JPH06506360A - タンパク質により誘導される形態形成 - Google Patents
タンパク質により誘導される形態形成Info
- Publication number
- JPH06506360A JPH06506360A JP4509427A JP50942792A JPH06506360A JP H06506360 A JPH06506360 A JP H06506360A JP 4509427 A JP4509427 A JP 4509427A JP 50942792 A JP50942792 A JP 50942792A JP H06506360 A JPH06506360 A JP H06506360A
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Abstract
Description
Claims (45)
- 1.哺乳動物の中の始原細胞の数を増加させるための組成物であって、始原細胞 群が刺激されて増殖するのに十分な濃度と時間で生体外でモルフォゲンにさらす ことによって刺激された始原細胞群を含むもの。
- 2.哺乳動物の中で非軟骨形成性組織の成長を誘導するための組成物であって、 その始原細胞群か、生体内で組織の局所に置かれたとき、前記局所において、そ の非軟骨形成性組織に特異な分化および増殖ができるようにするために十分な濃 度と時間モルフォゲンにさらすことによって刺激された始原細胞群を含むもの。
- 3.請求項1または2の組成物であって、前記始原細胞群が造血性の多能性幹細 胞群である組成物。
- 4.請求項1または2の組成物であって、前記始原細胞群が間充織由来である組 成物。
- 5.哺乳動物の組織局所に非軟骨形成性の置換組織の形成を誘導するための組成 物であって、前記組織に特異な成分を持ち、形態形成を許容する組織特異な環境 を提供することができる、生体適合性のある非細胞のマトリックスと、前記マト リックス上に吸収されかつ置換組織を必要とする組織特異な局所に置かれたとき 、前記局所に複数の発達段階をたどる組織形態形成を誘導することができるよう なモルフォゲンを含むもの。
- 6.哺乳動物の組織局所に非軟骨形成性の置換組織の形成を誘導するための組成 物であって、形態形成を許容する組織特異な環境を提供することができる、生体 適合性のある非細胞マトリックスと、前記マトリックス上に吸収させ、置換組織 を必要とする組織特異の局所に与えたとき、前記局所に複数の発達段階をたどる 組織形態形成を誘導することができるようなモルフォゲンを含むもの。
- 7.請求項5または6の組成物であって、前記マトリックスが体内で分解され得 るものである組成物。
- 8.請求項5または6の組成物であって、前記マトリックスが器官特異の組織か ら作られたものである組成物。
- 9.請求項5または6の組成物であって、前記マトリックスが、コラーゲンおよ びグリコサミノグリカン類およびプロテオグリカン類からなるグループから選ば れる細胞付着因子群を含むもの。
- 10.請求項5または6の組成物であって、前記マトリックスが、前記哺乳動物 の体からの移動してくる始原細胞群の流入、分化および増殖を許容するに十分な 寸法の孔を持つもの。
- 11.請求項1、2、5または6の組成物であって、前記モルフォゲンが、hO P1(Seq.ID No.5)、mOP1(Seq.ID No.6)、hO P2(Seq.ID No.7);mOP2(Seq.ID No.8)、CB MP2A(fx)(Seq.ID No.9)、CBMP2B(fx)(Seq .ID No.10)、DPP(fx)(Seq.ID No.11)、Vgl (f)(Seq.ID No.12)、V8r−1(fx)(Seq.ID N o.13)およびGDF−1(fx)(Seq.ID No.14)からなるグ ループから選ばれた配列の1つと少なくとも70%の相同性があるアミノ酸配列 を含むもの。
- 12.請求項11の組成物であって、前記モルフォゲンが、前記グループから選 ばれた配列の1つと少なくとも80%の相同性のあるアミノ酸配列を含むもの。
- 13.請求項12の組成物であって、前記モルフォゲンがSeq.ID No. 5(hOP1)の残基43−139の配列と60%よりも大きい同一性があるア ミノ酸配列を含むもの。
- 14.請求項13の組成物であって、前記モルフォゲンがSeq.ID No. 5(hOP1)の残基43−139の配列と65%より大きい同一性があるアミ ノ酸配列を含むもの。
- 15.始原細胞群の増殖を刺激するのに十分なある濃度とある時間、始原細胞群 をモルフォゲンと接触させるステップを含むことからなる、始原細胞群個体数を 増加させる方法。
- 16.哺乳動物内で始原細胞の数を増加させるための請求項15の方法であって 、前記刺激された始原細胞群を、哺乳動物体内でその始原細胞の個体数を増加さ せるために、前記哺乳動物に入れるもう1つのステップを含む方法。
- 17.哺乳動物の中で非軟骨形成性組織の成長を誘導するための方法てあって、 その始原細胞群が、生体内で組織特異な局所に置かれたとき、前記局所において 、その非軟骨形成性組織に特異な分化と増殖ができるようにするために十分な濃 度と時間で、始原細胞をモルフォゲンに接触させるステップを含む方法。
