JPH0597653A - Cosmetic - Google Patents

Cosmetic

Info

Publication number
JPH0597653A
JPH0597653A JP3265388A JP26538891A JPH0597653A JP H0597653 A JPH0597653 A JP H0597653A JP 3265388 A JP3265388 A JP 3265388A JP 26538891 A JP26538891 A JP 26538891A JP H0597653 A JPH0597653 A JP H0597653A
Authority
JP
Japan
Prior art keywords
extract
water
rheum
cosmetic
skin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3265388A
Other languages
Japanese (ja)
Inventor
Tsuneo Nanba
恒雄 難波
Yukio Hattori
征雄 服部
Kenji Shimomura
健次 下村
Masami Nakamura
雅美 中村
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mikimoto Pharmaceutical Co Ltd
Original Assignee
Mikimoto Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mikimoto Pharmaceutical Co Ltd filed Critical Mikimoto Pharmaceutical Co Ltd
Priority to JP3265388A priority Critical patent/JPH0597653A/en
Publication of JPH0597653A publication Critical patent/JPH0597653A/en
Pending legal-status Critical Current

Links

Landscapes

  • Cosmetics (AREA)

Abstract

PURPOSE:To provide a cosmetic excellent in the skin-whitening activity and in the prevention of the skin roughness and fine wrinkles and guaranteed at the point of safety. CONSTITUTION:A cosmetic contains the solvent extract of Rheum in a dry amount of 0.00001-5wt.%, preferably 0.0001-2wt.%. The Rheum is extracted with a hydrophilic organic solvent such as a lower alcohol, a polyhydric alcohol or acetone and water, or the mixed solvents, preferably ethanol, water or the mixture as an extraction solvent. The extracted solution or its dry powder obtained by a lyophilization method, etc., is mixed with other raw materials (e.g. a liquid oil, a solid oil, various active agents, a humectant, various chemicals) and subsequently prepared into the cosmetics having various preparation shapes.

Description

【発明の詳細な説明】Detailed Description of the Invention

【0001】[0001]

【産業上の利用分野】本発明は美白作用が高く、皮膚を
滑らかにし、若々しい皮膚を保つ化粧品に関する。
BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic having a high whitening effect, smoothing the skin and keeping youthful skin.

【0002】大黄は医薬品として広く用いられている。
目的は大腸性瀉下剤、消炎性健胃薬として、漢方では実
証タイプの人の結毒を排除し、通利を促し、胸満、宿
食、便秘による腹痛、化膿性腫脹を治す要薬であり、日
本薬局方にも記載された原料であるが、これを化粧品に
利用した前例はない。
Rhubarb is widely used as a medicine.
The purpose is to treat colonic laxatives and anti-inflammatory stomachic agents as a drug to eliminate toxic type poisoning in Chinese herbs, promote profitability, and cure chest fullness, lodging, abdominal pain due to constipation, and purulent swelling. Although it is a raw material described in the Japanese Pharmacopoeia, there is no precedent for using it in cosmetics.

【0003】[0003]

【発明が解決しようとする課題】本発明の目的は、美白
作用が高く、皮膚を滑らかにし、若々しい皮膚を保ち、
且つ安全性が高く、原料が入手しやすい化粧品原料を配
合した化粧品を提供することである。
DISCLOSURE OF THE INVENTION The object of the present invention is to have a high whitening effect, to make the skin smooth, to keep youthful skin,
Another object of the present invention is to provide a cosmetic product that is highly safe and has a raw material that is easily available.

【0004】[0004]

【課題を解決するための手段】本発明者らは、前記の課
題を解決するため、鋭意研究を行い、古くより漢方にて
内用薬として用いられ、安全性が確認されている原料に
ついて、化粧品としての効果を調べた結果、優れた美白
作用等があることを見い出し、本発明を完成した。
[Means for Solving the Problems] In order to solve the above-mentioned problems, the present inventors have conducted diligent research and, regarding the raw materials that have been used as internal medicines in Kampo for a long time and whose safety has been confirmed, As a result of investigating the effect as a cosmetic, it was found that it has an excellent whitening effect, and the present invention was completed.

