EP0489062A4 - Bone-specific protein - Google Patents

Bone-specific protein

Info

Publication number
EP0489062A4
EP0489062A4 EP19900912603 EP90912603A EP0489062A4 EP 0489062 A4 EP0489062 A4 EP 0489062A4 EP 19900912603 EP19900912603 EP 19900912603 EP 90912603 A EP90912603 A EP 90912603A EP 0489062 A4 EP0489062 A4 EP 0489062A4
Authority
EP
European Patent Office
Prior art keywords
leu
asn
ile
lys
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19900912603
Other languages
English (en)
Other versions
EP0489062A1 (fr
Inventor
Hanne Bentz
Ranga Nathan
David M. Rosen
James R. Dasch
Saeid M. Seyedin
Karl A. Piez
Yasushi Ogawa
William H. Andrews
Frank H. Stephenson
Joel Hedgpeth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celtrix Pharmaceuticals Inc
Original Assignee
Celtrix Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celtrix Laboratories Inc filed Critical Celtrix Laboratories Inc
Publication of EP0489062A1 publication Critical patent/EP0489062A1/fr
Publication of EP0489062A4 publication Critical patent/EP0489062A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
EP19900912603 1989-08-21 1990-08-21 Bone-specific protein Withdrawn EP0489062A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39777989A 1989-08-21 1989-08-21
US397779 1989-08-21

Publications (2)

Publication Number Publication Date
EP0489062A1 EP0489062A1 (fr) 1992-06-10
EP0489062A4 true EP0489062A4 (en) 1992-08-12

Family

ID=23572594

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19900912603 Withdrawn EP0489062A4 (en) 1989-08-21 1990-08-21 Bone-specific protein

Country Status (5)

Country Link
EP (1) EP0489062A4 (fr)
JP (1) JPH05500503A (fr)
AU (1) AU632160B2 (fr)
CA (1) CA2064878A1 (fr)
WO (1) WO1991002744A1 (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5459047A (en) * 1986-07-01 1995-10-17 Genetics Institute, Inc. BMP-6 proteins
US5543394A (en) * 1986-07-01 1996-08-06 Genetics Institute, Inc. Bone morphogenetic protein 5(BMP-5) compositions
US5939388A (en) * 1986-07-01 1999-08-17 Rosen; Vicki A. Methods of administering BMP-5 compositions
US5366875A (en) * 1986-07-01 1994-11-22 Genetics Institute, Inc. Methods for producing BMP-7 proteins
US6150328A (en) 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
US5187076A (en) * 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
US6432919B1 (en) 1986-07-01 2002-08-13 Genetics Institute, Inc. Bone morphogenetic protein-3 and compositions
DE01201546T1 (de) * 1988-04-08 2004-07-08 Stryker Corp., Kalamazoo Osteogene Einrichtungen
US6586388B2 (en) 1988-04-08 2003-07-01 Stryker Corporation Method of using recombinant osteogenic protein to repair bone or cartilage defects
US5670336A (en) * 1988-04-08 1997-09-23 Stryker Corporation Method for recombinant production of osteogenic protein
US5258494A (en) * 1988-04-08 1993-11-02 Stryker Corporation Osteogenic proteins
US5324819A (en) * 1988-04-08 1994-06-28 Stryker Corporation Osteogenic proteins
US5284756A (en) * 1988-10-11 1994-02-08 Lynn Grinna Heterodimeric osteogenic factor
US7378392B1 (en) 1990-05-16 2008-05-27 Genetics Institute, Llc Bone and cartilage inductive proteins
US5688678A (en) * 1990-05-16 1997-11-18 Genetics Institute, Inc. DNA encoding and methods for producing BMP-8 proteins
US5650276A (en) * 1991-03-11 1997-07-22 Creative Biomolecules, Inc. Morphogenic protein screening method
US5707810A (en) * 1991-03-11 1998-01-13 Creative Biomolecules, Inc. Method of diagnosing renal tissue damage or disease
DK0592562T3 (da) * 1991-06-25 1999-08-30 Genetics Inst BMP-9-præparater
US6287816B1 (en) 1991-06-25 2001-09-11 Genetics Institute, Inc. BMP-9 compositions
EP0601129B1 (fr) * 1991-08-30 2000-11-15 Creative Biomolecules, Inc. Procede de triage de proteines morphogeniques
ATE238417T1 (de) * 1991-11-04 2003-05-15 Inst Genetics Llc Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung
US6492508B1 (en) 1996-06-03 2002-12-10 United States Surgical Corp. A Division Of Tyco Healthcare Group Nucleic acids encoding extracellular matrix proteins
US5928940A (en) * 1996-09-24 1999-07-27 Creative Biomolecules, Inc. Morphogen-responsive signal transducer and methods of use thereof
US6034062A (en) * 1997-03-13 2000-03-07 Genetics Institute, Inc. Bone morphogenetic protein (BMP)-9 compositions and their uses

