JPH05502456A - 放射線診断用および腫瘍治療のための並びに放射線診断用剤および腫瘍治療剤の製造のための放射性金属イオンと全―シス―１，３，５―トリアミノ―２，４，６―シクロヘキサントリオールおよびその誘導体との錯体の使用 - Google Patents

放射線診断用および腫瘍治療のための並びに放射線診断用剤および腫瘍治療剤の製造のための放射性金属イオンと全―シス―１，３，５―トリアミノ―２，４，６―シクロヘキサントリオールおよびその誘導体との錯体の使用

Info

Publication number
JPH05502456A
JPH05502456A JP3514779A JP51477991A JPH05502456A JP H05502456 A JPH05502456 A JP H05502456A JP 3514779 A JP3514779 A JP 3514779A JP 51477991 A JP51477991 A JP 51477991A JP H05502456 A JPH05502456 A JP H05502456A
Authority
JP
Japan
Prior art keywords
groups
formulas
alkyl group
general formula
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3514779A
Other languages
English (en)
Japanese (ja)
Inventor
エアニ，イージドール
シユナイダー，ヴアルター
ヘゲチユヴアイラー，ハンス・カスパル
ガイセル，ペーター
Original Assignee
ラボラトーリエン・ハウスマン・アクチエンゲゼルシヤフト
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ラボラトーリエン・ハウスマン・アクチエンゲゼルシヤフト filed Critical ラボラトーリエン・ハウスマン・アクチエンゲゼルシヤフト
Publication of JPH05502456A publication Critical patent/JPH05502456A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP3514779A 1990-09-05 1991-09-05 放射線診断用および腫瘍治療のための並びに放射線診断用剤および腫瘍治療剤の製造のための放射性金属イオンと全―シス―１，３，５―トリアミノ―２，４，６―シクロヘキサントリオールおよびその誘導体との錯体の使用 Pending JPH05502456A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4028139.6 1990-09-05
DE4028139A DE4028139A1 (de) 1990-09-05 1990-09-05 Verwendung der komplexe radioaktiver metallionen mit all-cis-1,3,5-triamino-2,4,6-cyclohexantriol und seinen derivaten fuer roentgendiagnostische zwecke und in der tumortherapie sowie zur herstellung von mitteln fuer roentgendiagnostische zwecke und fuer die tumortherapie

Publications (1)

Publication Number Publication Date
JPH05502456A true JPH05502456A (ja) 1993-04-28

Family

ID=6413642

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3514779A Pending JPH05502456A (ja) 1990-09-05 1991-09-05 放射線診断用および腫瘍治療のための並びに放射線診断用剤および腫瘍治療剤の製造のための放射性金属イオンと全―シス―１，３，５―トリアミノ―２，４，６―シクロヘキサントリオールおよびその誘導体との錯体の使用

Country Status (10)

Country Link
EP (1) EP0504339A1 (de)
JP (1) JPH05502456A (de)
KR (1) KR920702235A (de)
AU (1) AU658148B2 (de)
CA (1) CA2073050A1 (de)
DE (1) DE4028139A1 (de)
MX (1) MX9100967A (de)
PT (1) PT98869A (de)
TW (1) TW197951B (de)
WO (1) WO1992004056A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016519112A (ja) * 2013-04-25 2016-06-30 バイエル・ファルマ・アクティエンゲゼルシャフト Ｘ線画像化のためのビスアザイノシトールハフニウム錯体

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830430A (en) 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
EP2849804A1 (de) * 2012-05-18 2015-03-25 Bayer Pharma Aktiengesellschaft Bis-azainositol-schwermetallkomplexe zur röntgenbildgebung
EP2873670A1 (de) 2013-11-14 2015-05-20 Bayer Pharma Aktiengesellschaft Bis Azainositolzirkoniumkomplexe zur Röntgendiagnostik

