JPH10234361A - 造血幹細胞分離・保存システム - Google Patents
造血幹細胞分離・保存システムInfo
- Publication number
- JPH10234361A JPH10234361A JP9054300A JP5430097A JPH10234361A JP H10234361 A JPH10234361 A JP H10234361A JP 9054300 A JP9054300 A JP 9054300A JP 5430097 A JP5430097 A JP 5430097A JP H10234361 A JPH10234361 A JP H10234361A
- Authority
- JP
- Japan
- Prior art keywords
- cell
- capturing means
- circuit
- cell capturing
- stem cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000003995 blood forming stem cell Anatomy 0.000 title abstract 6
- 210000004027 cell Anatomy 0.000 claims abstract description 110
- 239000007788 liquid Substances 0.000 claims abstract description 39
- 210000003743 erythrocyte Anatomy 0.000 claims abstract description 21
- 239000000463 material Substances 0.000 claims abstract description 9
- 230000008014 freezing Effects 0.000 claims abstract 2
- 238000007710 freezing Methods 0.000 claims abstract 2
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 39
- 238000000034 method Methods 0.000 claims description 15
- 210000005087 mononuclear cell Anatomy 0.000 claims description 12
- 238000000926 separation method Methods 0.000 claims description 12
- 238000004321 preservation Methods 0.000 claims description 9
- 238000007599 discharging Methods 0.000 claims description 2
- 238000010257 thawing Methods 0.000 claims description 2
- 210000001616 monocyte Anatomy 0.000 abstract description 5
- 238000011144 upstream manufacturing Methods 0.000 abstract 2
- 230000008018 melting Effects 0.000 abstract 1
- 238000002844 melting Methods 0.000 abstract 1
- 210000004700 fetal blood Anatomy 0.000 description 13
- 239000002994 raw material Substances 0.000 description 11
- 239000000243 solution Substances 0.000 description 9
- 229920001917 Ficoll Polymers 0.000 description 4
- 238000005138 cryopreservation Methods 0.000 description 4
- 210000005259 peripheral blood Anatomy 0.000 description 4
- 239000011886 peripheral blood Substances 0.000 description 4
- 210000001185 bone marrow Anatomy 0.000 description 3
- 210000000130 stem cell Anatomy 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 238000002054 transplantation Methods 0.000 description 3
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- 238000010241 blood sampling Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 239000004745 nonwoven fabric Substances 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 239000002759 woven fabric Substances 0.000 description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000002338 cryopreservative effect Effects 0.000 description 1
- 239000002577 cryoprotective agent Substances 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000011134 hematopoietic stem cell transplantation Methods 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000011147 inorganic material Substances 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 210000004967 non-hematopoietic stem cell Anatomy 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000011476 stem cell transplantation Methods 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 210000003954 umbilical cord Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9054300A JPH10234361A (ja) | 1997-02-24 | 1997-02-24 | 造血幹細胞分離・保存システム |
| AU55763/98A AU731766B2 (en) | 1997-01-24 | 1998-01-22 | Cell separation method |
| CNB98802828XA CN1330752C (zh) | 1997-01-24 | 1998-01-22 | 细胞分离方法 |
| EP98900701A EP0987325B1 (en) | 1997-01-24 | 1998-01-22 | Method for separating cells |
| PCT/JP1998/000244 WO1998032840A1 (en) | 1997-01-24 | 1998-01-22 | Method for separating cells |
| US09/341,879 US6268119B1 (en) | 1997-01-24 | 1998-01-22 | Method for separating cells |
| CA2278208A CA2278208C (en) | 1997-01-24 | 1998-01-22 | Cell separation method |
| AT98900701T ATE509094T1 (de) | 1997-01-24 | 1998-01-22 | Methode zur zelltrennung |
| US09/871,645 US20010036624A1 (en) | 1997-01-24 | 2001-06-04 | Cell separation method |
| US09/947,374 US20020031757A1 (en) | 1997-01-24 | 2001-09-07 | Method of regenerating a tissue |
| US10/373,704 US20030180705A1 (en) | 1997-01-24 | 2003-02-27 | Method of regenerating blood vessels |
| US10/834,191 US20040224300A1 (en) | 1997-01-24 | 2004-04-29 | Method for separating nucleated cells |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9054300A JPH10234361A (ja) | 1997-02-24 | 1997-02-24 | 造血幹細胞分離・保存システム |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH10234361A true JPH10234361A (ja) | 1998-09-08 |
| JPH10234361A5 JPH10234361A5 (enExample) | 2004-10-21 |
Family
ID=12966729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9054300A Pending JPH10234361A (ja) | 1997-01-24 | 1997-02-24 | 造血幹細胞分離・保存システム |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPH10234361A (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013514806A (ja) * | 2009-12-22 | 2013-05-02 | リキッド・バイオプシー・エイビイ | 生体試料の精製及び濃縮のための装置及び方法 |
-
1997
- 1997-02-24 JP JP9054300A patent/JPH10234361A/ja active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013514806A (ja) * | 2009-12-22 | 2013-05-02 | リキッド・バイオプシー・エイビイ | 生体試料の精製及び濃縮のための装置及び方法 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20060222 |
|
| A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20060414 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20060607 |