JPH08507791A - 複素環含有大環状免疫調節剤 - Google Patents

複素環含有大環状免疫調節剤

Info

Publication number
JPH08507791A
JPH08507791A JP6521157A JP52115794A JPH08507791A JP H08507791 A JPH08507791 A JP H08507791A JP 6521157 A JP6521157 A JP 6521157A JP 52115794 A JP52115794 A JP 52115794A JP H08507791 A JPH08507791 A JP H08507791A
Authority
JP
Japan
Prior art keywords
group
compound
hydrogen
hydroxy
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6521157A
Other languages
English (en)
Japanese (ja)
Inventor
カワイ,メグミ
オア,ヤツト・サン
ラリー,ジエイ・アール
Original Assignee
アボツト・ラボラトリーズ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by アボツト・ラボラトリーズ filed Critical アボツト・ラボラトリーズ
Publication of JPH08507791A publication Critical patent/JPH08507791A/ja
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18Bridged systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP6521157A 1993-03-17 1994-03-14 複素環含有大環状免疫調節剤 Pending JPH08507791A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3295893A 1993-03-17 1993-03-17
US08/032,958 1993-07-30
PCT/US1994/002741 WO1994021258A1 (en) 1993-03-17 1994-03-14 Heterocycle-containing macrocyclic immunomodulators

Publications (1)

Publication Number Publication Date
JPH08507791A true JPH08507791A (ja) 1996-08-20

Family

ID=21867796

Family Applications (2)

Application Number Title Priority Date Filing Date
JP6521157A Pending JPH08507791A (ja) 1993-03-17 1994-03-14 複素環含有大環状免疫調節剤
JP6521150A Pending JPH08507790A (ja) 1993-03-17 1994-03-14 大環状カルバメート免疫調節剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP6521150A Pending JPH08507790A (ja) 1993-03-17 1994-03-14 大環状カルバメート免疫調節剤

Country Status (5)

Country Link
US (1) US5457194A (OSRAM)
EP (2) EP0689546A4 (OSRAM)
JP (2) JPH08507791A (OSRAM)
CA (2) CA2156067A1 (OSRAM)
WO (3) WO1994021644A1 (OSRAM)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011088934A (ja) * 1998-08-14 2011-05-06 Eisai Inc 視覚および記憶の疾患のためのピペコリン酸誘導体

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5604234A (en) * 1991-09-05 1997-02-18 Abbott Laboratories Substituted thiol macrolactam immunomodulators
US5708002A (en) * 1991-09-05 1998-01-13 Abbott Laboratories Macrocyclic immunomodulators
AR004480A1 (es) * 1995-04-06 1998-12-16 Amico Derin C D Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen
US6187757B1 (en) * 1995-06-07 2001-02-13 Ariad Pharmaceuticals, Inc. Regulation of biological events using novel compounds
FR2736550B1 (fr) * 1995-07-14 1998-07-24 Sandoz Sa Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule
MY122454A (en) * 1998-06-05 2006-04-29 Upjohn Co Use of oxazolidinones for the preparation of a medicament for transdermal delivery
MXPA01009935A (es) * 1999-03-31 2002-05-06 Abbott Lab Inmunomoduladores macorciclicos que contienen fosfato.
ATE264863T1 (de) * 1999-08-24 2004-05-15 Ariad Gene Therapeutics Inc 28-epirapaloge
US7067526B1 (en) 1999-08-24 2006-06-27 Ariad Gene Therapeutics, Inc. 28-epirapalogs
JP2003192773A (ja) * 2001-12-26 2003-07-09 Mitsui Chemicals Inc 生体吸収性ポリヒドロキシカルボン酸及びその製造法
WO2004060346A2 (en) 2002-12-30 2004-07-22 Angiotech International Ag Drug delivery from rapid gelling polymer composition
ATE457995T1 (de) 2003-06-18 2010-03-15 Tranzyme Pharma Inc Makrozyklische motilin rezeptorantagonisten
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
US20070045902A1 (en) 2004-07-13 2007-03-01 Brauker James H Analyte sensor
US20060020192A1 (en) 2004-07-13 2006-01-26 Dexcom, Inc. Transcutaneous analyte sensor
US20060189551A1 (en) * 2004-10-04 2006-08-24 Duke University Combination therapies for fungal pathogens
GB0428020D0 (en) 2004-12-22 2005-01-26 Amersham Health As Stabilisation of radiopharmaceutical precursors
TW200637552A (en) * 2005-01-20 2006-11-01 Array Biopharma Inc Macrocyclic analogs for the treatment of immunoregulatory disorders and respiratory diseases
EP2200443B2 (en) * 2007-09-17 2021-06-30 Cornell University Branched chain fatty acids for prevention or treatment of gastrointestinal disorders
US8921642B2 (en) * 2008-01-11 2014-12-30 Massachusetts Eye And Ear Infirmary Conditional-stop dimerizable caspase transgenic animals
CA2905229C (en) 2013-06-11 2023-10-10 Clontech Laboratories, Inc. Protein enriched microvesicles and methods of making and using the same
ES2873962T3 (es) * 2014-06-06 2021-11-04 Scripps Research Inst Compuestos de fluoruro de azufre (VI) y métodos para la preparación de los mismos
JP7104627B2 (ja) 2016-02-04 2022-07-21 ザ・ジョンズ・ホプキンス・ユニバーシティ ラパグルチン(rapaglutins)、glutの新規阻害剤及びその使用
ES2837484T3 (es) 2016-02-04 2021-06-30 Univ Johns Hopkins Rapadocinas, inhibidores del transportador de nucleósidos equilibrativo 1 y usos de los mismos

