JPH0592917A - Cosmetic - Google Patents

Abstract

PURPOSE:To obtain a cosmetic, excellent in beautifying and whitening actions on the skin, capable of smoothing the skin and preventing the skin from roughening and fine winkles from forming and having guaranteed safety. CONSTITUTION:A cosmetic is obtained by including a solvent extract from Fraxini Cortex (a dried bark of Fraxinus japonica Blume) which has been utilized as an antiphlogistic agent, an antidiarrheal agent, an antipyretic agent or a tonic from old times in an amount of 0.00005-5wt.%, preferably 0.005-2wt.% expressed in terms of a dry substance. A hydrophilic organic solvent such as ethanol, methanol, acetone, propylene glycol, glycerol or 1,3-butylene glycol and water alone or a mixed solution is used as the extracting solvent. The above-mentioned extract is capable of producing inhibitory effects on tyrosinase activity and suppressing effects on active oxygen.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic having a high whitening effect, smoothing the skin and keeping youthful skin.

[0002]

2. Description of the Related Art Qin skin is a dicotyledonous net, a leaflet sub net, a mosquito, and a ash belonging to the genus Ash of the family Fraxinus japonica and Aodamo Fraxinus lanu.
ginosa, ash F
The bark of raxinus rhynchophylla or the like is dried. All of them are dioecious deciduous trees, and because they are hard trees, they are used for guns, baseball bats, and the like.

Qin peel is also used for medicinal purposes, and causes febrile diarrhea,
It has long been used as an antipyretic, eye wash, tonic, and anti-inflammatory agent. Not currently used as cosmetics. It has been used for a long time as an anti-inflammatory, anti-diarrheal, antipyretic and tonic. It is used as an antiallergic food in JP-A-61-15834, but not as a cosmetic at all.

[0004]

DISCLOSURE OF THE INVENTION The object of the present invention is to provide a cosmetic which is safe and has a whitening effect when applied to the skin, smoothes the skin, keeps youthful skin, and keeps the skin smooth. Especially.

[0005]

Means for Solving the Problems The inventors of the present invention tested a number of plant extracts that are easily available, and found that the extract of Qin peel was very effective as a cosmetic composition. Arrived

That is, the present invention is a cosmetic containing a solvent extract of Qin peel.

Qin bark obtained by drying the bark of ash etc. is already sold as a crude drug and as a raw material for medicines (internal drug), and it is possible to collect the one naturally grown in the mountains of Japan.

This is extracted with a hydrophilic organic solvent and water alone or as a mixed solution. As the hydrophilic organic solvent, ethanol, methanol, acetone, propylene glycol,
Glycerin, 1,3 butylene glycol or the like is used.

This substance can be used as other cosmetic raw materials such as liquid oils such as squalane and jojoba oil, solid oils such as beeswax and cetyl alcohol, various activators, humectants such as glycerin and 1,3 butylene glycol, and various drugs. It can be added to adjust various dosage forms of cosmetics. For example, a lotion, a cream, a milky lotion, a pack or the like may be used depending on the purpose. The effect of the extract of Qin peel varies depending on the dosage form to be blended, the purpose of the product, or the presence or absence of a coexisting drug, but in terms of dry matter, 0.00005 to 5% by weight, preferably 0.005 to 5% by weight.
2% by weight is suitable.

[0010]

EXAMPLES The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to these examples.

(Production Example 1) 200 g of methanol was added to 20 g of dried Qin husk, and a reflux condenser was attached and heated for 3 hours. After filtration, it was freeze-dried.

(Production Example 2) 50 g of dried Qin peel was added to 20 g.
Add 200 ml of% methanol, attach a reflux condenser, and 3
Heated for hours. After filtration, it was freeze-dried.

(Production Example 3) To 20 g of dried Qin husk, 200 ml of purified water was added, and a reflux condenser was attached, followed by heating for 3 hours. After filtration, it was freeze-dried.

(Production Example 4) 50 g of dried Qin peel was added to 20 g.
200 ml of ethanol was added and the mixture was left for 10 days. This was filtered and freeze-dried. The yield was 0.54g.

(Production Example 5) 200 g of ethanol was added to 20 g of dried Qin peel and left for 10 days. This was filtered and freeze-dried. The yield was 1.03 g.

(Example 1) Lotion Extract of Production Example 1 1.0 Ethanol 80.0 Purified water 19.0

Example 2 Cream A Squalane 20.0 Jojoba Oil 5.0 Beeswax 5.0 Cetostearyl Alcohol 2.0 Glycerin Monostearate 1.0 Sorbitan Monostearate 2.0 Extract 1 of Production Example 1 0.0 B Purified water 55.9 Polyoxyethylene (20 E.O.) sorbitan monostearate 2.0 Polyoxyethylene (60 E.O.) Hydrogenated castor oil 1.0 Glycerin 5.0 Methyl paraoxybenzoate 0.1 A and B are weighed individually, heated to 70 ° C., A is gradually added to B with stirring, and then 30 with slow stirring.
Cooled to ° C.

(Example 3) The extract of Qin peel of Production Example 1 of Example 1 was replaced with the extract of Production Example 5.

(Example 4) The extract of Qin peel of Production Example 2 of Example 2 was replaced by the extract of Production Example 3.

