JPH0696579B2 - ６―アルキリデンペネム誘導体及びその製法 - Google Patents
６―アルキリデンペネム誘導体及びその製法Info
- Publication number
- JPH0696579B2 JPH0696579B2 JP60013393A JP1339385A JPH0696579B2 JP H0696579 B2 JPH0696579 B2 JP H0696579B2 JP 60013393 A JP60013393 A JP 60013393A JP 1339385 A JP1339385 A JP 1339385A JP H0696579 B2 JPH0696579 B2 JP H0696579B2
- Authority
- JP
- Japan
- Prior art keywords
- penem
- methyl
- formula
- group
- production example
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848402085A GB8402085D0 (en) | 1984-01-26 | 1984-01-26 | Compounds |
| GB848417659A GB8417659D0 (en) | 1984-07-11 | 1984-07-11 | Compounds |
| GB848425889A GB8425889D0 (en) | 1984-10-12 | 1984-10-12 | Compounds |
| GB8402085 | 1984-10-12 | ||
| GB8417659 | 1984-10-12 | ||
| GB8425889 | 1984-10-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS60185786A JPS60185786A (ja) | 1985-09-21 |
| JPH0696579B2 true JPH0696579B2 (ja) | 1994-11-30 |
Family
ID=27262267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60013393A Expired - Lifetime JPH0696579B2 (ja) | 1984-01-26 | 1985-01-25 | ６―アルキリデンペネム誘導体及びその製法 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4798828A (enExample) |
| EP (1) | EP0154132B1 (enExample) |
| JP (1) | JPH0696579B2 (enExample) |
| KR (1) | KR850005444A (enExample) |
| AU (1) | AU569366B2 (enExample) |
| CA (1) | CA1272479A (enExample) |
| DE (1) | DE3585095D1 (enExample) |
| DK (1) | DK32485A (enExample) |
| ES (3) | ES8707244A1 (enExample) |
| FI (1) | FI82471C (enExample) |
| GR (1) | GR850208B (enExample) |
| HU (1) | HU197013B (enExample) |
| IL (1) | IL74153A (enExample) |
| NO (1) | NO850314L (enExample) |
| NZ (1) | NZ210929A (enExample) |
| PH (1) | PH23447A (enExample) |
| PL (1) | PL149297B1 (enExample) |
| PT (1) | PT79873B (enExample) |
| YU (1) | YU45695B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8518422D0 (en) * | 1985-07-22 | 1985-08-29 | Beecham Group Plc | Compounds |
| GB8711391D0 (en) * | 1987-05-14 | 1987-06-17 | Beecham Group Plc | Process |
| GB8729614D0 (en) * | 1987-12-18 | 1988-02-03 | Beecham Group Plc | Novel compounds |
| GB8729613D0 (en) * | 1987-12-18 | 1988-02-03 | Beecham Group Plc | Novel compounds |
| EP0416810B1 (en) * | 1989-09-04 | 1995-02-08 | Beecham Group p.l.c. | Cephalosporin compounds, process for their preparation, pharmaceutical compositions and intermediates |
| GB9222700D0 (en) * | 1992-10-29 | 1992-12-09 | Smithkline Beecham Plc | Chemical compounds |
| GB9305837D0 (en) * | 1993-03-20 | 1993-05-05 | Smithkline Beecham Plc | Novel compounds |
| GB9326248D0 (en) * | 1993-12-23 | 1994-02-23 | Smithkline Beecham Plc | Pharmaceutical formulations |
| US5464616A (en) * | 1994-08-04 | 1995-11-07 | Synphar Laboratories, Ind. | 6β-substituted penicillanic acids as beta-lactamase inhibitors |
| AR039774A1 (es) | 2002-05-01 | 2005-03-02 | Wyeth Corp | 6-alquiliden-penems biciclicos como inhibidores de beta-lactamasas |
| AR039475A1 (es) | 2002-05-01 | 2005-02-23 | Wyeth Corp | 6-alquiliden-penems triciclicos como inhibidores de beta-lactamasa |
| US20060105941A1 (en) * | 2004-11-12 | 2006-05-18 | Allergan, Inc. | Mixed antibiotic codrugs |
| AU2012233003B2 (en) * | 2005-12-07 | 2014-12-18 | Basilea Pharmaceutica Ag | Useful combinations of monobactam antibiotics with beta-lactamase inhibitors |