- 18.請求項14または16の方法であって、前記始原細胞群が間充織由来であ る方法。
- 19.始原細胞群が刺激されてそれらの表現型を発現するのに十分な濃度と時間 、始原細胞群をモルフォゲンと接触させるステップを含む、哺乳動物中の分化細 胞群の表現型の発現を維持する方法。
- 20.請求項19の方法であって、前記分化細胞群が老化性または静止性の細胞 群である方法。
- 21.哺乳動物の組織局所に非軟骨形成性組織成長を誘導するための方法であっ て、前記組織局所に、モルフォゲンを、該タンパク質が形態形成を許容する組織 特異な局所に与えられたとき、前記局所に複数の発達段階をたどる組織形態形成 を誘導することができるような濃度と時間、与えることを含む方法。
- 22.請求項21の方法であって、前記非軟骨形成組織が肝組織であり、前記組 織局所が肝臓である方法。
- 23.請求項22の方法であって、前記プロテインが生体適合性のある非細胞性 のマトリックスとともに前記局所に与えられる方法。
- 24.請求項23の方法であって、前記マトリックスが前記組織に特異性のある 成分群を含むものである方法。
- 25.請求項23の方法であって、前記マトリックスが体内で分解され得るもの である方法。
- 26.請求項23の方法であって、前記マトリックスが器官特異の組織から作ら れるものである方法。
- 27.請求項23の方法であって、前記マトリックスがコラーゲンおよび前記組 織に特異の細胞付着因子群を含む方法。
- 28.請求項23の方法であって、前記マトリックスが前記哺乳動物の体から移 動してくる始原細胞群の流入、分化および増殖を許容する十分な寸法の孔を有す る方法。
- 29.請求項14、16、17または20の方法であって、前記モルフォゲンが hOP1(Seq.ID No.5)、mOP1(Seq.ID No.6)、 hOP2(Seq.ID No.7)、mOP2(Seq.IDNo.8)、C BMP2A(fx)(Seq.IDNo.9)、CBMP2B(fx)(Seq .ID No.10)、DPP(fx)(Seq.ID No.11)、Vgl (fx)(Seq.ID No.12)、Vgr−1(fx)(Seq.ID No.13)およびGDF−1(fx)(Seq.ID No.14)から成る グループから選ばれた配列の1つと少なくとも70%の相同性が有るアミノ酸配 列を含むものである方法。
- 30.哺乳動物の肝臓の損傷組織局所に肝組織の形成を誘導する方法であって、 少なくともhOP−1(Seq.ID No.5)のアミノ酸残基43−139 を含むモルフォゲンの治療量を前記局所に与えることを含む方法。
- 31.ヒトの組織の機能不全を診断するする方法であって、次のステップ (a)ヒトの中に存在する内在性の抗−モルフォゲン抗体の濃度を検出するステ ップを、1つの時間間隔で繰り返すこと、 (b)前記検出された濃度を比較すること、検出された濃度の変化が前記組織の 状態を示す、 を含む方法。
- 32.組織の状態を評価する方法であって、前記組織中に存在するモルフォゲン の濃度を検出するステップを含む方法。
- 33.請求項32の方法であて、さらに(a)前記組織中に存在するモルフォゲ ンの濃度を検出するステップを一定時間間隔で繰り返すること、(b)前記検出 された濃度を比較すること、前記検出された濃度の変化がその組織の状態を示す 、を含む方法。
- 34.請求項33の方法であって、前記モルフォゲンがhOP1(Seq.ID No.5);mOP1(Seq.ID No.6);hOP2(Seq.ID No.7);mOP2(Seq.ID No.8);CBMP2A(fx)( Seq.ID No.9);CBMP2B(fx)(Seq.ID No.10 );DPP(fx)(Seq.ID No.11);Vgl(fx)(Seq. ID No.12);Vgr1(fx)(Seq.ID No.13);および GDF1(fx)(Seq.ID No.14)で構成されるグループから選ば れたものである方法。
- 35.非軟骨形成性の哺乳動物組織の成長の誘導に用いる医薬品の製造に有用な モルフォゲン。
- 36.始原細胞の増殖の誘導に用いる医薬品の製造に有用なモルフォゲン。
- 37.哺乳動物の分化細胞群の表現型発現の維持に用いる医薬品の製造に有用な モルフォゲン。
- 38.肝組織の成長の誘導に用いる医薬品の製造に有用なモルフォゲン。
- 39.請求項35、36、37または38のモルフォゲンであって、hOP1( Seq.ID No.5)、mOP1(Seq.ID No.6)、hOP2( Seq.ID No.7)、mOP2(Seq.ID No.8)、CBMP2 A(fx)(Seq.IDNo.9)、CBMP2B(fx)(Seq.ID No.10)、DPP(fx)(Seq.ID No.11)、Vgl(fx) (Seq.ID No.12)、Vgr1(fx)(Seq.ID No.13 )およびGDF1(fx)(Seq.ID No.14)から成るグループから 選ばれた配列の1つと少なくとも70%の相同性を有するアミノ酸配列を含むも の。
- 40.請求項39のモルフォゲンであって、前記グループから選ばれた配列の1 つと少なくとも80%の相同性を有するアミノ酸配列を含むもの。
- 41.腫瘍細胞の成長を抑止するための医薬品の製造に有用なモルフォゲン。
