JPH0613448B2 - 皮膚弾力線維症予防剤 - Google Patents
皮膚弾力線維症予防剤Info
- Publication number
- JPH0613448B2 JPH0613448B2 JP60146029A JP14602985A JPH0613448B2 JP H0613448 B2 JPH0613448 B2 JP H0613448B2 JP 60146029 A JP60146029 A JP 60146029A JP 14602985 A JP14602985 A JP 14602985A JP H0613448 B2 JPH0613448 B2 JP H0613448B2
- Authority
- JP
- Japan
- Prior art keywords
- kojic acid
- skin
- present
- preventive agent
- elastic fibrosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 206010016654 Fibrosis Diseases 0.000 title claims description 14
- 230000004761 fibrosis Effects 0.000 title claims description 14
- 230000003449 preventive effect Effects 0.000 title claims description 7
- BEJNERDRQOWKJM-UHFFFAOYSA-N kojic acid Chemical compound OCC1=CC(=O)C(O)=CO1 BEJNERDRQOWKJM-UHFFFAOYSA-N 0.000 claims abstract description 35
- 229960004705 kojic acid Drugs 0.000 claims abstract description 35
- WZNJWVWKTVETCG-UHFFFAOYSA-N kojic acid Natural products OC(=O)C(N)CN1C=CC(=O)C(O)=C1 WZNJWVWKTVETCG-UHFFFAOYSA-N 0.000 claims abstract description 35
- 239000002674 ointment Substances 0.000 claims abstract description 5
- 239000003795 chemical substances by application Substances 0.000 claims description 13
- 208000002197 Ehlers-Danlos syndrome Diseases 0.000 claims description 8
- 239000004480 active ingredient Substances 0.000 claims description 8
- 239000002537 cosmetic Substances 0.000 claims description 5
- 229920000858 Cyclodextrin Polymers 0.000 abstract description 9
- 239000003814 drug Substances 0.000 abstract description 9
- 229940079593 drug Drugs 0.000 abstract description 8
- 239000006071 cream Substances 0.000 abstract description 7
- 241000700159 Rattus Species 0.000 abstract description 6
- 239000000839 emulsion Substances 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 4
- 241001465754 Metazoa Species 0.000 abstract description 2
- 231100000053 low toxicity Toxicity 0.000 abstract description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 abstract 2
- 239000001116 FEMA 4028 Substances 0.000 abstract 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 abstract 1
- 235000011175 beta-cyclodextrine Nutrition 0.000 abstract 1
- 229960004853 betadex Drugs 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000005562 fading Methods 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 10
- 239000003921 oil Substances 0.000 description 10
- 210000003491 skin Anatomy 0.000 description 10
- 239000008213 purified water Substances 0.000 description 9
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 239000008346 aqueous phase Substances 0.000 description 6
- 235000011187 glycerol Nutrition 0.000 description 5
- 229960005150 glycerol Drugs 0.000 description 5
- 239000006210 lotion Substances 0.000 description 5
- -1 packs Substances 0.000 description 5
- 239000012071 phase Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 239000002253 acid Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 229940057995 liquid paraffin Drugs 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 4
- 241000228212 Aspergillus Species 0.000 description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 3
- 235000013871 bee wax Nutrition 0.000 description 3
- 239000012166 beeswax Substances 0.000 description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 description 3
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 3
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 3
