JPH08500601A - 調製済みのアゾセミド(azosemide)注射液 - Google Patents
調製済みのアゾセミド(azosemide)注射液Info
- Publication number
- JPH08500601A JPH08500601A JP6506853A JP50685394A JPH08500601A JP H08500601 A JPH08500601 A JP H08500601A JP 6506853 A JP6506853 A JP 6506853A JP 50685394 A JP50685394 A JP 50685394A JP H08500601 A JPH08500601 A JP H08500601A
- Authority
- JP
- Japan
- Prior art keywords
- solution
- azosemide
- injection
- salt
- injection solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.1種の溶媒を含有する水溶性で生理学的に十分許容できるアゾセミドの塩の 調製済み注射液であって、少なくとも1種のアゾセミドの有機アミン塩と、必要 ならば生理学的に十分許容できる緩衝剤を含有する水性注射液。 2.メグルミン(N−メチル−グルコサミン)−アゾセミドおよび/またはトリ エタノールアミン−アゾセミド塩を含有する、請求の範囲1記載の注射液。 3.有機溶媒がプロピレングリコール、ポリエチレングリコールおよびエタノー ルからなる群から選択され、好ましくは重量で約5から25%の濃度で使用される 、請求の範囲2記載の注射液。 4.緩衝剤が炭酸ナトリウム、アルギニンリン酸ナトリウム、N−メチルグルコ サミンおよびトロメタモール(Trometamol)からなる群から選択される、請求の 範囲1−3のいずれか1つに記載の注射液。5.pH値が約7より大きい、請求 の範囲1−4のいずれか1つに記載の注射液。 6.滴定塩基度が多くとも塩酸約0.3mmol/注射液1mlである、請求の範囲1− 5のいずれか1つに記載の注射液。 7.pH値が約8.9と約10.3の間にあり、溶液が生理学的に十分許容できるアル カリ緩衝剤を含有し、滴定塩基度が塩酸約0.001−約0.06 mmol/注射液1mlで ある、請求の範囲5または6記載の注射液。 8.少なくとも1種の、特に請求の範囲1−7のいずれか1つに記載の、水溶性 で生理学的に十分許容できるアゾセミドの塩を含有する、調製済みの水性注射液 の製造方法であって、この塩 を水、有機溶媒、そして必要ならば生理学的に十分許容できる緩衝剤を含有する 混合液に溶解する方法。 9.アゾセミド塩を製造するための塩形成剤と、必要ならば生理学的に十分許容 できる緩衝剤とを、水と有機溶媒を含有する混合物中に添加し、アゾセミドを懸 濁させ、塩を形成させることによって溶解し、pH値を設定値に調整することか らなる、請求の範囲8記載の方法。 10.溶液の緩衝能を最大で塩酸約0.lmmol/注射液1ml、好ましくは最大で塩酸 約0.03mmol/注射液1mlに調整することからなる、請求の範囲8または9記載の 方法。 11.溶液を殺菌濾過し、アンプルに入れ、そして好ましくは121℃で約20分間殺 菌することからなる、請求の範囲8-10のいずれか1つに記載の方法。 12.活性物質をアルカリ溶液中で凍結乾燥し、凍結乾燥物を注射用水の他に有機 溶媒と界面活性剤を含有する混合物に溶解することからなる、請求の範囲8-11の いずれか1つに記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4228926A DE4228926A1 (de) | 1992-08-31 | 1992-08-31 | Spritzfertige Azosemid-Injektionslösungen |
DE4228926.2 | 1992-08-31 | ||
PCT/EP1993/002331 WO1994005286A1 (de) | 1992-08-31 | 1993-08-28 | Spritzfertige azosemid-injektionslösungen |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH08500601A true JPH08500601A (ja) | 1996-01-23 |
JP3242924B2 JP3242924B2 (ja) | 2001-12-25 |
Family
ID=6466824
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50685394A Expired - Lifetime JP3242924B2 (ja) | 1992-08-31 | 1993-08-28 | 調製済みのアゾセミド(azosemide)注射液 |
Country Status (9)
Country | Link |
---|---|
US (1) | US5504099A (ja) |
EP (1) | EP0656777B1 (ja) |
JP (1) | JP3242924B2 (ja) |
AT (1) | ATE148343T1 (ja) |
AU (1) | AU4954993A (ja) |
CA (1) | CA2142445C (ja) |
DE (2) | DE4228926A1 (ja) |
ES (1) | ES2099972T3 (ja) |
WO (1) | WO1994005286A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006102667A (ja) * | 2004-10-06 | 2006-04-20 | Ngk Insulators Ltd | 薬液調合装置及び薬液調合方法 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013021660A1 (ja) * | 2011-08-08 | 2013-02-14 | 株式会社 三和化学研究所 | アゾセミドを有効成分とするコーティング製剤 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1815922C3 (de) * | 1968-12-20 | 1979-04-26 | Boehringer Mannheim Gmbh, 6800 Mannheim | 5-Phenyltetrazol-Derivate |
DE2423550A1 (de) * | 1974-05-15 | 1975-11-27 | Boehringer Mannheim Gmbh | Pharmazeutisches praeparat |
DE2556001C3 (de) * | 1975-12-12 | 1979-11-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Spritzfertige injizierbare Lösungen mit einem Gehalt an Alkalicanrenoat |
-
1992
- 1992-08-31 DE DE4228926A patent/DE4228926A1/de not_active Withdrawn
-
1993
- 1993-08-28 ES ES93919210T patent/ES2099972T3/es not_active Expired - Lifetime
- 1993-08-28 AU AU49549/93A patent/AU4954993A/en not_active Abandoned
- 1993-08-28 WO PCT/EP1993/002331 patent/WO1994005286A1/de active IP Right Grant
- 1993-08-28 CA CA002142445A patent/CA2142445C/en not_active Expired - Lifetime
- 1993-08-28 AT AT93919210T patent/ATE148343T1/de active
- 1993-08-28 US US08/387,819 patent/US5504099A/en not_active Expired - Lifetime
- 1993-08-28 DE DE59305354T patent/DE59305354D1/de not_active Expired - Lifetime
- 1993-08-28 EP EP93919210A patent/EP0656777B1/de not_active Expired - Lifetime
- 1993-08-28 JP JP50685394A patent/JP3242924B2/ja not_active Expired - Lifetime
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2006102667A (ja) * | 2004-10-06 | 2006-04-20 | Ngk Insulators Ltd | 薬液調合装置及び薬液調合方法 |
JP4633430B2 (ja) * | 2004-10-06 | 2011-02-16 | 日本碍子株式会社 | 薬液調合装置及び薬液調合方法 |
Also Published As
Publication number | Publication date |
---|---|
AU4954993A (en) | 1994-03-29 |
EP0656777B1 (de) | 1997-01-29 |
DE4228926A1 (de) | 1994-03-03 |
ES2099972T3 (es) | 1997-06-01 |
CA2142445A1 (en) | 1994-03-17 |
ATE148343T1 (de) | 1997-02-15 |
JP3242924B2 (ja) | 2001-12-25 |
US5504099A (en) | 1996-04-02 |
EP0656777A1 (de) | 1995-06-14 |
CA2142445C (en) | 2005-04-12 |
WO1994005286A1 (de) | 1994-03-17 |
DE59305354D1 (de) | 1997-03-13 |
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