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0336760A2 (fr) * 1988-04-06 1989-10-11 Celtrix Pharmaceuticals, Inc. Protéines induisant la croissance des os

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4455256A (en) * 1981-05-05 1984-06-19 The Regents Of The University Of California Bone morphogenetic protein
US4789732A (en) * 1980-08-04 1988-12-06 Regents Of The University Of California Bone morphogenetic protein composition
US4294753A (en) * 1980-08-04 1981-10-13 The Regents Of The University Of California Bone morphogenetic protein process
US4434094A (en) * 1983-04-12 1984-02-28 Collagen Corporation Partially purified osteogenic factor and process for preparing same from demineralized bone
CA1229789A (fr) * 1983-06-06 1987-12-01 David Baylink Polypeptides stimulant la croissance du tissu osseaux
US4795804A (en) * 1983-08-16 1989-01-03 The Regents Of The University Of California Bone morphogenetic agents
US4608199A (en) * 1984-03-20 1986-08-26 Arnold Caplan Bone protein purification process
US4627982A (en) * 1984-07-16 1986-12-09 Collagen Corporation Partially purified bone-inducing factor
ATE128715T1 (de) * 1984-07-16 1995-10-15 Celtrix Pharma Polypeptide induzierende faktoren in knochen und knorpel.
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Factors that soak bone formation
US4816442A (en) * 1986-11-07 1989-03-28 Collagen Corporation Method of inhibiting tumor growth sensitive to CIF-βtreatment

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0336760A2 (fr) * 1988-04-06 1989-10-11 Celtrix Pharmaceuticals, Inc. Protéines induisant la croissance des os

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DNA AND CELL BIOLOGY vol. 9, no. 5, June 1990, pages 303 - 309; LINDA MADISEN ET AL.: 'Molecular Cloning of a Novel Bone-Forming Compound: Osteoinductive Factor' *
JOURNAL OF BIOLOGICAL CHEMISTRY. vol. 265, no. 9, 25 March 1990, BALTIMORE US pages 5024 - 5029; HANNE BENTZ ET AL.: 'Amino Acid Sequence of Bovine Osteoinductive Factor' *
See also references of WO9102744A1 *

Also Published As

Publication number Publication date
CA2064878A1 (fr) 1991-02-22
AU6187090A (en) 1991-04-03
WO1991002744A1 (fr) 1991-03-07
EP0489062A1 (fr) 1992-06-10
JPH05500503A (ja) 1993-02-04
AU632160B2 (en) 1992-12-17

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 19920220

AK Designated contracting states

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Designated state(s): AT BE CH DE DK ES FR GB IT LI LU NL SE

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: CELTRIX PHARMACEUTICALS, INC.

A4 Supplementary search report drawn up and despatched

Effective date: 19920622

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18D Application deemed to be withdrawn

Effective date: 19941105