JPH11513802A - 抗ポリマー抗体の検出方法およびシリコーン関連疾患(srd)の診断を援助するのに有用な診断試験キット - Google Patents
抗ポリマー抗体の検出方法およびシリコーン関連疾患(srd)の診断を援助するのに有用な診断試験キットInfo
- Publication number
- JPH11513802A JPH11513802A JP9515863A JP51586397A JPH11513802A JP H11513802 A JPH11513802 A JP H11513802A JP 9515863 A JP9515863 A JP 9515863A JP 51586397 A JP51586397 A JP 51586397A JP H11513802 A JPH11513802 A JP H11513802A
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- polymer
- antibody
- silicone
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
- G01N33/545—Synthetic resin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2430/00—Assays, e.g. immunoassays or enzyme assays, involving synthetic organic compounds as analytes
- G01N2430/60—Synthetic polymers other than synthetic polypeptides as analytes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
- G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.抗ポリマー抗体の検出方法であって、 a)抗ポリマー抗体に関して試験すべき試料を供給する工程; b)ポリアクリルアミド、部分重合アクリルアミド、シリコーンおよびコラー ゲンからなる群より選ばれたポリマーと前記試料とを、抗ポリマー抗体が前記ポ リマーと反応するのに十分な時間混合して、複合体を形成する工程;及び c)指示薬と前記工程b)から得られた物質とを反応させて前記試料中の抗ポ リマー抗体の有無を示す工程 を含む、前記方法。 2.前記ポリマーを固相に結合する工程を更に含む、請求項1記載の抗ポリマー 抗体の検出方法。 3.該固相がニトロセルロース膜、ポリビニリデンジフルオリド(PVDF)お よびナイロンを含む群より選ばれる、請求項2記載の抗ポリマー抗体の検出方法 。 4.前記指示薬が、ヒト抗体に特異的でありかつ検出可能な標識に結合した結合 部材であり、前記試料及びポリマーと前記固体支持体上に標識三元複合体を形成 するのに十分な時間および条件下で混合される、請求項2記載の抗ポリマー抗体 の検出方法。 5.前記試料中の前記抗ポリマー抗体の有無を示す前記標識三元複合体の有無を 検出する工程を更に含む、請求項4記載の抗ポリマー抗体の検出方法。 6.抗ポリマー抗体を検出するのに有用な診断用キットであって、 支持物質に結合したポリアクリルアミド、部分重合アクリルアミド、シリコ ーンおよびコラーゲンを含む群より選ばれたポリマー抗原;及び ヒト抗体に特異的でありかつ検出可能な標識に結合した結合部材を含む指示 薬 を含む、前記診断用キット。 7.複合体を形成しない物質を抗ポリマー抗体とポリマー抗原の複合体から分離 する洗浄組成物を更に含む、請求項6記載の診断用キット。 8.該指示薬が酵素標識の存在下の比色または化学発光シグナルである、請求項 6記載の診断用キット。 9.シリコーン関連疾患(SRD)の診断方法であって、 a)抗ポリマー抗体に関して試験すべき試料を供給する工程; b)ポリアクリルアミド、部分重合アクリルアミド、シリコーンおよびコラー ゲンからなる群より選ばれたポリマー抗原と前記試料とを、抗ポリマー抗体が前 記ポリマー抗原と反応するのに十分な時間混合して、複合体を形成する工程; c)指示薬と前記工程b)から得られた物質とを反応させて前記試料中の抗ポ リマー抗体の有無を示す工程;及び d)工程c)から得られた物質中の反応した指示薬の有無を同定する工程 を含み、よって反応した指示薬の存在により、SRDの臨床診断と共に前記試 料を供給する個体におけるシリコーン関連疾患を同定する、前記方法。 10.線維筋痛症の診断方法であって、 a)抗ポリマー抗体に関して試験すべき試料を供給する工程; b)ポリアクリルアミド、部分重合アクリルアミド、シリコーンおよびコラー ゲンからなる群より選ばれたポリマー抗原と前記試料とを、抗ポリマー抗体が前 記ポリマー抗原と反応するのに十分な時間混合して、複合体を形成する工程; c)指示薬と前記工程b)から得られた物質とを反応させて前記試料中の抗ポ リマー抗体の有無を示す工程;及び d)工程c)から得られた物質中の反応した指示薬の有無を同定する工程 を含み、よって反応した指示薬の存在により、線維筋痛症の臨床診断と共に前 記試料を供給する個体における線維筋痛症を同定する、前記方法。 11.慢性疲労症候群(CFS)の診断方法であって、 a)抗ポリマー抗体に関して試験すべき試料を供給する工程; b)ポリアクリルアミド、部分重合アクリルアミド、シリコーンおよびコラー ゲンからなる群より選ばれたポリマー抗原と前記試料とを、抗ポリマー抗体が前 記ポリマー抗原と反応するのに十分な時間混合して、複合体を形成する工程; c)指示薬と前記工程b)から得られた物質とを反応させて前記試料中の抗ポ リマー抗体の有無を示す工程;及び d)工程c)から得られた物質中の反応した指示薬の有無を同定する工程 を含み、よって反応した指示薬の存在により、慢性疲労の臨床診断と共に前記 試料を供給する個体におけるCFSを同定する、前記方法。 12.シリコーン関連疾患(SRD)の診断を援助するのに有用な診断キットであ って、 支持物質に結合したポリアクリルアミド、部分重合アクリルアミド、シリコ ーンまたはコラーゲンを含む抗原;及び 前記抗原に結合した抗体の有無を示すことができる指示薬: を含む、前記診断キット。 13.線維筋痛症の診断を援助するのに有用な診断キットであって、 支持物質に結合したポリアクリルアミド、部分重合アクリルアミド、シリコ ーンまたはコラーゲンを含む抗原;及び 前記抗原に結合した抗体の有無を示すことができる指示薬: を含む、前記診断キット。 14.慢性疲労症候群(CFS)の診断を援助するのに有用な診断キットであって 、 支持物質に結合したポリアクリルアミド、部分重合アクリルアミド、シリコ ーンまたはコラーゲンを含む抗原;及び 前記抗原に結合した抗体の有無を示すことができる指示薬: を含む、前記診断キット。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/546,333 | 1995-10-20 | ||