【0005】すなわち、本発明は、大黄の溶媒抽出物を
含む化粧品である。大黄は古くより、内用薬として用い
られ、水製、或いはエタノールエキスが用いられ、その
安全性は充分に確認されている。大黄には、いろいろな
種類の植物が使われている。ショウヨウダイオウ(Rheu
m Palmatum Linne)、タングートダイオウ(Rheum tang
uticum Maximowicz )、ダイオウ(Rheum officinale B
aillon)、チョウセンダイオウ(Rheum coreanum Naka
i)またはそれらの種間雑種、例えば信州大黄等があ
る。これらの植物の根茎をもちいたのが大黄である。
That is, the present invention is a cosmetic product containing a solvent extract of Rhubarb. Daihaku has long been used as an internal medicine, and made of water or ethanol extract, and its safety has been sufficiently confirmed. Various types of plants are used for rhubarb. Rheu
m Palmatum Linne), Tangut rhubarb (Rheum tang
uticum Maximowicz), Rheum officinale B
aillon), Korean rhubarb (Rheum coreanum Naka
i) or their interspecific hybrids such as Shinshu Daihoku. The rhizome of these plants is rhubarb.

【0006】この大黄を抽出する溶媒としては、メタノ
ール、エタノール等の低級アルコール、グリセリン、プ
ロピレングリコール、1,3ブチレングリコール等の多
価アルコール、アセトン等の親水性有機溶媒、及び水、
あるいはこれらの溶媒群より選んだ2種以上の混合溶媒
を用いて抽出する。しかし、化粧品原料の抽出として
は、エタノールか水或いはこれらの混合液が最適であ
る。抽出時間は、大黄の刻み方、温度、撹拌条件によっ
て選択する。
As a solvent for extracting the rhubarb, lower alcohols such as methanol and ethanol, polyhydric alcohols such as glycerin, propylene glycol and 1,3 butylene glycol, hydrophilic organic solvents such as acetone, and water,
Alternatively, extraction is performed using a mixed solvent of two or more kinds selected from these solvent groups. However, ethanol, water, or a mixture thereof is most suitable for extracting cosmetic raw materials. The extraction time is selected according to the method of chopping the rhubarb, the temperature, and the stirring conditions.

【0007】この抽出液又はそれを凍結乾燥等によっ
て、有効成分を分解させることなく乾燥した乾燥粉末を
他の化粧品原料例えばスクワラン、ホホバ等の液状油、
ミツロウ、セチルアルコール等の固体油、各種の活性
剤、グリセリン、1,3ブチレングリコール等の保湿剤
や各種薬剤を添加して、さまざまな剤形の化粧品を調製
することができる。例えば、ローション、クリーム、乳
液、パック等で目的に応じて利用形態を考えればよい。
The extract or a dry powder obtained by freeze-drying the extract without decomposing the active ingredient is used as another cosmetic raw material, for example, liquid oil such as squalane and jojoba.
Cosmetics of various dosage forms can be prepared by adding solid oils such as beeswax and cetyl alcohol, various activators, humectants such as glycerin and 1,3 butylene glycol, and various agents. For example, a lotion, a cream, a milky lotion, a pack or the like may be used depending on the purpose.

【0008】この抽出物の配合物は配合する剤形、製品
の目的によって、或いは共存させる薬剤の有無、大黄の
産地や種類等によって、その効果の発現は異なるのであ
るが、乾燥物換算にして0.00001〜5%重量%、
好ましくは0.0001〜2重量%が適当である。
The effect of the compound of this extract varies depending on the dosage form to be compounded, the purpose of the product, the presence or absence of coexisting agents, the origin and type of rhubarb, etc. 0.00001 to 5% by weight,
It is preferably 0.0001 to 2% by weight.

【0009】[0009]

【実施例】以下に実施例により、本発明を更に具体的に
説明するが、本発明は、この実施例によって何ら限定さ
れるものではない。先づ実施例で使用した溶媒抽出物の
製造方法について述べる。
The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to these examples. First, the method for producing the solvent extract used in the examples will be described.

【0010】(製造例1)大黄(Rheum officinale Bai
llon)50gに50%メタノール500mlを加えて、3
時間還流冷却管をつけて加熱した。冷却後、濾過した
後、凍結乾燥した。
(Production Example 1) Rheum officinale Bai
llon) 50g methanol 50ml methanol 500ml 3
It was heated with a reflux condenser for an hour. After cooling, filtration and freeze-drying were performed.

【0011】(製造例2)大黄(Rheum officinale Bai
llon)50gにメタノール500mlを加えて、3時間還
流冷却管をつけて加熱した。冷却後、濾過した後、凍結
乾燥した。
(Production Example 2) Rheum officinale Bai
Llon) (50 g) was added with methanol (500 ml), and the mixture was heated for 3 hours with a reflux condenser attached. After cooling, filtration and freeze-drying were performed.

