JPH06504620A - 抗rna抗体の検出方法 - Google Patents
抗rna抗体の検出方法Info
- Publication number
- JPH06504620A JPH06504620A JP4502495A JP50249592A JPH06504620A JP H06504620 A JPH06504620 A JP H06504620A JP 4502495 A JP4502495 A JP 4502495A JP 50249592 A JP50249592 A JP 50249592A JP H06504620 A JPH06504620 A JP H06504620A
- Authority
- JP
- Japan
- Prior art keywords
- rna
- antibodies
- antibody
- disease
- serum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
Abstract
Description
Claims (10)
- 1.自己免疫疾患の活動度をモニターする方法であって、自己免疫疾患の患者の 検査液中に存在する抗RNA抗体にRNAを接触させ、それによって前記RNA と抗RNA抗体との間に反応を生起させ、その後、RNAと反応する抗体の決定 によって疾患の重度を明らかにすることからなる方法。
- 2.RNAと反応する抗体の決定が、RNAと反応する抗体の数の定量的決定で あり、それによって疾患の重度の変化が明らかにされることを特徴とする請求項 1に記載の方法。
- 3.抗RNA抗体が抗(U1)RNA反応性抗体であることを特徴とする請求項 1又は2に記載の方法。
- 4.抗(U1)RNA反応性抗体が、(U1)RNAのBステムループドメイン を含むRNAに対して反応性を示すことを特徴とする請求項3に記載の方法。
- 5.抗(U1)RNA反応性抗体が、(U1)RNAのEステムループドメイン を含むRNAに対して反応性を示すことを特徴とする請求項3に記載の方法。
- 6.RNAが修飾又は標識されたRNAであることを特徴とする請求項1から5 のいずれか一項に記載の方法。
- 7.RNAが固相に結合していることを特徴とする請求項1から6のいずれか一 項に記載の方法。
- 8.検査液が血清、血漿又は血液であることを特徴とする請求項1から7のいず れか一項に記載の方法。
- 9.検査液が、SLE又はSLEオーバーラップ症候群のような結合組織疾患の 患者に由来する血清、血漿又は血液であることを特徴とする請求項8に記載の方 法。
- 10.請求項1に記載の方法を実施するためのテストキット。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP91200121 | 1991-01-22 | ||
AT91200121.1 | 1991-01-22 | ||
PCT/EP1992/000106 WO1992013276A1 (en) | 1991-01-22 | 1992-01-16 | Method for detection of anti-rna-antibodies |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH06504620A true JPH06504620A (ja) | 1994-05-26 |
JP3288041B2 JP3288041B2 (ja) | 2002-06-04 |
Family
ID=8207502
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50249592A Expired - Fee Related JP3288041B2 (ja) | 1991-01-22 | 1992-01-16 | 抗rna抗体の検出方法 |
Country Status (15)
Country | Link |
---|---|
US (1) | US5385824A (ja) |
EP (1) | EP0568554B1 (ja) |
JP (1) | JP3288041B2 (ja) |
KR (1) | KR100244799B1 (ja) |
AT (1) | ATE126599T1 (ja) |
AU (1) | AU658860B2 (ja) |
CA (1) | CA2101166C (ja) |
DE (1) | DE69204157T2 (ja) |
DK (1) | DK0568554T3 (ja) |
ES (1) | ES2078733T3 (ja) |
FI (1) | FI107359B (ja) |
GR (1) | GR3017975T3 (ja) |
IE (1) | IE66750B1 (ja) |
WO (1) | WO1992013276A1 (ja) |
ZA (1) | ZA92389B (ja) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5576186A (en) * | 1994-09-01 | 1996-11-19 | The University Of Kansas | Diagnosis and monitoring of rheumatological diseases by detection of anti-EF1-α antibodies |
EP1334113A4 (en) * | 2000-10-20 | 2007-08-08 | Expression Diagnostics Inc | EVALUATION OF LEUCOCYTAIRE EXPRESSION LEVEL |
US7026121B1 (en) | 2001-06-08 | 2006-04-11 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
US7235358B2 (en) | 2001-06-08 | 2007-06-26 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
US6905827B2 (en) * | 2001-06-08 | 2005-06-14 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases |
US7892745B2 (en) * | 2003-04-24 | 2011-02-22 | Xdx, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
WO2006029184A2 (en) * | 2004-09-08 | 2006-03-16 | Expression Diagnostics, Inc. | Genes useful for diagnosing and monitoring inflammation related disorders |
WO2006122295A2 (en) * | 2005-05-11 | 2006-11-16 | Expression Diagnostics, Inc. | Methods of monitoring functional status of transplants using gene panels |
