JPH0559118B2 - - Google Patents

Info

Publication number
JPH0559118B2
JPH0559118B2 JP59083557A JP8355784A JPH0559118B2 JP H0559118 B2 JPH0559118 B2 JP H0559118B2 JP 59083557 A JP59083557 A JP 59083557A JP 8355784 A JP8355784 A JP 8355784A JP H0559118 B2 JPH0559118 B2 JP H0559118B2
Authority
JP
Japan
Prior art keywords
agent
allergic
lower alkyl
treating
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP59083557A
Other languages
English (en)
Japanese (ja)
Other versions
JPS60226882A (ja
Inventor
Norihiko Kitamura
Akimoto Oonishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Zoki Pharmaceutical Co Ltd
Original Assignee
Nippon Zoki Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Zoki Pharmaceutical Co Ltd filed Critical Nippon Zoki Pharmaceutical Co Ltd
Priority to JP59083557A priority Critical patent/JPS60226882A/ja
Priority to AT85810182T priority patent/ATE51231T1/de
Priority to EP85810182A priority patent/EP0163599B1/en
Priority to DE8585810182T priority patent/DE3576690D1/de
Publication of JPS60226882A publication Critical patent/JPS60226882A/ja
Priority to US07/277,447 priority patent/US4886807A/en
Publication of JPH0559118B2 publication Critical patent/JPH0559118B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP59083557A 1984-04-24 1984-04-24 新規ピリミドピリミジン誘導体 Granted JPS60226882A (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP59083557A JPS60226882A (ja) 1984-04-24 1984-04-24 新規ピリミドピリミジン誘導体
AT85810182T ATE51231T1 (de) 1984-04-24 1985-04-24 Pyrimidopyrimidinderivate, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische zubereitungen und ihre verwendung als antiallergische mittel.
EP85810182A EP0163599B1 (en) 1984-04-24 1985-04-24 Pyrimidopyrimidine derivatives, processes for producing them, pharmaceutical compositions containing them and their use as anti-allergic agents
DE8585810182T DE3576690D1 (de) 1984-04-24 1985-04-24 Pyrimidopyrimidinderivate, verfahren zu ihrer herstellung, diese enthaltende pharmazeutische zubereitungen und ihre verwendung als anti-allergische mittel.
US07/277,447 US4886807A (en) 1984-04-24 1988-11-29 Novel pyrimidopyrimidine derivative, process for producing it and pharmaceutical composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP59083557A JPS60226882A (ja) 1984-04-24 1984-04-24 新規ピリミドピリミジン誘導体

Publications (2)

Publication Number Publication Date
JPS60226882A JPS60226882A (ja) 1985-11-12
JPH0559118B2 true JPH0559118B2 (en, 2012) 1993-08-30

Family

ID=13805812

Family Applications (1)

Application Number Title Priority Date Filing Date
JP59083557A Granted JPS60226882A (ja) 1984-04-24 1984-04-24 新規ピリミドピリミジン誘導体

Country Status (5)

