JPH09510386A - 柔軟組織の閉鎖システム - Google Patents
柔軟組織の閉鎖システムInfo
- Publication number
- JPH09510386A JPH09510386A JP7524609A JP52460995A JPH09510386A JP H09510386 A JPH09510386 A JP H09510386A JP 7524609 A JP7524609 A JP 7524609A JP 52460995 A JP52460995 A JP 52460995A JP H09510386 A JPH09510386 A JP H09510386A
- Authority
- JP
- Japan
- Prior art keywords
- implant
- collagen
- matrix
- soft tissue
- self
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/043—Proteins; Polypeptides; Degradation products thereof
- A61L31/044—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00004—(bio)absorbable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00646—Type of implements
- A61B2017/00654—Type of implements entirely comprised between the two sides of the opening
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
- A61B2017/00646—Type of implements
- A61B2017/00659—Type of implements located only on one side of the opening
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S128/00—Surgery
- Y10S128/08—Collagen
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.a)孔の平均径が約0.5μm〜約50μmである圧縮状態にあり、湿潤時 に、膨張状態での孔の平均径が約100μm〜約3,000μmとなるように自 己膨張性であることを特徴とする生体で再吸収可能な材料から形成され、一定の 長さを有するインプラント、 b)離れた端部にある出口および挿入深度ガイドを有する輸送手段であって、 挿入深度ガイドによって調節された深さまで空隙に挿入されることができ、また 該インプラントが圧縮状態で内部に配設されている輸送手段、及び c)柔軟組織の空隙を閉鎖できるように適合する膨張した含水マトリックスを 形成するように、該圧縮状態のインプラントを該出口から柔軟組織の空隙へと調 節された距離だけ放出する、引き込み式の放出手段であって、(i)挿入深度ガ イドと(ii)インプラントの長さと(iii)引き込み式放出手段との組み合わせ により空隙におけるインプラントの位置づけが調節される放出手段 を含む、生体の柔軟組織における空隙を閉鎖するための装置。 2.自己膨張性で再吸収可能なインプラントが、生物適合性でかつ生物再吸収可 能な材料から形成され、請求の範囲1の装置。 3.生物適合性でかつ生物再吸収可能な材料がI型コラーゲンである、請求の範 囲2の装置。 4.圧縮されたインプラントが、約0.1g/cm3〜約1.30g/cm3の密 度、約3cm3/cm3〜約100cm3/cm3の膨張能力、さらに約1秒〜約6 0秒の緩和回復時間を有する、請求の範囲1の装置。 5.輸送手段が長軸の管状部材であり、また放出手段が、該管状部材内に位置づ けられ出口からインプラントを押し出すべく長軸方向に移動するように配設され た加圧部材を含む、請求の範囲1の装置。 6.輸送手段が生物適合性の材料から形成される、請求の範囲5の装置。 7.生物適合性の材料が合成された重合性材料である、請求の範囲6の装置。 8.インプラントが、体液と接触した場合に組織の空隙に適合するよう自己膨張 する、請求の範囲1の装置。 9.インプラントが何らかの幾何学形状をしている、請求の範囲1の装置。 10.挿入深度ガイドが輸送手段の長軸から外側に伸びる突出部を含み、該突出 部と出口との距離が該輸送手段の挿入深度を規定する、請求の範囲1の装置。 11.輸送手段が挿入深度にまで挿入されたとき、突出部が生体の皮膚の最外層 上に残ったままである、請求の範囲1の装置。 12.輸送手段が挿入深度にまで挿入されたとき、突出部が導入用外筒の端部に 残ったままである、請求の範囲1の装置。 13.柔軟組織の空隙が皮膚の表面にまで延びる血管の壁における切開部位また は穿刺部位であり、また放出されるインプラントが該切開部位または穿刺部位で 該血管壁の外側に隣接して位置するように挿入深度が挿入の深度をガイドする、 請求の範囲1の装置。 