JPS6366109A - Skin cosmetic - Google Patents

Abstract

PURPOSE:To obtain a skin cosmetic showing improved beautifying effects on the skin by promoting water retaining function of skin characteristics, and by blending a skin cosmetic with TRAMATIC acid (2-dodecenedioic acid) obtained from pods of young fruits of leguminous plant such as kidney beans, etc., and/or a salt thereof. CONSTITUTION:A skin cosmetic such as lotion, milky lotion, cream, pack, etc., containing preferably 0.01-2wt% based on total amount of skin cosmetic of TRAMATIC acid which exists in a large amount in pods of young fruits of leguminous plant and is obtained by extracting with water or an organic solvent such as alcohol, ether, benzene, chloroform, etc., and/or a slat thereof. The cosmetic keeps the skin in a healthy state or restores and provides the skin with wetting properties, flexibility, elasticity and gloss.

Description

DETAILED DESCRIPTION OF THE INVENTION (Field of the Invention) The present invention relates to a skin cosmetic containing tramatic acid and/or a salt thereof, which can enhance the moisture retention function of the skin.

(Prior art) In order to maintain healthy skin, hydrophilic skin moisturizers and oily skin softeners that provide appropriate moisture and oil content to the skin have traditionally been blended into skin cosmetics. .

Skin moisturizers include glycerin, propylene glycol,
Polyethylene glycol, pyrrolidone carboxylate, etc. are used, but these may absorb water from the stratum corneum, the outermost layer of the skin, causing moisture loss in the skin, and they may also cause large amounts of water to be lost. However, skin cosmetics containing such substances have not always been satisfactory, such as giving an unpleasant feeling such as stickiness.

In addition, liquid paraffin, petrolatum, olive oil, squalane, lanolin, synthetic ester oil, etc. are used as skin softeners, but these are also included in skin cosmetics to the extent that they sufficiently prevent water evaporation from the epidermis. In some cases, they have the disadvantage of interfering with the normal metabolism of the skin.

(Disclosure of the Invention) In view of the above-mentioned drawbacks of skin moisturizers and emollients, the present inventors have determined that they rely only on the physical action of these ingredients to replenish moisture to the epidermis or prevent water evaporation from the epidermis. As a result of intensive research with the aim of providing skin cosmetics that maintain or repair the skin in a healthy state by enhancing the skin's inherent moisture retention function, we found that tramatic acid The present invention has been completed based on the discovery that a skin cosmetic containing the compound and/or its salt exhibits a synthetic effect for the purpose.

Water in the skin is transferred from the dermis to the basal saturated layer of the epidermis, and then to the stratum corneum.1. Along the gradient of moisture, which matures as the evening progresses, it always moves from the inside of the skin to the outer layer, passing through the stratum corneum to the outside. It is controlled by the protective function (firming function) consisting of the lamellar granules at the top of the granular layer, the stratum corneum, and the dense cell tissue, and the
ansepidermal Water l,oss)
For example, the iE of healthy skin (hereinafter referred to as T W +) is in the range of 0.2 to 0.3 + B/cm"/hr for the skin surface of the forearm under normal conditions, usually is kept below 0.25 mg/c+n2/11r culm degree↑JI.For dry skin (triskin) or aging skin, which is often crowded with kneading, T W L depending on the degree
(# indicates the tenth limit of the range listed in I, or a value larger than L, and the moisture retention function of the skin is decreased (-7). This is because in the case of dry skin, the stratum corneum This is due to the fact that the defense function is in a state that exceeds the normal control limit, or the poetry defense device 11L is weakening.

Therefore, the structure of the stratum corneum and lamina FI'i is densified,
If this defense function can be activated, 1. The moisture retention function of the skin can be improved by 4. The skin is kept in a healthy condition, and it also improves dry skin.
2 can be repaired. Therefore, the present inventors conducted research on the sexual effects of tramatic acid; 1. Normalize the tissue from the plate granules to the stratum corneum. , improves dry skin by enhancing the skin's own moisture retention function, or maintains the skin in a healthy state to prevent aging, and provides moisture to the skin (
17. It has been found that it has a smooth skin feel), flexibility (smooth feeling), elasticity, and smooth skin effect.

In the case of the skin cosmetics of the present invention, unlike conventional skin cosmetics, there is no need to incorporate the above-mentioned skin moisturizers and skin softeners in large amounts, and there is no risk that the normal physiological functions of the skin will be prevented.

