JPH08504419A - カルシウムチャンネル拮抗薬としてのアリールオキシアルキル置換環状アミンの使用および新規フェニルオキシアルキルピペリジン誘導体 - Google Patents
カルシウムチャンネル拮抗薬としてのアリールオキシアルキル置換環状アミンの使用および新規フェニルオキシアルキルピペリジン誘導体Info
- Publication number
- JPH08504419A JPH08504419A JP6513782A JP51378294A JPH08504419A JP H08504419 A JPH08504419 A JP H08504419A JP 6513782 A JP6513782 A JP 6513782A JP 51378294 A JP51378294 A JP 51378294A JP H08504419 A JPH08504419 A JP H08504419A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- piperidine
- ethyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Addiction (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9226111.4 | 1992-12-15 | ||
GB929226111A GB9226111D0 (en) | 1992-12-15 | 1992-12-15 | Madicaments |
PCT/EP1993/003473 WO1994013291A1 (fr) | 1992-12-15 | 1993-12-07 | Utilisation d'amines cycliques a substitution aryloxyalkyle comme antagonistes des canaux a calcium et nouveaux derives de piperidine phenyloxyalkyle |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH08504419A true JPH08504419A (ja) | 1996-05-14 |
Family
ID=10726633
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP6513782A Pending JPH08504419A (ja) | 1992-12-15 | 1993-12-07 | カルシウムチャンネル拮抗薬としてのアリールオキシアルキル置換環状アミンの使用および新規フェニルオキシアルキルピペリジン誘導体 |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0674514A1 (fr) |
JP (1) | JPH08504419A (fr) |
CN (1) | CN1091636A (fr) |
AU (1) | AU5698394A (fr) |
GB (1) | GB9226111D0 (fr) |
MX (1) | MX9307946A (fr) |
WO (1) | WO1994013291A1 (fr) |
ZA (1) | ZA939317B (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009508949A (ja) * | 2005-09-21 | 2009-03-05 | デコード ジェネティクス イーエイチエフ | 炎症治療のためのビアリール基置換複素環lta4h阻害剤 |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9314973D0 (en) * | 1993-07-20 | 1993-09-01 | Smithkline Beecham Plc | Medicaments |
GB9411052D0 (en) * | 1994-06-02 | 1994-07-20 | Smithkline Beecham Plc | Medicaments |
GB9411045D0 (en) * | 1994-06-02 | 1994-07-20 | Smithkline Beecham Plc | Compounds and use |
WO1996002494A1 (fr) * | 1994-07-14 | 1996-02-01 | Smithkline Beecham Plc | Derives de benzocycloalcoylamine utiles comme antagonistes du canal a calcium |
US5794887A (en) | 1995-11-17 | 1998-08-18 | Komerath; Narayanan M. | Stagnation point vortex controller |
US5843983A (en) * | 1996-02-15 | 1998-12-01 | Sankyo Company, Limited | Diphenylethane compounds containing a saturated heterocyclic group, their preparation, and their therapeutic use |
US6110937A (en) | 1997-04-03 | 2000-08-29 | Syntex Usa, Inc. | Phenoxymethyl piperidine derivatives for the treatment of neuropathic pain |
CA2232147A1 (fr) * | 1997-04-03 | 1998-10-03 | F. Hoffmann-La Roche Ag | Derives de la phenoxymethylpiperidine |
WO1999043658A1 (fr) | 1998-02-27 | 1999-09-02 | Warner-Lambert Company | Agents d'aniline heterocyclique substituee bloquant les canaux de calcium |
US6166052A (en) | 1998-03-11 | 2000-12-26 | Warner-Lambert Company | Heteroaryl alkyl alpha substituted peptidylamine calcium channel blockers |
KR100740477B1 (ko) * | 1999-12-21 | 2007-07-19 | 미쯔비시 웰 파마 가부시키가이샤 | 신경계 장애의 치료 및/또는 예방약 |
