JPH05500503A - 骨特異的タンパク質 - Google Patents

骨特異的タンパク質

Info

Publication number
JPH05500503A
JPH05500503A JP51192890A JP51192890A JPH05500503A JP H05500503 A JPH05500503 A JP H05500503A JP 51192890 A JP51192890 A JP 51192890A JP 51192890 A JP51192890 A JP 51192890A JP H05500503 A JPH05500503 A JP H05500503A
Authority
JP
Japan
Prior art keywords
polypeptide
protein
sequence
thr
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP51192890A
Other languages
English (en)
Japanese (ja)
Inventor
ベンツ，ハン
ネイタン，ランガ
ローゼン，デイビット　エム．
ダッシュ，ジェイムズ　アール．
セイエディン，サエイド　エム．
ピエツ，カール　エイ．
オガワ，ヤスシ
エイチ． アンドリュース，ウィリアム
スティーブンソン，フランク　エイチ．
ヘッジピース，ジョエル
Original Assignee
セルトリックス　ファーマシューティカルズ、インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by セルトリックス　ファーマシューティカルズ、インコーポレイテッド filed Critical セルトリックス　ファーマシューティカルズ、インコーポレイテッド
Publication of JPH05500503A publication Critical patent/JPH05500503A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
JP51192890A 1989-08-21 1990-08-21 骨特異的タンパク質 Pending JPH05500503A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39777989A 1989-08-21 1989-08-21
US397,779 1989-08-21

Publications (1)

Publication Number Publication Date
JPH05500503A true JPH05500503A (ja) 1993-02-04

Family

ID=23572594

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51192890A Pending JPH05500503A (ja) 1989-08-21 1990-08-21 骨特異的タンパク質

Country Status (5)

Country Link
EP (1) EP0489062A4 (fr)
JP (1) JPH05500503A (fr)
AU (1) AU632160B2 (fr)
CA (1) CA2064878A1 (fr)
WO (1) WO1991002744A1 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5459047A (en) * 1986-07-01 1995-10-17 Genetics Institute, Inc. BMP-6 proteins
US5543394A (en) * 1986-07-01 1996-08-06 Genetics Institute, Inc. Bone morphogenetic protein 5(BMP-5) compositions
US5939388A (en) * 1986-07-01 1999-08-17 Rosen; Vicki A. Methods of administering BMP-5 compositions
US5366875A (en) * 1986-07-01 1994-11-22 Genetics Institute, Inc. Methods for producing BMP-7 proteins
US6150328A (en) 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US5187076A (en) * 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US6432919B1 (en) 1986-07-01 2002-08-13 Genetics Institute, Inc. Bone morphogenetic protein-3 and compositions
DE01201546T1 (de) * 1988-04-08 2004-07-08 Stryker Corp., Kalamazoo Osteogene Einrichtungen
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US5670336A (en) * 1988-04-08 1997-09-23 Stryker Corporation Method for recombinant production of osteogenic protein
US5258494A (en) * 1988-04-08 1993-11-02 Stryker Corporation Osteogenic proteins
US5324819A (en) * 1988-04-08 1994-06-28 Stryker Corporation Osteogenic proteins
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
US7378392B1 (en) 1990-05-16 2008-05-27 Genetics Institute, Llc Bone and cartilage inductive proteins
US5688678A (en) * 1990-05-16 1997-11-18 Genetics Institute, Inc. DNA encoding and methods for producing BMP-8 proteins
US5650276A (en) * 1991-03-11 1997-07-22 Creative Biomolecules, Inc. Morphogenic protein screening method
US5707810A (en) * 1991-03-11 1998-01-13 Creative Biomolecules, Inc. Method of diagnosing renal tissue damage or disease
DK0592562T3 (da) * 1991-06-25 1999-08-30 Genetics Inst BMP-9-præparater
US6287816B1 (en) 1991-06-25 2001-09-11 Genetics Institute, Inc. BMP-9 compositions
EP0601129B1 (fr) * 1991-08-30 2000-11-15 Creative Biomolecules, Inc. Procede de triage de proteines morphogeniques
ATE238417T1 (de) * 1991-11-04 2003-05-15 Inst Genetics Llc Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung
US6492508B1 (en) 1996-06-03 2002-12-10 United States Surgical Corp. A Division Of Tyco Healthcare Group Nucleic acids encoding extracellular matrix proteins
US5928940A (en) * 1996-09-24 1999-07-27 Creative Biomolecules, Inc. Morphogen-responsive signal transducer and methods of use thereof
US6034062A (en) * 1997-03-13 2000-03-07 Genetics Institute, Inc. Bone morphogenetic protein (BMP)-9 compositions and their uses

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4455256A (en) * 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
US4789732A (en) * 1980-08-04 1988-12-06 Regents Of The University Of California Bone morphogenetic protein composition
US4294753A (en) * 1980-08-04 1981-10-13 The Regents Of The University Of California Bone morphogenetic protein process
US4434094A (en) * 1983-04-12 1984-02-28 Collagen Corporation Partially purified osteogenic factor and process for preparing same from demineralized bone
CA1229789A (fr) * 1983-06-06 1987-12-01 David Baylink Polypeptides stimulant la croissance du tissu osseaux
US4795804A (en) * 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
US4608199A (en) * 1984-03-20 1986-08-26 Arnold Caplan Bone protein purification process
US4627982A (en) * 1984-07-16 1986-12-09 Collagen Corporation Partially purified bone-inducing factor
ATE128715T1 (de) * 1984-07-16 1995-10-15 Celtrix Pharma Polypeptide induzierende faktoren in knochen und knorpel.
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Factors that soak bone formation
US4816442A (en) * 1986-11-07 1989-03-28 Collagen Corporation Method of inhibiting tumor growth sensitive to CIF-βtreatment
AU3433989A (en) * 1988-04-06 1989-11-03 Celtrix Laboratories, Inc. Bone-inducing protein

Also Published As

Publication number Publication date
CA2064878A1 (fr) 1991-02-22
AU6187090A (en) 1991-04-03
EP0489062A4 (en) 1992-08-12
WO1991002744A1 (fr) 1991-03-07
EP0489062A1 (fr) 1992-06-10
AU632160B2 (en) 1992-12-17

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