【0012】(製造例3)大黄(Rheum officinale Bai
llon)50gに精製水500mlを加えて、80℃で3時
間加熱した。冷却後、濾過した後、凍結乾燥した。
(Production Example 3) Rheum officinale Bai
Llon) (50 g) was added with purified water (500 ml) and heated at 80 ° C. for 3 hours. After cooling, filtration and freeze-drying were performed.

【0013】(製造例4)大黄(局方市販品)50gに
50%エタノール500mlを加えて、5日間室温放置し
た。濾過した後、凍結乾燥した。
(Production Example 4) 500 g of 50% ethanol was added to 50 g of Daihaku (commercially available in Japan) and left at room temperature for 5 days. After filtration, it was freeze-dried.

【0014】(製造例5)信州大黄50gに50%エタ
ノール500mlを加えて、5日間室温放置した。濾過し
た後、凍結乾燥した。
(Production Example 5) 50 g of 50% ethanol was added to 50 g of Shinshu Daio and left at room temperature for 5 days. After filtration, it was freeze-dried.

【0015】(製造例6)大黄(錦紋)50gに50%
エタノール500mlを加えて、5日間室温放置した。濾
過した後、凍結乾燥した。
(Production Example 6) 50% in 50 g of Daio (Nishikimon)
After adding 500 ml of ethanol, the mixture was left at room temperature for 5 days. After filtration, it was freeze-dried.

【0016】(実施例1)ローション 重量部 製造例1の抽出物 1.0 精製水 94.0 グリセリン 4.9 パラオキシ安息香酸メチル 0.1(Example 1) Lotion part by weight Extract of Production Example 1 1.0 Purified water 94.0 Glycerin 4.9 Methyl paraoxybenzoate 0.1

【0017】(実施例2)クリーム A 重量部 スクワラン 20.0 ホホバ油 5.0 ミツロウ 5.0 セトステアリルアルコール 2.0 グリセリンモノステアレート 1.0 ソルビタンモノステアレート 2.0 B 重量部 精製水 54.9 ポリオキシエチレン(20E.O.)ソルビタンモノステアレート 2.0 ポリオキシエチレン(60E.O.)硬化ヒマシ油 1.0 グリセリン 5.0 パラオキシ安息香酸メチル 0.1 製造例2の抽出物 2.0 AとBを夫々計量し、70℃まで加温し、BにAを撹拌
しつつ徐々に加えた後、ゆっくり撹拌しつつ30℃まで
冷却した。
(Example 2) Cream A 2 parts by weight Squalane 20.0 Jojoba oil 5.0 Beeswax 5.0 Cetostearyl alcohol 2.0 Glycerin monostearate 1.0 Sorbitan monostearate 2.0 B Parts by weight Purified water 54.9 Polyoxyethylene (20E.O.) sorbitan monostearate 2.0 Polyoxyethylene (60E.O.) hydrogenated castor oil 1.0 glycerin 5.0 methyl paraoxybenzoate 0.1 Extraction of Production Example 2 Material 2.0 A and B were weighed and heated to 70 ° C., A was gradually added to B with stirring and then cooled to 30 ° C. with slow stirring.

【0018】(実施例3)実施例1の製造例1の抽出物
を製造例3の抽出物に置き換えたもの。
Example 3 The extract of Production Example 1 of Example 1 was replaced with the extract of Production Example 3.

【0019】(実施例4)実施例2の製造例2の抽出物
を製造例4の抽出物に置き換えたもの。
Example 4 The extract of Production Example 2 of Example 2 was replaced with the extract of Production Example 4.

【0020】(実施例5)実施例1の製造例1の抽出物
を製造例5の抽出物に置き換えたもの。
Example 5 The extract of Production Example 1 of Example 1 was replaced with the extract of Production Example 5.

【0021】(実施例6)実施例2の製造例2の抽出物
を製造例6の抽出物に置き換えたもの。
Example 6 The extract of Production Example 2 of Example 2 was replaced with the extract of Production Example 6.

【0022】(比較例1)実施例1の製造例1の抽出物
を精製水に置き換えたもの。
Comparative Example 1 The extract of Production Example 1 of Example 1 was replaced with purified water.

