JPH05286971A - β−ラクタムのエステル開裂方法 - Google Patents

β−ラクタムのエステル開裂方法

Info

Publication number
JPH05286971A
JPH05286971A JP5024157A JP2415793A JPH05286971A JP H05286971 A JPH05286971 A JP H05286971A JP 5024157 A JP5024157 A JP 5024157A JP 2415793 A JP2415793 A JP 2415793A JP H05286971 A JPH05286971 A JP H05286971A
Authority
JP
Japan
Prior art keywords
alkyl
group
substituted
phenyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP5024157A
Other languages
English (en)
Japanese (ja)
Inventor
Jack W Fisher
ジャック・ウェイン・フィッシャー
Kristina Lynn Thomas
クリスティナ・リン・トーマス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JPH05286971A publication Critical patent/JPH05286971A/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/02—Preparation
    • C07D463/06—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP5024157A 1992-02-18 1993-02-12 β−ラクタムのエステル開裂方法 Withdrawn JPH05286971A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/836,640 US5302711A (en) 1992-02-18 1992-02-18 Ester cleavage process for use with β-lactams
US836640 2001-04-18

Publications (1)

Publication Number Publication Date
JPH05286971A true JPH05286971A (ja) 1993-11-02

Family

ID=25272395

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5024157A Withdrawn JPH05286971A (ja) 1992-02-18 1993-02-12 β−ラクタムのエステル開裂方法

Country Status (10)

Country Link
US (1) US5302711A (enExample)
EP (1) EP0557035A3 (enExample)
JP (1) JPH05286971A (enExample)
KR (1) KR930017907A (enExample)
BR (1) BR9300542A (enExample)
CA (1) CA2089540A1 (enExample)
HU (1) HUT64351A (enExample)
IL (1) IL104699A0 (enExample)
MX (1) MX9300761A (enExample)
TW (1) TW232694B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2379650C (en) 1999-07-30 2008-09-02 Eisai Co., Ltd. Process for producing a basic antibiotic inorganic acid salt, and oxalate intermediate
CN103588790A (zh) * 2013-11-29 2014-02-19 中国科学院长春应用化学研究所 7-氨基-3-氯-3-头孢-4-羧酸-对硝基苄基酯的制备方法
CN106866704B (zh) * 2017-02-08 2019-06-14 河北科技大学 催化氢化脱除对硝基苄酯以制备7-acca的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1546757A (en) * 1975-04-10 1979-05-31 Lilly Industries Ltd Crystalline cephalosporin salts
JPS52106891A (en) * 1976-03-03 1977-09-07 Shionogi & Co Ltd Removal of carboxyl protecting group
DE2725519A1 (de) * 1977-06-06 1978-12-21 Shionogi & Co Verfahren zur herstellung freier carbonsaeuren durch esterspaltung
IL72412A (en) * 1983-07-22 1988-05-31 Lilly Co Eli Deesterification of beta-lactam antibiotic esters
EP0263901A1 (en) * 1986-10-08 1988-04-20 The Upjohn Company Conversion of cephalosporin hydrohalide salt to alkali metal salt
WO1987001117A2 (en) * 1985-08-12 1987-02-26 The Upjohn Company Conversion of cephalosporin hydrohalide salt to alkali metal salt
ATE171705T1 (de) * 1989-03-30 1998-10-15 Pfizer Cephalosporine und ihre homologen, verfahren zu ihrer herstellung und pharmazeutische präparate
US5043439A (en) * 1990-03-08 1991-08-27 Bristol-Myers Squibb Company Process for production of cephalosporins
US5095107A (en) * 1990-11-05 1992-03-10 Eli Lilly And Company Process for cleavage of esters during the production of cephalosporins

Also Published As

Publication number Publication date
CA2089540A1 (en) 1993-08-19
HU9300384D0 (en) 1993-04-28
EP0557035A2 (en) 1993-08-25
KR930017907A (ko) 1993-09-20
HUT64351A (en) 1993-12-28
IL104699A0 (en) 1993-06-10
BR9300542A (pt) 1993-08-24
TW232694B (enExample) 1994-10-21
US5302711A (en) 1994-04-12
MX9300761A (es) 1993-09-01
EP0557035A3 (en) 1993-12-01

Similar Documents

Publication Publication Date Title
JP5793766B2 (ja) 抗菌剤として有用なｎ−結合型ヒドロキサム酸誘導体
JP6847458B2 (ja) 抗真菌化合物のプロセス
US5883102A (en) Pharmaceutically active compounds
KR100947253B1 (ko) 신규의 벤조페논유도체 또는 그 염
EP2922832B1 (en) Glutaminase inhibitors and methods of use
JP2021503438A (ja) Ｐａｄ阻害剤としての複素環式化合物
SE461913B (sv) Nya beta-laktamasinhibitor-foereningar vilka aer mellanprodukter vid frammstaellning av antibiotiskt verksamma beta-laktamasfoereningar
AU2013347771A1 (en) Compounds and their methods of use
JP2021535207A (ja) 甲状腺ホルモン受容体ベータアゴニスト化合物
JPS61254589A (ja) ７−置換二環系ピラゾリジノン類
BR112013022536B1 (pt) Derivados flúor-piridinona, suas composições farmacêuticas e usos como agentes antibacterianos
JPS6248672A (ja) チアゾリジンカルボン酸誘導体
FR2514004A1 (fr) Antibiotiques de dioximino-cephalosporines
IE55839B1 (en) Azetidine compounds
DE2063268C2 (de) Verfahren zur Acylierung von 6-Aminopenicillansäure oder einer 7-Aminocephalosporansäure
JP7826572B2 (ja) 複素環式ｓｉｋ阻害薬
JPH05286971A (ja) β−ラクタムのエステル開裂方法
US5162524A (en) Processes for making cephems from allenylazetidinone derivatives
PL94780B1 (pl) Sposob wytwarzania cefaleksyny
US4101656A (en) 7β-Acylamino-3-(alkanesulfonamidoalkyl substituted tetrazolylthiomethyl) cephalosporins, antibacterial compositions containing them and methods of treating bacterial infections with them
EP0243924B1 (en) 2-oxo-1-(substituted phosphorous)azetidines
US5266691A (en) Processes for making cephems from allenylazetidinone derivatives
JP2003533444A (ja) ６−ｏ−プロパルギルエリスロマイシン誘導体の調製法
US4351766A (en) Production of penicillins
CA2000272A1 (en) 3-aryloxymethyl-cephalosporin derivatives, their preparation and their medical use

Legal Events

Date Code Title Description
A300 Application deemed to be withdrawn because no request for examination was validly filed

Free format text: JAPANESE INTERMEDIATE CODE: A300

Effective date: 20000509