JPH0649701B2 - キノリジノン化合物およびその製法 - Google Patents
キノリジノン化合物およびその製法Info
- Publication number
- JPH0649701B2 JPH0649701B2 JP63-312576A JP31257688A JPH0649701B2 JP H0649701 B2 JPH0649701 B2 JP H0649701B2 JP 31257688 A JP31257688 A JP 31257688A JP H0649701 B2 JPH0649701 B2 JP H0649701B2
- Authority
- JP
- Japan
- Prior art keywords
- group
- nmr
- ester
- nujol
- quinolizin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
- C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
-
- C07F7/1856—
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8408292 | 1984-03-30 | ||
| GB848408292A GB8408292D0 (en) | 1984-03-30 | 1984-03-30 | Quinolizinone compound |
| GB8429710 | 1984-11-23 | ||
| GB848429710A GB8429710D0 (en) | 1984-11-23 | 1984-11-23 | Pharmaceutical composition |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63100967A Division JPS63284174A (ja) | 1984-03-30 | 1988-04-22 | キノリジノン化合物およびその製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH0649701B2 true JPH0649701B2 (ja) | 1994-06-29 |
| JPH0649701B1 JPH0649701B1 (enExample) | 1994-06-29 |
Family
ID=26287537
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63-312576A Expired - Lifetime JPH0649701B2 (ja) | 1984-03-30 | 1985-03-29 | キノリジノン化合物およびその製法 |
| JP63100967A Granted JPS63284174A (ja) | 1984-03-30 | 1988-04-22 | キノリジノン化合物およびその製造法 |
| JP63312576A Pending JPH01193268A (ja) | 1984-03-30 | 1988-12-09 | キノリジノン化合物およびその製法 |
| JP1133926A Granted JPH0215029A (ja) | 1984-03-30 | 1989-05-25 | キノリジノン化合物またはその塩を含有する抗潰瘍剤 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63100967A Granted JPS63284174A (ja) | 1984-03-30 | 1988-04-22 | キノリジノン化合物およびその製造法 |
| JP63312576A Pending JPH01193268A (ja) | 1984-03-30 | 1988-12-09 | キノリジノン化合物およびその製法 |
| JP1133926A Granted JPH0215029A (ja) | 1984-03-30 | 1989-05-25 | キノリジノン化合物またはその塩を含有する抗潰瘍剤 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US4650804A (enExample) |
| EP (1) | EP0157346B1 (enExample) |
| JP (4) | JPH0649701B2 (enExample) |
| DE (1) | DE3575724D1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4889848A (en) * | 1984-11-06 | 1989-12-26 | Hoffmann-La Roche Inc. | Tricyclic pyridine derivatives |
| CA1317945C (en) * | 1985-12-13 | 1993-05-18 | Ulf Fischer | Tricyclic pyridazopyridone derivatives |
| US4877795A (en) * | 1987-01-30 | 1989-10-31 | Kissei Pharmaceutical Co., Ltd. | 4H-quinolizin-4-one compounds useful for the treatment of allergic bronchial asthma, allergic rhinitis atropic dermatitis and the like |
| EP0294599A3 (de) * | 1987-06-12 | 1990-05-09 | F. Hoffmann-La Roche Ag | Tricyclische Pyridonderivate |
| US4806525A (en) * | 1987-06-18 | 1989-02-21 | Mavi S.R.L. | Formulation comprising gelatin and glycine for treating the dryness of skin |
| ZA885263B (en) * | 1987-07-28 | 1989-03-29 | Fujisawa Pharmaceutical Co | Crystalline monohydrate of sodium n-(1h-tetrazol-5-yl)-1-phenoxy-4h-quinolizin-4-one-3-carboxamide |
| US4921857A (en) * | 1987-09-18 | 1990-05-01 | Merck & Co., Inc. | 4-Oxo-4h-quinolizine-3-carboxylic acids and derivatives thereof |
| US4904657A (en) * | 1987-09-24 | 1990-02-27 | Kissei Pharmaceutical Co., Ltd. | 4H-quinolizin-4-one compounds exhibiting therapeutic activities |
| AU616916B2 (en) * | 1987-11-20 | 1991-11-14 | Kissei Pharmaceutical Co. Ltd. | 4h-quinolizin-4-one compounds exhibiting therapeutic activities |
| US4940715A (en) * | 1988-05-17 | 1990-07-10 | Kissei Pharmaceutical Co., Ltd. | 5H-pyrazolo[4,3-A] quinolizin-5-one compounds exhibiting therapeutic activities |
| US5599816A (en) * | 1990-05-02 | 1997-02-04 | Abbott Laboratories | Quinolizinone type compounds |
| CA2081891C (en) * | 1990-05-02 | 1999-03-16 | Daniel T. Chu | Quinolizinone type compounds |
| WO1993022313A1 (fr) * | 1992-04-27 | 1993-11-11 | Mochida Pharmaceutical Co., Ltd. | Compose tricyclique dote d'un effet antiallergique |