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5266692A (en) * 1984-12-03 1993-11-30 Fujisawa Pharmaceutical Co., Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
JPS6317884A (ja) * 1986-05-30 1988-01-25 Fujisawa Pharmaceut Co Ltd トリシクロ化合物
IE904050A1 (en) * 1989-11-13 1991-05-22 Merck & Co Inc Aminomacrolides and derivatives having immunosuppressive¹activity
US5208228A (en) * 1989-11-13 1993-05-04 Merck & Co., Inc. Aminomacrolides and derivatives having immunosuppressive activity
WO1991013899A1 (en) * 1990-03-12 1991-09-19 Fujisawa Pharmaceutical Co., Ltd. Tricyclo compounds
US5262533A (en) * 1991-05-13 1993-11-16 Merck & Co., Inc. Amino O-aryl macrolides having immunosuppressive activity
US5250678A (en) * 1991-05-13 1993-10-05 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
US5189042A (en) * 1991-08-22 1993-02-23 Merck & Co. Inc. Fluoromacrolides having immunosuppressive activity
US5208241A (en) * 1991-09-09 1993-05-04 Merck & Co., Inc. N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity
US5247076A (en) * 1991-09-09 1993-09-21 Merck & Co., Inc. Imidazolidyl macrolides having immunosuppressive activity
US5252732A (en) * 1991-09-09 1993-10-12 Merck & Co., Inc. D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity
US5250687A (en) * 1992-08-28 1993-10-05 The United States Of America As Represented By The Secretary Of The Army Process for preparation of RDX
DE4336458A1 (de) * 1993-10-26 1995-04-27 Sandoz Ag Heteroatome enthaltende tricyclische Verbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011088934A (ja) * 1998-08-14 2011-05-06 Eisai Inc 視覚および記憶の疾患のためのピペコリン酸誘導体

Also Published As

Publication number Publication date
EP0688217A4 (OSRAM) 1996-01-10
CA2156068A1 (en) 1994-09-29
EP0689546A4 (en) 1996-04-03
JPH08507790A (ja) 1996-08-20
US5457194A (en) 1995-10-10
WO1994021258A1 (en) 1994-09-29
CA2156067A1 (en) 1994-09-29
EP0689546A1 (en) 1996-01-03
EP0688217A1 (en) 1995-12-27
WO1994021644A1 (en) 1994-09-29
WO1994021643A1 (en) 1994-09-29

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