US08/546,333 US5834215A (en) | 1994-10-05 | 1995-10-20 | Method for detecting antipolymer antibodies and diagnosing silicone related disease (SRD) fibromyalgia and chronic fatigue syndrome (CFS) |
PCT/US1996/016107 WO1997014963A1 (en) | 1995-10-20 | 1996-10-08 | A method for detecting antipolymer antibodies and a diagnostic test kit for use in aiding the diagnosis of silicone related diseases (srd) |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH11513802A true JPH11513802A (ja) | 1999-11-24 |
JP3630689B2 JP3630689B2 (ja) | 2005-03-16 |
Family
ID=24179940
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51586397A Expired - Fee Related JP3630689B2 (ja) | 1995-10-20 | 1996-10-08 | 抗ポリマー抗体の検出方法およびシリコーン関連疾患(srd)の診断を援助するのに有用な診断試験キット |
Country Status (9)
Country | Link |
---|---|
US (1) | US5834215A (ja) |
EP (1) | EP0873518B1 (ja) |
JP (1) | JP3630689B2 (ja) |
AT (1) | ATE234466T1 (ja) |
AU (1) | AU710252B2 (ja) |
CA (1) | CA2235316C (ja) |
DE (1) | DE69626683T2 (ja) |
ES (1) | ES2194116T3 (ja) |
WO (1) | WO1997014963A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009524031A (ja) * | 2006-01-18 | 2009-06-25 | ヴィック、イミュノロジッシェ ダイアグノステック ウー.ベラートゥング カーゲー | シリコンに接着するポリペプチドおよび細胞を分析するための試験系 |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6562629B1 (en) | 1999-08-11 | 2003-05-13 | Cedars-Sinai Medical Center | Method of diagnosing irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth by detecting the presence of anti-saccharomyces cerivisiae antibodies (asca) in human serum |
US7048906B2 (en) | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
US6861053B1 (en) | 1999-08-11 | 2005-03-01 | Cedars-Sinai Medical Center | Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth |
ITFI980099A1 (it) * | 1998-04-27 | 1999-10-27 | Univ Firenze | Metodo diagnostico per patologie algiche |
AU783760B2 (en) * | 1999-08-13 | 2005-12-01 | David E. Berg | Method for detecting, treating, and monitoring conditions associated with activation of the coagulation response |
US6692969B1 (en) | 1999-08-13 | 2004-02-17 | David E. Berg | Method for detecting, treating, and monitoring conditions associated with activation of the coagulation response |
DE60033665T2 (de) * | 2000-10-31 | 2007-10-31 | Micronas Gmbh | Gemusterte Polymeroberflächen geeignet für Biokonjugationen und Verfahren zu ihrer Herstellung |
US7178152B2 (en) * | 2001-03-01 | 2007-02-13 | Sony Corporation | Application programming interface for communication between audio/video file system and audio video controller |
WO2009085968A1 (en) * | 2007-12-19 | 2009-07-09 | Great Lakes Biosciences, Llc | Brain-related chronic pain disorder diagnosis and assessment method |
US8706243B2 (en) | 2009-02-09 | 2014-04-22 | Rainbow Medical Ltd. | Retinal prosthesis techniques |
US8150526B2 (en) | 2009-02-09 | 2012-04-03 | Nano-Retina, Inc. | Retinal prosthesis |
DE102011005878A1 (de) | 2010-03-22 | 2011-12-01 | Wilfried P. Bieger | Verfahren und Testbestecks zur Bestimmung von neuroregulatorischen und psychischen Störungen |
DE202010004193U1 (de) | 2010-03-22 | 2011-05-05 | Bieger, Wilfried P., Priv.-Doz. Dr.med.habil. | Testbestecks zur Bestimmung von neuroregulatorischen und psychischen Störungen |