| HRP20110841T1 (hr) * | 2005-12-07 | 2012-01-31 | Basilea Pharmaceutica Ag | Korisni monobaktamski antibiotici |
| US10399041B2 (en) * | 2014-11-17 | 2019-09-03 | Qatar Foundation For Education, Science And Community Development | Two-dimensional metal carbide antimicrobial membrane and antimicrobial agent |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0041768B1 (en) * | 1980-04-24 | 1987-11-11 | Beecham Group Plc | Beta-lactam compounds, their preparation and use |
| GB2083462B (en) * | 1980-08-16 | 1984-05-02 | Beecham Group Ltd | 2-thiopenem derivatives |
| EP0120613A1 (en) * | 1983-03-02 | 1984-10-03 | Beecham Group Plc | Penem derivatives and precursors |
-
1985
- 1985-01-15 FI FI850174A patent/FI82471C/fi not_active IP Right Cessation
- 1985-01-18 DE DE8585100521T patent/DE3585095D1/de not_active Expired - Fee Related
- 1985-01-18 EP EP85100521A patent/EP0154132B1/en not_active Expired - Lifetime
- 1985-01-24 PH PH31766A patent/PH23447A/en unknown
- 1985-01-24 GR GR850208A patent/GR850208B/el unknown
- 1985-01-24 AU AU38058/85A patent/AU569366B2/en not_active Ceased
- 1985-01-24 DK DK32485A patent/DK32485A/da not_active Application Discontinuation
- 1985-01-24 PT PT79873A patent/PT79873B/pt unknown
- 1985-01-24 CA CA000472745A patent/CA1272479A/en not_active Expired - Fee Related
- 1985-01-24 KR KR1019850000435A patent/KR850005444A/ko not_active Withdrawn
- 1985-01-24 IL IL74153A patent/IL74153A/xx unknown
- 1985-01-24 NZ NZ210929A patent/NZ210929A/en unknown
- 1985-01-24 US US06/694,607 patent/US4798828A/en not_active Expired - Fee Related
- 1985-01-25 PL PL1985251703A patent/PL149297B1/pl unknown
- 1985-01-25 JP JP60013393A patent/JPH0696579B2/ja not_active Expired - Lifetime
- 1985-01-25 NO NO850314A patent/NO850314L/no unknown
- 1985-01-25 ES ES539853A patent/ES8707244A1/es not_active Expired
- 1985-01-25 YU YU11685A patent/YU45695B/sh unknown
- 1985-01-25 HU HU85300A patent/HU197013B/hu not_active IP Right Cessation
- 1985-10-18 ES ES548033A patent/ES8609338A1/es not_active Expired
-
1986
- 1986-04-01 ES ES553604A patent/ES8800683A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES8609338A1 (es) | 1986-09-01 |
| YU11685A (en) | 1988-02-29 |
| FI850174A0 (fi) | 1985-01-15 |
| JPS60185786A (ja) | 1985-09-21 |
| GR850208B (enExample) | 1985-05-24 |
| YU45695B (sh) | 1992-07-20 |
| EP0154132A1 (en) | 1985-09-11 |
| DE3585095D1 (de) | 1992-02-20 |
| FI850174L (fi) | 1985-07-27 |
| AU3805885A (en) | 1985-08-01 |
| PT79873A (en) | 1985-02-01 |
| KR850005444A (ko) | 1985-08-26 |
| PL251703A1 (en) | 1985-12-03 |
| NO850314L (no) | 1985-07-29 |
| PT79873B (pt) | 1986-06-02 |
| PH23447A (en) | 1989-08-07 |
| DK32485D0 (da) | 1985-01-24 |
| ES539853A0 (es) | 1987-07-16 |
| DK32485A (da) | 1985-07-27 |
| ES8707244A1 (es) | 1987-07-16 |
| US4798828A (en) | 1989-01-17 |
| ES8800683A1 (es) | 1987-11-16 |
| IL74153A (en) | 1990-04-29 |
| ES548033A0 (es) | 1986-09-01 |
| FI82471B (fi) | 1990-11-30 |
| CA1272479A (en) | 1990-08-07 |
| NZ210929A (en) | 1987-08-31 |
| EP0154132B1 (en) | 1992-01-08 |
| HUT38352A (en) | 1986-05-28 |
| FI82471C (fi) | 1991-03-11 |
| AU569366B2 (en) | 1988-01-28 |
| ES553604A0 (es) | 1987-11-16 |
| PL149297B1 (en) | 1990-01-31 |
| HU197013B (en) | 1989-02-28 |
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