- 42.モルフォゲンを含む癌治療剤。
- 43.組織の成長を誘導するための治療薬で、モルフォゲンを含む治療薬。
- 44.分化細胞群の表現型の発現を誘導するための治療薬で、モルフォゲンを含 む治療薬。
- 45.始原細胞の増殖を誘導するための治療薬で、モルフォゲンを含む治療薬。
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2007101552A (ja) * | 1997-05-30 | 2007-04-19 | Creative Biomolecules Inc | 組織形態形成および活性を評価するための方法 |
JP2009227679A (ja) * | 1992-07-31 | 2009-10-08 | Stryker Corp | 組織形成因子誘導による神経の再生と修復 |
JP2009543665A (ja) * | 2006-07-19 | 2009-12-10 | アボット カーディオヴァスキュラー システムズ インコーポレイテッド | 血管及び関連障害を治療するための、核内受容体リガンドを含有する埋込み型デバイス |
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1992
- 1992-03-11 AU AU17543/92A patent/AU660019B2/en not_active Expired
- 1992-03-11 ES ES92910260T patent/ES2161693T3/es not_active Expired - Lifetime
- 1992-03-11 DK DK92910260T patent/DK0575555T3/da active
- 1992-03-11 EP EP92910260A patent/EP0575555B1/en not_active Revoked
- 1992-03-11 AT AT92910260T patent/ATE203166T1/de not_active IP Right Cessation
- 1992-03-11 WO PCT/US1992/001968 patent/WO1992015323A1/en active IP Right Grant
- 1992-03-11 JP JP50942792A patent/JP3627985B2/ja not_active Expired - Lifetime
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009227679A (ja) * | 1992-07-31 | 2009-10-08 | Stryker Corp | 組織形成因子誘導による神経の再生と修復 |
US7713933B2 (en) | 1995-10-21 | 2010-05-11 | Renovo Limited | Pharmaceutical composition containing an activin or inhibin stimulator |
JP2007101552A (ja) * | 1997-05-30 | 2007-04-19 | Creative Biomolecules Inc | 組織形態形成および活性を評価するための方法 |
JP2009198507A (ja) * | 1997-05-30 | 2009-09-03 | Stryker Corp | 組織形態形成および活性を評価するための方法 |
JP2013137314A (ja) * | 1997-05-30 | 2013-07-11 | Stryker Corp | 組織形態形成および活性を評価するための方法 |
JP2009543665A (ja) * | 2006-07-19 | 2009-12-10 | アボット カーディオヴァスキュラー システムズ インコーポレイテッド | 血管及び関連障害を治療するための、核内受容体リガンドを含有する埋込み型デバイス |
Also Published As
Publication number | Publication date |
---|---|
JP3627985B2 (ja) | 2005-03-09 |
ATE203166T1 (de) | 2001-08-15 |
EP0575555B1 (en) | 2001-07-18 |
EP0575555A1 (en) | 1993-12-29 |
ES2161693T3 (es) | 2001-12-16 |
WO1992015323A1 (en) | 1992-09-17 |
AU660019B2 (en) | 1995-06-08 |
DK0575555T3 (da) | 2001-11-05 |
DE69231946D1 (de) | 2001-08-23 |
GR3036950T3 (en) | 2002-01-31 |
AU1754392A (en) | 1992-10-06 |
EP0575555A4 (en) | 1994-11-02 |
DE69231946T2 (de) | 2002-04-04 |
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