- 229960000541 cetyl alcohol Drugs 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 210000004177 elastic tissue Anatomy 0.000 description 3
- YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 description 3
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 3
- 239000012188 paraffin wax Substances 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 239000004166 Lanolin Substances 0.000 description 2
- 208000000453 Skin Neoplasms Diseases 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- 238000005538 encapsulation Methods 0.000 description 2
- 239000010696 ester oil Substances 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- 235000019388 lanolin Nutrition 0.000 description 2
- 229940039717 lanolin Drugs 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 239000002304 perfume Substances 0.000 description 2
- 230000037394 skin elasticity Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 229940032094 squalane Drugs 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 206010004146 Basal cell carcinoma Diseases 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 238000002738 Giemsa staining Methods 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010023347 Keratoacanthoma Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 206010029098 Neoplasm skin Diseases 0.000 description 1
- 241000228143 Penicillium Species 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 108010013296 Sericins Proteins 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 208000009621 actinic keratosis Diseases 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000001760 anti-analgesic effect Effects 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000001364 causal effect Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 description 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000003883 ointment base Substances 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 229940056211 paraffin Drugs 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 229940043274 prophylactic drug Drugs 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 201000000849 skin cancer Diseases 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 238000013223 sprague-dawley female rat Methods 0.000 description 1
- 206010041823 squamous cell carcinoma Diseases 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Electroluminescent Light Sources (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pyrane Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60146029A JPH0613448B2 (ja) | 1985-07-02 | 1985-07-02 | 皮膚弾力線維症予防剤 |
| IE148186A IE59082B1 (en) | 1985-07-02 | 1986-06-04 | Preventive drugs for elastosis |
| KR1019860004420A KR890004556B1 (ko) | 1985-07-02 | 1986-06-04 | 피부탄력 섬유증(纖維症) 예방제의 제법 |
| ZA864166A ZA864166B (en) | 1985-07-02 | 1986-06-04 | Preventive drugs for elastosis |
| CA000510952A CA1282332C (en) | 1985-07-02 | 1986-06-05 | Preventive drugs for elastosis |
| IN440/CAL/86A IN165985B (cg-RX-API-DMAC7.html) | 1985-07-02 | 1986-06-12 | |
| AU58897/86A AU591680B2 (en) | 1985-07-02 | 1986-06-16 | Preventive drugs for elastosis |
| PH33945A PH22349A (en) | 1985-07-02 | 1986-06-25 | Preventive drugs dor elastosis |
| GR861671A GR861671B (en) | 1985-07-02 | 1986-06-26 | Preventive drugs for elastosis |
| EP86108952A EP0207499B1 (en) | 1985-07-02 | 1986-07-01 | Use of kojic acid or its beta-cyclodextrin inclusion complex for the prevention of elastosis |
| DE8686108952T DE3685060D1 (de) | 1985-07-02 | 1986-07-01 | Verwendung von kojic-saeure oder ihres beta-cyclodextrin-einschlusskomplexes zur praevention von elastosis. |