US7294637B2 (en) | 2000-09-11 | 2007-11-13 | Sepracor, Inc. | Method of treating addiction or dependence using a ligand for a monamine receptor or transporter |
AU9087301A (en) | 2000-09-11 | 2002-03-26 | Sepracor Inc | Ligands for monoamine receptors and transporters, and methods of use thereof |
JP4610480B2 (ja) | 2003-03-07 | 2011-01-12 | アステラス製薬株式会社 | 2,6−ジ置換スチリルを有する含窒素ヘテロ環誘導体 |
EP1735302B1 (fr) | 2004-02-27 | 2010-06-16 | Eli Lilly And Company | Derives de 4-amino-piperidine utilises en tant qu'inhibiteurs de l'absorption des monoamines |
US7417040B2 (en) | 2004-03-01 | 2008-08-26 | Bristol-Myers Squibb Company | Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3 |
US7576102B2 (en) * | 2005-12-21 | 2009-08-18 | Decode Genetics Ehf | Biaryl substituted nitrogen containing heterocycle inhibitors of LTA4H for treating inflammation |
EP3288384A4 (fr) * | 2015-05-01 | 2019-01-23 | Georgia State University Research Foundation | Dérivés benzhydrol pour la prise en charge d'états associés à des facteurs inductibles par l'hypoxie |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1096441A (en) * | 1964-01-15 | 1967-12-29 | Bristol Myers Co | Ethers of benzyl phenols and a process for the preparation thereof |
US3381013A (en) * | 1964-01-15 | 1968-04-30 | Bristol Myers Co | Heterocyclicamino ethers of benzylphenols |
GB1203149A (en) * | 1968-06-10 | 1970-08-26 | Ici Ltd | Piperidine derivatives |
GB1319252A (en) * | 1969-06-05 | 1973-06-06 | Ciba Geigy Ag | 1-phenyl-alkanols and process for making same |
DE2728898A1 (de) * | 1977-06-27 | 1979-01-18 | Thomae Gmbh Dr K | Neue morpholinderivate |
DE2811952A1 (de) * | 1978-03-18 | 1979-10-31 | Merck Patent Gmbh | Phenoxyalkylamine und verfahren zu ihrer herstellung |
FR2443246A1 (fr) * | 1978-12-05 | 1980-07-04 | Pharmindustrie | Nouveaux medicaments a base de derives de la phenyl-1 (piperidyl-4)-3 propanone-1 |
DK231088D0 (da) * | 1988-04-28 | 1988-04-28 | Ferrosan As | Piperidinforbindelser, deres fremstilling og anvendelse |
IE66332B1 (en) * | 1986-11-03 | 1995-12-27 | Novo Nordisk As | Piperidine compounds and their preparation and use |
US4822778A (en) * | 1988-01-19 | 1989-04-18 | Gunnar Aberg | Membrane stabilizing phenoxy-piperidine compounds and pharmaceutical compositions employing such compounds |
US5169855A (en) * | 1990-03-28 | 1992-12-08 | Du Pont Merck Pharmaceutical Company | Piperidine ether derivatives as psychotropic drugs or plant fungicides |
MX9100513A (es) * | 1990-08-06 | 1992-04-01 | Smith Kline French Lab | Compuestos |
MX9100517A (es) * | 1990-08-06 | 1992-04-01 | Smith Kline French Lab | Compuestos |
GB9113031D0 (en) * | 1991-06-17 | 1991-08-07 | Smithkline Beecham Plc | Compounds |
AU3364493A (en) * | 1992-01-28 | 1993-09-01 | Smithkline Beecham Plc | Compounds as calcium channel antagonists |
-
1992
- 1992-12-15 GB GB929226111A patent/GB9226111D0/en active Pending
-
1993
- 1993-12-07 JP JP6513782A patent/JPH08504419A/ja active Pending
- 1993-12-07 EP EP94902735A patent/EP0674514A1/fr not_active Withdrawn