【0023】(比較例2)実施例2の製造例2の抽出物
を精製水に置き換えたもの。
(Comparative Example 2) The extract of Production Example 2 of Example 2 was replaced with purified water.

【0024】(チロシナーゼ活性阻害率の測定) (試験方法)マックルバルン(Mcllvaln)緩衝液0.9
ml、1.66mMチロシン(Tyrosine)溶液1.0ml、前
記試料(乾燥物)をエタノールに溶解させ、水を加えた
後、エバポレータでエタノールを除去した後、0.1重
量(乾燥物)/容量%の規定濃度に調整した試料液1.
0mlをスクリューバイアルにとり、37℃恒温水槽中で
5分以上加温した。チロシナーゼ溶液(Sigma 社製、マ
ッシュルーム由来、914ユニット/ml)0.1mlを加
え、37℃恒温水槽中で保温し、10分後に475nmで
吸光度を測定した。対照として、前記試料液のかわりに
純水を加え同様に測定した。
(Measurement of Tyrosinase Activity Inhibition Rate) (Test Method) Mcllvaln Buffer Solution 0.9
ml, 1.66 mM Tyrosine solution 1.0 ml, the sample (dry product) was dissolved in ethanol, water was added, and ethanol was removed by an evaporator, and then 0.1 weight (dry product) / volume Sample liquid adjusted to a specified concentration of 1.
0 ml was placed in a screw vial and heated in a 37 ° C. constant temperature water bath for 5 minutes or more. 0.1 ml of tyrosinase solution (manufactured by Sigma, mushroom-derived, 914 units / ml) was added, and the mixture was kept warm in a constant temperature water bath at 37 ° C., and after 10 minutes, the absorbance was measured at 475 nm. As a control, pure water was added instead of the sample solution, and the same measurement was performed.

【0025】(計算式) A:試料検体の吸光度 B:対照の吸光度 P:試料検体の着色による吸光度(3倍希釈) チロシナーゼ活性阻害率(%)={B−(A−P)}/
B×100 その測定結果を表1に示す。
(Calculation formula) A: Absorbance of sample specimen B: Absorbance of control P: Absorbance due to coloring of sample specimen (3-fold dilution) Tyrosinase activity inhibition rate (%) = {B- (AP)} /
B × 100 The measurement results are shown in Table 1.

【0026】[0026]

【表1】 [Table 1]

【0027】(活性酸素生成阻害試験)大気中には21
%の酸素があり、これがないと生物(嫌気性のものを除
く)は存在しえない。しかし、酸素は紫外線や酵素等の
影響を受けて活性酸素になる。活性酸素は脂肪酸を酸化
し過酸化物を生成させる。生体の生体膜のリン脂質も酸
化させ、障害を与える。且つ、生成した過酸化物と活性
酸素はDNAに損傷を与え、老化を促進すると言われて
いる。また、チロシンからメラニンを作る機構にも影響
を与え、皮膚の黒化にも関与している。この活性酸素を
抑制することは皮膚にとって重要な、言い換えれば化粧
料に求められる重要な要素の一つである。
(Active oxygen production inhibition test) 21 in the atmosphere
There is% oxygen, without which no organisms (other than anaerobics) can exist. However, oxygen becomes active oxygen under the influence of ultraviolet rays and enzymes. Active oxygen oxidizes fatty acids and produces peroxides. It also oxidizes and damages the phospholipids of biological membranes in the body. Moreover, it is said that the generated peroxide and active oxygen damage DNA and accelerate aging. It also influences the mechanism of melanin production from tyrosine and is involved in skin darkening. Suppressing this active oxygen is one of the important factors required for the skin, in other words, for cosmetics.

