JPH0710877B2 - プレグナン誘導体の製造方法 - Google Patents

プレグナン誘導体の製造方法

Info

Publication number
JPH0710877B2
JPH0710877B2 JP60203586A JP20358685A JPH0710877B2 JP H0710877 B2 JPH0710877 B2 JP H0710877B2 JP 60203586 A JP60203586 A JP 60203586A JP 20358685 A JP20358685 A JP 20358685A JP H0710877 B2 JPH0710877 B2 JP H0710877B2
Authority
JP
Japan
Prior art keywords
general formula
hydroxy
dione
acid
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP60203586A
Other languages
English (en)
Japanese (ja)
Other versions
JPS61129197A (ja
Inventor
ヘルムート・ホーフマイスター
クラウス・アネン
ヘンリー・ラウレント
ルドルフ・ヴイーヒエルト
Original Assignee
シエ−リング・アクチエンゲゼルシヤフト
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by シエ−リング・アクチエンゲゼルシヤフト filed Critical シエ−リング・アクチエンゲゼルシヤフト
Publication of JPS61129197A publication Critical patent/JPS61129197A/ja
Publication of JPH0710877B2 publication Critical patent/JPH0710877B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Glass Compositions (AREA)
  • Paper (AREA)
  • Sewage (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP60203586A 1984-09-17 1985-09-17 プレグナン誘導体の製造方法 Expired - Lifetime JPH0710877B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3434448.9 1984-09-17
DE19843434448 DE3434448A1 (de) 1984-09-17 1984-09-17 Verfahren zur herstellung von pregnan-derivaten

Publications (2)

Publication Number Publication Date
JPS61129197A JPS61129197A (ja) 1986-06-17
JPH0710877B2 true JPH0710877B2 (ja) 1995-02-08

Family

ID=6245838

Family Applications (1)

Application Number Title Priority Date Filing Date
JP60203586A Expired - Lifetime JPH0710877B2 (ja) 1984-09-17 1985-09-17 プレグナン誘導体の製造方法

Country Status (15)

Country Link
US (2) US4708823A (fr)
EP (1) EP0181442B1 (fr)
JP (1) JPH0710877B2 (fr)
AT (1) ATE44532T1 (fr)
CA (1) CA1260929A (fr)
CS (1) CS250695B2 (fr)
DD (1) DD238387A5 (fr)
DE (2) DE3434448A1 (fr)
DK (1) DK420985A (fr)
ES (1) ES8604987A1 (fr)
FI (1) FI853560L (fr)
GR (1) GR852241B (fr)
HU (1) HU194905B (fr)
PL (1) PL255391A1 (fr)
SU (1) SU1440351A3 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0523132A1 (fr) * 1990-03-27 1993-01-20 Schering Corporation PROCEDE DE DESHYDRATATION DE 9$g(a)-HYDROXY STEROIDES
AP141A (en) * 1990-04-25 1991-08-25 Richter Gedeon Vegyeszet Novel steroid doils.
WO1995030684A1 (fr) * 1994-05-09 1995-11-16 Pharmacia & Upjohn Company SYNTHESE DU 17β-CYANO-3-ETHOXY-17α-HYDROXY-6-METHYLANDROSTA-3,5,9(11)-TRIENE
JPH10191658A (ja) * 1996-01-09 1998-07-21 Nikon Corp 振動アクチュエータ
US5879711A (en) * 1997-11-07 1999-03-09 Sequeira; Joel A. Stable antiandrogenic gel composition
US6696592B2 (en) 2001-05-22 2004-02-24 Nicox-S.A. Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
CN103833814A (zh) * 2014-03-06 2014-06-04 浙江仙居君业药业有限公司 17羟基-孕甾-4-烯-3,20-二酮-21-醋酸酯的制备方法
CN105017364A (zh) * 2015-07-06 2015-11-04 湖南新合新生物医药有限公司 甲基泼尼松龙中间体及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3067214A (en) * 1960-04-20 1962-12-04 Merck & Co Inc Haloethisterone compounds
DE2625306C2 (de) * 1976-06-02 1978-06-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von Pregnan-Derivaten
HU185797B (en) * 1981-04-16 1985-03-28 Richter Gedeon Vegyeszet Process for producing 3-oxo-17-alpha-ethinyl-17beta-trifluoroacetoxy-gonane derivatives
EP0063368B1 (fr) * 1981-04-16 1984-07-25 Richter Gedeon Vegyeszeti Gyar R.T. Procédé de préparation de dérivés du pregn-4-ène-3,20-dione, ainsi que les dérivés du 17-alpha-éthynyl-17-bêta-trifluoroacétoxy-gon-4-ène-3-one et médicaments contenant ces derniers
HU183397B (en) * 1981-04-16 1984-04-28 Richter Gedeon Vegyeszet Process for preparing 17alpha-hydroxy-pregn-4-ene-3,20-dione derivatives
US4342702A (en) * 1981-05-18 1982-08-03 The Upjohn Company Metallated halogenated acetylene corticoid synthesis
DE3315324A1 (de) * 1983-04-25 1984-10-31 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur herstellung von 17(alpha)-(br oder j)-ethinyl-17ss-or-steroiden

Also Published As

Publication number Publication date
ATE44532T1 (de) 1989-07-15
EP0181442B1 (fr) 1989-07-12
HUT38951A (en) 1986-07-28
DK420985D0 (da) 1985-09-17
HU194905B (en) 1988-03-28
JPS61129197A (ja) 1986-06-17
PL255391A1 (en) 1986-07-15
ES8604987A1 (es) 1986-03-16
DK420985A (da) 1986-03-18
ES546995A0 (es) 1986-03-16
GR852241B (fr) 1986-01-17
CS250695B2 (en) 1987-05-14
SU1440351A3 (ru) 1988-11-23
US4708823A (en) 1987-11-24
FI853560A0 (fi) 1985-09-17
US4956482A (en) 1990-09-11
DE3571441D1 (en) 1989-08-17
DE3434448A1 (de) 1986-03-27
DD238387A5 (de) 1986-08-20
EP0181442A1 (fr) 1986-05-21
CA1260929A (fr) 1989-09-26
FI853560L (fi) 1986-03-18

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