(Objective of the Invention) The object of the present invention is to maintain or repair the skin in a healthy state by enhancing the skin's inherent moisture retention function, thereby achieving excellent skin beautification effects. The purpose of the present invention is to provide skin cosmetics having the following properties.

(Structure of the Invention) The present invention relates to a skin cosmetic containing 1 to llamatic acid and/or a salt thereof.

(Constituent glue, physical explanation) 1-Lamatic acid used in the present invention is a substance that has the activity of inducing cell fractionation, which is present in the young fruits of kidney beans, and is widely used in plants, including leguminous plants. exists in I
The characteristic values are listed in S.

Chemical name: 2-1'desendioi tsuquaside (2-
rlodecenedioic acid＞(Iloo
C (CIl
Solubility: Very soluble in water, easily dissolved in ether, benzene, and chloroform. Soak in water or an organic solvent such as alcohol, ether, benzene, Chloro I:1 hol J4, etc. for 30~
Easily extracted by heating to 50°C. Regarding its extraction method, see Proceedings of National Academic Science, Vol. 25, p. 323, 1939 (Pr.
oc,.

Nat, Acad, Sci, 25,323+ 1939
) It is described in.

Tramatic acid or its salt contained in the skin cosmetic of the present invention has the effect of promoting division of epidermal basal cells and enhancing skin function. Furthermore, it promotes blood circulation in the skin, restores or improves the skin's inherent functions, maintains the skin in a healthy state, and creates smooth, glossy, and finely textured skin. It is recognized that there is an effect of maintaining the condition.

Sil1, its effectiveness is 11, especially when applied to aging skin.
Recognized by author /i.

The salts of tramatic acid that can be used in the present invention are monosalts or di-salts consisting of l-ramatic acid and a base,
Examples include alkali metal salts such as potassium salts and sodium salts, basic amino acid salts such as lysine salts, ornithine salts, and arginine salts, and alkanolamine salts such as monoethanolamine salts and triethanolamine salts.

In the present invention, the blending amount of tramatic acid and/or its salt is 0 based on the total amount of the skin cosmetic (composition).
．． A range of 0.01% to 0.02% is suitable. The amount added is 0.0
If the amount is less than 1% by weight, the effect will not be sufficiently achieved, while if it exceeds the double-viewing percentage, no improvement in the effect commensurate with the increase can be expected.

The skin cosmetics of the present invention include, for example, lotions, milky lotions,
It can be applied to creams, packs, etc.

In addition to the above, pigments, fragrances, preservatives, surfactants, pigments, antioxidants, and the like may be appropriately incorporated into the skin cosmetic of the present invention within a range that achieves the object of the present invention.

(Example) Hereinafter, the present invention will be explained in detail based on Examples and Test Examples.

The methods for measuring or evaluating the T W L value, T W +-value conversion rate, stratum corneum turnover rate, and exfoliation properties of corneocytes are shown below.

fllTWL value A method was used in which the humidity change in the air above the sealed skin surface within a certain period of time was measured using electrical resistance.

That is, the test subject's skin surface was sealed in a measurement cell, forced dry air was vented into the cell to fully replace the inside of the cell with dry air, and then the ventilation of dry air was stopped and the test was carried out at that point. The relative humidity R+(s (%)) inside the cell was determined, and then the relative humidity RH+o (%) inside the cell was measured again after being left for 10 minutes, and the TWL value was calculated from the humidity change at this time using the following formula.

However, Dt = Density of saturated water vapor in the air at the measurement temperature (t ''c ) (mg/7V: Volume of the cell (7S: Measurement area (cm2) +21 TWL value change rate Sample on the skin (skin) The TWL values before and after applying the cosmetic (cosmetics) were determined, and the rate of change was calculated using the following formula to evaluate the TWL reduction effect (moisture retention function enhancement effect).

T W L value before sample (skin cosmetic) application: TW
L.

TWl after application of sample (skin cosmetic), value: TWL
A (3) Method for measuring the turnover rate of the stratum corneum 5% by weight of the fluorescent dye danzyl chloride in white petrolatum
A blended ointment is prepared and applied as an occlusive patch to the skin of the subject's forearm for 24 hours to allow danzyl chloride to penetrate and bind to the stratum corneum. Thereafter, the test sample was applied to the same area 102 times (morning and evening), and the fluorescence of danzyl chloride was examined every day.The number of days until the fluorescence disappeared was defined as the turnover rate of the skin stratum corneum. Note that the normal turnover rate of the stratum corneum of the skin is 14 to 16 days, but in aged skin, the turnover rate increases to around 18 days. On the other hand, if the anti-aging effect appears, the time will be shortened to around 12 days.

