JPH0567605B2 - - Google Patents
Info
- Publication number
- JPH0567605B2 JPH0567605B2 JP63307068A JP30706888A JPH0567605B2 JP H0567605 B2 JPH0567605 B2 JP H0567605B2 JP 63307068 A JP63307068 A JP 63307068A JP 30706888 A JP30706888 A JP 30706888A JP H0567605 B2 JPH0567605 B2 JP H0567605B2
- Authority
- JP
- Japan
- Prior art keywords
- soluble
- liposomes
- phospholipid
- oil
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000002502 liposome Substances 0.000 claims description 49
- 239000000126 substance Substances 0.000 claims description 43
- 239000002537 cosmetic Substances 0.000 claims description 27
- 239000000203 mixture Substances 0.000 claims description 26
- 230000000975 bioactive effect Effects 0.000 claims description 22
- 150000003904 phospholipids Chemical class 0.000 claims description 22
- 239000007788 liquid Substances 0.000 claims description 19
- 239000000284 extract Substances 0.000 claims description 17
- 238000004519 manufacturing process Methods 0.000 claims description 12
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims description 9
- 239000008344 egg yolk phospholipid Substances 0.000 claims description 8
- 229940068998 egg yolk phospholipid Drugs 0.000 claims description 8
- 239000008347 soybean phospholipid Substances 0.000 claims description 7
- 239000002562 thickening agent Substances 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 6
- 229940092258 rosemary extract Drugs 0.000 claims description 6
- 235000020748 rosemary extract Nutrition 0.000 claims description 6
- 239000001233 rosmarinus officinalis l. extract Substances 0.000 claims description 6
- 239000003205 fragrance Substances 0.000 claims description 5
- 102000016359 Fibronectins Human genes 0.000 claims description 4
- 108010067306 Fibronectins Proteins 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 4
- 229920001285 xanthan gum Polymers 0.000 claims description 4
- 239000000230 xanthan gum Substances 0.000 claims description 4
- 235000010493 xanthan gum Nutrition 0.000 claims description 4
- 229940082509 xanthan gum Drugs 0.000 claims description 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 3
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 3
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 3
- 241001465754 Metazoa Species 0.000 claims description 3
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 3
- 229920002125 Sokalan® Polymers 0.000 claims description 3
- 229920002674 hyaluronan Polymers 0.000 claims description 3
- 229960003160 hyaluronic acid Drugs 0.000 claims description 3
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 3
- 210000002826 placenta Anatomy 0.000 claims description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 3
- 239000011782 vitamin Substances 0.000 claims description 3
- 235000013343 vitamin Nutrition 0.000 claims description 3
- 229940088594 vitamin Drugs 0.000 claims description 3
- 229930003231 vitamin Natural products 0.000 claims description 3
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
- 102000016942 Elastin Human genes 0.000 claims description 2
- 108010014258 Elastin Proteins 0.000 claims description 2
- 229920000161 Locust bean gum Polymers 0.000 claims description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 2
- 210000004556 brain Anatomy 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
- 229920002549 elastin Polymers 0.000 claims description 2
- 239000000711 locust bean gum Substances 0.000 claims description 2
- 235000010420 locust bean gum Nutrition 0.000 claims description 2
- 239000000419 plant extract Substances 0.000 claims description 2
- 230000002992 thymic effect Effects 0.000 claims description 2