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3503614A1 (de) * 1985-02-02 1986-08-07 Laboratorien Hausmann AG, St. Gallen All-cis-1,3,5-triamino-2,4,6-cyclohexantriol-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische praeparate
GB8900719D0 (en) * 1989-01-13 1989-03-08 Nycomed As Compounds
CH679742A5 (de) * 1990-01-09 1992-04-15 Byk Gulden Lomberg Chem Fab

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016519112A (ja) * 2013-04-25 2016-06-30 バイエル・ファルマ・アクティエンゲゼルシャフト Ｘ線画像化のためのビスアザイノシトールハフニウム錯体

Also Published As

Publication number Publication date
AU8436791A (en) 1992-03-30
TW197951B (de) 1993-01-11
EP0504339A1 (de) 1992-09-23
KR920702235A (ko) 1992-09-03
PT98869A (pt) 1992-07-31
MX9100967A (es) 1992-05-04
WO1992004056A1 (de) 1992-03-19
AU658148B2 (en) 1995-04-06
DE4028139A1 (de) 1992-03-12
CA2073050A1 (en) 1992-03-06

Similar Documents

Publication Publication Date Title
JP2537502B2 (ja) １−置換−１，４，７−トリスカルボキシメチル−１，４，７，１０−テトラアザシクロドデカンおよび類縁体
JP3097755B2 (ja) 遷移金属の窒化物錯体の製造方法
US4560548A (en) Bone seeking Tc-99m complexes of phosphonate derivatives of bis(aminoalkyl)piperazine
JPH01132594A (ja) レニウムジオキシ錯体のレニウムおよび放射性同位体のホウ酸アダクト
JPH05502456A (ja) 放射線診断用および腫瘍治療のための並びに放射線診断用剤および腫瘍治療剤の製造のための放射性金属イオンと全―シス―１，３，５―トリアミノ―２，４，６―シクロヘキサントリオールおよびその誘導体との錯体の使用
US6627176B2 (en) Metal complexes for use in medical and therapeutic applications
CA1204766A (en) Cationic technetium complexes useful as radiodiagnostic agents
CN114269724A (zh) 放射性金属络合物的制造方法
JPH04120066A (ja) １０−（２’−ヒドロキシ−３’−ポリオキサアルキル）−１，４，７−トリスカルボキシメチル−１，４，７，１０−テトラアザシクロドデカン
JPH04120065A (ja) １０−（２’−ヒドロキシ−３’−アルコキシ）−１，４，７−トリスカルボキシメチル−１，４，７，１０−テトラアザシクロドデカン
US11690923B2 (en) Multinuclear complexes and their preparation
JPH02304068A (ja) 置換された１，４，７，１０‐テトラアザシクロトリデカン
US4921944A (en) Method of pharmaceutic production
Terova Synthesis, characterization and inertness studies of gallium (III) and indium (III) complexes of dicarboxymethyl pendant-armed cross-bridged cyclam
Davey Synthesis and Characterisation of a Bifunctional Chelator for Gallium-68 Radiopharmaceuticals
JPH05508162A (ja) イソニトリルリガンド含有金属―放射性核種錯化合物
JPS58124797A (ja) 新規１，２−シクロヘキサンジアミン白金錯体
Park et al. Synthesis and characterization of 99mTc‐labelled biologically active molecules using borohydride exchange resin as a reducing agent for the preparation of radiopharmaceuticals
JPS6372694A (ja) 新生物の診断薬の製造方法
Bates Radiosynthesis and Biological Studies with Platinum and Carbon Labelled JM216, an Orally Active Platinum Anti-Tumour Complex
Tsosane Rhenium (1) tricarbonyl schiff base complexes: a mechanistic study
Gniazdowska et al. Synthesis of novel'4+ 1'Tc (III)/Re (III) mixed-ligand complexes with dendritically modified ligands
Boros Acyclic chelates for imaging with radiometals
JPH07509226A (ja) 放射線撮影イメージング剤に有用な六座配位子類
Abhayawardhana Development of New Linking Chemistry with the Fac-{Re I (Co) 3}+ Core for Eventual Applications in Radiopharmaceuticals in Imaging and Therapy