Country Link
US (1) US4886807A (en, 2012)
EP (1) EP0163599B1 (en, 2012)
JP (1) JPS60226882A (en, 2012)
AT (1) ATE51231T1 (en, 2012)
DE (1) DE3576690D1 (en, 2012)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8928346D0 (en) * 1989-12-15 1990-02-21 Smith Kline French Lab Chemical compounds
TW517055B (en) * 1997-07-02 2003-01-11 Smithkline Beecham Corp Novel substituted imidazole compounds
AU8389498A (en) * 1997-07-11 1999-02-08 Eli Lilly And Company Combinatorial process for preparing fused substituted pyrimidine libraries
JP2001526230A (ja) 1997-12-19 2001-12-18 スミスクライン・ビーチャム・コーポレイション ヘテロアリール置換イミダゾール化合物、その医薬組成物および使用
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
EP1080092B1 (en) 1998-05-26 2008-07-23 Warner-Lambert Company LLC Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation
US20040044012A1 (en) * 1998-05-26 2004-03-04 Dobrusin Ellen Myra Bicyclic pyrimidines and bicyclic 3,4-dihydropyrimidines as inhibitors of cellular proliferation
ES2221426T3 (es) 1998-08-20 2004-12-16 Smithkline Beecham Corporation Nuevos compuestos de triazol sustituidos.
JP2000119272A (ja) 1998-10-15 2000-04-25 Nippon Zoki Pharmaceut Co Ltd 新規７−アミノピリド〔２，３−ｄ〕ピリミジン誘導体
DE69914357T2 (de) * 1998-11-04 2004-11-11 Smithkline Beecham Corp. Pyridin-4-yl oder pyrimidin-4-yl substituierte pyrazine
JP2003528043A (ja) 1999-11-23 2003-09-24 スミスクライン・ビーチャム・コーポレイション ＣＳＢＰ／ｐ３８キナーゼ阻害剤としての３，４‐ジヒドロ−（１Ｈ）キナゾリン−２−オン化合物
EP1235814B1 (en) 1999-11-23 2004-11-03 Smithkline Beecham Corporation 3,4-DIHYDRO-(1H)QUINAZOLIN-2-ONE COMPOUNDS AS CSBP/p38 KINASE INHIBITORS
AU1783201A (en) 1999-11-23 2001-06-04 Smithkline Beecham Corporation 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors
US6759410B1 (en) 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
MY141144A (en) * 2000-03-02 2010-03-15 Smithkline Beecham Corp 1, 5-disubstituted-3,4-dihydro-1h-pyrimido 4,5-dipyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
US7235551B2 (en) * 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
TWI243055B (en) 2000-04-13 2005-11-11 Nippon Zoki Pharmaceutical Co Pharmaceutical composition for use in treatment of dermatitis
CN1847229B (zh) * 2000-10-23 2011-05-04 史密丝克莱恩比彻姆公司 2，4，8-三取代-8H-吡啶并[2，3-d]嘧啶-7-酮化合物
US7629350B2 (en) * 2002-04-19 2009-12-08 Smithkline Beecham Corporation Compounds
PA8577501A1 (es) * 2002-07-25 2004-02-07 Warner Lambert Co Inhibidores de quinasas
US7084270B2 (en) * 2002-08-14 2006-08-01 Hoffman-La Roche Inc. Pyrimido compounds having antiproliferative activity
US7129351B2 (en) * 2002-11-04 2006-10-31 Hoffmann-La Roche Inc. Pyrimido compounds having antiproliferative activity
EP1615928A1 (en) * 2003-04-10 2006-01-18 F.Hoffmann-La Roche Ag Pyrimido compounds
CA2554566A1 (en) * 2003-08-05 2005-02-17 Vertex Pharmaceuticals Incorporated Condensed pyramidine compounds as inhibitors of voltage-gated ion channels
SG160438A1 (en) * 2005-03-25 2010-04-29 Glaxo Group Ltd Process for preparing pyrido[2,3-d]pyrimidin-7-one and 3,4-dihydropyrimido[4,5- d]pyrimidin-2(1h)-one derivatives
US20090137550A1 (en) * 2005-03-25 2009-05-28 Glaxo Group Limited Novel Compounds
MY145281A (en) 2005-03-25 2012-01-13 Glaxo Group Ltd Novel compounds
AR053450A1 (es) * 2005-03-25 2007-05-09 Glaxo Group Ltd Derivados de 3,4-dihidro-pirimido(4,5-d)pirimidin-2-(1h)-ona 1,5,7 trisustituidos como inhibidores de la quinasa p38
US8006342B2 (en) 2007-04-12 2011-08-30 Dr. Fresh, Inc. Illuminated flashing toothbrush and method of use
CN102816162B (zh) * 2011-06-10 2016-04-27 中国科学院广州生物医药与健康研究院 嘧啶并嘧啶酮类化合物及其药用组合物和应用
US9044083B2 (en) 2012-08-15 2015-06-02 Children Oral Care, Llc Illuminated multi-light flashing toothbrush and method of use
CN104418860B (zh) * 2013-08-20 2016-09-07 中国科学院广州生物医药与健康研究院 嘧啶并杂环类化合物及其药用组合物和应用
WO2021011778A1 (en) * 2019-07-16 2021-01-21 Arizona Board Of Regents On Behalf Of The University Of Arizona Small molecule inhibitors of ku70/80 and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4832899A (en, 2012) * 1971-08-28 1973-05-02
JPS5826757B2 (ja) * 1975-04-15 1983-06-04 ヒサミツセイヤク カブシキガイシヤ シンキナピリミド（４ ５−ｄ）ピリミジンユウドウタイノ セイゾウホウ
JPS5920675B2 (ja) * 1975-06-05 1984-05-15 久光製薬 （株） 新規なピリミド〔４，５−ｄ〕ピリミジン誘導体の製造法
JPS5920676B2 (ja) * 1975-06-05 1984-05-15 久光製薬 （株） 新規なピリミド〔４，５−ｄ〕ピリミジン誘導体の製造法
JPS5920677B2 (ja) * 1975-07-23 1984-05-15 久光製薬 （株） 新規なピリミド〔４、５−ｄ〕ピリミジンジオン誘導体の製造法

Also Published As

Publication number Publication date
EP0163599A2 (en) 1985-12-04
JPS60226882A (ja) 1985-11-12
US4886807A (en) 1989-12-12
ATE51231T1 (de) 1990-04-15
EP0163599A3 (en) 1987-02-25
EP0163599B1 (en) 1990-03-21
DE3576690D1 (de) 1990-04-26

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