- 1993-12-07 WO PCT/EP1993/003473 patent/WO1994013291A1/fr not_active Application Discontinuation
- 1993-12-07 AU AU56983/94A patent/AU5698394A/en not_active Abandoned
- 1993-12-13 ZA ZA939317A patent/ZA939317B/xx unknown
- 1993-12-14 CN CN93112828A patent/CN1091636A/zh active Pending
- 1993-12-14 MX MX9307946A patent/MX9307946A/es unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009508949A (ja) * | 2005-09-21 | 2009-03-05 | デコード ジェネティクス イーエイチエフ | 炎症治療のためのビアリール基置換複素環lta4h阻害剤 |
Also Published As
Publication number | Publication date |
---|---|
EP0674514A1 (fr) | 1995-10-04 |
ZA939317B (en) | 1995-06-13 |
AU5698394A (en) | 1994-07-04 |
GB9226111D0 (en) | 1993-02-10 |
MX9307946A (es) | 1994-08-31 |
WO1994013291A1 (fr) | 1994-06-23 |
CN1091636A (zh) | 1994-09-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JPH08504419A (ja) | カルシウムチャンネル拮抗薬としてのアリールオキシアルキル置換環状アミンの使用および新規フェニルオキシアルキルピペリジン誘導体 | |
RU2213743C2 (ru) | Производное тиенилазолилалкоксиэтанамина, способ его получения (варианты), фармацевтическая композиция, промежуточный продукт и способ его получения (варианты) | |
JPH06500093A (ja) | N―ヒドロカルビル―4―置換ピペリジン、それらの調製およびカルシウム遮断薬としての使用 | |
BG61323B2 (bg) | Производни на пиперидина,тяхното получаване и използването им като лекарства | |
JPH07503463A (ja) | カルシウムチャンネル拮抗薬としてのアザビシクロ化合物 | |
JPH07503461A (ja) | カルシウムチャンネル拮抗薬としての化合物 | |
AU649468B2 (en) | 3-substituted piperidine derivatives | |
KR100694682B1 (ko) | 4-치환 피페리딘 유도체 불화물 | |
HU185523B (en) | Method for producing a phenyl-alkyl-aminoethyl-salicylamide | |
JPH09510719A (ja) | 置換シクロアルキルアミン誘導体およびそのカルシウムチャネルアンタゴニストとしての使用 | |
WO1992022527A2 (fr) | Derives de pyrrolidine 3-substitues comme antagonistes du calcium | |
JP5165578B2 (ja) | イソキノリンおよびベンゾ[h]イソキノリン誘導体、調製およびヒスタミンh3受容体のアンタゴニストとしてのこの治療上の使用 | |
IE902750A1 (en) | Coumarin derivatives, their preparation and their use in the¹treatment of cerebrovascular disorders | |
AU705427B2 (en) | Alpha-(substituted alkylphenyl) -4-(hydroxydiphenylmethyl)-1-piperidine butanol derivatives, their preparation and their use as anti-histamines, anti-allergy agents and bronchodilators | |
JPH09500383A (ja) | カルシウムチャネル拮抗剤活性を有するキノリジジン | |
JPH07503462A (ja) | カルシウムチャンネル拮抗薬としてのアザビシクロ化合物 | |
EP1137646A1 (fr) | Derive paroxetinique | |
FR2549058A1 (fr) | Nouveaux derives de la 1,4-dihydropyridine, leur preparation et leur utilisation comme medicaments | |
JPH09504014A (ja) | カルシウムチャネル拮抗薬としてのアミン誘導体類 | |
SK162795A3 (en) | N-substituted azaheterocyclic carboxylic acids and esters thereof, preparation method thereof and pharmaceutical compositions containing them | |
FR2753970A1 (fr) | Derives de n-(benzothiazol-2-yl) piperidine-1-ethanamine, leur preparation et leur application en therapeutique | |
US5373023A (en) | Tetrahydronaphtalene derivatives, their preparation and pharmaceutical compositions containing them | |
JPH10500967A (ja) | カルシウムチャンネルアンタゴニストとしてのフェノキシアルキル置換ピペリジン、ピロリジン、モルホリンおよびチオモルホリン | |
BE893095Q (fr) | Phenylpiperidines leur preparation et leur utilisation | |
EA010666B1 (ru) | Производные 2-(1h-индолилсульфанил)бензиламина в качестве ssri |