- 229920002554 vinyl polymer Polymers 0.000 claims description 2
- 239000002994 raw material Substances 0.000 description 31
- 239000000243 solution Substances 0.000 description 16
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 12
- 239000004615 ingredient Substances 0.000 description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 10
- 238000000034 method Methods 0.000 description 9
- 210000002966 serum Anatomy 0.000 description 9
- 150000002632 lipids Chemical class 0.000 description 7
- 239000004094 surface-active agent Substances 0.000 description 7
- 239000007864 aqueous solution Substances 0.000 description 5
- 235000011187 glycerol Nutrition 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 239000008213 purified water Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 235000010469 Glycine max Nutrition 0.000 description 4
- 230000003796 beauty Effects 0.000 description 4
- 238000000502 dialysis Methods 0.000 description 4
- 239000000839 emulsion Substances 0.000 description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 238000013329 compounding Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 210000004927 skin cell Anatomy 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- FJKROLUGYXJWQN-UHFFFAOYSA-N 4-hydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
- 235000001543 Corylus americana Nutrition 0.000 description 2
- 240000007582 Corylus avellana Species 0.000 description 2
- 235000007466 Corylus avellana Nutrition 0.000 description 2
- 239000000232 Lipid Bilayer Substances 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000005538 encapsulation Methods 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000000693 micelle Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 210000001541 thymus gland Anatomy 0.000 description 2
- JQWAHKMIYCERGA-UHFFFAOYSA-N (2-nonanoyloxy-3-octadeca-9,12-dienoyloxypropoxy)-[2-(trimethylazaniumyl)ethyl]phosphinate Chemical compound CCCCCCCCC(=O)OC(COP([O-])(=O)CC[N+](C)(C)C)COC(=O)CCCCCCCC=CCC=CCCCCC JQWAHKMIYCERGA-UHFFFAOYSA-N 0.000 description 1
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- JRLTTZUODKEYDH-UHFFFAOYSA-N 8-methylquinoline Chemical group C1=CN=C2C(C)=CC=CC2=C1 JRLTTZUODKEYDH-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 1
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 241000208680 Hamamelis mollis Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 235000013709 carrot oil Nutrition 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229940101267 panthenol Drugs 0.000 description 1
- 235000020957 pantothenol Nutrition 0.000 description 1
- 239000011619 pantothenol Substances 0.000 description 1
- -1 paraben (paraben Chemical compound 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000002691 unilamellar liposome Substances 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229940118846 witch hazel Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/14—Liposomes; Vesicles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1019870015266A KR900000848B1 (ko) | 1987-12-30 | 1987-12-30 | 리포좀을 함유한 화장료의 제조방법 |
| KR1987-15266 | 1987-12-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH01197419A JPH01197419A (ja) | 1989-08-09 |
| JPH0567605B2 true JPH0567605B2 (fr) | 1993-09-27 |
Family
ID=19267581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63307068A Granted JPH01197419A (ja) | 1987-12-30 | 1988-12-06 | リポソームを含む化粧料の製造法 |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPH01197419A (fr) |
| KR (1) | KR900000848B1 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4575755B2 (ja) * | 2004-11-22 | 2010-11-04 | 興和株式会社 | 外用液剤 |
| WO2006084353A1 (fr) * | 2005-02-14 | 2006-08-17 | Dpm Therapeutics Corp. | Préparations stabilisées pour administration locale et méthodes d'élaboration desdites préparations |
