ZA949701B - 3'-Aziridino-anthracycline derivatives - Google Patents

3'-Aziridino-anthracycline derivatives

Info

Publication number
ZA949701B
ZA949701B ZA949701A ZA949701A ZA949701B ZA 949701 B ZA949701 B ZA 949701B ZA 949701 A ZA949701 A ZA 949701A ZA 949701 A ZA949701 A ZA 949701A ZA 949701 B ZA949701 B ZA 949701B
Authority
ZA
South Africa
Prior art keywords
group
hydrogen
linear
alkyl
formula
Prior art date
Application number
ZA949701A
Other languages
English (en)
Inventor
Alberto Bargiotti
Michele Caruso
Maria Grandi
Marina Ripamonti
Antonino Suarato
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of ZA949701B publication Critical patent/ZA949701B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
ZA949701A 1993-12-13 1994-12-06 3'-Aziridino-anthracycline derivatives ZA949701B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939325417A GB9325417D0 (en) 1993-12-13 1993-12-13 3'- aziridino-anthracycline derivatives

Publications (1)

Publication Number Publication Date
ZA949701B true ZA949701B (en) 1995-12-12

Family

ID=10746494

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA949701A ZA949701B (en) 1993-12-13 1994-12-06 3'-Aziridino-anthracycline derivatives

Country Status (26)

Country Link
US (1) US5532218A (f)
EP (1) EP0683788B1 (f)
JP (1) JPH08506835A (f)
KR (1) KR100352734B1 (f)
CN (1) CN1039123C (f)
AT (1) ATE157369T1 (f)
AU (1) AU676625B2 (f)
CA (1) CA2154890A1 (f)
DE (1) DE69405214T2 (f)
DK (1) DK0683788T3 (f)
ES (1) ES2107294T3 (f)
FI (1) FI108036B (f)
GB (1) GB9325417D0 (f)
GR (1) GR3025266T3 (f)
HK (1) HK1011692A1 (f)
HU (1) HU217630B (f)
IL (1) IL111725A (f)
MY (1) MY117086A (f)
NO (1) NO304951B1 (f)
NZ (1) NZ276401A (f)
PL (1) PL178806B1 (f)
RU (1) RU2149163C1 (f)
TW (1) TW336235B (f)
UA (1) UA43839C2 (f)
WO (1) WO1995016695A2 (f)
ZA (1) ZA949701B (f)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5948896A (en) * 1997-08-13 1999-09-07 Gem Pharmaceuticals Processes for preparing 13-deoxy anthracycline derivatives
US5942605A (en) * 1998-03-03 1999-08-24 Gem Pharmaceuticals, Inc. 5-imino-13-deoxy anthracycline derivatives, their uses, and processes for preparing them
GB9806324D0 (en) * 1998-03-24 1998-05-20 Pharmacia & Upjohn Spa Antitumour synergetic composition
GB9808027D0 (en) * 1998-04-15 1998-06-17 Pharmacia & Upjohn Spa 13-dihydro-3' aziridino anthracyclines
GB9904387D0 (en) * 1999-02-25 1999-04-21 Pharmacia & Upjohn Spa Antitumour synergistic composition
GB9904386D0 (en) * 1999-02-25 1999-04-21 Pharmacia & Upjohn Spa Antitumour synergistic composition
GB0006601D0 (en) * 2000-03-17 2000-05-10 Pharmacia & Upjohn Spa Crystalline alkycycline derivative
GB0117403D0 (en) * 2001-07-17 2001-09-05 Pharmacia & Upjohn Spa Solvent-free crystalline anthracycline derivatives
US7737123B2 (en) * 2005-05-12 2010-06-15 The Ohio State University Research Foundation Multidrug resistant anticancer anthracyclines
CA2721140C (en) * 2008-04-11 2016-02-09 Tianjin Hemay Bio-Tech Co. Ltd. Tetracyclic anthraquinone antibiotic derivatives with high activity, process for preparing the same and use thereof
CN101912600B (zh) * 2010-01-11 2014-01-29 杨国汉 改善胰岛素在溶液中稳定性的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54141759A (en) * 1978-04-24 1979-11-05 Microbial Chem Res Found Novel anthracycline derivative
GB8614323D0 (en) * 1986-06-12 1986-07-16 Erba Farmitalia Anthracyclines
US5413992A (en) * 1992-07-31 1995-05-09 The Scripps Research Institute Daunomycin derivative with reduced cytotoxicity toward normal cells

Also Published As

Publication number Publication date
CN1039123C (zh) 1998-07-15
JPH08506835A (ja) 1996-07-23
PL178806B1 (pl) 2000-06-30
DE69405214D1 (de) 1997-10-02
IL111725A0 (en) 1995-01-24
FI953784A (fi) 1995-08-09
FI953784A0 (fi) 1995-08-09
HU217630B (hu) 2000-03-28
UA43839C2 (uk) 2002-01-15
FI108036B (fi) 2001-11-15
GR3025266T3 (en) 1998-02-27
WO1995016695A2 (en) 1995-06-22
DK0683788T3 (da) 1997-10-27
NO953163D0 (no) 1995-08-11
HUT73172A (en) 1996-06-28
TW336235B (en) 1998-07-11
ES2107294T3 (es) 1997-11-16
AU676625B2 (en) 1997-03-13
NO304951B1 (no) 1999-03-08
US5532218A (en) 1996-07-02
AU1066095A (en) 1995-07-03
KR960701074A (ko) 1996-02-24
CA2154890A1 (en) 1995-06-22
HU9502662D0 (en) 1995-11-28
KR100352734B1 (ko) 2003-02-17
RU2149163C1 (ru) 2000-05-20
GB9325417D0 (en) 1994-02-16
MY117086A (en) 2004-05-31
CN1117734A (zh) 1996-02-28
WO1995016695A3 (en) 1995-07-13
NO953163L (no) 1995-10-02
ATE157369T1 (de) 1997-09-15
IL111725A (en) 1998-07-15
PL310177A1 (en) 1995-11-27
EP0683788B1 (en) 1997-08-27
EP0683788A1 (en) 1995-11-29
HK1011692A1 (en) 1999-07-16
NZ276401A (en) 1997-10-24
DE69405214T2 (de) 1998-01-29

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