ES8604987A1 - Procedimiento para la preparacion de derivados de pregnano - Google Patents

Procedimiento para la preparacion de derivados de pregnano

Info

Publication number
ES8604987A1
ES8604987A1 ES546995A ES546995A ES8604987A1 ES 8604987 A1 ES8604987 A1 ES 8604987A1 ES 546995 A ES546995 A ES 546995A ES 546995 A ES546995 A ES 546995A ES 8604987 A1 ES8604987 A1 ES 8604987A1
Authority
ES
Spain
Prior art keywords
formula
17alpha
formyl
hydroxy
iii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES546995A
Other languages
English (en)
Other versions
ES546995A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of ES546995A0 publication Critical patent/ES546995A0/es
Publication of ES8604987A1 publication Critical patent/ES8604987A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Glass Compositions (AREA)
  • Paper (AREA)
  • Sewage (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE PREGNANO. COMPRENDE: A) ESTERIFICAR A UN DERIVADO DE ANDROSTANO DE FORMULA (II) CON ACIDO NITRICO, ACIDO TRIFLUOROACETICO O ACIDO TRICLOROACETICO, EN PRESENCIA DE PIRIDINA, ENTRE C30JC Y 10JC DURANTE 10 A 120 MIN, PARA PRODUCIR ESTERES DE FORMULA (III); Y B) TRATAR A (III) CON ACIDO FORMICO CONCENTRADO, EN PRESENCIA DE ACETATO, SULFATO O FLUORURO DE AG, EN TRIETILAMINA, DIMETILFORMAMIDA O N-DIMETILACETAMIDA, ENTRE 0JC Y 150JC, PARA OBTENER DERIVADOS DE PREGNANO DE FORMULA (I). SIENDO: ... UN ENLACE SIMPLE O DOBLE; R1, HIDROGENO O METILO; R2, UN GRUPO FORMILO; R3, CLORO; X, GRUPO NITRO, GRUPO TRIFLUOROACETICO O UN GRUPO TRICLOROACETILO; Y N, 1 O 2
ES546995A 1984-09-17 1985-09-16 Procedimiento para la preparacion de derivados de pregnano Expired ES8604987A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843434448 DE3434448A1 (de) 1984-09-17 1984-09-17 Verfahren zur herstellung von pregnan-derivaten

Publications (2)

Publication Number Publication Date
ES546995A0 ES546995A0 (es) 1986-03-16
ES8604987A1 true ES8604987A1 (es) 1986-03-16

Family

ID=6245838

Family Applications (1)

Application Number Title Priority Date Filing Date
ES546995A Expired ES8604987A1 (es) 1984-09-17 1985-09-16 Procedimiento para la preparacion de derivados de pregnano

Country Status (15)

Country Link
US (2) US4708823A (es)
EP (1) EP0181442B1 (es)
JP (1) JPH0710877B2 (es)
AT (1) ATE44532T1 (es)
CA (1) CA1260929A (es)
CS (1) CS250695B2 (es)
DD (1) DD238387A5 (es)
DE (2) DE3434448A1 (es)
DK (1) DK420985A (es)
ES (1) ES8604987A1 (es)
FI (1) FI853560L (es)
GR (1) GR852241B (es)
HU (1) HU194905B (es)
PL (1) PL255391A1 (es)
SU (1) SU1440351A3 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991014700A2 (en) * 1990-03-27 1991-10-03 Schering Corporation PROCESS FOR 9α-HYDROXY STEROID DEHYDRATION
AP141A (en) * 1990-04-25 1991-08-25 Richter Gedeon Vegyeszet Novel steroid doils.
CN1147816A (zh) * 1994-05-09 1997-04-16 法玛西雅厄普约翰公司 17β-氰基-3-乙氧基-17α-羟基-6-甲基雄甾-3，5，9(11)-三烯的合成
JPH10191658A (ja) * 1996-01-09 1998-07-21 Nikon Corp 振動アクチュエータ
US5879711A (en) * 1997-11-07 1999-03-09 Sequeira; Joel A. Stable antiandrogenic gel composition
US6696592B2 (en) 2001-05-22 2004-02-24 Nicox-S.A. Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
CN103833814A (zh) * 2014-03-06 2014-06-04 浙江仙居君业药业有限公司 17羟基-孕甾-4-烯-3,20-二酮-21-醋酸酯的制备方法
CN105017364A (zh) * 2015-07-06 2015-11-04 湖南新合新生物医药有限公司 甲基泼尼松龙中间体及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3067214A (en) * 1960-04-20 1962-12-04 Merck & Co Inc Haloethisterone compounds
DE2625306C2 (de) * 1976-06-02 1978-06-15 Schering Ag, 1000 Berlin Und 4619 Bergkamen Verfahren zur Herstellung von Pregnan-Derivaten
HU185797B (en) * 1981-04-16 1985-03-28 Richter Gedeon Vegyeszet Process for producing 3-oxo-17-alpha-ethinyl-17beta-trifluoroacetoxy-gonane derivatives
HU183397B (en) * 1981-04-16 1984-04-28 Richter Gedeon Vegyeszet Process for preparing 17alpha-hydroxy-pregn-4-ene-3,20-dione derivatives
DE3260444D1 (en) * 1981-04-16 1984-08-30 Richter Gedeon Vegyeszet Process for the preparation of pregn-4-ene-3,20-dione derivatives and 17-alpha-ethynyl-17-beta-trifluoroacetoxy-gon-4-ene-3-one derivatives, and pharmaceutical compositions containing the latter compounds
US4342702A (en) * 1981-05-18 1982-08-03 The Upjohn Company Metallated halogenated acetylene corticoid synthesis
DE3315324A1 (de) * 1983-04-25 1984-10-31 Schering AG, 1000 Berlin und 4709 Bergkamen Verfahren zur herstellung von 17(alpha)-(br oder j)-ethinyl-17ss-or-steroiden

Also Published As

Publication number Publication date
JPS61129197A (ja) 1986-06-17
DE3434448A1 (de) 1986-03-27
FI853560A0 (fi) 1985-09-17
CS250695B2 (en) 1987-05-14
JPH0710877B2 (ja) 1995-02-08
US4956482A (en) 1990-09-11
HU194905B (en) 1988-03-28
GR852241B (es) 1986-01-17
ES546995A0 (es) 1986-03-16
SU1440351A3 (ru) 1988-11-23
CA1260929A (en) 1989-09-26
PL255391A1 (en) 1986-07-15
EP0181442A1 (de) 1986-05-21
FI853560L (fi) 1986-03-18
HUT38951A (en) 1986-07-28
EP0181442B1 (de) 1989-07-12
DE3571441D1 (en) 1989-08-17
DD238387A5 (de) 1986-08-20
ATE44532T1 (de) 1989-07-15
DK420985A (da) 1986-03-18
US4708823A (en) 1987-11-24
DK420985D0 (da) 1985-09-17

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