KR100447825B1 - Cosmetic Compositions Comprising Traumatic Acid for Enhancing Collagen Biosynthesis - Google Patents

Abstract

The present invention relates to a cosmetic composition for improving wrinkles comprising tramatic acid as an active ingredient, the cosmetic composition of the present invention can prevent and improve the skin aging phenomenon because it has excellent wrinkle removal effect by promoting collagen synthesis.

Description

Cosmetic composition for promoting collagen biosynthesis containing tramatic acid {Cosmetic Compositions Comprising Traumatic Acid for Enhancing Collagen Biosynthesis}

The present invention relates to a cosmetic composition, and more particularly, to a cosmetic composition for improving wrinkles, including tramatic acid as an active ingredient.

As human skin ages, its function is degraded by various internal and external factors. Internally, the activity and biosynthesis of biological components are reduced due to the deterioration of cell activity, and cellular components are attacked by active oxygen and the like, and their roles are structurally and functionally reduced. Externally, phenomena such as skin drying, decreased skin elasticity, and pigmentation due to ultraviolet rays are strongly shown. In particular, strong irritation caused by ultraviolet light promotes the destruction of constituents in the skin. Representative phenomena include the destruction of cells in the skin and the production of collagen degrading enzymes due to the increase in free radicals, the breakdown of collagen and elastin. And the like. Collagen is an insoluble crosslinking substance produced and secreted by dermal cells and is a protein that plays an important role in maintaining skin elasticity. In order for the skin to remain elastic and glossy, collagen production and decomposition must be performed properly. As the skin ages, collagen biosynthesis and degradation process increases. In relation to collagen biosynthesis, vitamin C, retinol, natural herbal extracts (such as ginseng and yulpi extract) have been researched and developed in various ways, and are currently used in various cosmetic products. As described above, substances having a collagen biosynthesis promoting effect are highly available as cosmetic raw materials for improving skin wrinkles and are actually used in many cases.

Meanwhile, as an example of a cosmetic composition for improving wrinkles, Korean Patent Application No. 1996-000388 discloses a cosmetic composition for improving wrinkles containing vitamin A, vitamin E and aloe, and Korean Patent Application No. 2000-052223 discloses , Discloses a cosmetic composition for improving wrinkles comprising a natural moist ingredient and eochocho component, and Korean Patent Application No. 1999-031433 discloses a cosmetic cream composition for improving wrinkles comprising red grape extract powder as an active ingredient. .

Throughout this specification many patent documents are referenced and their citations are indicated. The disclosures of the cited patent documents are incorporated by reference herein in their entirety, and the level of the technical field to which the present invention belongs and the contents of the present invention are more clearly described.

The present inventors earnestly researched to develop a cosmetic composition excellent in wrinkle improvement effect, when using the tramatic acid as an active ingredient, the present invention was completed by confirming that there is an excellent wrinkle improvement effect.

Accordingly, it is an object of the present invention to provide a cosmetic composition for improving wrinkles comprising tramatic acid.

The present invention provides a cosmetic composition for improving wrinkles comprising traumatic acid as an active ingredient.

Tramatic acid, which is used as an active ingredient in the composition of the present invention, is known as a substance present in legumes, and the name of IUPAC is 2-dodecenedioic acid (C ₁₂ H ₂₀ O ₄ , MW 228.28). In addition, it is known that it is possible to easily separate tramatic acid from legumes (English et al., Proc. Nat. Acad. Sci. 25: 323 (1939)). In vivo function of tramatic acid is known as a hormone.

As clearly shown in the following examples, the tramatic acid of the cosmetic composition of the present invention promotes collagen synthesis to prevent wrinkle formation and to remove the formed wrinkles.

According to a preferred embodiment of the present invention, the amount of tramatic acid is 0.01 to 5% by weight, more preferably 0.05 to 3% by weight, most preferably 0.1 to 2% by weight based on the total cosmetic composition. .

The components included in the cosmetic composition of the present invention include components conventionally used in cosmetic compositions in addition to tramatic acid as an active ingredient, and include, for example, conventional auxiliaries such as antioxidants, stabilizers, solubilizers, vitamins, pigments and flavorings, And carriers.

The composition for alleviating the skin irritation of the present invention may be prepared in any formulation commonly prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactants -Can be formulated with, but not limited to, cleansing, oils, powder foundations, emulsion foundations, wax foundations, sprays, and the like. More specifically, it may be prepared in the form of a flexible lotion, nutrition lotion, nutrition cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder.

When the formulation of the present invention is a paste, cream or gel, animal oils, vegetable oils, waxes, paraffins, starches, trachants, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide may be used as carrier components. Can be.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, in particular in the case of a spray, additionally chlorofluorohydrocarbon, propane Propellant such as butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 Fatty acid esters of, 3-butylglycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan.

When the formulation of the present invention is a suspension, liquid carrier diluents such as water, ethanol or propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystals Soluble cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used.

When the formulation of the present invention is a surfactant-containing cleansing, the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, isethionate, an imidazolinium derivative, a methyltaurate, a sarcosinate, a fatty acid amide. Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, it is to those skilled in the art that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention. Will be self-evident.