US8956859B1 (en) | 2010-08-13 | 2015-02-17 | Aviex Technologies Llc | Compositions and methods for determining successful immunization by one or more vaccines |
CN103180731B (zh) * | 2010-10-08 | 2015-09-09 | 阿克西斯股份有限公司 | 纤维肌痛症的诊断剂、诊断方法及治疗剂 |
US8571669B2 (en) | 2011-02-24 | 2013-10-29 | Nano-Retina, Inc. | Retinal prosthesis with efficient processing circuits |
DE102012215515A1 (de) * | 2012-08-31 | 2014-03-06 | Klinikum Der Universität München | Verfahren zur Detektion von Schäden an Silikonimplantaten und Computertomographiegerät |
US9720477B2 (en) | 2012-11-21 | 2017-08-01 | Nano-Retina, Inc. | Weak power supply operation and control |
JP6674759B2 (ja) | 2015-10-01 | 2020-04-01 | 国立大学法人北海道大学 | 線維筋痛症の判定のための方法及びキット |
US10330686B2 (en) | 2016-10-20 | 2019-06-25 | Autoimmune Technologies, Llc | Assay for anti-polyvinyl alcohol antibodies |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK169987D0 (da) * | 1987-04-03 | 1987-04-03 | Jens Christian Jensenius | Human tumor-associated antigen, ca-ou1 |
US4918165A (en) * | 1987-07-16 | 1990-04-17 | Ophthalmic Research Corporation | Mitotic inhibitor and method for preventing posterior lens capsule opacification after extracapsular extraction |
EP0324455A3 (en) * | 1988-01-15 | 1991-03-27 | Hans O. Ribi | Novel polymeric immunological adjuvants |
US5340720A (en) * | 1989-11-29 | 1994-08-23 | University Of Kansas | Methods of diagnosing and monitoring rheumatic diseases |
GB9204409D0 (en) * | 1992-02-29 | 1992-04-15 | Ciba Geigy Ag | Determination method |
WO1994020857A1 (en) * | 1993-03-11 | 1994-09-15 | The Regents Of The University Of California | Assay for humoral immunity to macromolecules |
-
1995
- 1995-10-20 US US08/546,333 patent/US5834215A/en not_active Expired - Lifetime
-
1996
- 1996-10-08 WO PCT/US1996/016107 patent/WO1997014963A1/en active IP Right Grant
- 1996-10-08 AU AU72604/96A patent/AU710252B2/en not_active Ceased
- 1996-10-08 DE DE69626683T patent/DE69626683T2/de not_active Expired - Lifetime
- 1996-10-08 EP EP96934107A patent/EP0873518B1/en not_active Expired - Lifetime
- 1996-10-08 JP JP51586397A patent/JP3630689B2/ja not_active Expired - Fee Related
- 1996-10-08 ES ES96934107T patent/ES2194116T3/es not_active Expired - Lifetime
- 1996-10-08 CA CA002235316A patent/CA2235316C/en not_active Expired - Fee Related
- 1996-10-08 AT AT96934107T patent/ATE234466T1/de active
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2009524031A (ja) * | 2006-01-18 | 2009-06-25 | ヴィック、イミュノロジッシェ ダイアグノステック ウー.ベラートゥング カーゲー | シリコンに接着するポリペプチドおよび細胞を分析するための試験系 |
Also Published As
Publication number | Publication date |
---|---|
WO1997014963A1 (en) | 1997-04-24 |
ES2194116T3 (es) | 2003-11-16 |
ATE234466T1 (de) | 2003-03-15 |
AU710252B2 (en) | 1999-09-16 |
CA2235316C (en) | 2005-12-20 |
DE69626683D1 (de) | 2003-04-17 |
CA2235316A1 (en) | 1997-04-24 |
EP0873518A1 (en) | 1998-10-28 |
JP3630689B2 (ja) | 2005-03-16 |
EP0873518B1 (en) | 2003-03-12 |
DE69626683T2 (de) | 2003-08-28 |
AU7260496A (en) | 1997-05-07 |
US5834215A (en) | 1998-11-10 |
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