| PT82889A PT82889B (pt) | 1985-07-02 | 1986-07-01 | Processo para a preparacao de composicoes farmaceuticas contendo acido cojico com accao preventiva da elastose |
| DK313786A DK166429B1 (da) | 1985-07-02 | 1986-07-01 | Anvendelse af kojisyre eller kojisyre/beta-cyclodextrinindlejringskompleks til fremstilling af laegemidler til forebyggelse af elastosis |
| AT86108952T ATE75396T1 (de) | 1985-07-02 | 1986-07-01 | Verwendung von kojic-saeure oder ihres betacyclodextrin-einschlusskomplexes zur praevention von elastosis. |
| FI862806A FI862806A0 (fi) | 1985-07-02 | 1986-07-01 | Medel foer foerhindrande av elastosis. |
| US07/198,637 US4891361A (en) | 1985-07-02 | 1988-05-18 | Method of minimizing erythema and elastosis |
| HK51594A HK51594A (en) | 1985-07-02 | 1994-05-19 | Use of Kojic acid or its beta-cyclodextrin inclusion complex for the prevention of elastosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60146029A JPH0613448B2 (ja) | 1985-07-02 | 1985-07-02 | 皮膚弾力線維症予防剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS625909A JPS625909A (ja) | 1987-01-12 |
| JPH0613448B2 true JPH0613448B2 (ja) | 1994-02-23 |
Family
ID=15398494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60146029A Expired - Lifetime JPH0613448B2 (ja) | 1985-07-02 | 1985-07-02 | 皮膚弾力線維症予防剤 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4891361A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0207499B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JPH0613448B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR890004556B1 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE75396T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU591680B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA1282332C (cg-RX-API-DMAC7.html) |
| DE (1) | DE3685060D1 (cg-RX-API-DMAC7.html) |
| DK (1) | DK166429B1 (cg-RX-API-DMAC7.html) |
| FI (1) | FI862806A0 (cg-RX-API-DMAC7.html) |
| GR (1) | GR861671B (cg-RX-API-DMAC7.html) |
| HK (1) | HK51594A (cg-RX-API-DMAC7.html) |
| IE (1) | IE59082B1 (cg-RX-API-DMAC7.html) |
| IN (1) | IN165985B (cg-RX-API-DMAC7.html) |
| PH (1) | PH22349A (cg-RX-API-DMAC7.html) |
| PT (1) | PT82889B (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA864166B (cg-RX-API-DMAC7.html) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2809429B2 (ja) * | 1989-05-26 | 1998-10-08 | 湧永製薬株式会社 | 制ガン剤ならびに制ガン剤として有用な新規複素環化合物またはそれらの塩 |
| JPH04298437A (ja) * | 1991-03-26 | 1992-10-22 | Fuji Photo Film Co Ltd | 画像形成装置 |
| US5296472A (en) * | 1991-12-05 | 1994-03-22 | Vyrex Corporation | Methods for delipidation of skin and cerumen removal |
| JP3566739B2 (ja) * | 1993-09-30 | 2004-09-15 | 三省製薬株式会社 | 皮膚外用剤の安定化方法 |
| US5874463A (en) | 1994-10-24 | 1999-02-23 | Ancira; Margaret | Hydroxy-kojic acid skin peel |
| US6596263B1 (en) * | 1995-07-14 | 2003-07-22 | Stc English Ideas, Inc. | Cyclodextrin compositions |
| GB2307176A (en) * | 1995-11-15 | 1997-05-21 | Todd Selwyn Everest | Anti-inflammatory clathrating agents for topical use |
| KR100471372B1 (ko) * | 2001-12-04 | 2005-03-08 | 주식회사 태평양 | 피부 탄력 향상용 화장료 조성물 |
| US20040126339A1 (en) * | 2002-12-31 | 2004-07-01 | Roszell James A. | Sunscreen composition and methods for manufacturing and using a sunscreen composition |
| US20080070982A1 (en) * | 2006-09-15 | 2008-03-20 | Graham Timmins | System and methods of melanoma prevention |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS533538A (en) * | 1976-06-28 | 1978-01-13 | Sansho Seiyaku Kk | Skin bleach cosmetics |