| KR100861980B1 (ko) * | 2006-09-22 | 2008-10-07 | 한국콜마 주식회사 | 피부유사막을 갖는 비수계 액정상 캡슐기제 조성물 및 이를이용한 화장료 조성물 및 그 제조방법 |
| JP2010180193A (ja) * | 2009-02-09 | 2010-08-19 | Fine Co Ltd | 高品質化粧料 |
| CN113712886A (zh) * | 2021-10-14 | 2021-11-30 | 江苏沂岸花卉股份有限公司 | 金丝皇菊润唇膏及其制备方法 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5441279A (en) * | 1977-08-05 | 1979-04-02 | Battelle Memorial Institute | Manufacture of liposome solution or suspension in aqueous medium |
| JPS57112321A (en) * | 1980-12-29 | 1982-07-13 | Japan Atom Energy Res Inst | Preparation of prolonged release composite |
| JPS5976007A (ja) * | 1982-10-22 | 1984-04-28 | Shiseido Co Ltd | 化粧料 |
| JPS61238712A (ja) * | 1985-04-17 | 1986-10-24 | Shiseido Co Ltd | 皮膚化粧料 |
| JPS62215513A (ja) * | 1985-12-11 | 1987-09-22 | エルヴェエムアッシュ・ルシェルシュ | レチノイドまたはカロチノイドを含む含水脂質ラメラ相からなる薬剤組成物 |
-
1987
- 1987-12-30 KR KR1019870015266A patent/KR900000848B1/ko not_active IP Right Cessation
-
1988
- 1988-12-06 JP JP63307068A patent/JPH01197419A/ja active Granted
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5441279A (en) * | 1977-08-05 | 1979-04-02 | Battelle Memorial Institute | Manufacture of liposome solution or suspension in aqueous medium |
| JPS57112321A (en) * | 1980-12-29 | 1982-07-13 | Japan Atom Energy Res Inst | Preparation of prolonged release composite |
| JPS5976007A (ja) * | 1982-10-22 | 1984-04-28 | Shiseido Co Ltd | 化粧料 |
| JPS61238712A (ja) * | 1985-04-17 | 1986-10-24 | Shiseido Co Ltd | 皮膚化粧料 |
| JPS62215513A (ja) * | 1985-12-11 | 1987-09-22 | エルヴェエムアッシュ・ルシェルシュ | レチノイドまたはカロチノイドを含む含水脂質ラメラ相からなる薬剤組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| KR890009375A (ko) | 1989-08-01 |
| JPH01197419A (ja) | 1989-08-09 |
| KR900000848B1 (ko) | 1990-02-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4508703A (en) | Production of pulverulent mixtures of lipidic and hydrophobic constituents | |
| US4917951A (en) | Lipid vesicles formed of surfactants and steroids | |
| JP4203394B2 (ja) | 高濃度のトリテルペノイドを含有する微小化リポソーム及びその製造方法 | |
| US4217344A (en) | Compositions containing aqueous dispersions of lipid spheres | |
| US5171577A (en) | Process for the preparation of foams which can be used in the cosmetics and pharmaceutical field and foams obtained by this process | |
| US4855090A (en) | Method of producing high aqueous volume multilamellar vesicles | |
| US5021200A (en) | Process for the production of aqueous dispersions of lipid spheres | |
| JP2617346B2 (ja) | 表面活性剤とステロイドから形成される脂質小胞 | |
| US20020187174A1 (en) | Cosmetic or dermatological composition in the form of a dispersion of an oily phase and an aqueos phase, stabilized with cubic gel particles | |
| US5711965A (en) | Alcoholic aqueous gel-type phospholipid composition, its use and topical preparation containing it | |
| EP1153601A1 (fr) | Preparation pour la peau a usage externe | |
| JPH09506593A (ja) | プロピレングリコールステアレート小胞 | |
| JPS6185312A (ja) | 多相リポソーム薬剤送達系 | |
| JPH06507185A (ja) | 脂質小胞の分散物を含有する化粧品学的または製薬学的組成物、その分散物の製造方法並に脂質小胞の分散物 | |
| JPH0413322B2 (fr) | ||
| JPH044284B2 (fr) | ||
| JPH01153608A (ja) | リボソーム含有化粧品及び医薬品上の配合品並びにこのような配合品の利用方法 | |
| EA021149B1 (ru) | Косметические или дерматологические пенные составы, их применение и способы получения | |
| JPH0753661B2 (ja) | プロ―リポソーム組成物及びリポソームの水性分散物を作る方法 | |
| KR100530880B1 (ko) | 나노사이즈의 인지질 리포좀 화장료 및 그 제조방법 | |
| US5405615A (en) | Sucrose distearate lipid vesicles | |
| CA2346016C (fr) | Liposome paucilamellaire a glucosides | |
| JPH0567605B2 (fr) | ||
| JPH05502882A (ja) | アルコール含有水性ゲル状リン脂質組成物、該リン脂質組成物を希釈するリポソーム溶液の製造方法及び該リン脂質組成物を含有する局所適用調製物 | |
| JPH0616536A (ja) | リン脂質／糖脂質の混合物よりなるベシクルを含有する、化粧品用または皮膚科製薬用組成物 |