AU5698394A - Use of aryloxyalkyl substituted cyclic amines as calcium channel antagonists and new phenyloxyalkyl piperidin derivatives - Google Patents
Use of aryloxyalkyl substituted cyclic amines as calcium channel antagonists and new phenyloxyalkyl piperidin derivativesInfo
- Publication number
- AU5698394A AU5698394A AU56983/94A AU5698394A AU5698394A AU 5698394 A AU5698394 A AU 5698394A AU 56983/94 A AU56983/94 A AU 56983/94A AU 5698394 A AU5698394 A AU 5698394A AU 5698394 A AU5698394 A AU 5698394A
- Authority
- AU
- Australia
- Prior art keywords
- phenyloxyalkyl
- new
- calcium channel
- cyclic amines
- substituted cyclic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Addiction (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929226111A GB9226111D0 (en) | 1992-12-15 | 1992-12-15 | Madicaments |
GB9226111 | 1992-12-15 | ||
PCT/EP1993/003473 WO1994013291A1 (fr) | 1992-12-15 | 1993-12-07 | Utilisation d'amines cycliques a substitution aryloxyalkyle comme antagonistes des canaux a calcium et nouveaux derives de piperidine phenyloxyalkyle |
Publications (1)
Publication Number | Publication Date |
---|---|
AU5698394A true AU5698394A (en) | 1994-07-04 |
Family
ID=10726633
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU56983/94A Abandoned AU5698394A (en) | 1992-12-15 | 1993-12-07 | Use of aryloxyalkyl substituted cyclic amines as calcium channel antagonists and new phenyloxyalkyl piperidin derivatives |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0674514A1 (fr) |
JP (1) | JPH08504419A (fr) |
CN (1) | CN1091636A (fr) |
AU (1) | AU5698394A (fr) |
GB (1) | GB9226111D0 (fr) |
MX (1) | MX9307946A (fr) |
WO (1) | WO1994013291A1 (fr) |
ZA (1) | ZA939317B (fr) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9314973D0 (en) * | 1993-07-20 | 1993-09-01 | Smithkline Beecham Plc | Medicaments |
GB9411052D0 (en) * | 1994-06-02 | 1994-07-20 | Smithkline Beecham Plc | Medicaments |
GB9411045D0 (en) * | 1994-06-02 | 1994-07-20 | Smithkline Beecham Plc | Compounds and use |
AU2982595A (en) * | 1994-07-14 | 1996-02-16 | Smithkline Beecham Plc | Benzocycloalkylamine derivatives as calcium chanel antagonists |
US5794887A (en) | 1995-11-17 | 1998-08-18 | Komerath; Narayanan M. | Stagnation point vortex controller |
EP0790235A1 (fr) * | 1996-02-15 | 1997-08-20 | Sankyo Company Limited | Dérivés de diaryle-alkanes contenant un groupe alicyclique, leur préparation et leurs applications thérapeutiques et prophylactiques |
CA2232147A1 (fr) * | 1997-04-03 | 1998-10-03 | F. Hoffmann-La Roche Ag | Derives de la phenoxymethylpiperidine |
US6110937A (en) * | 1997-04-03 | 2000-08-29 | Syntex Usa, Inc. | Phenoxymethyl piperidine derivatives for the treatment of neuropathic pain |
AU1600599A (en) | 1998-02-27 | 1999-09-15 | Warner-Lambert Company | Heterocyclic substituted aniline calcium channel blockers |
US6166052A (en) * | 1998-03-11 | 2000-12-26 | Warner-Lambert Company | Heteroaryl alkyl alpha substituted peptidylamine calcium channel blockers |
CA2394633A1 (fr) * | 1999-12-21 | 2001-06-28 | Mitsubishi Pharma Corporation | Agent therapeutique ou prophylactique pour trouble du systeme nerveux |
EP1318988A2 (fr) | 2000-09-11 | 2003-06-18 | Sepracor, Inc. | Ligands pour les recepteurs de monoamine et transporteurs, et procedes d'utilisation de ces derniers (neurotransmission) |
US7294637B2 (en) | 2000-09-11 | 2007-11-13 | Sepracor, Inc. | Method of treating addiction or dependence using a ligand for a monamine receptor or transporter |
WO2004078715A1 (fr) | 2003-03-07 | 2004-09-16 | Astellas Pharma Inc. | Derive heterocyclique azote contenant du styryl 2,6-disubstitue |
WO2005092885A1 (fr) | 2004-02-27 | 2005-10-06 | Eli Lilly And Company | Derives de 4-amino-piperidine utilises en tant qu'inhibiteurs de l'absorption des monoamines |
US7417040B2 (en) | 2004-03-01 | 2008-08-26 | Bristol-Myers Squibb Company | Fused tricyclic compounds as inhibitors of 17β-hydroxysteroid dehydrogenase 3 |
US7402684B2 (en) * | 2005-09-21 | 2008-07-22 | Decode Genectics Ehf. | Biaryl substituted heterocycle inhibitors of LTA4H for treating inflammation |
CA2634701C (fr) * | 2005-12-21 | 2014-07-29 | Decode Genetics Ehf | Inhibiteurs heterocycliques de lta4h a substitution biaryl, contenant de l'azote, destines au traitement d'inflammations |
US10772858B2 (en) | 2015-05-01 | 2020-09-15 | Georgia State University Research Foundation, Inc. | Benzhydrol derivatives for the management of conditions related to hypoxia inducible factors |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3381013A (en) * | 1964-01-15 | 1968-04-30 | Bristol Myers Co | Heterocyclicamino ethers of benzylphenols |
GB1096441A (en) * | 1964-01-15 | 1967-12-29 | Bristol Myers Co | Ethers of benzyl phenols and a process for the preparation thereof |