【0028】(測定法)活性酸素を抑制する効果を測定
する方法は各種あるが、本発明では以下の方法を利用し
て測定した。 pH7.8 50mM リン酸カリウム緩衝液(1,3mM DETAPAC含有)133 ml 40unit/ml カタラーゼの上記のリン酸カリウム緩衝液 5ml 2mM ニトロブルーテトラゾリウムの上記のリン酸カリウム緩衝液 5ml 1.8mM キサンチンの上記のリン酸カリウム緩衝液 17ml 160ml 上記の試薬の混合物を2.4ml、検体(前記試料液)を
0.3ml加えてキサンチンオキシナーゼ(予め検体を水
とし、実験するとき、吸光度が1分当り0.02前後上
昇するように上記のリン酸カリウム緩衝液で調整してお
く)液を0.3ml加えて直ちに吸光度(560nm)を測
定する。(測定は2分位し、直線性を確認する) 計算式 阻害率=(A−B)/A×100 A:検体を水としたときの1分当りの吸光度の変化 B:検体の1分当りの吸光度の変化
(Measurement method) Measuring the effect of suppressing active oxygen
There are various methods to do this, but in the present invention, the following method is used.
Was measured. pH 7.8 50 mM potassium phosphate buffer (containing 1,3 mM DETAPAC) 133 ml 40 unit / ml Catalase above potassium phosphate buffer 5 ml 2 mM nitroblue tetrazolium above potassium phosphate buffer 5 ml17 ml of the above potassium phosphate buffer solution containing 1.8 mM xanthine  160 ml 2.4 ml of the mixture of the above reagents and the sample (the above sample solution)
Add 0.3 ml of xanthine oxynase
When performing an experiment, the absorbance is about 0.02 per minute or more
Adjust with the above potassium phosphate buffer so that it rises.
(3) Add 0.3 ml of the solution and immediately measure the absorbance (560 nm).
Set. (Measurement is performed for 2 minutes to confirm linearity) Calculation formula Inhibition rate = (A−B) / A × 100 A: Change in absorbance per minute when the sample is water B: 1 minute of sample Change in absorbance per hit

【0029】その結果を表2に示す。The results are shown in Table 2.

【表2】 [Table 2]

【0030】(使用テスト)女性15名を3班に分け、
各5名について、顔面を左右に分け、一方を実施例、も
う一方を比較例として下記の試料を表3のように、毎日
1回以上使用してもらって、3月後、アンケートした。
(Use test) 15 women are divided into 3 groups,
For each of 5 persons, the face was divided into left and right sides, one of which was used as an example and the other was used as a comparative example, and the following samples were used once or more daily as shown in Table 3, and a questionnaire was conducted after 3 months.

【表3】 [Table 3]

【0031】判定基準は以下のようでアンケートの結果
をまとめたのが表4である。 実施例の方が非常によい 3 実施例の方がかなりよい 2 実施例の方がややよい 1 差がない 0 比較例の方がややよい −1 比較例の方がかなりよい −2 比較例の方が非常によい −3
The judgment criteria are as follows, and the results of the questionnaire are summarized in Table 4. Example is very good 3 Example is considerably good 2 Example is slightly good 1 No difference 0 Comparative example is slightly good -1 Comparative example is quite good -2 Comparative example Is very good -3

【0032】[0032]

【表4】 [Table 4]

【0033】[0033]

【発明の効果】実施例によって明らかなように、大黄の
抽出物は美白、肌荒防止、小皺防止に役に立ち、しかも
安全性については永年漢方薬として内用され、保証され
ており、化粧品の原料として最適なものである。
[Effects of the Invention] As is clear from the examples, the extract of Rhubarb is useful for whitening, preventing rough skin, and preventing wrinkles, and its safety has been used and guaranteed as a herbal medicine for many years. It is the best one.

─────────────────────────────────────────────────────
─────────────────────────────────────────────────── ───

【手続補正書】[Procedure amendment]

【提出日】平成3年12月10日[Submission date] December 10, 1991

【手続補正1】[Procedure Amendment 1]

【補正対象書類名】明細書[Document name to be amended] Statement

【補正対象項目名】0026[Correction target item name] 0026

【補正方法】変更[Correction method] Change

【補正内容】[Correction content]

【0026】[0026]

【表1】 [Table 1]

【手続補正2】[Procedure Amendment 2]

【補正対象書類名】明細書[Document name to be amended] Statement

【補正対象項目名】0029[Name of item to be corrected] 0029

【補正方法】変更[Correction method] Change

【補正内容】[Correction content]

【0029】その結果を表2に示す。The results are shown in Table 2.