14.a)コラーゲンを含む水性分散液を生成し、 b)該水性分散液を型に注入し、 c)該水性分散液を凍結乾燥してコラーゲンマトリックスを形成し、 d)該コラーゲンマトリックスを架橋剤を用いて処理することにより架橋し、 e)該架橋されたコラーゲンマトリックスを水蒸気とともに噴霧し、 f)該水蒸気処理されたコラーゲンマトリックスを圧縮すること を含む、自己膨張性で再吸収可能なコラーゲンインプラントを製造する方法。 15.分散液がさらに、抗体、成長因子、トロンビン、グリコサミノグリカン、 プロスタグランジン、II型〜XIV型のコラーゲン、糖タンパク質、ファイブロネ クチン、ラミニン、およびその混合物を含む薬剤を含有する、請求の範囲14の 方法。 16.架橋剤がホルムアルデヒドである請求の範囲14の方法。 17.架橋の程度が、コラーゲンインプラントが約2週間から約10週間で再吸 収されるような程度である、請求の範囲16の方法。 18.再吸収可能なコラーゲンインプラントが、圧縮状態で約0.1g/cm3 〜約1.30g/cm3の密度を有し、また膨張状態で約0.01g/cm3〜約 0.5g/cm3の密度を有する、請求の範囲14の方法。 19.再吸収可能なコラーゲンインプラントが、約3cm3/cm3〜約100c m3/cm3の膨張能力を有する、請求の範囲14の方法。 20.再吸収可能なコラーゲンインプラントが、約1秒〜約60秒の緩和回復時 間を有する、請求の範囲14の方法。 21.再吸収可能なコラーゲンインプラントが、約50℃〜約75℃の熱収縮温 度を有する、請求の範囲14の方法。 22.a)長軸を有し、離れた端部に出口を有する輸送手段を、該輸送手段に設 けられた挿入深度ガイドにより調節された深さまで、柔軟組織の空隙に挿入し、 b)調節された距離だけ、調節された位置に、一定の長さを有するインプラン トを該輸送手段から該空隙へと放出し(ここで、インプラントは、孔の平均径が 約0.5μm〜約50μmである圧縮状態にあり、湿潤時に、膨張状態での孔の 平均径が約100μm〜約3,000μmとなるように自己膨張可能である、生 体で再吸収されうる材料からなり、そして(i)挿入深度ガイドと(ii)インプ ラントの長さと(iii)放出手段との組み合わせにより空隙内での該インプラン トの位置づけが調節される)、 c)該インプラントが自己膨張し、柔軟組織の空隙に適合しその空隙を閉鎖す る含水マトリックスを形成するように、輸送手段を除去すること を含む、生体の柔軟組織における空隙を閉鎖するための方法。 23.柔軟組織の空隙が皮膚の表面にまで延びる血管の壁における切開部位また は穿刺部位であり、また放出されるインプラントが該切開部位または穿刺部位で 該血管壁の外側に隣接して位置するように該挿入深度が該輸送装置の挿入の深度 をガイドする、請求の範囲22の方法。 24.生体が最外層を有する皮膚を有しており、また輸送手段の長軸から外側に 伸びる突出部を含み、該輸送手段の挿入深度を規定する該突出部と出口との距離 を規定する挿入深度ガイドによって、挿入深度が調節され、該輸送手段が挿入深 度にまで挿入されたとき該突出部が生体の皮膚の最外層上に残ったままである、 請求の範囲22の方法。 25.インプラントが生物適合性の重合性材料である請求の範囲22の方法。 26.生物適合性の重合性材料が、コラーゲンを含有する材料である、請求の範 囲25の方法。 27.インプラントが体液または血液と接触した場合に自己膨張する、請求の範 囲22の方法。 28.圧縮されたインプラントが、圧縮状態で約0.10g/cm3〜約1.3 0g/cm3の密度、膨張状態で約0.01g/cm3〜約0.50g/cm3の 密度、約3cm3/cm3〜約100cm3/cm3の膨張能力、約50℃〜約75 ℃の熱収縮温度、さらに約1秒〜約60秒の緩和回復時間を有する、請求の範囲 22の方法。 29.圧縮されたインプラントがさらに、抗体、成長因子、トロンビン、グリコ サミノグリカン、プロスタグランジン、I型〜XIV型のコラーゲン、糖タンパク質 、ファイブロネクチン、ラミニン、およびその混合物を含む薬剤を含有する、請 求の範囲22の方法。 30.請求の範囲14の方法により調製された自己膨張性で再吸収可能なコラー ゲンインプラント。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/881,213 US5326350A (en) | 1992-05-11 | 1992-05-11 | Soft tissue closure systems |
PCT/US1994/002973 WO1995025481A1 (en) | 1992-05-11 | 1994-03-18 | Soft tissue closure systems |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004272748A Division JP4225960B2 (ja) | 2004-09-21 | 2004-09-21 | 柔軟組織の閉鎖システム |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH09510386A true JPH09510386A (ja) | 1997-10-21 |