CA2648580A1 (en) * | 2006-04-07 | 2008-05-02 | Xdx, Inc. | Steroid responsive nucleic acid expression and prediction of disease activity |
US7993832B2 (en) * | 2006-08-14 | 2011-08-09 | Xdx, Inc. | Methods and compositions for diagnosing and monitoring the status of transplant rejection and immune disorders |
WO2008140484A2 (en) * | 2006-11-09 | 2008-11-20 | Xdx, Inc. | Methods for diagnosing and monitoring the status of systemic lupus erythematosus |
WO2012068107A2 (en) * | 2010-11-17 | 2012-05-24 | University Of Florida Research Foundation, Inc. | Autoantibody to rna-protein complex detected by quantitative pcr |
WO2015164635A2 (en) * | 2014-04-24 | 2015-10-29 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for detecting anti-drug antibodies |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4784942A (en) * | 1984-11-05 | 1988-11-15 | The Board Of Regents For The University Of Oklahoma | Monoclonal antibodies against autoimmune RNA proteins |
WO1990010229A1 (en) * | 1989-02-27 | 1990-09-07 | Biostar Medical Products, Inc. | Method and diagnostic test kit for detection of autoimmune antibody |
-
1992
- 1992-01-16 ES ES92902145T patent/ES2078733T3/es not_active Expired - Lifetime
- 1992-01-16 EP EP92902145A patent/EP0568554B1/en not_active Expired - Lifetime
- 1992-01-16 KR KR1019930702203A patent/KR100244799B1/ko not_active IP Right Cessation
- 1992-01-16 IE IE920132A patent/IE66750B1/en not_active IP Right Cessation
- 1992-01-16 DE DE69204157T patent/DE69204157T2/de not_active Expired - Lifetime
- 1992-01-16 AT AT92902145T patent/ATE126599T1/de not_active IP Right Cessation
- 1992-01-16 JP JP50249592A patent/JP3288041B2/ja not_active Expired - Fee Related
- 1992-01-16 CA CA002101166A patent/CA2101166C/en not_active Expired - Lifetime
- 1992-01-16 WO PCT/EP1992/000106 patent/WO1992013276A1/en active IP Right Grant
- 1992-01-16 DK DK92902145.9T patent/DK0568554T3/da active
- 1992-01-16 US US08/090,147 patent/US5385824A/en not_active Expired - Lifetime
- 1992-01-16 AU AU11615/92A patent/AU658860B2/en not_active Ceased
- 1992-01-20 ZA ZA92389A patent/ZA92389B/xx unknown
-
1993
- 1993-07-21 FI FI933291A patent/FI107359B/fi not_active IP Right Cessation
-
1995
- 1995-11-07 GR GR950403085T patent/GR3017975T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0568554A1 (en) | 1993-11-10 |
DK0568554T3 (da) | 1995-12-04 |
AU1161592A (en) | 1992-08-27 |
DE69204157T2 (de) | 1996-03-21 |
KR930703612A (ko) | 1993-11-30 |
IE920132A1 (en) | 1992-07-29 |
WO1992013276A1 (en) | 1992-08-06 |
CA2101166C (en) | 2003-05-20 |
EP0568554B1 (en) | 1995-08-16 |
FI933291A (fi) | 1993-08-18 |
ATE126599T1 (de) | 1995-09-15 |
ES2078733T3 (es) | 1995-12-16 |
FI107359B (fi) | 2001-07-13 |
US5385824A (en) | 1995-01-31 |
GR3017975T3 (en) | 1996-02-29 |
IE66750B1 (en) | 1996-02-07 |
JP3288041B2 (ja) | 2002-06-04 |
DE69204157D1 (de) | 1995-09-21 |
AU658860B2 (en) | 1995-05-04 |
FI933291A0 (fi) | 1993-07-21 |
CA2101166A1 (en) | 1992-07-23 |
ZA92389B (en) | 1992-09-30 |
KR100244799B1 (ko) | 2000-03-02 |
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