JPH0581588B2 - - Google Patents

Info

Publication number
JPH0581588B2
JPH0581588B2 JP63108909A JP10890988A JPH0581588B2 JP H0581588 B2 JPH0581588 B2 JP H0581588B2 JP 63108909 A JP63108909 A JP 63108909A JP 10890988 A JP10890988 A JP 10890988A JP H0581588 B2 JPH0581588 B2 JP H0581588B2
Authority
JP
Japan
Prior art keywords
group
formula
compound
dihydropyridine
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP63108909A
Other languages
English (en)
Japanese (ja)
Other versions
JPS63297365A (ja
Inventor
Fureizaa Kyanpuberu Shimon
Jon Hanfurii Maikeru
Sutoobii Aran
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of JPS63297365A publication Critical patent/JPS63297365A/ja
Publication of JPH0581588B2 publication Critical patent/JPH0581588B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Dental Preparations (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP63108909A 1987-05-02 1988-04-30 ジヒドロピリジン類 Granted JPS63297365A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8710493 1987-05-02
GB878710493A GB8710493D0 (en) 1987-05-02 1987-05-02 Dihydropyridines

Publications (2)

Publication Number Publication Date
JPS63297365A JPS63297365A (ja) 1988-12-05
JPH0581588B2 true JPH0581588B2 (enExample) 1993-11-15

Family

ID=10616773

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63108909A Granted JPS63297365A (ja) 1987-05-02 1988-04-30 ジヒドロピリジン類

Country Status (13)

Country Link
US (1) US4806557A (enExample)
EP (1) EP0290211B1 (enExample)
JP (1) JPS63297365A (enExample)
AT (1) ATE66915T1 (enExample)
CA (1) CA1326672C (enExample)
DE (1) DE3864573D1 (enExample)
DK (1) DK172094B1 (enExample)
ES (1) ES2031595T3 (enExample)
FI (1) FI90415C (enExample)
GB (1) GB8710493D0 (enExample)
GR (1) GR3002767T3 (enExample)
IE (1) IE60055B1 (enExample)
PT (1) PT87361B (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5270323A (en) * 1990-05-31 1993-12-14 Pfizer Inc. Method of treating impotence
US6057344A (en) 1991-11-26 2000-05-02 Sepracor, Inc. Methods for treating hypertension, and angina using optically pure (-) amlodipine
PT1196414E (pt) * 1999-06-25 2003-12-31 Vertex Pharma Pro-farmacos de inibidores carbamato de impdh
GB0008332D0 (en) * 2000-04-04 2000-05-24 Pfizer Ltd Treament
US6521647B2 (en) 2000-04-04 2003-02-18 Pfizer Inc. Treatment of renal disorders
AT5874U1 (de) 2000-12-29 2003-01-27 Bioorg Bv Pharmazeutische zubereitungen enthaltend amlodipinmaleat
EP1346214A2 (en) 2000-12-29 2003-09-24 Pfizer Limited Reference standards and processes for determining the purity or stability of amlodipine maleate
ES2254495T4 (es) 2000-12-29 2007-06-16 Pfizer Limited Hemimaleato de amlodipina.
US6653481B2 (en) 2000-12-29 2003-11-25 Synthon Bv Process for making amlodipine
MXPA03005882A (es) 2000-12-29 2005-04-19 Pfizer Ltd Derivado amida de amlodipina.
CA2433181C (en) 2000-12-29 2005-11-22 Pfizer Limited Amlodipine hemifumarate
SI1309555T1 (sl) 2000-12-29 2005-12-31 Pfizer Ltd Postopek izdelave amlodipin-maleata
US7335380B2 (en) 2000-12-29 2008-02-26 Synthon Ip Inc. Amlodipine free base
EP1309554A1 (en) 2000-12-29 2003-05-14 Synthon Licensing, Ltd. Amide derivative of amlodipine
GB2372036B (en) 2000-12-29 2004-05-19 Bioorg Bv Aspartate derivative of amlodipine
US6699892B2 (en) 2002-06-04 2004-03-02 Yung Shin Pharmaceutical Industrial Co., Ltd. Pharmaceutically acceptable salt of amlodipine and method of preparing the same
KR100462304B1 (ko) * 2002-07-30 2004-12-17 씨제이 주식회사 암로디핀의 유기산염
KR20040011751A (ko) * 2002-07-30 2004-02-11 씨제이 주식회사 암로디핀의 유기산염
KR100496436B1 (ko) * 2002-07-30 2005-06-20 씨제이 주식회사 암로디핀의 유기산염
KR100538641B1 (ko) * 2002-07-30 2005-12-22 씨제이 주식회사 암로디핀의 유기산염
KR100467669B1 (ko) * 2002-08-21 2005-01-24 씨제이 주식회사 암로디핀의 유기산염
BR112012028153A2 (pt) 2010-05-03 2018-08-07 Tsh Biopharm Corporation Ltd composição farmacêutica e método para o tratamento de hipertensão

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1552911A (en) * 1975-07-02 1979-09-19 Fujisawa Pharmaceutical Co 1,4 dihydropyridine derivatives and the preparation thereof
US4447613A (en) * 1979-08-24 1984-05-08 Zoecon Corporation Pyridyl esters and thiolesters of aminoalkanoic acids
CS228917B2 (en) * 1981-03-14 1984-05-14 Pfizer Method of preparing substituted derivatives of 1,4-dihydropyridine
DK161312C (da) * 1982-03-11 1991-12-09 Pfizer Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden
GB8306666D0 (en) * 1983-03-10 1983-04-13 Pfizer Ltd Therapeutic agents
US4568677A (en) * 1983-07-23 1986-02-04 Pfizer Inc. 2-(4-Pyrimidone alkoxyalkyl) dihydropyridine anti-ischaemic and antihypertensive agents

Also Published As

Publication number Publication date
IE881283L (en) 1988-11-02
PT87361B (pt) 1992-08-31
GB8710493D0 (en) 1987-06-03
CA1326672C (en) 1994-02-01
DK172094B1 (da) 1997-10-20
FI90415C (fi) 1994-02-10
IE60055B1 (en) 1994-05-18
ES2031595T3 (es) 1992-12-16
JPS63297365A (ja) 1988-12-05
EP0290211A1 (en) 1988-11-09
GR3002767T3 (en) 1993-01-25
FI882001A7 (fi) 1988-11-03
PT87361A (pt) 1989-05-31
EP0290211B1 (en) 1991-09-04
FI90415B (fi) 1993-10-29
US4806557A (en) 1989-02-21
DK234388A (da) 1989-01-19
ATE66915T1 (de) 1991-09-15
DE3864573D1 (en) 1991-10-10
DK234388D0 (da) 1988-04-28
FI882001A0 (fi) 1988-04-28

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