(4) Peeling characteristics of keratinocytes Scotch tape (chihan mending tape) was applied to the skin, and this was peeled off to allow the keratinocytes on the skin surface to adhere to the tape. Next, the condition of the keratinocytes was observed in detail using a scanning electron microscope, and the exfoliation characteristics of the keratinocytes were classified based on the criteria shown in Table 1, and their indices were determined.

Table 1: Judgment criteria for peeling properties of corneocytes.These serve as indicators for judging the building properties of corneocytes, and in general, in dry skin and aging skin, the intercellular bond strength is weak and the density of the structure is also low. It has been confirmed that the index increases from

Examples 1 to 3 Comparative Example 1 [Skin Cream] Examples 1 to 3 of the present invention and Comparative Example (11 composition (wt%) (2 ) Preparation method Components (A) and (B) were heated and dissolved at 80°C and mixed together, and cooled to 30°C with stirring to prepare each skin cream.

Test Example 1 When the skin creams of the present invention of Examples 1 to 3 and the skin cream of Comparative Example 1 were applied, their effects on T W L value and keratin cell exfoliation properties were investigated.

(1) Test method 60 healthy subjects with normal skin (age 20-25)
20 subjects (20 to 25 years old) were divided into 3 groups (groups A, C, and E), and 60 subjects (20 to 25 years old) with normal dry skin were divided into 3 groups (groups A, C, and E). Groups (B, D, and F) Prior to the test, T W L
The values were measured and the average value was calculated for each group. next,
The skin cream of Comparative Example 1 was applied to the skin surface of the forearm of the test subjects for all the test subjects on the left forearm, and the skin cream of Example 1 was applied to the right forearm of each group for groups A and B, and for groups C and D. In Example 2, E and F groups, each skin cream of Example 3 was applied twice a day (morning and evening) for one month continuously, and the cream was applied to all test subjects on the day after the final application. The T W L values of the skin surface areas of the left and right forearms were measured, and the time release characteristics of corneocytes #I were also evaluated.

After the application test, a doctor diagnosed no abnormalities in the skin or physical condition of the forearm of any of the test subjects.

C21 Results TWL values before and after application of skin cream Those TW
The rate of change in TWL value obtained from the L value and the index of keratinocyte exfoliation properties (both values are the average value of 20 people in each group) were calculated as the second
Shown in the table.

From the results shown in Table 2, Example 1 of the present invention is as follows.
The effects of skin creams 2 and 3 were observed.

■ In normal healthy skin of groups A, C, and E, the moisture retention function of the skin is originally maintained in a normal state.
) Although the effect of coating is difficult to become apparent, a slight improvement is still observed compared to Comparative Example 1.

■ For dry skin in Groups B, D, and F, the skin surface of the right forearm to which the skin cream of the present invention (Examples 1, 2, and 3) was applied, and the skin surface of the left forearm (skin of Comparative Example 1) A significant improvement in the TWL value was observed compared to the cream), and the value was equal to or approaching that of healthy skin. When comparing the creams of the present invention, Example 3 had the highest moisture retention function improvement effect, followed by Example 2.1. Furthermore, similar results were obtained in the corneum cell peeling test.

That is, the skin creams of Examples 1, 2, and 3 of the present invention showed the effect of maintaining healthy skin in groups A, C, and E, and also showed the effect of maintaining healthy skin in groups B, D, and F. It is clear that it has an effect.

These results show that tramatic acid and/or its salts contained in the skin creams of Examples 1.2 and 3 of the present invention effectively act on epidermal cells, improve the intercellular bonding ability of the stratum corneum, and Test Example 2 The skin cream of the present invention of Example 3 and the skin cream of Comparative Example 1 have a dense structure, reduce the moisture retention function of the skin, and do not inhibit the physiological functions of healthy skin. The effects of 20% on the TWL value and stratum corneum turnover rate of healthy skin and aged dry skin were investigated.

(11 Test method) We newly added 20 test subjects (women aged 20 to 25 years old) with healthy ViiI skin as G group, and 20 test subjects with dry skin due to aging as H group (20 test subjects with dry skin due to aging) as G group. For a total of 40 women aged 50 to 60 years old, the TWL values on the skin surfaces of the left and right forearms were measured in advance, and ointment containing danzyl chloride was applied to the left and right forearms for 24 hours.