(Example 5) A product obtained by replacing the extract of Qin peel of Production Example 2 of Example 2 with the extract of Production Example 4.

(Measurement of Tyrosinase Activity Inhibition Rate) (Test Method) Mcllvaln Buffer Solution 0.9 m
1.0 ml of a 1.66 mM Tyrosine solution and the above sample (extracted dried product) were dissolved in ethanol, water was added, and ethanol was removed by an evaporator.
1.0 ml of a normal concentration aqueous solution adjusted to 1 weight (dry matter) / volume% was placed in a screw vial and heated in a 37 ° C. constant temperature water tank for 5 minutes or more. Tyrosinase solution (Sigma,
Mushroom-derived, 914 units / ml) 0.1 ml was added and kept in a 37 ° C constant temperature water bath, and after 10 minutes 475 nm
The absorbance was measured with. As a control, pure water was added instead of the sample solution and the same measurement was performed.

(Calculation formula) A: Absorbance of sample specimen B: Absorbance of control P: Absorbance due to coloring of sample specimen (3-fold dilution) Tyrosinase activity inhibition rate (%) = {B- (AP)} / B
× 100

[0023]

[Table 1]

(Measurement of Active Oxygen Suppression Effect) 2 in the atmosphere
There is 1% oxygen, without which no organisms (except anaerobic) can exist. However, oxygen becomes active oxygen under the influence of ultraviolet rays and enzymes. Active oxygen oxidizes fatty acids and produces peroxides. It also oxidizes and damages the phospholipids of biological membranes in the body. Moreover, it is said that the generated peroxide and active oxygen damage DNA and accelerate aging. It also affects the mechanism of melanin production from tyrosine and is involved in skin darkening. Suppressing this active oxygen is one of the important factors required for the skin, in other words, for cosmetics.

A method for measuring the effect of suppressing active oxygen is
There are various types, but the following method was used this time. pH 7.8 50 mM potassium phosphate buffer (containing 1.3 mM DETAPAC) 133 ml 40 unit / ml Catalase above potassium phosphate buffer 5 ml 2 mM nitroblue tetrazolium above potassium phosphate buffer 5 ml17 ml of the above potassium phosphate buffer solution containing 1.8 mM xanthine  2.4 ml of a mixture of the reagents above 160 ml, sample (the above-mentioned dried extract)
0.1 wt / v% aqueous solution), add 0.3 ml, and
Xinase (absorbance when using water as the sample in advance)
The above-mentioned phosphoric acid
Immediately after adding 0.3 ml of the solution)
Then, the absorbance (560 nm) is measured. (Measurement is 2 quantiles
And check the linearity. )

Calculation formula Inhibition rate = (A−B) / A × 100 where A: change in absorbance per minute when the sample is water B: change in absorbance per minute of the sample The result is 50 It is shown in Table 2 in terms of% active oxygen production inhibition concentration (%).

[0027]

[Table 2]

(Usage Test) Faces of 5 women were divided into right and left sides, one of which was used as an example and the other of which was used as a comparative example once a day for one or more times, and a questionnaire was taken after 3 months. In addition, 15 people were divided into 3 groups and an experiment was performed using the samples in Table 3.

[Table 3] The criteria are as follows, and the results of the questionnaire are summarized in Table 4 below. Example is very good 3 Example is considerably good 2 Example is slightly good 1 No difference 0 Comparative example is slightly good -1 Comparative example is quite good -2 Comparative example Is very good -3

[0029]

[Table 4]

[0030]

The cosmetic composition of the present invention has an excellent whitening effect, and has effects of smoothing the skin, preventing rough skin, and preventing wrinkles. It has been used internally as a crude drug since ancient times and is therefore guaranteed to be safe.

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[Procedure amendment]

[Submission date] December 10, 1991

[Procedure Amendment 1]

[Document name to be amended] Statement

[Name of item to be corrected] 0023

[Correction method] Change

[Correction content]

[0023]

[Table 1]

[Procedure Amendment 2]

[Document name to be amended] Statement

[Name of item to be corrected] 0027

[Correction method] Change

[Correction content]

[0027]

[Table 2]

[Procedure 3]

[Document name to be amended] Statement

[Correction target item name] 0028

[Correction method] Change

[Correction content]

(Usage test) The faces of five women were divided into left and right sides, one of which was an example and the other was a comparative example (example 1,
Comparative Examples 1 and 2 were obtained by removing the production example from 2)
I had them use it more than once every day, and after 3 months I conducted a questionnaire. In addition, 15 people were divided into 3 groups and an experiment was performed using the samples in Table 3.

[Table 3] The criteria are as follows, and the results of the questionnaire are summarized in Table 4 below. Example is very good 3 Example is considerably good 2 Example is slightly good 1 No difference 0 Comparative example is slightly good -1 Comparative example is quite good -2 Comparative example Is very good -3

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Masao Hattori 2556-4-22-203 Gofuku Suehiro-cho, Toyama City, Toyama Prefecture (72) Inventor Kenji Shimomura 3-16-32 Funae, Ise City, Mie Prefecture (72) Inventor Nakamura Masami 6-32 Ikegami Town, Toba City, Mie Prefecture

Claims (1)

[Claims] 1. A cosmetic containing a solvent extract of Qin peel.