| WO1994013289A1 (en) * | 1992-12-10 | 1994-06-23 | Tsentr Po Khimii Lekarstvennykh Sredstv | Pharmaceutical compound with anti-ulcer properties |
| DE69426528T2 (de) * | 1993-07-13 | 2001-08-23 | Janssen Pharmaceutica N.V., Beerse | Antiallergische imidazoazepine |
| US5869500A (en) * | 1996-12-13 | 1999-02-09 | Hoffmann-La Roche Inc. | Pyridone compounds useful in treating Alzheimer's disease |
| WO2000017197A1 (en) * | 1998-09-21 | 2000-03-30 | Biochem Pharma Inc. | Quinolizinones as integrin inhibitors |
| US6706528B2 (en) * | 2000-03-24 | 2004-03-16 | The United States Of America As Represented By The Department Of Health And Human Services | Fluorescent magnesium indicators |
| EP2465537B1 (en) | 2002-10-10 | 2016-06-29 | ONO Pharmaceutical Co., Ltd. | Microspheres comprising ONO-1301 |
| US7745459B2 (en) * | 2004-09-21 | 2010-06-29 | Japan Tobacco Inc. | Quinolizinone compound and use thereof as HIV integrase inhibitor |
| DE602006011299D1 (de) * | 2005-04-07 | 2010-02-04 | Astrum Therapeutics Pty Ltd | Verbindungen zur behandlung von amyloidose und verhinderung des tods von beta-zellen bei diabetes mellitus typ 2 |
| BRPI0608907A2 (pt) | 2005-05-10 | 2010-02-17 | Itermune Inc | método de modulação de sistema de proteìna cinase ativada por estresse |
| KR100785088B1 (ko) | 2006-05-23 | 2007-12-12 | 한국과학기술연구원 | 두 개의 엑소 메틸렌을 가지는 고리가 접합된 락탐화합물과이의 제조방법 |
| TW200838534A (en) | 2007-02-07 | 2008-10-01 | Astellas Pharma Inc | Treatment for irritable bowel syndrome |
| WO2009102574A1 (en) * | 2008-02-13 | 2009-08-20 | Merck & Co., Inc. | Quinolizidinone m1 receptor positive allosteric modulators |
| EP2296653B1 (en) | 2008-06-03 | 2016-01-27 | Intermune, Inc. | Compounds and methods for treating inflammatory and fibrotic disorders |
| AU2009302703A1 (en) | 2008-10-06 | 2010-04-15 | Merck Sharp & Dohme Corp. | Quinolizidinone M1 receptor positive allosteric modulators |
| US8754220B2 (en) * | 2009-11-20 | 2014-06-17 | Merck Sharp & Dohme Corp. | Quinolizidinone carboxamide M1 receptor positive allosteric modulators |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| RU2692485C2 (ru) | 2014-04-02 | 2019-06-25 | Интермьюн, Инк. | Противофиброзные пиридиноны |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1433151A (en) * | 1973-04-05 | 1976-04-22 | Allen & Hanburys Ltd | Benzo-ij-quinolizines |
| IE52670B1 (en) * | 1981-03-03 | 1988-01-20 | Leo Ab | Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation |
-
1985
- 1985-03-18 US US06/712,435 patent/US4650804A/en not_active Expired - Lifetime
- 1985-03-26 DE DE8585103596T patent/DE3575724D1/de not_active Expired - Fee Related
- 1985-03-26 EP EP85103596A patent/EP0157346B1/en not_active Expired - Lifetime
- 1985-03-29 JP JP63-312576A patent/JPH0649701B2/ja not_active Expired - Lifetime
- 1985-08-30 US US06/770,953 patent/US4698349A/en not_active Expired - Lifetime
-
1988
- 1988-04-22 JP JP63100967A patent/JPS63284174A/ja active Granted
- 1988-12-09 JP JP63312576A patent/JPH01193268A/ja active Pending
-
1989
- 1989-05-25 JP JP1133926A patent/JPH0215029A/ja active Granted
Non-Patent Citations (6)
| Title |
|---|
| Ｊ．Ｃｈｅｍ．Ｓｏｃ．，１９６５，ｐｐ．２６３３−２６３６ |
| Ｊ．Ｈｅｔｅｒｏｃｙｃｌ．Ｃｈｅｍ．，１０［２，（１９７３）ｐｐ．１３９ |
| Ｊ．Ｏｒｇ．Ｃｈｅｍ．，４３［１８，（１９７８），ｐｐ．３５３６−３５３９ |
| Ｍｏｎａｔｓｈ．Ｃｈｅｍ．，９８［３，（１９６７）ｐｐ．８７４−８８６ |
| Ｔｅｔｒａｈｅｄｒｏｎ，２３［９，（１９６７），ｐｐ．３８５１−３８５８ |
| Ｚ．Ｎａｔｕｒｆｏｒｓｃｈ．，Ｂ：Ａｎｏｒｇ．Ｃｈｅｍ．，Ｏｒｇ．Ｃｈｅｍ．，３４Ｂ［５，（１９７９），ｐｐ．７１６−７１９ |
Also Published As
| Publication number | Publication date |
|---|---|
| US4698349A (en) | 1987-10-06 |
| EP0157346B1 (en) | 1990-01-31 |
| DE3575724D1 (de) | 1990-03-08 |
| EP0157346A2 (en) | 1985-10-09 |
| JPS63284174A (ja) | 1988-11-21 |
| JPH039113B2 (enExample) | 1991-02-07 |
| EP0157346A3 (en) | 1986-02-05 |
| JPH01193268A (ja) | 1989-08-03 |
| JPH039088B2 (enExample) | 1991-02-07 |
| US4650804A (en) | 1987-03-17 |
| JPH0215029A (ja) | 1990-01-18 |
| JPH0649701B1 (enExample) | 1994-06-29 |
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