Example 1 Collagen Synthesis Enhancement Effect by Tramatic Acid

Human normal fibroblasts were seeded in 96-well microplates with DMEM medium (2 × 10 ⁴ cells / well) and incubated for 24 hours. Subsequently, the medium was replaced with serum-free DMEM medium, in which 0.01%, 0.05%, 0.1% or 0.2% of tramatic acid (Aldrich, USA) was added together with the medium and incubated for 48 hours. The one without addition of the tramic acid was used. After incubation, the supernatant of each well was collected and the amount of procollagen (procollagen) type I C-peptide was measured by PCIP assay kit (Takara, Japan), and the results are shown in Table 1 below.

Concentration (%) Collagen Synthesis Rate (%) 0.01 13.5 0.05 56.4 0.1 76.5 0.2 88.5

As shown in Table 1, it was found that the synthesis of collagen increases as the concentration of tramatic acid increases, and it was confirmed that the tramatic acid may exhibit an anti-wrinkle effect by promoting collagen synthesis in the skin.

Example 2: Wrinkle improvement effect of the cosmetics containing tramatic acid

Using 20 hairless mice, the anti-wrinkle effect of tramatic acid on the wrinkles induced by ultraviolet light was measured as follows: 20 hairless mice (purchased from the Korea Research Institute of Chemical Technology) were divided into 10 rats and UV light was applied to the back. Irradiation of a certain amount to promote the formation of wrinkles. Subsequently, a cosmetic composition containing 2.0% by weight of tramatic acid and having the composition of Formulation Example 3 was applied twice a day for 3 months. The control group was applied with a cosmetic composition containing no tramatic acid. After application for 3 months, the degree of wrinkle improvement was visually observed, and the results are shown in Table 2 below.

Wrinkle improvement Experimental group Control Excellent effect 12 horses Three Slightly improved 5 horses Three no effect Three 14 horses

As shown in Table 2, it can be seen that the cosmetic composition of the present invention containing tramatic acid has an excellent effect of improving wrinkles formed by ultraviolet rays.

In summary, the results of Example 1 and Example 2, it can be seen that the cosmetic composition of the present invention containing tramatic acid promotes the synthesis of collagen and exhibits the effect of wrinkle improvement.

Formulation Example 1

Formulation examples of the flexible lotion in the cosmetics containing tramatic acid are as follows.

ingredient Content (% by weight) Glycerin tramatate 1.3-butylene glycol pager 1500 allantoin DL-panthenol EDTA-2Nabenzophenone-9 sodium hyaluronate ethanol octyldodeces-16 polysorbate 20 preservatives, fragrance, distilled water 1.05.03.01.00.10.30.020.045.010.00.20.2 Balance Sum 100

Formulation Example 2

An example of the formulation of the nourishing lotion in the cosmetic containing tramatic acid is as follows.

ingredient Content (% by weight) Glyceryl stearate SE stearyl alcohol lanolin polysorbate 60 sorbitan stearate hardened plant oil oils squalane trioctanoindimethicone acetate tocopherol carboxyvinyl polymer glycerin 1.3-butylene glycol sodium hyaluronate tri ethanolamine preservative , Distilled water 1.51.51.51.51.30.51.05.03.02.00.80.50.125.03.05.00.12Balance Sum 100

Formulation Example 3

An example of the formulation of the nourishing cream in the cosmetic containing tramatic acid is as follows.

ingredient Content (% by weight) Tramatic acid-type monostearate glycerine cetearyl alcohol stearic acid beeswax polysorbate 60 sorbitan stearate hardened plant oil squalane mineral oil trioctanoindimethicone sodium magnesium silicate glycerin betaine triethanolamine sodium hyaluronate preservative, flavor, pigment distillation 2.02.02.21.51.01.50.61.03.05.05.01.00.15.03.01.04.0Balance Sum 100

Formulation Example 4

Examples of the formulation of the essence in the cosmetics containing tramic acid are as follows.

ingredient Content (% by weight) Glycerin betaine phosphine 1500 allantoin DL-panthenol EDTA-2Na benzophenone-9 hydroxyethyl cellulose sodium hyaluronate carboxyvinyl polymer triethanolamine octyl dodecanol octyl dodeces-16 ethanol preservative, flavor, pigment distilled water 2.010.05.02.00.10.30.020.040.18.00.20.180.30.46.0 Sum 100

As described above in detail, the present invention provides an anti-wrinkle cosmetic composition. Since the cosmetic composition of the present invention contains the tramatic acid, it is excellent in wrinkle removal effect by promoting collagen synthesis, thereby preventing and improving skin aging phenomenon.

Claims (4)

delete It contains the tramatic acid as an active ingredient, the amount of the tramatic acid is 0.01-5% by weight based on the total composition, the tramatic acid is a cosmetic for promoting collagen biosynthesis, characterized in that to promote collagen biosynthesis in fibroblasts Composition. The method of claim 2, wherein the cosmetic composition for improving wrinkles, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing, oils, powder foundations, emulsion foundations, wax foundations and Cosmetic composition for promoting collagen biosynthesis, characterized in that it has a formulation selected from the group consisting of a spray. The cosmetic composition according to claim 3, wherein the cosmetic composition is tramatic acid, lipophilic monostearate glycerine, cetearyl alcohol, stearic acid, beeswax, polysorbate 60, sorbitan stearate, hardened vegetable oil, squalane, mineral oil, trioctanoin, A cosmetic composition for promoting collagen biosynthesis, comprising a cream formulation comprising dimethicone, sodium magnesium silicate, glycerin, betaine, triethanolamine, sodium hyaluronate and distilled water.