GB1203149A (en) * | 1968-06-10 | 1970-08-26 | Ici Ltd | Piperidine derivatives |
GB1319252A (en) * | 1969-06-05 | 1973-06-06 | Ciba Geigy Ag | 1-phenyl-alkanols and process for making same |
DE2728898A1 (de) * | 1977-06-27 | 1979-01-18 | Thomae Gmbh Dr K | Neue morpholinderivate |
DE2811952A1 (de) * | 1978-03-18 | 1979-10-31 | Merck Patent Gmbh | Phenoxyalkylamine und verfahren zu ihrer herstellung |
FR2443246A1 (fr) * | 1978-12-05 | 1980-07-04 | Pharmindustrie | Nouveaux medicaments a base de derives de la phenyl-1 (piperidyl-4)-3 propanone-1 |
IE66332B1 (en) * | 1986-11-03 | 1995-12-27 | Novo Nordisk As | Piperidine compounds and their preparation and use |
DK231088D0 (da) * | 1988-04-28 | 1988-04-28 | Ferrosan As | Piperidinforbindelser, deres fremstilling og anvendelse |
US4822778A (en) * | 1988-01-19 | 1989-04-18 | Gunnar Aberg | Membrane stabilizing phenoxy-piperidine compounds and pharmaceutical compositions employing such compounds |
US5169855A (en) * | 1990-03-28 | 1992-12-08 | Du Pont Merck Pharmaceutical Company | Piperidine ether derivatives as psychotropic drugs or plant fungicides |
MX9100513A (es) * | 1990-08-06 | 1992-04-01 | Smith Kline French Lab | Compuestos |
MX9100517A (es) * | 1990-08-06 | 1992-04-01 | Smith Kline French Lab | Compuestos |
GB9113031D0 (en) * | 1991-06-17 | 1991-08-07 | Smithkline Beecham Plc | Compounds |
JPH07503461A (ja) * | 1992-01-28 | 1995-04-13 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | カルシウムチャンネル拮抗薬としての化合物 |
-
1992
- 1992-12-15 GB GB929226111A patent/GB9226111D0/en active Pending
-
1993
- 1993-12-07 JP JP6513782A patent/JPH08504419A/ja active Pending
- 1993-12-07 AU AU56983/94A patent/AU5698394A/en not_active Abandoned
- 1993-12-07 WO PCT/EP1993/003473 patent/WO1994013291A1/fr not_active Application Discontinuation
- 1993-12-07 EP EP94902735A patent/EP0674514A1/fr not_active Withdrawn
- 1993-12-13 ZA ZA939317A patent/ZA939317B/xx unknown
- 1993-12-14 CN CN93112828A patent/CN1091636A/zh active Pending
- 1993-12-14 MX MX9307946A patent/MX9307946A/es unknown
Also Published As
Publication number | Publication date |
---|---|
ZA939317B (en) | 1995-06-13 |
JPH08504419A (ja) | 1996-05-14 |
MX9307946A (es) | 1994-08-31 |
CN1091636A (zh) | 1994-09-07 |
GB9226111D0 (en) | 1993-02-10 |
WO1994013291A1 (fr) | 1994-06-23 |
EP0674514A1 (fr) | 1995-10-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AU5698394A (en) | Use of aryloxyalkyl substituted cyclic amines as calcium channel antagonists and new phenyloxyalkyl piperidin derivatives | |
AU4791190A (en) | Cyclic amine compounds and their use | |
AU4825493A (en) | Cyclohexyl amine derivatives and their use as tachykinin antagonists | |
AU5704894A (en) | Phenyl derivatives useful as tachykinin antagonists | |
HUP0000478A3 (en) | Substituted cyclic amine as metalloprotease inhibitors and use of them for producing pharmaceutical compositions | |
FR2640503B1 (fr) | Compositions de ciments dentaires d'ionomere-verre | |
AU2002792A (en) | Substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use | |
AU4718093A (en) | Substituted amines as tachykinin receptor antagonists | |
AU2308192A (en) | Instrument for registration of the dental bite | |
BR9204525A (pt) | Composto ou mistura de compostos e composicao | |
AU3364693A (en) | Azabricyclic compounds as calcium channel antagonists | |
AU1530692A (en) | Calcium channel antagonists and methodology for their identification | |
AU3364493A (en) | Compounds as calcium channel antagonists | |
NO943687D0 (no) | 4-(4'-piperidinyl eller 3'-pirrolidinyl) substituerte imidazoler som H3-reseptorantagonister og terapeutiske anvendelser derav | |
AU6721494A (en) | Oral compositions containing triclosan for the treatment of aphthous ulcers | |
AU8653091A (en) | Crystallizing enamel composition and method of using the same | |
AU2028892A (en) | Novel benzopyrido piperidylidene compounds, compositions, methods of manufacture and methods of use | |
BR9407743A (pt) | Composiçao oral de peróxido de cálcio-bicarbonato | |
AU3220993A (en) | Crystallizing enamel composition and method of making and using the same | |
NO924793D0 (no) | Fremgangsmaate for fremstilling av kalsiumhydrosilikatbundne formlegemer | |
BR9307800A (pt) | ComposiçÕes anticárie | |
AU2355092A (en) | Substituted amide derivatives of piperizinylcamphorsulfonyl oxytocin antagonists | |
KR950700305A (ko) | 칼슘 통로 길항제로서 아자바이사이클로 화합물(Azabicyclo compounds as calcium channel antagonists) | |
AU7294094A (en) | Substituted 6,11-ethano-6,11-dihydrobenzo(b) quinolizinium salts and compositions and methods of use thereof | |
TR27833A (tr) | Antelmintik'lerin uygulanmasina mahsus ''pour-on'' formülasyonu. |