JP3256369B2 - Skin cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin cosmetic having an effect of improving rough skin and having a good feeling in use.

[0002]

2. Description of the Related Art Conventionally, skin cosmetics having an effect of improving rough skin have been developed (for example, Japanese Patent Publication No. 5-1763). However, the effect is not enough, and further development is desired.

On the other hand, when diisopropylamine dichloroacetate and γ-aminobutyric acid, which are known to be present in living tissues, are added to maintain healthy skin, the moisturizing function of the skin is enhanced. (JP-B 4-65047, JP-A-62-1)
48414), however, the effect was not sufficient, and the feeling of use was not sufficiently satisfactory.

In view of such circumstances, the present inventors have conducted intensive studies to improve the disadvantages of the prior art, and as a result, have obtained diisopropylamine dichloroacetate (hereinafter referred to as DADA).
Abbreviated) or a γ- aminobutyric acid, lactic acid and salts thereof and,
A skin cosmetic comprising at least one selected from α-hydroxyoctanoic acid , improves the rough skin by synthesizing and densifying and enhancing the structure of rough skin, and further improves the feeling of use. It was also found that the present invention was excellent, and the present invention was completed.

An object of the present invention is to provide a skin cosmetic which has an effect of improving rough skin and which has an excellent feeling upon use.

[0006]

The purpose of the Means for Solving the Problems], the diisopropylamine dichloroacetate or with from 0.001 to 3.0% by weight of γ- aminobutyric acid, lactic acid and its salts, alpha-human
At least one selected from droxyoctanoic acid ;
001 to 25% by weight .

Lactic acid used in the skin cosmetic of the present invention and
The salt, α-hydroxyoctanoic acid, is a known substance and can be easily obtained.

DADA used in the skin cosmetic of the present invention
Is a known substance and can be easily obtained. Sudden·
Chronic hepatitis, liver damage such as fatty liver and cerebral hemorrhage, cerebral thrombosis,
It has been applied as a therapeutic agent for hypertension and the like.

[0009] γ-Aminobutyric acid used in the skin cosmetic of the present invention is a known substance and can be easily obtained. It is widely found in the plant kingdom in free form and is found in animals in the brain and plays an important role in brain metabolism. It is used to improve sequelae of cerebrovascular disorders and muscular atrophy. Also,
It is said that the nuclear substance has an effect on the skin by enhancing the skin effect by a skin peripheral vasodilatory action, healing fatigue and sagging of the skin, and preventing aging and wrinkles.

Lactic acid and its salts, α-hydroxyoctane
The amount of the skin cosmetic of the present invention the acid, based on the total amount, 0. 001 to 25% by weight (hereinafter referred to as wt%).

If the amount is less than 0.001% by weight, the effect of the present invention is not so satisfactory. On the other hand, if the amount exceeds 25% by weight,
The improvement of the effect corresponding to the increase cannot be greatly expected.

[0012] DADA, the amount of the skin cosmetic of the present invention of γ- aminobutyric acid, based on the total amount, 0.001
~ 3.0 wt%.

If the content of these components is less than 0.001% by weight, the desired effects of the present invention are not so sufficient. On the other hand, even if the content of each of these components exceeds 3.0% by weight, the increase is not so large. The corresponding improvement in the effect cannot be greatly expected.

The skin cosmetic composition of the present invention can be made into a dosage form such as lotions, emulsions, creams, packs, etc. according to a conventional method.

The skin cosmetics of the present invention may be appropriately blended with pigments, fragrances, preservatives, surfactants, pigments and the like within a range that achieves the object of the present invention.

[0016]

The present invention will be described below in detail based on examples and comparative examples.

(1) Practical test for rough skin described in Examples
(2) Sensory test Each test method is as follows.

(1) Practical test for rough skin Female subjects (25-50 years old) who complain of rough skin, dry skin, etc.
A sample and a base were applied to the affected area twice a day twice a day for three consecutive months in 20 subjects. In addition, evaluation was shown by the number of persons who answered that the skin was moistened in the sample application part.

(2) Sensory Test (Feeling of Use) The characteristics of the sample were evaluated after 20 test subjects continuously used the sample for 10 days. The evaluation was shown by the number of respondents who answered "moisture on the skin" and "good affinity to the skin" for the questionnaire items on wettability and affinity, respectively.

Examples 1 to 5 and Comparative Examples 1 to 5 In the raw material compositions shown in Table 1, active ingredients were blended as shown in Table 2, lotions were prepared as described below, and the above-mentioned various tests were carried out.

[0021]

[Table 1]

[0022]

[Table 2]

(1) Preparation method After B component shown in Table 1 is uniformly dissolved in A component and C component is uniformly dissolved in D component, A component and D component are uniformly mixed, stirred and dispersed, and then filled into a container. I do. When used, the contents are shaken and dispersed uniformly. (2) Characteristics Table 2 shows the results of various tests.

As shown in Table 2, Comparative Example 1 did not show good results in various tests. On the other hand, the skin cosmetics of the present invention of Examples 1 to 5 showed clearly good results in all tests.

Examples 6 to 9 and Comparative Examples 6 to 9 Skin creams were prepared by mixing active ingredients as shown in Table 4 in the raw material compositions shown in Table 3, and the above-mentioned tests were carried out.

[0026]

[Table 3]

[0027]

[Table 4]

(1) Preparation method The F component shown in Table 3 is mixed with the E component, and the E component and the H component are each heated and dissolved uniformly to bring the temperature to 80 ° C. Next, the H component is poured into the E component, mixed with stirring, cooled while stirring, and the G component is introduced at about 50 ° C and cooled to 30 ° C.

(2) Characteristics Table 4 shows the results of the various tests. As shown in Table 4, Examples 6 to 9 showed clearly good results in all of the tests. In contrast, Comparative Examples 6 to 9 were significantly inferior.

[0030]

As described above, it is apparent that the present invention provides a useful skin cosmetic which has a remarkable effect of improving rough skin and has an excellent feeling upon use.

Continuation of the front page (56) References JP-A-51-148041 (JP, A) JP-A-53-136528 (JP, A) JP-A-60-184005 (JP, A) JP-A-61-56114 (JP) JP-A-62-19511 (JP, A) JP-A-62-87506 (JP, A) JP-A-62-93212 (JP, A) JP-A-62-148414 (JP, A) 63-150209 (JP, A) JP-A 64-22810 (JP, A) JP-A-5-43448 (JP, A) JP-A 5-117137 (JP, A) JP-A 55-19291 (JP, A) A) JP-A-58-134009 (JP, A) JP-A-63-166837 (JP, A) JP-A-5-139947 (JP, A) (58) Fields investigated (Int. Cl. ⁷ , DB name) ) A61K 7/00-7/50

Claims (1)

(57) [Claims] 1. A diisopropylamine dichloroacetate or a 0.001 to 3.0% by weight of γ- amino butyric acid,
Lactic acid and its salts, selected from α-hydroxyoctanoic acid
Skin cosmetic, characterized in that at least one of containing and 0.001 wt% that.