Next, the skin cream of Comparative Example 1 was applied to the skin surface of the left forearm of all the test subjects in Groups G and ■, and the skin cream of Example 1 was applied to the skin surface of the right forearm twice a day (in the morning, Evening) The solution was applied continuously for one month, and the fluorescence was examined every day. On the day after the final application, the TWL values of the skin surface areas of the left and right forearms to which the cream was applied were measured for all test subjects.

In addition, after the completion of the application test, the doctor will give a diagnosis of 15.
No abnormalities were observed in the skin or physical condition of the bent arms of any of the subjects.

(2) Results T W L 4 shifts before and after skin cream application (
Average value of 20 people in each group) 1, those 1” W 1-
The T W L, value conversion rate, and stratum corneum turnover rate (average value of 20 people in each group) calculated from the 1 value were calculated in the third
From the results shown in Table 3, the effects of the skin cream of Example 3 of the present invention were recognized as follows.

0) In the healthy normal skin of group G, the skin function status is maintained normally, so the skin cream of the present invention (Example 3) does not increase the turnover rate of the stratum corneum. I was not able to admit.

In addition, the same results as in Test Example 1 were obtained for 'T'WL.
! ■ For aged dry skin in Group 11, the skin surface of the right forearm to which the skin cream of the present invention (Example 3) was applied was applied, and the skin surface of the left forearm area (the skin cream of Comparative Example 1) was applied.
A reduction in the turnover rate of the stratum corneum was observed as compared to the application of a cream, and the value approached that of normal skin. Regarding the T W L value,
rSimilar to what was observed in normal dry skin in Test Example 1
(The application of the cream of the present invention (Example 3) showed a significant decrease in N (TWl, value), and the value was equivalent to that of a normal person.
Or something close to that value.

1!11 The skin cream of Example 1 of the present invention brings the turnover rate of the stratum corneum of aging dry skin close to that of healthy skin, and has a high water retention function. I can say that.

Test Example 3 The creams of Comparative Example 1 and Examples 1 to 3 were applied twice a day (morning and evening) to 30 test subjects (2 females aged 1 to 34 years) who complained of dry skin. The drug was applied for 11 consecutive months.As a result of the diagnosis by a doctor, no abnormality was observed in the skin or physical condition of all the birds tested.

Table 1 shows the results of a survey conducted on all test subjects to determine the effect of imparting moisturized (L) feeling, softness (smooth feeling), elasticity, and elasticity to the skin after applying the cream. It was shown to.

As is clear from the results in Table 4, the risk skin creams of Examples 1 to 3 that contain l.
Table Examples 4 to 5, Comparative Example 2 [Skin lotion (two-layer type)] In the same manner as in Example 1, each skin lotion was prepared by blending the sterol glucoside obtained in the above experimental example, and various tests were conducted.

(2) Preparation method After uniformly dissolving components (A) and (B),
) and component (B) are mixed, stirred and dispersed, and then filled into a container.

When using, shake and disperse the contents evenly and apply to the skin.

Test Example 4 The skin lotions of Comparative Example 2 and Examples 4 to 5 were administered twice a day (morning and evening) for one consecutive month to 30 test subjects (women aged 26 to 34 years old) who complained of dry skin. Coated. Diagnosis by a doctor revealed no abnormalities in the skin or physical condition of all test subjects.

Next, Table 5 shows the results of an investigation on all test subjects regarding the effect of imparting moisture (moist feeling), flexibility (smooth feeling), elasticity, and elasticity to the skin after applying the skin lotion.

Table 5 As is clear from the results in Table 5, Examples 4 to 4 of the present invention
All of the skin lotions of Example 5 show better results than Comparative Example 2, but especially the skin lotion of Example 5 shows a remarkable skin improvement effect.

(Effects of the Invention) The skin cosmetics of the present invention containing l-lamatic acid and/or its salt maintain the skin in a healthy state by promoting the skin's inherent moisture retention function. The object of the present invention is to provide a skin cosmetic that maintains or repairs the skin, imparts moisture, flexibility, elasticity, and luster to the skin, and has an excellent skin beautifying effect.

Claims (1)

[Claims] A skin cosmetic comprising tramatic acid and/or a salt thereof.