JP3622972B2 JP3622972B2 (ja) | 2005-02-23 |
Family
ID=25378009
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52460995A Expired - Fee Related JP3622972B2 (ja) | 1992-05-11 | 1994-03-18 | 柔軟組織の閉鎖システム |
Country Status (5)
Country | Link |
---|---|
US (2) | US5326350A (ja) |
EP (1) | EP0751750A4 (ja) |
JP (1) | JP3622972B2 (ja) |
CA (1) | CA2185789C (ja) |
WO (1) | WO1995025481A1 (ja) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004523484A (ja) * | 2000-11-17 | 2004-08-05 | ヴァージニア コモンウェルス ユニバーシティ インテレクチュアル プロパティー ファンデーション | 電気処理されたコラーゲン |
JP2006507047A (ja) * | 2002-11-01 | 2006-03-02 | サイオン カーディオバスキュラー インコーポレイテッド | 止血パッド |
JP2007516004A (ja) * | 2003-07-25 | 2007-06-21 | ルビコー メディカル インコーポレイテッド | 生検後の空洞処理移植物及び方法 |
JP2012515035A (ja) * | 2009-01-16 | 2012-07-05 | ガイストリヒ・ファーマ・アクチェンゲゼルシャフト | 組織再生のための方法および膜 |
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US6074840A (en) | 1994-02-18 | 2000-06-13 | The Regents Of The University Of Michigan | Recombinant production of latent TGF-beta binding protein-3 (LTBP-3) |
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- 1994-03-18 WO PCT/US1994/002973 patent/WO1995025481A1/en active Application Filing
- 1994-03-18 EP EP94915344A patent/EP0751750A4/en not_active Withdrawn
- 1994-03-18 JP JP52460995A patent/JP3622972B2/ja not_active Expired - Fee Related
- 1994-03-18 CA CA002185789A patent/CA2185789C/en not_active Expired - Fee Related
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2004523484A (ja) * | 2000-11-17 | 2004-08-05 | ヴァージニア コモンウェルス ユニバーシティ インテレクチュアル プロパティー ファンデーション | 電気処理されたコラーゲン |
JP2006507047A (ja) * | 2002-11-01 | 2006-03-02 | サイオン カーディオバスキュラー インコーポレイテッド | 止血パッド |
JP2007516004A (ja) * | 2003-07-25 | 2007-06-21 | ルビコー メディカル インコーポレイテッド | 生検後の空洞処理移植物及び方法 |
JP2012515035A (ja) * | 2009-01-16 | 2012-07-05 | ガイストリヒ・ファーマ・アクチェンゲゼルシャフト | 組織再生のための方法および膜 |
JP2012515066A (ja) * | 2009-01-16 | 2012-07-05 | ガイストリヒ・ファーマ・アクチェンゲゼルシャフト | 皮膚再生のための方法および膜 |
Also Published As
Publication number | Publication date |
---|---|
CA2185789C (en) | 2005-02-15 |
EP0751750A1 (en) | 1997-01-08 |
EP0751750A4 (en) | 1998-09-16 |
JP3622972B2 (ja) | 2005-02-23 |
US5326350A (en) | 1994-07-05 |
WO1995025481A1 (en) | 1995-09-28 |
CA2185789A1 (en) | 1995-09-28 |
US5571181A (en) | 1996-11-05 |
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