| JPS55157509A (en) * | 1979-05-24 | 1980-12-08 | Sansho Seiyaku Kk | Ultraviolet ray intercepting agent safe to skin |
| JPS61109705A (ja) * | 1984-11-01 | 1986-05-28 | Sansho Seiyaku Kk | 色白化粧料 |
-
1985
- 1985-07-02 JP JP60146029A patent/JPH0613448B2/ja not_active Expired - Lifetime
-
1986
- 1986-06-04 ZA ZA864166A patent/ZA864166B/xx unknown
- 1986-06-04 KR KR1019860004420A patent/KR890004556B1/ko not_active Expired
- 1986-06-04 IE IE148186A patent/IE59082B1/en not_active IP Right Cessation
- 1986-06-05 CA CA000510952A patent/CA1282332C/en not_active Expired - Lifetime
- 1986-06-12 IN IN440/CAL/86A patent/IN165985B/en unknown
- 1986-06-16 AU AU58897/86A patent/AU591680B2/en not_active Expired
- 1986-06-25 PH PH33945A patent/PH22349A/en unknown
- 1986-06-26 GR GR861671A patent/GR861671B/el unknown
- 1986-07-01 AT AT86108952T patent/ATE75396T1/de active
- 1986-07-01 FI FI862806A patent/FI862806A0/fi not_active Application Discontinuation
- 1986-07-01 EP EP86108952A patent/EP0207499B1/en not_active Expired - Lifetime
- 1986-07-01 PT PT82889A patent/PT82889B/pt not_active IP Right Cessation
- 1986-07-01 DK DK313786A patent/DK166429B1/da not_active IP Right Cessation
- 1986-07-01 DE DE8686108952T patent/DE3685060D1/de not_active Expired - Lifetime
-
1988
- 1988-05-18 US US07/198,637 patent/US4891361A/en not_active Expired - Lifetime
-
1994
- 1994-05-19 HK HK51594A patent/HK51594A/en not_active IP Right Cessation
Non-Patent Citations (1)
| Title |
|---|
| 「日皮会誌」９１（５），（１９８１）第５４３〜５４７頁 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU591680B2 (en) | 1989-12-14 |
| FI862806A0 (fi) | 1986-07-01 |
| HK51594A (en) | 1994-05-27 |
| DK313786D0 (da) | 1986-07-01 |
| PT82889A (en) | 1986-08-01 |
| DK313786A (da) | 1987-01-03 |
| GR861671B (en) | 1986-10-30 |
| EP0207499A2 (en) | 1987-01-07 |
| ZA864166B (en) | 1987-02-25 |
| DE3685060D1 (de) | 1992-06-04 |
| IE59082B1 (en) | 1994-01-12 |
| US4891361A (en) | 1990-01-02 |
| PT82889B (pt) | 1988-05-27 |
| KR870000931A (ko) | 1987-03-10 |
| EP0207499B1 (en) | 1992-04-29 |
| IE861481L (en) | 1987-01-02 |
| IN165985B (cg-RX-API-DMAC7.html) | 1990-02-17 |
| CA1282332C (en) | 1991-04-02 |
| JPS625909A (ja) | 1987-01-12 |
| AU5889786A (en) | 1987-01-08 |
| ATE75396T1 (de) | 1992-05-15 |
| KR890004556B1 (ko) | 1989-11-15 |
| EP0207499A3 (en) | 1989-04-26 |
| PH22349A (en) | 1988-08-12 |
| DK166429B1 (da) | 1993-05-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP3609834B2 (ja) | 皮膚外用剤 | |
| KR100615116B1 (ko) | 다소포 에멀젼 국소 전달 시스템 | |
| JP2564690B2 (ja) | メラニン生成抑制外用剤 | |
| JPH09110628A (ja) | 脂漏症を処理するための活性剤としてアスコルビン酸を含む化粧用および／または皮膚科学用組成物 | |
| JP2764510B2 (ja) | 美白化粧料 | |
| JPH0613448B2 (ja) | 皮膚弾力線維症予防剤 | |
| EP1192939A2 (en) | Methods for reduction of inflammation and erythema | |
| JPH05262635A (ja) | 皮膚外用剤 | |
| JP2691662B2 (ja) | 化粧料 | |
| JPH11139951A (ja) | 化粧料 | |
| JPS63301826A (ja) | 外用剤 | |
| JPH08104635A (ja) | フィチン酸亜鉛を有効成分とする外用製剤 | |
| JP2000007548A (ja) | 皮膚外用剤 | |
| JP2566792B2 (ja) | 発毛、養毛促進剤 | |
| JP2000256168A (ja) | 皮膚外用剤 | |
| JP2610310B2 (ja) | 外用剤 | |
| JPH09263510A (ja) | 乳化組成物 | |
| JPH0640858A (ja) | 養毛料 | |
| JPH06321747A (ja) | 皮膚外用剤 | |
| JPH03127712A (ja) | 外用剤 | |
| JP2787451B2 (ja) | 養毛料 | |
| JPH0519526B2 (cg-RX-API-DMAC7.html) | ||
| JPH03279316A (ja) | 皮膚外用剤 | |
| JPH07277930A (ja) | 養毛料 | |
| JPH1072333A (ja) | 皮膚外用剤 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| EXPY | Cancellation because of completion of term |