JPH08502513A - セフェム化合物、およびそれらの医薬組成物 - Google Patents

セフェム化合物、およびそれらの医薬組成物

Info

Publication number
JPH08502513A
JPH08502513A JP6510881A JP51088194A JPH08502513A JP H08502513 A JPH08502513 A JP H08502513A JP 6510881 A JP6510881 A JP 6510881A JP 51088194 A JP51088194 A JP 51088194A JP H08502513 A JPH08502513 A JP H08502513A
Authority
JP
Japan
Prior art keywords
vinyl
cephem
nmr
pyridin
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6510881A
Other languages
English (en)
Japanese (ja)
Inventor
浩二 川端
武志 寺澤
綾子 中村
英子 中村
文幸 白井
和夫 坂根
Original Assignee
藤沢薬品工業株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929222291A external-priority patent/GB9222291D0/en
Priority claimed from GB939314495A external-priority patent/GB9314495D0/en
Application filed by 藤沢薬品工業株式会社 filed Critical 藤沢薬品工業株式会社
Publication of JPH08502513A publication Critical patent/JPH08502513A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
JP6510881A 1992-10-23 1993-10-19 セフェム化合物、およびそれらの医薬組成物 Pending JPH08502513A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9222291.8 1992-10-23
GB929222291A GB9222291D0 (en) 1992-10-23 1992-10-23 New cephem compounds
GB9314495.4 1993-07-12
GB939314495A GB9314495D0 (en) 1993-07-12 1993-07-12 New cephem compounds
PCT/JP1993/001505 WO1994010177A1 (en) 1992-10-23 1993-10-19 Cephem compounds, and their pharmaceutical compositions

Publications (1)

Publication Number Publication Date
JPH08502513A true JPH08502513A (ja) 1996-03-19

Family

ID=26301852

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6510881A Pending JPH08502513A (ja) 1992-10-23 1993-10-19 セフェム化合物、およびそれらの医薬組成物

Country Status (9)

Country Link
EP (1) EP0665847A1 (ko)
JP (1) JPH08502513A (ko)
KR (1) KR950704331A (ko)
CN (1) CN1144222A (ko)
CA (1) CA2147609A1 (ko)
IL (1) IL107359A0 (ko)
MX (1) MX9306572A (ko)
TW (1) TW255894B (ko)
WO (1) WO1994010177A1 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE354577T1 (de) 1996-11-06 2007-03-15 Basilea Pharmaceutica Ag Vinylpyrrolidinon-cephalosporin-derivate
TW415949B (en) * 1996-12-19 2000-12-21 Hoffmann La Roche Vinyl pyrrolidine cephalosporin derivatives with basic substituents
DE60014390T2 (de) * 1999-07-30 2005-10-06 Eisai Co., Ltd. Verfahren zur herstellung basischer additionssalze eines antibiotikums mit einer anorganischen säure und oxalat-zwischenprodukte

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4546101A (en) * 1982-09-10 1985-10-08 Fujisawa Pharmaceutical Co., Ltd. New cephem compounds useful for treating infectious diseases in human being and animals and processes for preparation thereof
GB8519606D0 (en) * 1985-08-05 1985-09-11 Fujisawa Pharmaceutical Co 3 7-d substituted-3-cephem compounds
JPH0686463B2 (ja) * 1988-07-01 1994-11-02 明治製菓株式会社 新規セフェム化合物、その製造法及び抗菌剤

Also Published As

Publication number Publication date
MX9306572A (es) 1994-04-29
WO1994010177A1 (en) 1994-05-11
TW255894B (ko) 1995-09-01
IL107359A0 (en) 1994-01-25
CN1144222A (zh) 1997-03-05
EP0665847A1 (en) 1995-08-09
KR950704331A (ko) 1995-11-17
CA2147609A1 (en) 1994-05-11

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