 in which both components were blended at the same time covered all of the tests. Good results were observed.
実施例７〜12、比較例６〜10 〔スキンクリーム〕 実施例１と同様に、下記の組成にて各々のスキンクリ
ームを調製し、諸試験を実施した結果を第２表に示し
た。Examples 7 to 12 and Comparative Examples 6 to 10 [Skin cream] Similar to Example 1, each skin cream having the following composition was prepared and various tests were carried out. The results are shown in Table 2.
（２）調製法 （Ｃ）成分のセラミド類を予め（Ａ）成分中に、
（Ｄ）成分のDADA、GABAを（Ｂ）成分中に溶解した後、
（Ａ）成分と（Ｂ）成分を各々80℃に加温溶解したもの
を混合した。次いで攪拌しつつ30℃まで冷却して各スキ
ンクリームを調製した。 (2) Preparation method The ceramides of the component (C) are previously added to the component (A),
After dissolving the (D) component DADA and GABA in the (B) component,
Each of the components (A) and (B) dissolved by heating at 80 ° C. was mixed. Then, each skin cream was prepared by cooling to 30 ° C. with stirring.
（３）特性 第２表に示す如く、本発明の皮膚化粧料である実施例
７〜12のスキンクリームは、比較例６〜10と比較して諸
特性の全てに亘って優れていることは明らかであり、配
合特性に於いても異常は認められなかった。(3) Characteristics As shown in Table 2, the skin creams of Examples 7 to 12, which are the skin cosmetics of the present invention, are superior to Comparative Examples 6 to 10 in all characteristics. Obviously, no abnormality was found in the compounding characteristics.
（発明の効果） 以上記載の如く、本発明の皮膚化粧料は、皮膚機能を
亢進し、皮膚の老化防止に顕著な効果を発現し、かつ美
肌作用を有する優れた皮膚化粧料を提供することが明ら
かである。(Effects of the Invention) As described above, the skin cosmetic of the present invention provides an excellent skin cosmetic that enhances skin function, exerts a remarkable effect in preventing skin aging, and has a skin-beautifying effect. Is clear.
Claims (1)
シルセラミドの少なくとも一種と、ジイソプロピルアミ
ンジクロロアセテートまたはγ−アミノ酪酸を配合して
なる皮膚化粧料。1. A skin cosmetic comprising at least one of ceramide, glucosylceramide and galactosylceramide, and diisopropylamine dichloroacetate or γ-aminobutyric acid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17690587A JP2511820B2 (en) | 1987-07-15 | 1987-07-15 | Skin cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17690587A JP2511820B2 (en) | 1987-07-15 | 1987-07-15 | Skin cosmetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6422810A JPS6422810A (en) | 1989-01-25 |
| JP2511820B2 true JP2511820B2 (en) | 1996-07-03 |
Family
ID=16021805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP17690587A Expired - Fee Related JP2511820B2 (en) | 1987-07-15 | 1987-07-15 | Skin cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2511820B2 (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2099188C (en) * | 1992-07-24 | 2005-12-13 | Paul A. Bowser | Use of a cosmetic composition |
| FR2714829B1 (en) * | 1994-01-10 | 1996-02-02 | Oreal | Cosmetic and / or dermatological composition for the treatment of aging containing ceramides, its use. |
| JP3256369B2 (en) * | 1994-03-03 | 2002-02-12 | カネボウ株式会社 | Skin cosmetics |
| US5723645A (en) * | 1996-09-05 | 1998-03-03 | Pacific Corporation | Method for preparing 3-aminopropane phosphoric acid |
| JP2003160462A (en) * | 2001-11-21 | 2003-06-03 | Pola Chem Ind Inc | Functional skin care preparation having barrier function |
| JP2005281257A (en) | 2004-03-30 | 2005-10-13 | Snow Brand Milk Prod Co Ltd | Skin-beautifying agent |
| JP5208428B2 (en) | 2007-01-30 | 2013-06-12 | 雪印メグミルク株式会社 | Skin care |
-
1987
- 1987-07-15 JP JP17690587A patent/JP2511820B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6422810A (en) | 1989-01-25 |
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