【表2】 [Table 2]

───────────────────────────────────────────────────── フロントページの続き (72)発明者 服部 征雄 富山県富山市五福末広町2556−4 2− 203 (72)発明者 下村 健次 三重県伊勢市船江3−16−32 (72)発明者 中村 雅美 三重県鳥羽市池上町6−32 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Masao Hattori 2556-4-22-203 Gofuku Suehiro-cho, Toyama City, Toyama Prefecture (72) Inventor Kenji Shimomura 3-16-32 Funae, Ise City, Mie Prefecture (72) Inventor Nakamura Masami 6-32 Ikegami Town, Toba City, Mie Prefecture

Claims (1)

【特許請求の範囲】[Claims] 【請求項1】 大黄の溶媒抽出物を含む化粧品。1. A cosmetic product containing a solvent extract of Rhubarb.
JP3265388A 1991-09-18 1991-09-18 Cosmetic Pending JPH0597653A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP3265388A JPH0597653A (en) 1991-09-18 1991-09-18 Cosmetic

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3265388A JPH0597653A (en) 1991-09-18 1991-09-18 Cosmetic

Publications (1)

Publication Number Publication Date
JPH0597653A true JPH0597653A (en) 1993-04-20

Family

ID=17416486

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3265388A Pending JPH0597653A (en) 1991-09-18 1991-09-18 Cosmetic

Country Status (1)

Country Link
JP (1) JPH0597653A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06345636A (en) * 1993-06-08 1994-12-20 Nonogawa Shoji Kk Cosmetic
KR20010018655A (en) * 1999-08-20 2001-03-15 유상옥 A cosmetic composition containing Rheum coreanum extracts
JP2001122765A (en) * 2000-09-28 2001-05-08 Naris Cosmetics Co Ltd Active oxygen scavenger and cosmetic
WO2011019239A2 (en) * 2009-08-14 2011-02-17 (주)아모레퍼시픽 Composition containing a natural extract
JP2014074074A (en) * 2008-08-18 2014-04-24 Zhongshan Hospital of Fudan University Ceramide production accelerant
CN108434035A (en) * 2018-05-21 2018-08-24 杭州千岛湖蓝色天使实业有限公司 It is a kind of to moisten smooth active essence cream and preparation method thereof

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06345636A (en) * 1993-06-08 1994-12-20 Nonogawa Shoji Kk Cosmetic
KR20010018655A (en) * 1999-08-20 2001-03-15 유상옥 A cosmetic composition containing Rheum coreanum extracts
JP2001122765A (en) * 2000-09-28 2001-05-08 Naris Cosmetics Co Ltd Active oxygen scavenger and cosmetic
JP2014074074A (en) * 2008-08-18 2014-04-24 Zhongshan Hospital of Fudan University Ceramide production accelerant
US10610561B2 (en) 2008-08-18 2020-04-07 Zhongshan Hospital of Fudan University Ceramide production-accelerating agent
WO2011019239A2 (en) * 2009-08-14 2011-02-17 (주)아모레퍼시픽 Composition containing a natural extract
WO2011019239A3 (en) * 2009-08-14 2011-06-03 (주)아모레퍼시픽 Composition containing a natural extract
US9603789B2 (en) 2009-08-14 2017-03-28 Amorepacific Corporation Composition containing a natural extract
CN108434035A (en) * 2018-05-21 2018-08-24 杭州千岛湖蓝色天使实业有限公司 It is a kind of to moisten smooth active essence cream and preparation method thereof

Similar Documents

Publication Publication Date Title
JP2003194809A (en) Drug treating skin itching, skin roughness, sensitive skin, and for skin whitening by suppressing production- releasing of stem cell factor
JPH1025238A (en) Preparation for external use for skin
KR20140083459A (en) Skin external composition having remarkable moisturizing effect
JPH0597653A (en) Cosmetic
JPH05163135A (en) Beautifying cosmetic composition
JPH05306214A (en) Cosmetic
JP2600036B2 (en) Cosmetics
EP2845624B1 (en) Mucoadhesive devil's claw extracts (harpagophytum procumbens) and uses thereof
JP3235922B2 (en) Cosmetics
JPH05124952A (en) Cosmetic
JPH0892053A (en) External preparation for skin
JP3235919B2 (en) Cosmetics
JPH05320063A (en) Active oxygen-inhibiting agent
JP3545057B2 (en) Cosmetics
JP3496967B2 (en) Antiplasmin agent
JPH0597649A (en) Cosmetic
JPH05306213A (en) Cosmetic
JP3113009B2 (en) Whitening cosmetics
JP2774882B2 (en) Whitening and anti-aging cosmetics
JPH05320035A (en) Cosmetic
JP2778855B2 (en) Cosmetics
JP3792745B2 (en) Tyrosinase inhibitor
JP3547155B2 (en) Active oxygen suppressant
JPH05155735A (en) Skin-beautifying cosmetic
JP3100194B2 (en) Whitening cosmetics

Legal Events

Date Code Title Description
LAPS Cancellation because of no payment of annual fees