JPH08506835A - ３′−アジリジノ−アンスラサイクリン誘導体 - Google Patents

３′−アジリジノ−アンスラサイクリン誘導体

Info

Publication number
JPH08506835A
JPH08506835A JP7516486A JP51648695A JPH08506835A JP H08506835 A JPH08506835 A JP H08506835A JP 7516486 A JP7516486 A JP 7516486A JP 51648695 A JP51648695 A JP 51648695A JP H08506835 A JPH08506835 A JP H08506835A
Authority
JP
Japan
Prior art keywords
formula
group
deamino
aziridinyl
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP7516486A
Other languages
English (en)
Japanese (ja)
Inventor
バルジオツテイ，アルベルト
カルーソ，ミケーレ
グランデイ，マリア
リパモンテイ，マリーナ
スアラート，アントニーノ
Original Assignee
フアルマシア・エツセ・ピー・アー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by フアルマシア・エツセ・ピー・アー filed Critical フアルマシア・エツセ・ピー・アー
Publication of JPH08506835A publication Critical patent/JPH08506835A/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
JP7516486A 1993-12-13 1994-11-21 ３′−アジリジノ−アンスラサイクリン誘導体 Ceased JPH08506835A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9325417.5 1993-12-13
GB939325417A GB9325417D0 (en) 1993-12-13 1993-12-13 3'- aziridino-anthracycline derivatives
PCT/EP1994/003840 WO1995016695A2 (en) 1993-12-13 1994-11-21 3'-aziridino-anthracycline derivatives

Publications (1)

Publication Number Publication Date
JPH08506835A true JPH08506835A (ja) 1996-07-23

Family

ID=10746494

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7516486A Ceased JPH08506835A (ja) 1993-12-13 1994-11-21 ３′−アジリジノ−アンスラサイクリン誘導体

Country Status (26)

Country Link
US (1) US5532218A (f)
EP (1) EP0683788B1 (f)
JP (1) JPH08506835A (f)
KR (1) KR100352734B1 (f)
CN (1) CN1039123C (f)
AT (1) ATE157369T1 (f)
AU (1) AU676625B2 (f)
CA (1) CA2154890A1 (f)
DE (1) DE69405214T2 (f)
DK (1) DK0683788T3 (f)
ES (1) ES2107294T3 (f)
FI (1) FI108036B (f)
GB (1) GB9325417D0 (f)
GR (1) GR3025266T3 (f)
HK (1) HK1011692A1 (f)
HU (1) HU217630B (f)
IL (1) IL111725A (f)
MY (1) MY117086A (f)
NO (1) NO304951B1 (f)
NZ (1) NZ276401A (f)
PL (1) PL178806B1 (f)
RU (1) RU2149163C1 (f)
TW (1) TW336235B (f)
UA (1) UA43839C2 (f)
WO (1) WO1995016695A2 (f)
ZA (1) ZA949701B (f)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5948896A (en) * 1997-08-13 1999-09-07 Gem Pharmaceuticals Processes for preparing 13-deoxy anthracycline derivatives
US5942605A (en) * 1998-03-03 1999-08-24 Gem Pharmaceuticals, Inc. 5-imino-13-deoxy anthracycline derivatives, their uses, and processes for preparing them
GB9806324D0 (en) * 1998-03-24 1998-05-20 Pharmacia & Upjohn Spa Antitumour synergetic composition
GB9808027D0 (en) * 1998-04-15 1998-06-17 Pharmacia & Upjohn Spa 13-dihydro-3' aziridino anthracyclines
GB9904387D0 (en) * 1999-02-25 1999-04-21 Pharmacia & Upjohn Spa Antitumour synergistic composition
GB9904386D0 (en) * 1999-02-25 1999-04-21 Pharmacia & Upjohn Spa Antitumour synergistic composition
GB0006601D0 (en) * 2000-03-17 2000-05-10 Pharmacia & Upjohn Spa Crystalline alkycycline derivative
GB0117403D0 (en) * 2001-07-17 2001-09-05 Pharmacia & Upjohn Spa Solvent-free crystalline anthracycline derivatives
US7737123B2 (en) * 2005-05-12 2010-06-15 The Ohio State University Research Foundation Multidrug resistant anticancer anthracyclines
CA2721140C (en) * 2008-04-11 2016-02-09 Tianjin Hemay Bio-Tech Co. Ltd. Tetracyclic anthraquinone antibiotic derivatives with high activity, process for preparing the same and use thereof
CN101912600B (zh) * 2010-01-11 2014-01-29 杨国汉 改善胰岛素在溶液中稳定性的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54141759A (en) * 1978-04-24 1979-11-05 Microbial Chem Res Found Novel anthracycline derivative
GB8614323D0 (en) * 1986-06-12 1986-07-16 Erba Farmitalia Anthracyclines
US5413992A (en) * 1992-07-31 1995-05-09 The Scripps Research Institute Daunomycin derivative with reduced cytotoxicity toward normal cells

Also Published As

Publication number Publication date
CN1039123C (zh) 1998-07-15
PL178806B1 (pl) 2000-06-30
DE69405214D1 (de) 1997-10-02
IL111725A0 (en) 1995-01-24
FI953784A (fi) 1995-08-09
FI953784A0 (fi) 1995-08-09
HU217630B (hu) 2000-03-28
UA43839C2 (uk) 2002-01-15
FI108036B (fi) 2001-11-15
GR3025266T3 (en) 1998-02-27
WO1995016695A2 (en) 1995-06-22
DK0683788T3 (da) 1997-10-27
NO953163D0 (no) 1995-08-11
HUT73172A (en) 1996-06-28
TW336235B (en) 1998-07-11
ES2107294T3 (es) 1997-11-16
AU676625B2 (en) 1997-03-13
NO304951B1 (no) 1999-03-08
US5532218A (en) 1996-07-02
AU1066095A (en) 1995-07-03
KR960701074A (ko) 1996-02-24
CA2154890A1 (en) 1995-06-22
HU9502662D0 (en) 1995-11-28
KR100352734B1 (ko) 2003-02-17
RU2149163C1 (ru) 2000-05-20
GB9325417D0 (en) 1994-02-16
MY117086A (en) 2004-05-31
CN1117734A (zh) 1996-02-28
WO1995016695A3 (en) 1995-07-13
NO953163L (no) 1995-10-02
ATE157369T1 (de) 1997-09-15
IL111725A (en) 1998-07-15
PL310177A1 (en) 1995-11-27
EP0683788B1 (en) 1997-08-27
EP0683788A1 (en) 1995-11-29
HK1011692A1 (en) 1999-07-16
NZ276401A (en) 1997-10-24
DE69405214T2 (de) 1998-01-29
ZA949701B (en) 1995-12-12

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