JPH07505886A - マクロ環状キレート化剤の製造方法及びキレートの形成並びにその結合体 - Google Patents

マクロ環状キレート化剤の製造方法及びキレートの形成並びにその結合体

Info

Publication number
JPH07505886A
JPH07505886A JP5518572A JP51857293A JPH07505886A JP H07505886 A JPH07505886 A JP H07505886A JP 5518572 A JP5518572 A JP 5518572A JP 51857293 A JP51857293 A JP 51857293A JP H07505886 A JPH07505886 A JP H07505886A
Authority
JP
Japan
Prior art keywords
agent
chelate
polyazchelating
activated
chelating agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5518572A
Other languages
English (en)
Japanese (ja)
Inventor
チェン，ロバータ　シー．
フォーダイス，ウィリアム　エー．
ジェイ．，ジュニア クルパー，ウィリアム
リトウィンスキ，ジョージ　アール．
Original Assignee
ザ　ダウ　ケミカル　カンパニー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ザ　ダウ　ケミカル　カンパニー filed Critical ザ　ダウ　ケミカル　カンパニー
Publication of JPH07505886A publication Critical patent/JPH07505886A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
JP5518572A 1992-04-13 1993-04-13 マクロ環状キレート化剤の製造方法及びキレートの形成並びにその結合体 Pending JPH07505886A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86807892A 1992-04-13 1992-04-13
US868,078 1992-04-13
PCT/US1993/003483 WO1993020852A2 (en) 1992-04-13 1993-04-13 Macrocyclic chelating agents, chelates and conjugates thereof

Publications (1)

Publication Number Publication Date
JPH07505886A true JPH07505886A (ja) 1995-06-29

Family

ID=25351031

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5518572A Pending JPH07505886A (ja) 1992-04-13 1993-04-13 マクロ環状キレート化剤の製造方法及びキレートの形成並びにその結合体

Country Status (7)

Country Link
EP (1) EP0662842A1 (de)
JP (1) JPH07505886A (de)
AU (1) AU694074B2 (de)
CA (1) CA2117775A1 (de)
NO (1) NO943847D0 (de)
SG (1) SG52470A1 (de)
WO (1) WO1993020852A2 (de)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010223827A (ja) * 2009-03-24 2010-10-07 Japan Atomic Energy Agency 抗体標識が可能な無担体１７７Ｌｕの分離精製法
JP2011514334A (ja) * 2008-02-19 2011-05-06 ゲルベ 造影剤の薬学的製剤を調製する方法
JP2012051942A (ja) * 2003-04-15 2012-03-15 Algeta As 軟組織疾患の放射線治療におけるトリウム−２２７を用いた医薬組成物、複合体及びその調製方法、並びにキット

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0783326B1 (de) * 1994-09-07 2004-02-04 The Dow Chemical Company Verfahren zur herstellung von makrozyklischen agentien und ihren chelaten und konjugaten
GB201002508D0 (en) 2010-02-12 2010-03-31 Algeta As Product

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
US4994560A (en) * 1987-06-24 1991-02-19 The Dow Chemical Company Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies
HU219485B (hu) * 1988-06-24 2001-04-28 Dow Chemical Co. Eljárás 1,4,7,10-tetraaza-ciklododekán-származékok, ezek komplexei, valamint antitestekkel képzett konjugátumai, és ilyeneket tartalmazó gyógyszerkészítmények előállítására és a komplexeket, illetve konjugátumokat tartalmazó diagnosztikai készítmények
BR8907282A (pt) * 1988-12-23 1991-03-12 Dow Chemical Co Processo para preparar complexos de metal funcionalizados com isotiocianato

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012051942A (ja) * 2003-04-15 2012-03-15 Algeta As 軟組織疾患の放射線治療におけるトリウム−２２７を用いた医薬組成物、複合体及びその調製方法、並びにキット
JP2011514334A (ja) * 2008-02-19 2011-05-06 ゲルベ 造影剤の薬学的製剤を調製する方法
JP2014114306A (ja) * 2008-02-19 2014-06-26 Guerbet 造影剤の薬学的製剤を調製する方法
JP2010223827A (ja) * 2009-03-24 2010-10-07 Japan Atomic Energy Agency 抗体標識が可能な無担体１７７Ｌｕの分離精製法

Also Published As

Publication number Publication date
AU4285093A (en) 1993-11-18
AU2856397A (en) 1997-10-30
WO1993020852A2 (en) 1993-10-28
AU677006B2 (en) 1997-04-10
WO1993020852A3 (en) 1993-11-25
NO943847L (no) 1994-10-12
CA2117775A1 (en) 1993-10-28
AU694074B2 (en) 1998-07-09
NO943847D0 (no) 1994-10-12
SG52470A1 (en) 1998-09-28
EP0662842A1 (de) 1995-07-19

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